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Cervical cancer (CC) continues to be one of the most common cancers among females worldwide. It takes a few years or even decades for CC to arise in a minority of women with cervical precancers. An increasing corpus of studies today indicates that local microecology and carcinogenesis are intimately related. To investigate the changes in cericovaginal microecology with the development of cervical cancer, we performed 16S rDNA sequencing and metabolomic analysis in cericovaginal fluid from 10 LSIL patients, 10 HSIL patients, 10 CC patients and 10 healthy controls to reveal the differential flora and metabolites during cervical carcinogenesis. Carcinogenesis is associated with alterations in microbiome diversity, individual taxa, and functions with notable changes in Lactobacillus, Prevotella and Aquabacterium, as well as in cervicovaginal metabolites that correlate with cervicovaginal microbial patterns. Increased bacterial diversity and a decline in the relative abundance of Lactobacillus, the dominant species in the cericovaginal flora, are observed when cervical lesions advance. According to KEGG pathway enrichment analysis, lipids and organic acids change as cervical cancer progresses, and the phenylalanine, tyrosine, and tryptophan biosynthesis pathway is essential for the development of cervical cancer. Our results reveal that microbic and metabolomic profiling is capable of distinguishing CC from precancer and highlights potential biomarkers for the early detection of cervical dysplasia. These differential microorganisms and metabolites are expected to become a potential tool to assist in the diagnosis of cervical cancer.

Synthesis of NiHCCo precursors via simple co-precipitation and nickelâ€"cobalt tetraselenide composites grown on nitrogen-doped reduced graphene oxide (NiCoSe4/N-rGO) were fabricated using solvothermal method. The introduction of N-rGO used as a template effectively prevented agglomeration of NiCoSe4 nanoparticles and provided more active sites, which greatly increased the electrochemical and electrical conductivity for NiCoSe4/N-rGO. NiCoSe4/N-rGO-20 presents a remarkably elevated specific capacity of 120 mA h gâˆ'1 under current density of 1 A gâˆ'1. NiCoSe4/N-rGO-20 demonstrates an excellent cycle life and achieves a remarkable 83% retention rate over 3000 cycles with 10 A gâˆ'1. NiCoSe4/N-rGO-20//N-rGO asymmetric supercapacitor was constructed based on the NiCoSe4/N-rGO-20 as an anode, N-rGO as cathode by using 2 mol lâˆ'1 KOH as an electrolyte. NiCoSe4/N-rGO-20//N-rGO ASC demonstrates an ultra-big energy density of 14 Wh kgâˆ'1 and good circulation stability in the power density of 902 W kgâˆ'1. It is doubled in comparison to the NiCoSe4/N-rGO-20//rGO asymmetric supercapacitor (7 Wh kgâˆ'1). The NiCoSe4/N-rGO-20//N-rGO ASC capacity retention is still up to 93% over 5000 cycles (5 A gâˆ'1). The results reveal that this device would be a prospective cathode material of supercapacitors in actual applications. [ABSTRACT FROM AUTHOR]

The decomposition of phenol by four metal oxide nanomaterials was investigated by adsorption and photocatalytic degradation. The results from adsorption experiments were fit to a Langmuir model. The theoretical monolayer adsorption capacities for nano-TiO2, -Al2O3, -ZnO, and -CuO were approximately 14.35, 14.28, 13.72, and 5.29 mg/g, respectively. Nano-TiO2and -CuO had the largest Langmuir model coefficients: both were 0.0324 L/mg. The adsorption capacity of phenol was higher in basic conditions than in acidic solution. Photodegradation was characterized by pseudo-first-order models. The total removal rates for nano-TiO2, -Al2O3, -ZnO, and -CuO after 3 hours of irradiation were 89.0%, 70.8%, 57.3%, and 61.6%, respectively. The differences between phenol and total organic carbon concentrations for nano-TiO2, -Al2O3, -ZnO, and -CuO were 42.92%, 20.11%, 8.29%, and 16.78%, respectively. Nano-TiO2provided the maximum capacity for photodegradation and produced the most intermediates. The majority of the phenol was degraded to resorcinol and hydroquinone as intermediates to acetic acid. [ABSTRACT FROM AUTHOR]

Synthesis of NiHCCo precursors via simple co-precipitation and nickel-cobalt tetraselenide composites grown on nitrogen-doped reduced graphene oxide (NiCoSe 4 /N-rGO) were fabricated using solvothermal method. The introduction of N-rGO used as a template effectively prevented agglomeration of NiCoSe 4 nanoparticles and provided more active sites, which greatly increased the electrochemical and electrical conductivity for NiCoSe 4 /N-rGO. NiCoSe 4 /N-rGO-20 presents a remarkably elevated specific capacity of 120 mA h g -1 under current density of 1 A g -1 . NiCoSe 4 /N-rGO-20 demonstrates an excellent cycle life and achieves a remarkable 83% retention rate over 3000 cycles with 10 A g -1 . NiCoSe 4 /N-rGO-20//N-rGO asymmetric supercapacitor was constructed based on the NiCoSe 4 /N-rGO-20 as an anode, N-rGO as cathode by using 2 mol l -1 KOH as an electrolyte. NiCoSe 4 /N-rGO-20//N-rGO ASC demonstrates an ultra-big energy density of 14 Wh kg -1 and good circulation stability in the power density of 902 W kg -1 . It is doubled in comparison to the NiCoSe 4 /N-rGO-20//rGO asymmetric supercapacitor (7 Wh kg -1 ). The NiCoSe 4 /N-rGO-20//N-rGO ASC capacity retention is still up to 93% over 5000 cycles (5 A g -1 ). The results reveal that this device would be a prospective cathode material of supercapacitors in actual applications., (© 2022 IOP Publishing Ltd.)

This paper examines the biodegradation of chlorophenols by microbes and deals with the chlorophenols-degrading microbes and the usage of biotechnology with special emphasis on degradation mechanisms. Dechlorination is the first critical step in the bacterial degradation of many chloroniated pollutans. Under aerobic condition, the degradation of mono- and dichlorophenols is shown to be initiated by oxygenation into chlorocatechols, and dechlorination occurs only after ring cleavage of the chlorocatechols. The degradation of polychlorinated phenols starts by hydrolytic para-hydroxylation, yielding chlorinated para-hydroquinone. The anaerobic biodegradation of chlorophenols occurs by reductive dechlorination, a process by which chlorines are replaced with hydrogen.