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190 results on '"Zhan, Wenjun"'

14. Aurora Kinase B‐Instruct Release of AZD1152‐HQPA from Hydrogel to Enhance Cervical Cancer Suppression.

Author

Xu, Guangqiong, Weng, Qiao, Zhang, Lei, Song, Yaye, Zhan, Wenjun, Yin, Yuan, Liang, Gaolin, and Wang, Fuqiang

Subjects
AURORA kinases, CERVICAL cancer, SMALL molecules, DRUG target
Abstract

Aurora kinase B (AURKB) is an attractive and potential molecular target for cervical cancer therapy. To date, a variety of AURKB inhibitors are developed to suppress cervical tumors. Nevertheless, direct use of these small molecule inhibitors may cause severe side effects to patients, limiting their further clinical applications. Herein, a rationally designed hydrogelator Nap‐Phe‐Phe‐Arg‐Arg‐Lys‐Ser‐OH (S) is employed to co‐assemble AZD1152‐HQPA (AZD, an AURKB inhibitor) to develop an AURKB‐responsive hydrogel Gel S/AZD for enhanced cervical tumor suppression. Upon AURKB activation, hydrogelator S in Gel S/AZD evolves into its hydrophilic phosphate Nap‐Phe‐Phe‐Arg‐Arg‐Lys‐Ser(H2PO3)‐OH (Sp), triggering the disassembly of Gel S/AZD to release AZD in a sustained manner. Cell assays reveal that AURKB‐responsive release of AZD from Gel S/AZD potently induces the growth arrest and apoptosis of cervical cancer cells by downregulating the expression level of AURKB downstream protein phospho‐histone H3 (pH3). In vivo studies demonstrate that compared with free AZD, Gel S/AZD shows a superior tumor suppressive effect in orthotropic cervical tumor models. It is envisioned that the Gel S/AZD might be applied in clinic cervical cancer treatment in the near future. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Assembly drives regioselective azide-alkyne cycloaddition reaction.

Author

Jiang, Qiaochu, Zhan, Wenjun, Liu, Xiaoyang, Bai, Lin, Wang, Manli, Xu, Ying, and Liang, Gaolin

Subjects
RING formation (Chemistry), CHEMICAL labeling, METAL ions, CHEMICAL biology, COPPER, AQUEOUS solutions
Abstract

Azide-alkyne cycloaddition reaction is a very common organic reaction to synthesize nitrogen-containing heterocycles. Once catalyzed by Cu(I) or Ru(II), it turns out to be a click reaction and thus is widely applied in chemical biology for labeling. However, besides their poor regioselectivity towards this reaction, these metal ions are not biologically friendly. Hence, it is an urgent need to develop a metal-free azide–alkyne cycloaddition reaction for biomedical applications. In this work, we found that, in the absence of metal ions, supramolecular self-assembly in an aqueous solution could realize this reaction with excellent regioselectivity. Nap-Phe-Phe-Lys(azido)-OH firstly self-assembled into nanofibers. Then, Nap-Phe-Phe-Gly(alkynyl)-OH at equivalent concentration approached to react with the assembly to yield the cycloaddition product Nap-Phe-Phe-Lys(triazole)-Gly-Phe-Phe-Nap to form nanoribbons. Due to space confinement effect, the product was obtained with excellent regioselectivity. Employing the excellent properties of supramolecular self-assembly, we are applying this strategy to realize more reactions without metal ion catalysis. Metal-free versions of azide–alkyne cycloadditions could find widespread applications in biomedical contexts. Here, the authors report an assembly-driven, regioselective azide–alkyne cycloaddition. [ABSTRACT FROM AUTHOR]

Published
2023
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32. A robust and adaptive carrier recovery method for Chinese DTTB receiver

Author

Liang, Weiqiang, Chai, Jing, Guan, Yunfeng, Zhan, Wenjun, He, Dazhi, and Yang, Zhixing

Subjects
Television broadcasting -- Methods, Signal processing -- Methods, Digital signal processor, Business, Electronics, Mass communications
Abstract

This paper presents a robust and adaptive carrier recovery method for Chinese Digital Terrestrial Television Broadcasting (DTTB) system in which pilot signal and pseudnoise (PN) sequence are adopted to help carrier recovery. The conventional methods utilize pilot or PN sequence respectively. In this paper, we try to combine the advantage of each method together and propose a well designed state machine to control system state automatically. Moreover, as for using PN sequence, a fine PN tracking state is introduced to ensure the robustness of the proposed method. Software simulations show that the proposed method can provide large acquisition range, short acquisition time and small tracking jitter in severely distorted static and dynamic channels. Lab tests and Field trials also prove its good performance in real propagation environments. Index Terms--Carrier recovery, Chinese standard, DTTB, frequency sweeping, PN sequence.

Published
2008

44. In situActivatable Peptide-based Nanoprobes for Tumor Imaging

Author

Liu, Zhiyu, Liang, Gaolin, and Zhan, Wenjun

Abstract

Owing to its excellent biological properties, peptide has been widely used in the design of nanoprobes capable of enhancing tumor imaging signals. In recent years, a number of peptide-based nanoprobes with strong loading capacity and great biocompatibility have been developed for precision tumor imaging by coupling peptide motifs with different imaging agents. It is worth noting that, compared with “always on” mode, the use of stimulus-mediated in situactivatable mode to design and control the self-assembly or nanostructure transformation of peptide-based nanoprobes in vivocan achieve the significant improvement of imaging efficiency. Herein, we summarize the recent progress of in situactivatable peptide-based nanoprobes for tumor imaging in diverse imaging modes, including magnetic resonance imaging(MRI), fluorescence imaging(FI), photoacoustic imaging(PAI), radionuclide imaging(RI) and multimodal imaging. Finally, we briefly prospect the challenges and potential development directions of this field.

Published
2021
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45. Tandem Targeting and Dual Aggregation of an AIEgen for Enhanced Near-Infrared Fluorescence Imaging of Tumors

Author

Deng, Yu, Xu, Lingling, Liu, Xiaoyang, Jiang, Qiaochu, Sun, Xianbao, Zhan, Wenjun, and Liang, Gaolin

Abstract

Near-infrared (NIR) aggregation-induced emission luminogens (AIEgens) are excellent probes for tumor imaging, but there still is space to improve their imaging specificity and sensitivity. In this work, a strategy of tandem targeting and dual aggregation of an AIEgen is proposed to achieve these two purposes. An AIEgen, β-tBu-Ala-Cys(StBu)-Lys(Biotin)-Pra(QMT)-CBT (Ala-Biotin-QMT), is designed to tandem target the biotin receptor and leucine aminopeptidase of a cancer cell and thereafter undergo CBT-Cys click reaction-mediated dual aggregations in the cell. Experimental results show that Ala-Biotin-QMTrenders 4.8-fold and 7.9-fold higher NIR fluorescence signals over those in the “biotin + LAP inhibitor”-treated control groups in living HepG2 cells and HepG2 tumor-bearing mice, respectively. We anticipate that Ala-Biotin-QMT, which has the tandem targeting and dual aggregation property to simultaneously achieve enhanced tumor enrichment and fluorescence onset, could be applied for accurate cancer diagnosis in the clinic in the future.

Published
2024
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