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SnO2 nanotubes are synthesized via an oxalate-assisted “redox etching and precipitating” route between MnOOH nanowires and Sn2+ ions. The addition of oxalate is found to be crucial to guide the formation of uniform SnO2 nanotubes. To further improve the conductivity and stability, the as-obtained SnO2 nanotubes are coated with a thin carbon layer. The resulting carbon-confined SnO2 nanotubes possess superior rate performance as an anode material for lithium-ion batteries. [ABSTRACT FROM AUTHOR]

Background: Limited data are available on applying circulating tumor DNA (ctDNA) in metastatic triple-negative breast cancer (mTNBC) patients. Here, we investigated the value of ctDNA for predicting the prognosis and monitoring the treatment response in mTNBC patients., Methods: We prospectively enrolled 70 Chinese patients with mTNBC who had progressed after ≤2 lines of chemotherapy and collected blood samples to extract ctDNA for 457-gene targeted panel sequencing., Results: Patients with ctDNA+, defined by 12 prognosis-relevant mutated genes, had a shorter progression-free survival (PFS) than ctDNA- patients (5.16 months vs . 9.05 months, p=0.001), and ctDNA +was independently associated with a shorter PFS (HR, 95% CI: 2.67, 1.2-5.96; p=0.016) by multivariable analyses. Patients with a higher mutant-allele tumor heterogeneity (MATH) score (≥6.316) or a higher ctDNA fraction (ctDNA%≥0.05) had a significantly shorter PFS than patients with a lower MATH score (5.67 months vs .11.27 months, p=0.007) and patients with a lower ctDNA% (5.45 months vs . 12.17 months, p<0.001), respectively. Positive correlations with treatment response were observed for MATH score ( R =0.24, p=0.014) and ctDNA% ( R =0.3, p=0.002), but not the CEA, CA125, or CA153. Moreover, patients who remained ctDNA +during dynamic monitoring tended to have a shorter PFS than those who did not (3.90 months vs . 6.10 months, p=0.135)., Conclusions: ctDNA profiling provides insight into the mutational landscape of mTNBC and may reliably predict the prognosis and treatment response of mTNBC patients., Funding: This work was supported by the National Natural Science Foundation of China (Grant No. 81902713), Natural Science Foundation of Shandong Province (Grant No. ZR2019LZL018), Breast Disease Research Fund of Shandong Provincial Medical Association (Grant No. YXH2020ZX066), the Start-up Fund of Shandong Cancer Hospital (Grant No. 2020-PYB10), Beijing Science and Technology Innovation Fund (Grant No. KC2021-ZZ-0010-1)., Competing Interests: YC, DZ, FZ, BZ, LQ, GR, LS, BB, SF, JY, HL No competing interests declared, MS, BY Affiliated with Berry Oncology Corporation. The author has no financial interests to declare, JZ Jinxing Zhou is affiliated with Berry Oncology Corporation. The author has no financial interests to declare, (© 2023, Chi et al.)

Tin dioxide (SnO 2 ) has attracted much attention in lithium-ion batteries (LIBs) due to its abundant source, low cost, and high theoretical capacity. However, the large volume variation, irreversible conversion reaction limit its further practical application in next-generation LIBs. Here, a novel solvent-free approach to construct uniform metal-organic framework (MOF) shell-derived carbon confined SnO 2 /Co (SnO 2 /Co@C) nanocubes via a two-step heat treatment is developed. In particular, MOF-coated CoSnO 3 hollow nanocubes are for the first time synthesized as the intermediate product by an extremely simple thermal solid-phase reaction, which is further developed as a general strategy to successfully obtain other uniform MOF-coated metal oxides. The as-synthesized SnO 2 /Co@C nanocubes, when tested as LIB anodes, exhibit a highly reversible discharge capacity of 800 mAh g -1 after 100 cycles at 200 mA g -1 and excellent cycling stability with a retained capacity of 400 mAh g -1 after 1800 cycles at 5 A g -1 . The experimental analyses demonstrate that these excellent performances are mainly ascribed to the delicate structure and a synergistic effect between Co and SnO 2 . This facile synthetic approach will greatly contribute to the development of functional metal oxide-based and MOF-assisted nanostructures in many frontier applications., (© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

SnO 2 nanotubes are synthesized via an oxalate-assisted "redox etching and precipitating" route between MnOOH nanowires and Sn 2+ ions. The addition of oxalate is found to be crucial to guide the formation of uniform SnO 2 nanotubes. To further improve the conductivity and stability, the as-obtained SnO 2 nanotubes are coated with a thin carbon layer. The resulting carbon-confined SnO 2 nanotubes possess superior rate performance as an anode material for lithium-ion batteries.

Background: There is no effective regimen for recurrent small cell lung cancer patients now. The aim of this study is to assess the activity and toxicity of topotecan combined with cisplatin in the treatment of recurrent small cell lung cancer patients., Methods: Twenty-eight patients with progressive disease after one first-line regimen enrolled in the study from May 2002 to October 2004. Topotecan was given at the dose of 1.2mg/m² from 1st to 4th days and cisplatin was administered at the dose of 25mg/m² from 5th to 7th days in a cycle of 3 weeks. The patients could be evaluated at least after 2 cycles., Results: One patient got complete response and ten patients got partial response in this group. The overall response rate was 39.3% , and the response rate of refractory group and sensitive group was 37.5% (3/8) and 40.0% (8/20) respectively. The median time to progression was 4.2 months. The main toxicity was hematological toxicity. Grade III+IV neutropenia occurred in 42.9% (12/28) of the patients., Conclusions: The regimen of topotecan and cisplatin shows better activity in retreated small cell lung cancer patients. The main toxicity is hematological toxicity and can be tolerated.