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Objective To explore the etiology, clinical manifestations, diagnosis, differential diagnosis and treatment of idiopathic gingival fibromatosis, and to provide references for clinical diagnosis and treatment. Methods The clinical data and related literatures of a case of idiopathicgingival fibroma that occurred in the oral cavity were retrospectively analyzed. Results Total periodontal treatment was performed for the patient, and the gingival morphology was improved after periodontal surgery in the anterior region. Idiopathic gingival fibromatosis is a rare disease characterized by gingival tissue hyperplasia. The etiology and pathogenesis are unknown. The disease can occur in young children. Generally, it occurs after the permanent teeth erupt, and it manifests as extensive gingival hyperplasia, which can affect the entire gingival margin, gingival papilla and attached gingival, and can even reach the membrane-gingival junction. The pathological changes include thickening of the spinous layer of the gingival epithelium, significant increases in the epithelial styloid process, increases in the connective tissue volume, and filling with large collagen fiber bundles and a large number of fibroblasts. The blood vessels are relatively small, and inflammation is not obvious. Clinically, this disease needs to be distinguished from drug-induced gingival hyperplasia and chronic gingivitis with hyperplasia as the main manifestation. At present, the treatment of idiopathic gingival fibromatosis is mainly gingival angioplasty. The disease easily relapses after surgery. The recurrence rate is related to the quality of oral hygiene. After recurrence, it can be treated again. Conclusion Idiopathic gingival fibromatosis is relatively rare, and the diagnosis mainly depends on the history of inquiry, clinical manifestations and pathological examination. The treatment is mainly surgical resection, and future research should focus on finding a more effective treatment.

A large number of studies have confirmed that periodontitis is closely related to systemic multisystem diseases. Local inflammation of periodontal tissue may cause systemic inflammation. As an inflammatory factor, C-reactive protein (CRP) is widely used to monitor various inflammatory states. CRP is not only highly related to periodontitis but also closely related to systemic diseases. This article reviews the relationship between periodontitis and systemic disease epidemiology as well as the mechanism of CRP in the relationship between them. The literature review shows that periodontitis is closely related to cardiovascular diseases, diabetes, premature and low-birth-weight infants, chronic kidney disease, rheumatoid arthritis and other systemic diseases. Periodontitis, as a chronic inflammatory disease, can increase the level of serum CRP, thus increasing the risk of cardiovascular disease and affecting blood glucose control in diabetic patients, which may be related to the increased risk of premature delivery and low-birth-weight infants, may affect the development of chronic kidney disease, and may be used as one of the sensitive indicators of rheumatoid arthritis in the active stage. Through periodontal treatment, serum CRP levels can be reduced, which is helpful for the treatment of systemic diseases. CRP levels can be used as indicator for prevention, diagnosis and treatment of periodontitis and systemic diseases.