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30 results on '"Zhang, Hailou"'

16. Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus

Author

Sun, Yan, primary, Zhang, Hailou, additional, Wu, Zhangjie, additional, Yu, Xinlang, additional, Yin, Ying, additional, Qian, Shiyu, additional, Wang, Ziying, additional, Huang, Jiaru, additional, Wang, Wei, additional, Liu, Tao, additional, Xue, Wenda, additional, and Chen, Gang, additional

Published
2021
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18. Ganmaidazao-Shanzha Decoction Exerts Significant Antidepressant-Like Effects Involving the Hippocampal ProBDNF-mBDNF System in Different Ages of Mice

Author

Yu, Xinlang, primary, Wu, Zhangjie, additional, Li, Jianqing, additional, Yin, Ying, additional, Chen, Yifan, additional, Ge, Rui, additional, Zhang, Hailou, additional, Sun, Yan, additional, Wu, Haoxin, additional, Sun, Dongdong, additional, Zhou, Xin, additional, Wang, Wei, additional, and Xue, Wenda, additional

Published
2021
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20. Immediate and persistent antidepressant-like effects of Chaihu-jia-Longgu-Muli-tang are associated with instantly up-regulated BDNF in the hippocampus of mice

Author

Wang, Xing, primary, Chen, Jie, additional, Zhang, Hailou, additional, Huang, Zhiheng, additional, Zou, Zhilu, additional, Chen, Yin, additional, Sheng, Lei, additional, Xue, Wenda, additional, Tang, Juanjuan, additional, Wu, Haoxin, additional, Liu, Hongquan, additional, and Chen, Gang, additional

Published
2019
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25. Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice

Author

Tang, Juanjuan, primary, Xue, Wenda, additional, Xia, Baomei, additional, Ren, Li, additional, Tao, Weiwei, additional, Chen, Chang, additional, Zhang, Hailou, additional, Wu, Ruyan, additional, Wang, Qisheng, additional, Wu, Haoxin, additional, Duan, Jinao, additional, and Chen, Gang, additional

Published
2015
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29. Rapid Antidepressant Activity of Ethanol Extract of Gardenia jasminoides Ellis Is Associated with Upregulation of BDNF Expression in the Hippocampus.

Author

Zhang, Hailou, Xue, Wenda, Wu, Runjie, Gong, Tong, Tao, Weiwei, Zhou, Xin, Jiang, Jingjing, Zhang, Ying, Zhang, Nan, Cui, Yi, Chen, Chang, and Chen, Gang

Subjects
*ALTERNATIVE medicine, *ANIMAL behavior, *ANIMAL experimentation, *ANTIDEPRESSANTS, *HIPPOCAMPUS (Brain), *HISTOLOGICAL techniques, *INGESTION, *MEDICINAL plants, *CHINESE medicine, *MICE, *PLANT extracts, *STATISTICAL significance, *BRAIN-derived neurotrophic factor, *IN vivo studies, *PHARMACODYNAMICS
Abstract

Ethanol extract of Yueju pill, a Traditional Chinese Medicine herbal formula widely used to treat mood disorders, demonstrates rapid antidepressant effects similar to ketamine, likely via instant enhancement of brain-derived neurotrophic factor (BDNF) expression in the hippocampus. Here we investigated ethanol extracts of the constituent herbs of Yueju responsible for rapid antidepressant effects. Screening with tail suspension test in Kunming mice at 24 hours after a single administration of five individual constituent herbs of Yueju, we found that only Gardenia jasminoides Ellis (GJ) showed a significant effect. The antidepressant response started at 2 hours after GJ administration. Similar to Yueju and ketamine, a single administration of GJ significantly reduced the number of escape failures in the learned helplessness test. Furthermore, GJ decreased latency of food consumption in the novelty suppressed-feeding test. Additionally, starting from 2 hours and continuing for over 20 hours after GJ administration, BDNF expression in the hippocampus was upregulated, temporally linked with the antidepressant response. These findings suggest that GJ has rapid antidepressant effects, which are associated with the elevated expression of BDNF in the hippocampus. In Yueju formula, Yue represents GJ, as thus our study demonstrates the primary role of GJ in rapid antidepressant efficacy of Yueju. [ABSTRACT FROM AUTHOR]

Published
2015
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30. Expression of Disrupted-in-schizophrenia 1 in Hippocampus in Postpartum Depression Animal Models Induced by Pre-pregnancy Stress.

Author

Xia B, Chen C, Zhang H, Zhou X, Tao W, Wu H, and Chen G

Subjects
Animals, Corticosterone blood, Depression, Postpartum genetics, Disease Models, Animal, Estradiol blood, Female, Mice, Mice, Inbred BALB C, Nerve Tissue Proteins genetics, Pregnancy, Random Allocation, Depression, Postpartum metabolism, Hippocampus metabolism, Nerve Tissue Proteins metabolism, Stress, Psychological
Abstract

Objective To establish a postpartum depression animal model induced by pre-pregnancy stress,assess abnormal maternal depressive-like behavior,observe the expression of disrupted-in-schizophrenia 1 (DISC1) in the hippocampus,and detect serum estradiol and corticosterone.Methods A total of 32 female Balb/c were assigned to two groups using random number table:the control group and the pre-pregnancy stressed group(model group),and the model group was subjected to 3 weeks of chronic restraint stress. After the last stressor,the control group and the model group were housed with a male. About 4 weeks later,the mice gave birth to pups. Then at 3 weeks postpartum,open field test,tail suspension test,and sucrose preference test were carried out. The expressions of DISC1 mRNA and protein of hippocampus were detected by real-time quantitative polymerase chain reaction and Western blot,respectively. The serum levels of estradiol and corticosterone were detected with enzyme linked immunosorbent assay. Results After 3 weeks of postpartum,the model mice showed depression-like behaviors. In the open field test,there was no effect on the total distance moved or time spent in the center field (P>0.05). Immobility in tail suspension test was significantly increased (t=-4.950,P<0.001) and sucrose preference was significantly reduced in model group (t=2.475,P<0.05). There was significant statistical difference between control and model group on the expression of DISC1 mRNA (t=-8.915,P<0.001) and protein (t=-5.004,P<0.01) in hippocampus. There was no significant statistical difference on estradiol and corticosterone between two groups (P>0.05). Conclusion Chronic pre-pregnancy stress can induce dams into postpartum depression.The pathogenesis of postpartum depression may be related to the regulation of DISC1 in the hippocampus.

Published
2017
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