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2. Advances in the Delivery Systems for Improving the Processing Stability, Storage Stability and in Vivo Survival Rate of Probiotics

Author

ZHU Di, CHEN Shanan, MEI Xiaohong, YUE Qing, CHANG Ruxin, LI Xing, LIU Bin, ZHANG Hualei, HAN Xiaolong, LI Yuan

Subjects
probiotics, encapsulation, delivery system, microcapsule, viable count, intestinal colonization, Food processing and manufacture, TP368-456
Abstract

Probiotics offer numerous health benefits for human beings. However, it is difficult to achieve the expected beneficial effects of oral probiotics due to the viability loss during processing, storage and digestion. Oral delivery systems are effective ways to improve the processing and storage stability, gastric acid and bile salt tolerance, and intestinal adhesion and colonization ability of probiotics. This review focuses on the state of the art of oral delivery of probiotics, and summarizes the types of probiotics commonly used in probiotic products and their functional characteristics. Specifically, this review analyzes the effects of external environmental factors such as humidity, temperature, pH and oxygen, and internal environments such as the mouth, stomach, and small intestine on the survival rate of probiotics. Furthermore, the characteristics and applications of different oral delivery systems including microcapsule, hydrogel, oleogel, nanocoating, emulsion, and nanofiber are compared. Finally, this review proposes future prospects for cost reduction, intelligent packaging, co-packaging and population experiments of probiotic delivery systems, with the aim of providing technical support for the development of probiotic formulations with high storage stability and high viability suitable for intestinal targeted delivery.

Published
2023
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8. Legal Analysis of Labor Relations Disputes on Internet Platform

Author

Zhao, Jian, Zhang, Hualei, Xu, Yunfei, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, Hussain, Rosila Bee Binti Mohd, editor, Parc, Jimmyn, editor, and Li, Jia, editor

Published
2023
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9. Research on Labor Relations Model of Internet Platform Employment

Author

Zhao, Jian, Zhang, Hualei, Xu, Yunfei, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, Sedon, Mohd Fauzi bin, editor, Khan, Intakhab Alam, editor, BİRKÖK, Mehmet CÜNEYT, editor, and Chan, KinSun, editor

Published
2023
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10. Research on Organizational Effectiveness Evaluation Model of Internet Enterprises with High Resilience Energy Based on Multiple Integrations

Author

Cheng, Jiaxu, Li, Wenxuan, Xu, Jingce, Zhao, Jian, Wang, Youzi, Chang, Yan, Zang, Bingxin, Meng, Weixuan, Zhang, Hualei, Wang, Xuesong, Li, Xin, Dai, Gaoqi, Zhu, Wenhao, Han, Jiaping, Xu, Lanjun, Xia, Liyu, Sun, Lichun, Zhang, Xinsheng, Li, Kan, Editor-in-Chief, Li, Qingyong, Associate Editor, Fournier-Viger, Philippe, Series Editor, Hong, Wei-Chiang, Series Editor, Liang, Xun, Series Editor, Wang, Long, Series Editor, Xu, Xuesong, Series Editor, Yuan, Xueming, editor, Kurniawan, Yohannes, editor, and Ji, Zhenyan, editor

Published
2023
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11. Robust Respiration Sensing Based on Wi-Fi Beamforming

Author

Song, Wenchao, Wang, Zhu, Sun, Zhuo, Zhang, Hualei, Guo, Bin, Yu, Zhiwen, Ho, Chih-Chun, Chen, Liming, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Tsanas, Athanasios, editor, and Triantafyllidis, Andreas, editor

Published
2023
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13. Can experiment determine the stacking fault energy of metastable alloys?

Author

Suna, Xun, Lu, Song, Xie, Ruiwen, An, Xianghai, Li, Wei, Zhang, Tianlong, Liang, Chuanxin, Ding, Xiangdong, Wang, Yunzhi, Zhang, Hualei, and Vitos, Levente

Subjects
Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

Stacking fault energy (SFE) plays an important role in deformation mechanisms and mechanical properties of face-centered cubic (fcc) metals and alloys. In metastable fcc alloys, the SFEs determined from density functional theory (DFT) calculations and experimental methods often have opposite signs. Here, we show that the negative SFE by DFT reflects the thermodynamic instability of the fcc phase relative to the hexagonal close-packed one; while the experimentally determined SFEs are restricted to be positive by the models behind the indirect measurements. We argue that the common models underlying the experimental measurements of SFE fail in metastable alloys. In various concentrated solid solutions, we demonstrate that the SFEs obtained by DFT calculations correlate well with the primary deformation mechanisms observed experimentally, showing a better resolution than the experimentally measured SFEs. Furthermore, we believe that the negative SFE is important for understanding the abnormal behaviors of partial dislocations in metastable alloys under deformation. The present work advances the fundamental understanding of SFE and its relation to plastic deformations, and sheds light on future alloy design by physical metallurgy.

Published
2020

15. Theory of transformation-mediated twinning

Author

Lu, Song, Sun, Xun, An, Xianghai, Li, Wei, Chen, Yujie, Zhang, Hualei, and Vitos, Levente

Subjects
Condensed Matter - Materials Science, Physics - Applied Physics
Abstract

High-density and nanosized deformation twins in face-centered cubic (fcc)materials can effectively improve the combination of strength and ductility. However, the microscopic dislocation mechanisms enabling a high twinnability remain elusive. Twinning usually occurs via continuous nucleation and gliding of twinning partial dislocations on consecutive close-packed atomic planes. Here we unveil a completely different twinning mechanism being active in metastable fcc materials. The transformation-mediated twinning (TMT) is featured by a preceding displacive transformation from the fcc phase to the hexagonal close-packed (hcp) one, followed by a second-step transformation from the hcp phase to the fcc twin. The nucleation of the intermediate hcp phase is driven by the thermodynamic instability and the negative stacking fault energy of the metastable fcc phase. The intermediate hcp structure is characterized by the easy slips of Shockley partial dislocations on the basal planes, which leads to both fcc and fcc twin platelets during deformation, creating more twin boundaries and further enhancing the prosperity of twins. The disclosed fundamental understanding of the complex dislocation mechanism of deformation twinning in metastable alloys paves the road to design novel materials with outstanding mechanical properties.

Published
2019

18. Research on Organizational Effectiveness Evaluation Model of Internet Enterprises with High Resilience Energy Based on Multiple Integrations

Author

Cheng, Jiaxu, primary, Li, Wenxuan, additional, Xu, Jingce, additional, Zhao, Jian, additional, Wang, Youzi, additional, Chang, Yan, additional, Zang, Bingxin, additional, Meng, Weixuan, additional, Zhang, Hualei, additional, Wang, Xuesong, additional, Li, Xin, additional, Cheng, Jiaxu, additional, Dai, Gaoqi, additional, Zhu, Wenhao, additional, Han, Jiaping, additional, Xu, Lanjun, additional, Xia, Liyu, additional, Sun, Lichun, additional, and Zhang, Xinsheng, additional

Published
2023
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20. The Influencing Factor Model of Organizational Form in Power Grid Business

Author

Xu, Yunfei, Zhao, Jian, Zhang, Hualei, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, Holl, Augustin, editor, Chen, Jun, editor, and Guan, Guiyun, editor

Published
2022
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29. Evaluation of Mixed Ownership Reform Based on Fuzzy Logic

Author

Zhang, Hualei, Zhao, Jian, Huang, Liling, Wang, Jing, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Sugumaran, Vijayan, editor, Xu, Zheng, editor, and Zhou, Huiyu, editor

Published
2021
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30. LINC01232 targeting miR-1250-3p/MSH2 axis attenuates mesangial cell proliferation and fibrosis in diabetic nephropathy.

Author

Tu, Xian, Zhang, Hualei, and Ren, Hongyan

Abstract

The significance of long non-coding RNA (ncRNAs) in the initiation and progression of diabetic nephropathy (DN) has attracted much interest. The purpose of this work was to ascertain the role of LINC01232 in cell models and animal models of DN. C57BL/6 J mice were administered with streptozotocin (STZ) to develop animal models of DN, and mouse glomerular mesangial cells (MCs) were exposed to high glucose (HG) to establish cell models of DN. Expression levels of LINC01232, miR-1250-3p and MSH2 were identified by quantitative real-time PCR (qPCR) or western blotting. Fibrosis-related proteins were quantified by western blotting. MC proliferative capacity was checked by EdU assay. DN progression and fibrosis level in animal models were assessed by hematoxylin and eosin (HE) and Masson staining. The potential binding sites between miR-1250-3p and LINC01232 or MSH2 were examined by dual-luciferase reporter assay. LINC01232 expression was heightened in kidney tissues of DN patients. Its overexpression in HG-treated MCs alleviated MC proliferation and fibrosis. Overexpression of LINC01232 alleviated the pathological state of glomerular hypertrophy, MC hyperplasia, basement membrane thickening, and fibrosis in the DN models. LINC01232 bound to miR-1250-3p and competed for miR-1250-3p binding sites with MSH2. LINC01232 overexpression decoyed miR-1250-3p to increase MSH2 expression, and MSH2 depletion restored LINC01232 overexpression-inhibited MC proliferation and fibrosis. LINC01232 alleviated the mesangial cell proliferation and fibrosis in the progression of DN by targeting miR-1250-3p/MSH2 pathway. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Tensile strain-induced softening of iron at high temperature

Author

Li, Xiaoqing, Schönecker, Stephan, Simon, Eszter, Bergqvist, Lars, Zhang, Hualei, Szunyogh, László, Zhao, Jijun, Johansson, Börje, and Vitos, Levente

Subjects
Condensed Matter - Materials Science, Condensed Matter - Disordered Systems and Neural Networks
Abstract

In weakly ferromagnetic materials, already small changes in the atomic configuration triggered by temperature or chemistry can alter the magnetic interactions responsible for the non-random atomic-spin orientation. Different magnetic states, in turn, can give rise to substantially different macroscopic properties. A classical example is iron, which exhibits a great variety of properties as one gradually removes the magnetic long-range order by raising the temperature towards and beyond its Curie point of $T_{\text{C}}^{0}=1043$\,K. Using first-principles theory, here we demonstrate that uniaxial tensile strain can also destabilize the magnetic order in iron and eventually lead to a ferromagnetic to paramagnetic transition at temperatures far below $T_{\text{C}}^{0}$. In consequence, the intrinsic strength of the ideal single-crystal body-centered cubic iron dramatically weakens above a critical temperature of $\sim 500$\,K. The discovered strain-induced magneto-mechanical softening provides a plausible atomic-level mechanism behind the observed drop of the measured strength of Fe whiskers around $300-500$\,K. Alloying additions which have the capability to partially restore the magnetic order in the strained Fe lattice, push the critical temperature for the strength-softening scenario towards the magnetic transition temperature of the undeformed lattice. This can result in a surprisingly large alloying-driven strengthening effect at high temperature as illustrated here in the case of Fe-Co alloy., Comment: 3 figures

Published
2015
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36. The situation analysis on market-oriented selection and employment of talents in power grid business

Author

Xu Yunfei, Zhao Jian, and Zhang Hualei

Subjects
Social Sciences
Abstract

Talent is the "first resource" for state-owned enterprises to achieve high-quality development. Only by following the law of market economy can we realize the optimal allocation of talent elements and play the maximum value. The government has repeatedly stressed that it should not only introduce local talents from regions, but also seek all development talents, use good talents without sticking to one pattern, and gather talents from all over the world. The construction of market-oriented selection and employment mechanism is an important measure to implement the reform of state-owned enterprises. It is of great significance to improving the market-oriented operation mechanism of SOEs, stimulating the development vitality and endogenous impetus of SOEs, and promoting the high-quality development of SOEs. From the perspective of internal and external reform and development situation, this paper analyses the new requirements and challenges of the reform of state-owned enterprises and the market-oriented selection and employment of power grid business, and further clarifies the direction and policy requirements of the construction of the market-oriented selection and employment mechanism. The importance and necessity to promote market-oriented selection and employment mechanism are comprehensively and systematically expounded.

Published
2023
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