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With the development of sequencing technology and the dramatic drop in sequencing cost, the functions of noncoding genes are being characterized in a wide variety of fields (e.g. biomedicine). Enhancers are noncoding DNA elements with vital transcription regulation functions. Tens of thousands of enhancers have been identified in the human genome; however, the location, function, target genes and regulatory mechanisms of most enhancers have not been elucidated thus far. As high-throughput sequencing techniques have leapt forwards, omics approaches have been extensively employed in enhancer research. Multidimensional genomic data integration enables the full exploration of the data and provides novel perspectives for screening, identification and characterization of the function and regulatory mechanisms of unknown enhancers. However, multidimensional genomic data are still difficult to integrate genome wide due to complex varieties, massive amounts, high rarity, etc. To facilitate the appropriate methods for studying enhancers with high efficacy, we delineate the principles, data processing modes and progress of various omics approaches to study enhancers and summarize the applications of traditional machine learning and deep learning in multi-omics integration in the enhancer field. In addition, the challenges encountered during the integration of multiple omics data are addressed. Overall, this review provides a comprehensive foundation for enhancer analysis. [ABSTRACT FROM AUTHOR]

Household traffic surveys are widely used in travel behavior analysis, especially in travel time and distance analysis. Unfortunately, any one kind of household traffic surveys has its own problems. Even all household traffic survey data is accurate, it is difficult to get the trip routes information. To our delight, electric map API (e.g., Google Maps, Apple Maps, Baidu Maps, and Auto Navi Maps) could provide the trip route and time information, which remedies the traditional traffic survey's defect. Thus, we can take advantage of the two kinds of data and integrate them into travel behavior analysis. In order to test the validity of the Baidu electric map API data, a field study on 300 taxi OD pairs is carried out. According to statistical analysis, the average matching rate of total OD pairs is 90.74%, which reflects high accuracy of electric map API data. Based on the fused data of household traffic survey and electric map API, travel behavior on trip time and distance is analyzed. Results show that most purposes' trip distances distributions are concentrated, which are no more than 10 kilometers. It is worth noting that students have the shortest travel distance and company business's travel distance distribution is dispersed, which has the longest travel distance. Compared to travel distance, the standard deviations of all purposes' travel time are greater than the travel distance. Car users have longer travel distance than bus travelers, and their average travel distance is 8.58km., 1. Introduction It is axiomatic that a model can never be better than the data from which it is estimated [1]. Household traffic surveys are mainly used in transport planning [...]

A simple, broad‐scope rhodium(I)/chiral diene catalytic system for challenging asymmetric intramolecular cyclopropanation of various tri‐substituted allylic diazoacetates was successfully developed. The low coordination state RhI‐complex exhibits an extraordinarily high degree of tolerance to the variation in the extent of substitution of the allyl double bond, thus allowing the efficient construction of a wide range of penta‐substituted, fused‐ring cyclopropanes bearing three contiguous stereogenic centers, including two quaternary carbon stereocenters, in a highly enantioselective manner with ease at catalyst loading as low as 0.1 mol %. The stereoinduction mode of this RhI‐carbene‐directed asymmetric intramolecular cyclopropanation was investigated by DFT calculations, indicating that π‐π stacking interactions between the aromatic rings of chiral diene ligand and diazo substrate play a key role in the control of the reaction enantioselectivity. [ABSTRACT FROM AUTHOR]

The crash injury severity prediction of traffic accident is the prerequisite for driving decisions under dangerous conditions. This paper puts forward a new wrapper feature selection algorithm to improve the prediction accuracy of the injury severity. Firstly, based on Gini index and Mutual information, the importance of factors is analyzed by the comprehensive evaluation criteria, according to the importance score, the factors were selected by sequential backward selection. Secondly, three models, that is RF (Random Forest), C4.5 (C4.5 Decision Tree) and SVM (Support Vector Machine) are established to verify the prediction accuracy of selected subsets. In order to verify the proposed algorithm, based on the FARS(Fatality Analysis Reporting System) in the NHTSA(National Highway Traffic Safety Administration), a total of 6,295 rear-end accidents including 23 candidate factors were screened, the results demonstrate that the accuracy of the three models increases with the elimination of redundant variables, among them the SVM model has better predictive performance, the significant factors are obtained which include seat belts, airbag, the relative speed, vehicle weight, etc. finally the sensitivity analysis of significant factors is implemented and some suggestions are given to improve traffic safety. [ABSTRACT FROM AUTHOR]