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Perampanel (PER) is a new type of antiseizure medication used for partial or generalized seizures. However, the plasma concentration shows obvious individual variability in children. The present study aims to ascertain the effect of age, comedications, and cytochrome P450 (CYP) 3A4/5 polymorphisms on PER exposure in Chinese pediatric patients with epilepsy. Clinical data were retrospectively collected in a tertiary children's hospital medical records system from January 2021 to December 2022. The influence factors on the daily dose, plasma concentration, and concentration‐to‐dose ratio (CDR) of PER were investigated. A total of 135 pediatric patients with 178 blood samples were involved. With a median daily dose of 4.0 mg (interquartile range, 3.0‐5.0 mg), the median plasma concentration was 409.4 ng/mL (interquartile range, 251.7‐639.4 ng/mL). The CDR in patients aged less than 4 years was significantly decreased by 48.0% and 39.1% compared with those aged 4‐11 years and 12 years or older, respectively. Enzyme inducers significantly decreased the CDR of PER by 34.5%, while valproic acid showed an increase of 71.7%. In addition, genotype CYP3A5*3/*3 carriers presented a significant increase of 21.5% compared to the CYP3A5*1/*3 expresser. No correlations were observed between the CDR and CYP3A4∗1G polymorphism. PER showed high variations in individual plasma concentrations. Age younger than 4 years, comedication with enzyme inducers or valproic acid, and possession of the CYP3A5*3 genotype potentially predicted PER exposure in pediatric patients with epilepsy. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of diosmine on semen quality and sex hormone concentration in patients with spermatovenous ligation. Methods Clinical data were retrospectively collected from January 2019 to January 2022 on patients with varicocele admitted to Department of Urology, General Hospital of Southern Theater Command, divided into a control group and a study group based on whether they had a history of Diosmine use after surgery. Clinical data from both groups were matched using propensity score matching. Sperm quality and sex hormone tests were then compared before surgery, three months after surgery and six months after surgery. Results There were 73 in the control group and 73 in the study group. Both groups were balanced in terms of age, BMI, seminal fluid volume and testosterone (P > 0.05). Sperm motility, forward motility and testosterone were all increased 3 and 6 months after surgery, and sperm malformations, sperm DNA fragment index, follicle stimulating hormone and luteinizing hormone were all reduced significantly (P < 0.05 ). The results were also better than those in the control group for total sperm motility, forward motility, testosterone, sperm DNA fragment index, follicle stimulating hormone and luteinizing hormone (P < 0.05 ). Conclusions Diosmine can help to restore semen quality and improve sex hormone concentration in patients with varicocele after Laparoscopic varicocelectomy. [ABSTRACT FROM AUTHOR]

This study examined the effects of straw from cadmium (Cd)-accumulator plant species on the growth and Cd uptake of Ziziphus acidojujuba seedlings grown in Cd-containing soil. The treatments were independent applications of straw from seven Cd-accumulator plant species (Cardamine hirsuta, Gnaphalium polycaulon, Pterocypsela laciniata, Malachium aquaticum, Galium aparine, Conyza canadensis, and Stellaria media) and a no-straw control. The whole-plant biomass, total chlorophyll and soluble sugar contents, and antioxidant enzymes activities in Z. acidojujuba seedlings under the different straw treatments showed the following trend: P. laciniata > M. aquaticum > S. media > C. canadensis > G. polycaulon > control > G. aparine > C. hirsuta. Compared with the control, the Cd contents in roots of Z. acidojujuba seedlings after any straw application significantly decreased by 19.05%-43.76%, and the Cd contents in shoots decreased by 31.58%-54.39%, except after G. aparine, G. polycaulon, and C. hirsuta straws applications. Therefore, the application of P. laciniata, M. aquaticum, and S. media straws promoted the growth and reduced the Cd uptake of Z. acidojujuba seedlings most significantly, making them ideal remediation materials for Cd-contaminated jujuba orchards. [ABSTRACT FROM AUTHOR]

Herein, we prepared a pot experiment to explore the potential effects of cadmium (Cd) hyperaccumulator Solanum photeinocarpum and its post grafting generations straw on Cd accumulation in loquat seedlings. Two varieties ('Dawuxing' and 'Chuanzao') of loquat seedlings were planted in Cd-contaminated soil together with the straw of S. photeinocarpum (UG) and its post grafting generations with self-rooted grafting involving one S. photeinocarpum seedling (SG), self-rooted grafting involving two S. photeinocarpum seedling developmental stages (DG), and grafting on wild potato rootstock (PG). With the application of DG and PG straw, biomass of the root, stem, leaf, and shoot of loquat seedlings were slightly higher, whereas UG and SG straw had no apparent effects. DG and PG straw increased the Cd contents in various organs of loquat seedlings and elevated the Cd extractions in various organs of loquat seedlings to some extent while UG and SG had no apparent effects on that. These findings demonstrate that the straw of DG and PG can promote growth and increase the phytoremediation ability of loquat seedlings (not suitable for the resulting loquat tree), with PG as the best choice. [ABSTRACT FROM AUTHOR]