Search

Your search keyword '"Zhang, Daye"' showing total 4 results
Start Over Author "Zhang, Daye"
4 results on '"Zhang, Daye"'

3. Dexamethasone and lenvatinib inhibit migration and invasion of non-small cell lung cancer by regulating EKR/AKT and VEGF signal pathways.

Author

Zhang, Daye, Zhang, Yongxiang, Cai, Zeyuan, Tu, Ying, and Hu, Zhansong

Subjects
*NON-small-cell lung carcinoma, *EXTRACELLULAR signal-regulated kinases, *VASCULAR endothelial growth factors, *PROTEIN kinase B, *VASCULAR endothelial cells, *TRANSFORMING growth factors, *DEXAMETHASONE
Abstract

Migration and invasion is one of the most important features in tumor metastasis and development. Non-small cell lung cancer (NSCLC) is one of the most common types of cancer globally, and has been linked to air contamination. Evidence indicates that cysteine-rich angiogenic inducer 61 (CYR61) is associated with the migration and invasion of NSCLC. Overexpression of CYR61 protein promotes the migration and the transition of tumor-derived vascular endothelial cells in NSCLC. However, the association between CYR61 and NSCLC remains poorly understood. Lenvatinib is an oral multi-target drug that targets various receptors upon tumor angiogenesis. Dexamethasone is widely approved for combination therapy in patients with NSCLC. In the current study, the expression and function of CYR61 in NSCLC was analyzed during the progression of NSCLC. Inhibitory effects on migration and invasion induced by lenvatinib and dexamethasone were determined by migratory and invasion assays. Migratory pathways of extracellular signal-regulated kinases (ERK) and protein kinase B (AKT) were also investigated by targeting vascular endothelial growth factor (VEGF) and CYR61 via synergistic treatment with transforming growth factor-β1 (TGF-β1) and dexamethasone. Therapeutic outcomes of combined treatment with lenvatinib and dexamethasone were assessed in NSCLC-bearing mice. The results of the present study indicate that cooperative treatment of lenvatinib and dexamethasone significantly inhibited TGF-β1-induced cell migration and suppressed tumor growth (P<0.01). Notably, the results demonstrated that dexamethasone eradicated the promotion effects of TGF-β1 on the AKT/epithelial-mesenchymal transition process and lenvatinib extinguished tumor cell metastasis by targeting VEGF. The results of the current study also demonstrate that dexamethasone suppressed the expression of CAG-I and enhanced expression of matrix metalloproteinase-1. Synergistic treatment for NSCLC was demonstrated to be efficacious. In conclusion, dexamethasone inhibited AKT/ERK phosphorylation and lenvatinib antagonism bound VEGF leading to the limitation of migration and invasion of cancer cells in NSCLC. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

4. The World of a Tiny Insect : A Memoir of the Taiping Rebellion and Its Aftermath

Author

Zhang Daye and Zhang Daye

Subjects
HISTORY / Asia / China, BIOGRAPHY & AUTOBIOGRAPHY / Women
Abstract

'From the cry of a tiny insect, one can hear the sound of a vast world....'So begins Zhang Daye's preface to The World of a Tiny Insect, his haunting memoir of war and its aftermath. In 1861, when China's devastating Taiping rebellion began, Zhang was seven years old. The Taiping rebel army occupied Shaoxing, his hometown, and for the next two years, he hid from Taiping soldiers, local bandits, and imperial troops and witnessed gruesome scenes of violence and death. He lost friends and family and nearly died himself from starvation, illness, and encounters with soldiers on a rampage.Written thirty years later, The World of a Tiny Insect gives voice to this history. A rare premodern Chinese literary work depicting a child's perspective, Zhang's sophisticated text captures the macabre images, paranoia, and emotional excess that defined his wartime experience and echoed through his adult life. The structure, content, and imagery of The World of a Tiny Insect offer a carefully constructed, fragmented narrative that skips in time and probes the relationships between trauma and memory, revealing both history and its psychic impact. Xiaofei Tian's annotated translation includes an introduction that situates The World of a Tiny Insect in Chinese history and literature and explores the relevance of the book to the workings of traumatic memory.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results