Search

This study investigated the effects of amygdalin (AMY, a cyanogenic glycoside widely distributed in the fruits and seeds of Rosaceae plants) on cardiac performance and ventricular remodeling in a rat model of myocardial infarction (MI). We also investigated whether the combination of AMY with exercise training (ExT) has a beneficial synergistic effect in treating MI rats. MI was induced by the ligation of the left anterior descending coronary artery in male SD rats. ExT or AMY treatment was started 1 week after MI and continued for 1 week (short-term) or 8 weeks (long-term). Cardiac function was evaluated by echocardiographic and hemodynamic parameters. Heart tissues were harvested and subjected to 2,3,5-triphenyl-tetrazolium chloride, Masson's trichrome, hematoxylin-eosin, and immunohistochemical staining. Gene expression was determined by quantitative polymerase chain reaction. Western blot gave a qualitative assessment of protein levels. AMY or ExT improved cardiac function and reduced infarct size in MI rats. AMY or ExT also suppressed myocardial fibrosis and attenuated inflammation in the infarct border zone of hearts from MI rats, as evidenced by inhibition of collagen deposition, inflammatory cell infiltration, and pro-inflammatory markers (interleukin 1β, interleukin 6, tumor necrosis factor-α, and cyclooxygenase 2). Notably, the effects of AMY combined with ExT were superior to those of AMY alone or ExT alone. Mechanistically, these beneficial functions were correlated with the inhibition of MI-induced activation of the transforming growth factor-β/Smad pathway. Collectively, AMY and ExT exert a synergistic effect on improving cardiac performance and ameliorating cardiac inflammation and fibrosis after MI, and the effects of long-term intervention were better than short-term intervention. [ABSTRACT FROM AUTHOR]

Objective By analyzing changes of dental arch width and length during the aligning and leveling period (non ⁃ extraction case) with two kinds of self ⁃locking bracket, compare the difference between the active self ⁃locking bracket with the passive bracket. Methods The data of dental arch perimeter change amount and dental arch width and length change amount (WU/L3, WU/L4, WU/L5, WU/L6, U/LL) were statistically analyzed using the correlation and regression method by comparing active and passive brackets for the correction of dental arch variations. Two different brackets for the correction of the measured values of the dental arch variations was analyzed by t⁃test. Results There were statistical relationships between the amount of arch perimeter increase and the amount of width and length in⁃ crease. The regression equation was statistically significant (P < 0.05), It was greater impacted arch width increase to arch perimeter in the self⁃locking. The t⁃test results showed WU3, WL3, WL6, LR 4 measured values (P < 0.05) statisti⁃ cally significant in the active self⁃locking group and passive group. Conclusion Active and passive self⁃locking brack⁃ et have good arch expansion effecting. The active self⁃locking bracket is slightly dominant than the passive bracket in the expansion of the canine width whereas the active self⁃locking bracket is better than the passive in the expansion of the mandibular first molar and arch perimeter which should be widely applied to the appropriate cases.

Objective The aim of this study is to measure the labial alveolar bone thickness of the Angle Ⅱ，Divi⁃ sion 2 patients and healthy adults with CBCT technique, in order to provide reference for clinical dental orthodontic de⁃ sign. Methods Sixty cases were consecutively selected from the Fourth Affiliated Hospital outpatients of Inner Mongo⁃ lia Medical College. They were divided into the case group and control group. Each group contains 30 patients (15 men and 15 women). CBCT was used to scan maxillofacial region and 3D models were made on computer, software was used to measure labial alveolar bone thickness in three points of the teeth (the root, central and apical). Analyze the result fi⁃ nally. Results There was no significant difference between contralateral teeth. There was significant difference be⁃ tween the Angle Ⅱ, Division 2 patients and control group in different gender. There was significant difference between the case and control group in the thickness of incisor L1, L3, lateral incisor of L1, L3 and canine of L1, L2, L3. Conclu⁃ sions There is no difference in the thickness of labial alveolar bone wall of the same tooth in both groups. Maxillary anterior labial bone wall of male is thicker than female􀆳 in both groups. The maxillary anterior region of labial bone of Angle Ⅱ, Division 2 patients is thinner than normal adults in thecontrol group.

Fused teeth are one of the development abnormalities in tooth morphology which mainly occurred in the anterior teeth area and relatively rare in the posterior area. This paper reports one case of maxillary first molar and second molar tooth relative fusion, which provide reference for the clinical treatment of patients.