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Teacher training has entered the collaborative phase as faculty members from different universities worldwide have been sharing their teaching practices using the available educational technologies. This has made curriculum development more exciting and the ideas more diverse since other cultures may have different approaches to tackling subjects taken up in the curriculum. This study used a qualitative case study approach since it wanted to show a broader picture of the learning experiences; mainly, this study included ten professors and students from three universities and used collaborative teaching to show how a project can be achieved by different parties collaborating. This study investigated the online educational courses that have capitalized on the available educational technologies to show diversity in their curriculum. The researcher also conducted class observations where the students explored collaborative teaching methods across different cultures and compared their similarities and differences. The study also assessed how educational technology has helped achieve diversity in curriculum development as professors from different universities worldwide. Findings indicate a necessity for including additional training diversity in the best pedagogical approaches to facilitate cross-cultural collaborative experiences in both curriculums and online education environments.

CTNNB1, encoding β-catenin protein, is the most frequently altered proto-oncogene in hepatic neoplasms. In this study, we studied the significance and pathological mechanism of CTNNB1 gain-of-function mutations in hepatocarcinogenesis. Activated β-catenin not only triggered hepatic tumorigenesis but also exacerbated Tp53 deletion or hepatitis B virus infection-mediated liver cancer development in mouse models. Using untargeted metabolomic profiling, we identified boosted de novo pyrimidine synthesis as the major metabolic aberration in β-catenin mutant cell lines and livers. Oncogenic β-catenin transcriptionally stimulated AKT2, which then phosphorylated the rate-limiting de novo pyrimidine synthesis enzyme CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, dihydroorotase) on S1406 and S1859 to potentiate nucleotide synthesis. Moreover, inhibition of β-catenin/AKT2-stimulated pyrimidine synthesis axis preferentially repressed β-catenin mutant cell proliferation and tumor formation. Therefore, β-catenin active mutations are oncogenic in various preclinical liver cancer models. Stimulation of β-catenin/AKT2/CAD signaling cascade on pyrimidine synthesis is an essential and druggable vulnerability for β-catenin mutant liver cancer.

The concept of self-regulated learning in the field of educational psychology has been developed to comprehend how students learn autonomously. Motivation is a pivotal factor in learners' academic outcomes, and its connection with self-regulated learning is extensive. While self-regulated learning and motivational beliefs are both believed to play important roles in EFL learning, very little is known about their interplay in the Afghan context, and research on the relationship among these variables seems scarce. Therefore, to contribute to this knowledge gap, the overarching aim of the present survey was to investigate the phenomenon of self-regulated learning and motivational beliefs among EFL learners in higher education. Quantitative research was carried out on a sample size of 123 EFL learners. The data was collected through a survey questionnaire and analysed using SPSS v24 where both descriptive statistics and inferential statistics such as one-way ANOVA, correlation, and regression were used. The findings indicated that the majority of the learners experience a high level of test anxiety. Further, the results also revealed that there was a significant positive correlation between motivational beliefs and self-regulated learning. Foreign language learning can be enhanced by designing environments in a way that fosters self-regulated learning skills. Further research could be conducted with a larger sample size from other public universities to generate a more fine-grained understanding.

The influx of international students pursuing academic degrees in China in recent years has posed several challenges for educators who must cope with cultural and linguistic plurality. This qualitative dominant mixed-methods study explores how the engagement through partnership builds on and caters to cultural diversity. For one semester, seven international doctoral students of a course "Frontiers of the Learning Sciences" took on the role of course co-creators and discussion leaders. Classroom videos, student surveys, interviews, weekly reflection journals, and social media chatlogs were collected and analyzed. Results showed that engaging students as course co-creators was responsive to cultural diversity. Three interrelated factors emerged that defined the effectiveness of students' engagement within multicultural settings: language proficiency, academic ability, and personal attitude to the differences. Moreover, the study revealed four interconnected factors (time, challenge, competency, support) that should be considered in designing effective culturally responsive learning environments for international doctoral students.

With the rapid development of tourism, the rapid growth in the number of tourists caused by the imbalance of the passenger flow carrying capacity of tourist attractions, tourist crowding, overloading, and other problems caused by the frequent occurrence of safety accidents, to the tourist attractions has caused a huge negative impact. For this reason, this paper constructs a model for predicting passenger flows at tourist attractions based on the GWO algorithm. Optimizing the model involves using a differential evolutionary algorithm following a feature study with the Gray Wolf Optimization (GWO) algorithm. Then, for the problems that are prone to occur in the fusion of the GWO algorithm and DE algorithm for solving nonlinear systems of equations, a combined GWO-DE-SVM model is proposed to realize the accurate prediction of tourist attractions’ passenger flow. On this basis, the prediction effect of the GWO-DE-SVM combination model is examined. The loss values of the model in the training set and test set of this paper are around 0.034 and 0.029, respectively, with the lowest average error of 2.524% among all the models. The passenger flow and the total tourism revenue of W tourist attraction in the coming year are successfully predicted in the practical application, which is estimated to be 681 million and 106.88 million yuan, respectively. Million and 106.88 million yuan are the respective amounts. And two peaks of tourist attractions in W were predicted in May and October. This study provides a scientific basis for the management of scenic spots to prevent tourist crowding.

Although STEM is an essential feature of 21st-century education and learning, there is a lack of awareness about it in Pakistan, especially at the K-12 and tertiary levels. Recently many initiatives have been launched across Pakistan to create more interest in STEM education. In order to assist in raising the level of STEM awareness in Pakistan, this study sought to examine the current state of research and identify recent contributions and gaps in the literature. A systematic literature review was conducted using 22 research papers from five renowned databases. Results produced limited research in this area, with the majority being descriptive and only four being interventional studies. Regrettably, no research explored the engineering component of STEM education. Trends indicate that STEM education research has experienced a downward trend in Pakistan. The observed decline may have occurred due to a lack of understanding among Pakistani researchers regarding the importance of STEM education. Additionally, we identified the current gaps in research on STEM education and subsequently provided recommendations for future research.

Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the dependency of PCa cells on the androgen receptor (AR), a prostate master transcription factor. We generated 268 epigenomic datasets spanning two state transitions-from normal prostate epithelium to localized PCa to metastases-in specimens derived from human tissue. We discovered that reprogrammed AR sites in metastatic PCa are not created de novo; rather, they are prepopulated by the transcription factors FOXA1 and HOXB13 in normal prostate epithelium. Reprogrammed regulatory elements commissioned in metastatic disease hijack latent developmental programs, accessing sites that are implicated in prostate organogenesis. Analysis of reactivated regulatory elements enabled the identification and functional validation of previously unknown metastasis-specific enhancers at HOXB13, FOXA1 and NKX3-1. Finally, we observed that prostate lineage-specific regulatory elements were strongly associated with PCa risk heritability and somatic mutation density. Examining prostate biology through an epigenomic lens is fundamental for understanding the mechanisms underlying tumor progression.

This study presented a mathematical description of an arbitrary shape area, and after analyzing the characteristics of the near-polar orbital co-ground trajectory constellation that satisfies the revisit interval constraint, an optimization model of the orbital parameters design of reference satellites in regional coverage constellations was constructed. Then based on the designed area covering the constellation of common ground trajectories, a simple and effective two-pulse maneuvering scheme was adopted for the needs of sudden tasks, and an existing satellite scheduling optimization model using the golden section method to constrain the boundary of substellar point coverage was constructed. Finally, the optimal design of regional coverage constellations and existing satellite dispatches was carried out for the sea areas with the most frequent tropical cyclone activities in the northwest Pacific Ocean, and the simulation results verified the effectiveness of the proposed optimization model and have certain practical use value.

The importance of reflective thinking among teachers has long been recognized, and it remains a crucial indicator of learning and ensures teachers' professional development. This study's aim is to understand a teacher education program's impact on the reflective thinking of preservice teachers in Pakistan. Utilizing a mixed-method approach, 400 teacher education candidates participated in the quantitative analysis, which involved a follow-up that included 10 semi-structured interviews by teacher education candidates. The results showed that teacher education in Pakistan is characterized by the production of more graduates but lacks the focus to develop and generate reflective practitioners in the field. This research contributes to our understanding about the importance of reflective thinking in terms of how it can improve preservice teachers' thinking patterns and nurture teacher education. Furthermore, this study suggests that teacher-training institutions should focus on improving the quality of the trainings for students.

Atractylodis Rhizoma, a traditional Chinese medicine with an extensive history of treating gastrointestinal disorders and other diseases, undergoes various processing methods in China to enhance its therapeutic efficacy for specific conditions. However, a comprehensive report detailing the changes in chemical composition and pharmacological effects due to these processing methods is currently lacking. This article provides a systematic review of the commonly employed processing techniques for Atractylodis Rhizoma, including raw Atractylodis Rhizoma (SCZ), bran-fried Atractylodis Rhizoma (FCZ), deep-fried Atractylodis Rhizoma (JCZ), and rice water-processed Atractylodis Rhizoma (MCZ). It examines the alterations in chemical constituents and pharmacological activities resulting from these processes and elucidates the mechanisms of action of the primary components in the various processed forms of Atractylodis Rhizoma in the treatment of gastrointestinal diseases. [ABSTRACT FROM AUTHOR]