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Seismicity induced by fluid injection including wastewater injection, hydrofracking and enhanced geothermal system (EGS) site production draws public attention. Dense arrays have been deployed to improve monitoring capability. In 2016 March, the PoroTomo experiment deployed an 8.6-km-long fibre-optic cable for distributed acoustic sensing (DAS) in the geothermal field at Brady Hot Springs, Nevada, covering an area of 1.5 by 0.5 km. The goal was to assess an integrated technology for characterizing and monitoring temporal changes in the rock mechanical properties of an EGS reservoir in three dimensions. We applied a neural network designed for earthquake detection called ADE-Net2 to the DAS data set to detect seismic events in continuous records. We were able to detect a total of 90 earthquakes, which included 21 events that had not been reported by a previous template-matching study. Additionally, we were able to successfully detect almost all of the active source signals, with only seven events being missed. We used the STA/LTA (short-/long-term average) method to pick arrivals and a clustering method to remove outliers. We initially tried a standard event location algorithm, but the low signal-to-noise ratio resulted in significant picking uncertainty that is up to ∼0.5 s, leading to large location uncertainty. Therefore, we developed a new location method based on the similarity between the theoretical traveltime curve and picked moveout. A grid search scheme was adopted to find the optimal point at which the traveltime curve is most similar to the picked one. Most newly detected earthquakes locate southwest of the DAS array, where five earthquakes were reported by a local seismic network. The plant began shutting down at 19:15 UTC on the March 13, and most earthquakes occurred on the March 14, indicating a relationship between the seismicity and the pressure changes caused by the shutdown of the plant. The pressure changes at epicentres obtained from a simplified model range from 71 to 157 kPa, exceeding a typical earthquake trigger threshold of 10 kPa. [ABSTRACT FROM AUTHOR]

The discovery of drug–drug interactions (DDIs) that have a translational impact among in vitro pharmacokinetics (PK), in vivo PK and clinical outcomes depends largely on the quality of the annotated corpus available for text mining. We have developed a new DDI corpus based on an annotation scheme that builds upon and extends previous ones, where an abstract is fragmented and each fragment is then annotated along eight dimensions, namely, focus, polarity, certainty, evidence, directionality, study type, interaction type and mechanism. The guideline for defining these dimensions has undergone refinement during the annotation process. Our DDI corpus comprises 900 positive DDI abstracts and 750 that are not directly relevant to DDI. The abstracts in corpus are separated into eight categories of DDI or non-DDI evidence: DDI with pharmacokinetic (PK) mechanism, in vivo DDI PK, DDI clinical, drug–nutrition interaction, single drug, not drug related, in vitro pharmacodynamic (PD) and case report. Seven annotators, three annotators with drug–interaction research experience and four annotators with less drug–interaction research experience independently annotated the DDI corpus, where two researchers independently annotated each abstract. After two rounds of annotations with additional training in between, agreement improved from (0.79, 0.96, 0.86, 0.70, 0.91, 0.65, 0.78, 0.90) to (0.93, 0.99, 0.96, 0.94, 0.95, 0.93, 0.96, 0.97) for focus, certainty, evidence, study type, interaction type, mechanisms, polarity and direction, respectively. The novice-level annotators improved from 0.83 to 0.96, while the expert-level annotators stayed in high performance with some improvement, from 0.90 to 0.96. In summary, we achieved 96% agreement among each pair of annotators with regard to the eight dimensions. The annotated corpus is now available to the community for inclusion in their text-mining pipelines. Database URL https://github.com/zha204/DDI-Corpus-Database/tree/master/DDI%20corpus [ABSTRACT FROM AUTHOR]

Clinical notes are full of ambiguous medical abbreviations. Contextual knowledge has been leveraged by recent learning-based approaches for sense disambiguation. Previous findings indicated that structural elements of clinical notes entail useful characteristics for informing different interpretations of abbreviations, yet they have remained underutilized and have not been fully investigated. To our best knowledge, the only study exploring note structures simply enumerated the headers in the notes, where such representations are not semantically meaningful. This paper describes a learning-based approach using the note structure represented by the semantic types predefined in Unified Medical Language System (UMLS). We evaluated the representation in addition to the widely used N-gram with three learning models on two different datasets. Experiments indicate that our feature augmentation consistently improved model performance for abbreviation disambiguation, with the optimal F1 score of 0.93., (©2024 AMIA - All rights reserved.)