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522 results on '"Zhang, Fengrui"'

2. Data Valuation and Detections in Federated Learning

Author

Li, Wenqian, Fu, Shuran, Zhang, Fengrui, and Pang, Yan

Subjects
Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Computer Science - Cryptography and Security
Abstract

Federated Learning (FL) enables collaborative model training while preserving the privacy of raw data. A challenge in this framework is the fair and efficient valuation of data, which is crucial for incentivizing clients to contribute high-quality data in the FL task. In scenarios involving numerous data clients within FL, it is often the case that only a subset of clients and datasets are pertinent to a specific learning task, while others might have either a negative or negligible impact on the model training process. This paper introduces a novel privacy-preserving method for evaluating client contributions and selecting relevant datasets without a pre-specified training algorithm in an FL task. Our proposed approach FedBary, utilizes Wasserstein distance within the federated context, offering a new solution for data valuation in the FL framework. This method ensures transparent data valuation and efficient computation of the Wasserstein barycenter and reduces the dependence on validation datasets. Through extensive empirical experiments and theoretical analyses, we demonstrate the potential of this data valuation method as a promising avenue for FL research., Comment: CVPR 2024

Published
2023

34. HSV-2 triggers upregulation of MALAT1 in [CD4.sup.+] T cells and promotes HIV latency reversal

Author

Pierce, Carl A., Loh, Lip Nam, Steach, Holly R., Cheshenko, Natalia, Preston-Hurlburt, Paula, Zhang, Fengrui, Stransky, Stephanie, Kravets, Leah, Sidoli, Simone, Philbrick, William, Nassar, Michel, Krishnaswamy, Smita, Herold, Kevan C., and Herold, Betsy C.

Subjects
HIV (Viruses) -- Genetic aspects -- Physiological aspects -- Health aspects, Herpes simplex -- Complications and side effects -- Physiological aspects -- Genetic aspects, RNA -- Physiological aspects -- Health aspects, Virus activation -- Causes of -- Genetic aspects, Health care industry
Abstract

Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well defined. HSV-2 recurrences result in an influx of activated [CD4.sup.+] T cells to sites of viral replication and an increase in activated [CD4.sup.+] T cells in peripheral blood. We hypothesized that HSV-2 induces changes in these cells that facilitate HIV-1 reactivation and replication and tested this hypothesis in human [CD4.sup.+] T cells and 2D10 cells, a model of HIV-1 latency. HSV-2 promoted latency reversal in HSV-2-infected and bystander 2D10 cells. Bulk and single- cell RNA-Seq studies of activated primary human [CD4.sup.+] T cells identified decreased expression of HIV-1 restriction factors and increased expression of transcripts including MALAT1 that could drive HIV replication in both the HSV-2- infected and bystander cells. Transfection of 2D10 cells with VP16, an HSV-2 protein that regulates transcription, significantly upregulated MALAT1 expression, decreased trimethylation of lysine 27 on histone H3 protein, and triggered HIV latency reversal. Knockout of MALAT1 from 2D10 cells abrogated the response to VP16 and reduced the response to HSV-2 infection. These results demonstrate that HSV-2 contributes to HIV-1 reactivation through diverse mechanisms, including upregulation of MALAT1 to release epigenetic silencing., Introduction Herpes simplex virus type 2 (HSV-2) is a common coinfection in persons living with human immunodeficiency virus type 1 (HIV1) and is considered one of the most important cofactors [...]

Published
2023
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37. Weakly Polar Ether‐Aided Ionic Liquid Electrolyte Enables High‐Performance Sodium Metal Batteries over Wide Temperature Range

Author

Liu, Yang, primary, Lu, Suwan, additional, Wang, Zhicheng, additional, Xu, Jingjing, additional, Weng, Shixiao, additional, Xue, Jiangyan, additional, Tu, Haifeng, additional, Zhang, Fengrui, additional, Liu, Lingwang, additional, Gao, Yiwen, additional, Li, Hong, additional, Zheng, Jieyun, additional, and Wu, Xiaodong, additional

Published
2024
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