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14 results on '"Zhang, Huamiao"'

2. Nano-immunotherapy for lung cancer

Author

Lu, Yuting, Zeng, Tangye, Zhang, Huamiao, Li, Yang, Zhu, Xiaoling, Liu, Huiping, Sun, Beibei, Ji, Chaoran, Li, Ting, Huang, Leyi, Peng, Kesong, Tang, Zhe, and Tang, Longguang

Published
2023
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5. Neutrophil Targeting Platform Reduces Neutrophil Extracellular Traps for Improved Traumatic Brain Injury and Stroke Theranostics.

Author

Mu, Qingchun, Yao, Kai, Syeda, Madiha Zahra, Wan, Jinlong, Cheng, Qian, You, Zhen, Sun, Rui, Zhang, Yufei, Zhang, Huamiao, Lu, Yuting, Luo, Zhicheng, Li, Yang, Liu, Fuyao, Liu, Huiping, Zou, Xinyu, Zhu, Yanfen, Peng, Kesong, Huang, Chunming, Chen, Xiaoyuan, and Tang, Longguang

Subjects
NEUTROPHILS, BRAIN injuries, STROKE, ARGININE deiminase, VASCULAR remodeling, COMPANION diagnostics
Abstract

Traumatic brain injuries (TBI) and stroke are major causes of morbidity and mortality in both developing and developed countries. The complex and heterogeneous pathophysiology of TBI and cerebral ischemia‐reperfusion injury (CIRI), in addition to the blood‐brain barrier (BBB) resistance, is a major barrier to the advancement of diagnostics and therapeutics. Clinical data showed that the severity of TBI and stroke is positively correlated with the number of neutrophils in peripheral blood and brain injury sites. Furthermore, neutrophil extracellular traps (NETs) released by neutrophils correlate with worse TBI and stroke outcomes by impairing revascularization and vascular remodeling. Therefore, targeting neutrophils to deliver NETs inhibitors to brain injury sites and reduce the formation of NETs can be an optimal strategy for TBI and stroke therapy. Herein, the study designs and synthesizes a reactive oxygen species (ROS)‐responsive neutrophil‐targeting delivery system loaded with peptidyl arginine deiminase 4 (PAD4) inhibitor, GSK484, to prevent the formation of NETs in brain injury sites, which significantly inhibited neuroinflammation and improved neurological deficits, and improved the survival rate of TBI and CIRI. This strategy may provide a groundwork for the development of targeted theranostics of TBI and stroke. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Ligustrazine Nanoparticle Hitchhiking on Neutrophils for Enhanced Therapy of Cerebral Ischemia‐Reperfusion Injury

Author

Mu, Qingchun, primary, Yao, Kai, additional, Syeda, Madiha Zahra, additional, Zhang, Min, additional, Cheng, Qian, additional, Zhang, Yufei, additional, Sun, Rui, additional, Lu, Yuting, additional, Zhang, Huamiao, additional, Luo, Zhicheng, additional, Huang, Hanning, additional, Liu, Xiaojing, additional, Luo, Chunmei, additional, Zhu, Xiulong, additional, Wu, Shuyu, additional, Cui, Liao, additional, Huang, Chunming, additional, Chen, Xiaoyuan, additional, and Tang, Longguang, additional

Published
2023
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9. Reaction-free and MMP-independent fluorescent probes for long-term mitochondria visualization and tracking† †Electronic supplementary information (ESI) available: Materials and methods; synthetic details, NMR spectra and HRMS spectra; photophysical data; and imaging data. CCDC 1851638 and 1851639. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8sc05119d

Author

Zhang, Ruoyao, Niu, Guangle, Li, Xuechen, Guo, Lifang, Zhang, Huamiao, Yang, Rui, Chen, Yuncong, Yu, Xiaoqiang, and Tang, Ben Zhong

Subjects
Chemistry, sense organs, skin and connective tissue diseases
Abstract

We present two mitochondria-immobilized fluorescent probes ECPI-12 and IVPI-12 for long-term mitochondria visualization and tracking regardless of MMP changes., Visualizing and tracking mitochondrial dynamic changes is crucially important in the fields of physiology, pathology and pharmacology. Traditional electrostatic-attraction based mitochondrial probes fail to visualize and track the changes due to their leakage from mitochondria when mitochondrial membrane potential (MMP) decreases. Reaction-based MitoTracker probes can realize visualization and tracking of mitochondria changes independent of MMP changes. However, such probes impair mitochondrial proteins and exhibit high cytotoxicity. Therefore, it still remains challenging to explore reaction-free and highly biocompatible probes for visualizing and tracking mitochondrial dynamics independent of MMP fluctuations. Herein we synthesized two reaction-free fluorescent mitochondrial probes ECPI-12 and IVPI-12 bearing a long C12-alkyl chain. These cationic probes can firmly immobilize in the mitochondrial inner membrane by strong hydrophobic interaction between the C12-alkyl chain and lipid bilayer, resulting in high specificity and long-term mitochondrial staining regardless of MMP changes. They also exhibit large two-photon absorption cross-sections and show deep penetration in live tissues in two-photon microscopy. Furthermore, they display excellent biocompatibility and realize in situ and real-time mitophagy tracking in live cells. These excellent properties could make ECPI-12 and IVPI-12 the first selective tools for long-term visualization and tracking of mitochondrial dynamics.

Published
2018

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