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As diversity becomes more widespread within teams, it is crucial to examine the dynamics of person-team fit and its effect on team creativity. By exploring the interplay between complementary fit and supplementary fit, this study aims to shed light on how these two dimensions of person-team fit contribute to the creative processes within teams based on the optimal distinctiveness theory (ODT). A two-wave field survey was conducted among 363 frontline employees within 113 teams in hotels. The regression results indicated a positive association between complementary fit and team creativity. Furthermore, the mediating role of information elaboration in this relationship was observed. Supplementary fit played a positive moderating effect between complementary fit and team creativity whereby teams with higher levels of complementary fit demonstrated higher levels of team creativity, particularly when supplementary fit was also high. Our findings thus provide significant implications for organizations seeking to enhance team creativity, that is, ensuring an inclusive climate that promotes the emergence of shared perceptions regarding both complementary and supplementary fit. Plain language summary: Propose: this study seeks to explore how the interaction between two types of person-team fit (i.e., complementary fit and supplementary fit) influences team creativity based on the optimal distinctiveness theory (ODT). Methods: A two-wave field survey was conducted among 363 frontline employees within 113 teams in hotels. Conclusions: complementary fit was positively related to team creativity. Information elaboration mediated the above relationship. Supplementary fit played a positive moderating effect between complementary fit and team creativity in such a way that when supplementary fit was high, teams with higher complementary fit showed higher team creativity. Implications: our study enriches the fit literature by simultaneously considering two types of person-team fit and figuring out their effects on creativity. [ABSTRACT FROM AUTHOR]

Background: The first-line treatment for polycystic ovary syndrome (PCOS) is lifestyle modification. However, it is currently unknown whether digital medicine can assist patients with PCOS in maintaining a healthy lifestyle while alleviating PCOS symptoms. Objective: This study aims to evaluate the efficacy of WeChat-based digital intervention versus metformin treatment in women with PCOS and insulin resistance. Methods: A total of 80 women with PCOS and insulin resistance were recruited from an endocrinology clinic and randomly assigned to receive either a WeChat-based digital intervention (n=40, 50%) or metformin (n=40, 50%) for 12 weeks. The WeChat-based digital intervention consisted of 3 modules; a coach assisted the patients in using the intervention. The primary outcome was the change in a homeostatic model assessment for insulin resistance. At baseline and after the 12-week intervention, anthropometric parameters, menstruation frequency, sex hormone levels, metabolic factors, and body fat distribution were measured in the clinic. Furthermore, self-assessed web-based questionnaires on diet, exercise, sleep, anxiety, and depression were obtained. Results: A total of 72 participants completed the follow-up (for a 90% follow-up rate), including 35 of 40 (88%) participants from the digital intervention group and 37 of 40 (93%) participants from the metformin group. The homeostatic model assessment for insulin resistance in the digital intervention group was significantly improved after 12 weeks of treatment with a mean change of –0.93 (95% CI –1.64 to –0.23), but no statistical difference was observed between the groups (least squares mean difference –0.20; 95% CI –0.98 to 0.58; P =.62). Both digital intervention and metformin treatment significantly improved menstruation frequency (digital intervention: P <.001; metformin: P <.001) and reduced body weight (digital intervention: P <.001; metformin: P <.001) and total fat mass (digital intervention: P <.001; metformin: P <.001). Furthermore, the digital intervention had a significant advantage over metformin in improving waist circumference (least squares mean difference –1.84; 95% CI –3.44 to –0.24; P =.03), waist-to-hip ratio (least squares mean difference –0.02; 95% CI –0.03 to 0.00; P =.03), total fat mass (least squares mean difference –1.59; 95% CI –2.88 to –0.30; P =.02), and dehydroepiandrosterone sulfate (least squares mean difference –69.73; 95% CI –129.70 to –9.75; P =.02). In terms of safety, the main adverse events were sensations of hunger in the digital intervention group (2/40, 5%) and gastrointestinal adverse events in the metformin group (12/40, 30%). Conclusions: Our data suggest that digital intervention is an effective treatment option for patients with PCOS, with an efficacy comparable to that of metformin, and that it can also alleviate the negative effects of medications and make it easier and more efficient to adhere to lifestyle treatments. WeChat-based digital interventions have the potential to provide a new path for the improvement and health of women with PCOS in China. Trial Registration: ClinicalTrials.gov NCT05386706; https://clinicaltrials.gov/study/NCT05386706 [ABSTRACT FROM AUTHOR]

Objective: To explore the predictors of menstrual recovery in polycystic ovary syndrome (PCOS) women with obesity following laparoscopic sleeve gastrectomy (LSG). Methods: A total of 88 PCOS patients with obesity and 76 control patients with obesity aged 18– 45 years were enrolled between May 2013 and December 2020. PCOS was diagnosed using the Rotterdam diagnostic criteria (2003). Anthropometric measurements, biochemical parameters, sex hormones, and circulating fibrinogen-like protein 1 (FGL-1) levels were collected before and six-month after LSG. The data on postoperative menstrual status, body weight, and fertility were obtained through telephone follow-ups for all individuals with PCOS. Results: Patients with PCOS were followed up for at least six months after surgery, and the mean follow-up time was 3.23 years. At 6 months after LSG, circulating total testosterone (TT), calculated free testosterone (cFT), and FGL-1 levels declined significantly. The mean percent excess weight loss (%EWL) and percent total weight loss (%TWL) in PCOS patients at the final follow-up was 97.52% ± 33.90% and 31.65% ± 10.31%, respectively. The proportion of regular menstruation in PCOS patients significantly increased within six months (75.86% vs 0.03% at baseline). In the logistic regression analysis, time from PCOS diagnosis (P=0.007), body mass index (BMI) (P=0.007), TT (P=0.038) at baseline were demonstrated to be independent predictive factors for the regular menstruation in women with PCOS and obesity within 6 months after LSG. Conclusion: In PCOS patients with obesity, time from PCOS diagnosis, BMI, and TT levels at baseline were independently and negatively associated with menstrual recovery within 6 months after LSG, which could be applied in preoperative evaluation. [ABSTRACT FROM AUTHOR]

Smads are intracellular signallng molecules of the transforming growth factor-[beta] (TGF-[beta]) superfamily that play an important role in the activation of hepatic stellate cells (HSCs) and hepatic fibrosis. Excepting the regulation of Smad7, receptor-regulated Smad gene expression is still unclear. We employed rat HSCs to investigate the expression and regulation of the Smad1 gene, which is a bone morphogenetic protein (BMP) receptor-regulated Smad. We found that the expression and phosphorylation of Smadl are increased during the activation of HSCs. Moreover, TGF-[beta] significantly inhibits Smad1 gene expression in HSCs in a time- and dose-dependent manner. Furthermore, although both TGF-[beta]1 and BMP2 stimulate the activation of HSCs, they have different effects on HSC proliferation. In conclusion, Smad1 expression and phosphorylation are increased during the activation of HSCs and TGF-[beta]1 significantly inhibits the expression of the Smad1 gene. transforming growth factor-[beta]; Smad1; regulation