278 results on '"Zhang, Leike"'
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2. Dynamic characteristics analysis and vibration control of coupled bending-torsional system for axial flow hydraulic generating set
3. Transient vibration control on coupled unit-plant structure of pumped storage power station based on MRD optimal layout
4. Design of antiviral AGO2-dependent short hairpin RNAs
5. Vibration control on coupled unit-plant structure of pumped storage power station during sudden load-up process
6. Hsp90 β is critical for the infection of severe fever with thrombocytopenia syndrome virus
7. A nanoluciferase SFTSV for rapid screening antivirals and real-time visualization of virus infection in mice
8. Research on rub-impact rotor vibration of hydraulic generating set based on HB-AFT method
9. Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry
10. Correction: Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment
11. Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir
12. A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir
13. Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment
14. Transient vibration of shafting in coupled hydraulic-mechanical-electrical- structural system for hydropower station during start-up process
15. Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2
16. Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo-controlled, phase 1b trial
17. The stability analysis and nonlinear vibration control of shaft system for hydraulic generating set under multi-source excitation considering effects of dynamic and static eccentricities
18. Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety
19. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2
20. Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332
21. In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2
22. Visualizing lymphocytic choriomeningitis virus infection in cells and living mice
23. Vibration characteristics analysis of shaft system for bulb hydroelectric generating unit based on magnetorheological fluid damper
24. Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV‑2 by Blocking the Function of Cathepsin L.
25. Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model
26. Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association
27. CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity
28. Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
29. A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates
30. High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
31. Coupled bending-torsional vibration analysis for rotor-bearing system with rub-impact of hydraulic generating set under both dynamic and static eccentric electromagnetic excitation
32. Comprehensive interactome analysis of the spike protein of swine acute diarrhea syndrome coronavirus
33. Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CLpro Inhibitors as anti-SARS-CoV‑2 Drug Candidate.
34. Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2
35. Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19
36. Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin
37. Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
38. Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
39. Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro
40. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
41. SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells
42. Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
43. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur
44. Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
45. Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro
46. Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease
47. Design, synthesis, and evaluation of novel oxyacanthine derivatives for anti-SARS-CoV-2 activity
48. Transient vibration analysis of unit-plant structure for hydropower station in sudden load increasing process
49. Research on optimal allocation of flow and head in cascade pumping stations based on Harris hawks optimization
50. Repurposing of Rutan showed effective treatment for COVID-19 disease
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