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14 results on '"Zhai, Jiadai"'

7. Synthesis and biological activities evaluation of sanjuanolide and its analogues

Author

Zhai Jiadai, Rui Wang, Kong Ling, Rui Zhao, Li Yuanyuan, Zhiwei Chen, Feng Sang, Hongkuan Deng, Fu Lin, and Hongliang Liu

Subjects
Biological Products, Natural product, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biological activity, Antineoplastic Agents, Phytogenic, Biochemistry, Combinatorial chemistry, Structure-Activity Relationship, chemistry.chemical_compound, Chalcones, Aldol reaction, Cell Line, Tumor, Drug Discovery, Humans, Molecular Medicine, Drug Screening Assays, Antitumor, Cancer cell lines, Molecular Biology, Cell Proliferation
Abstract

Sanjuanolide, psorachalcone A and its seven new analogues were synthesized via a combinatorial strategy by aldol reaction. In order to investigate the effect between electron density in π-conjugated systems and biological activities, several electron-withdrawing and electron-donating groups were introduced at C-4 and the phenolic hydroxyl groups of sanjuanolide. The two natural products and its seven new analogues were investigated for their inhibitory effects against five cancer cell lines. Moreover, the hydroxyisoprenyl group may be important to maintain the biological activities of sanjuanolide.

Published
2019

11. Synthesis and antibacterial activity of four natural chalcones and their derivatives

Author

Shuxin Zhang, Sun Bingxia, Zhiwei Chen, Li Yuanyuan, Hongliang Liu, Feng Sang, Wenhai Xie, Zhai Jiadai, Fu Lin, Jing Zhang, and Hongkuan Deng

Subjects
Gram-negative bacteria, biology, Chemistry, Stereochemistry, Gram-positive bacteria, Organic Chemistry, Biological activity, Bacillus subtilis, medicine.disease_cause, biology.organism_classification, Biochemistry, Staphylococcus aureus, Drug Discovery, medicine, Antibacterial activity, Escherichia coli, Bacteria
Abstract

Four natural chalcones bearing hydroxyisoprenyl or prenyl groups, named Paratocarpin E (2), Xanthoangelol D (3), Angusticornin A (4) and Kanzonol C (5), were prepared by employing the Claisen-Schmidt condensation as the key step. In an attempt to investigate the effect of the hydroxyisoprenyl group on biological activity, two of their derivatives were also prepared for antibacterial activity research. The synthesized compounds were investigated for their expected antibacterial activities against Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus) as well as Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa). Paratocarpin E (2) was found to be the most potent against two Gram positive bacteria while the majority of the remaining compounds showed promising activity as well. However, all of the compounds were inactive against both Gram-negative bacteria.

Published
2019

12. Micheliolide Derivative DMAMCL Inhibits Glioma Cell Growth In Vitro and In Vivo

Author

An, Yinghong, primary, Guo, Wanjun, additional, Li, Linna, additional, Xu, Chengwang, additional, Yang, Dexuan, additional, Wang, Shanshan, additional, Lu, Yaxin, additional, Zhang, Quan, additional, Zhai, Jiadai, additional, Fan, Hongxia, additional, Qiu, Chuanjiang, additional, Qi, Jie, additional, Chen, Yue, additional, and Yuan, Shoujun, additional

Published
2015
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