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In this text, the new crystal forms of geffitinib were explored through evaporation solution crystallization experiment. The formation of salts was confirmed by the single crystal X-ray diffraction, powder X-ray diffraction, thermo gravimetric analysis and differential scanning calorimetry, Raman spectroscopy, hot-stage microscopy and Hirshfeld surface analysis. Furthermore, Hirshfeld surface analysis confirmed that the driving force and supporting force for the formation of crystals were C-C, C-H, N-H, H-H, O-H and Cl-H interactions. The dissolution rate of the new salts of gefitinib in phosphate buffer of pH 6.8 was evaluated, and the results showed a significant increase in solubility. [ABSTRACT FROM AUTHOR]

Biodegradable polymeric nanoparticles have received growing interest as one of the most promising agents for drug delivery. In the present work, functional and core-crosslinked poly(ethylene glycol) with poly(ϵ-caprolactone) (PEG 5k -PCL 10k ) block copolymer and lecithin as biodegradable polymer doped with polyaniline was used to assemble nanoparticles which were prepared for targeted delivery and controlled release of cisplatin. The morphology of the polyaniline nanoparticles was determined by dynamic light scattering and the prepared nanoparticles showed a size of 83(±1) nm and a uniform spherical shape. For targeting to HER2 receptors, Herceptin was applied to guide the nanoparticles to breast cancer cells. Studies on cellular uptake and drug release of the nanocarriers showed that the prepared nanoparticles were efficiently taken up by breast cancer cells and the drug was released efficiently under acidic conditions when exposed to a near-infrared laser (808 nm, 1.54 W) for 5 min. Our research highlights the great potential of near-infrared light and pH dual-responsive release by core-crosslinked nanoparticles in nanobiomedicine., (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)