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Byline: Qi. Wu, Han-dong. Wang, Qing-rong. Zhang, Xin. Zhang Background: Aneurysms located at distal posterior inferior cerebellar artery (PICA) are rare. These aneurysms are difficult for surgical or endovascular treatment, [...]

Abstract: A retrospective study was performed to compare the safety and efficacy in elderly patients of endovascular coiling, with clipping, for cerebral aneurysms. In total, 198 patients over 60years of age with ruptured intracranial aneurysms were treated by microsurgical clipping (n =122) or endovascular coiling (n =76). Endovascular coiling achieved favorable outcome in 88.2% of patients, which was significantly higher than for the microsurgical clipping group. The occurrence of re-bleeding, infarction, and hydrocephalus was similar between the two groups. Intraoperative time for microsurgical clipping was significantly longer than that for endovascular coiling. Length of hospitalization was shorter for the coiling group than for the clipping group. Our results suggest that endovascular coiling should be considered as the first-choice therapy in elderly patients with ruptured aneurysms, as it may reduce duration of both the operation and hospitalization. [Copyright &y& Elsevier]

About 15% couples suffer from infertility, half of which are caused by male factors. Male infertility usually manifests as teratozoospermia, oligospermia and/or asthenospermia, of which the most severe form is azoospermia. In this review, we summarize the recent progress in the study of genetic factors involved in nonobstructive azoospermia and teratozoospermia, Recently, with the rapid development of high-throughput chips and sequencing technologies, many genetic factors of spermatogenesis have been discovered and analyzed. For the nonobstructive azoospermia, genome-wide association studies (GWAS) and high-throughput sequencing revealed many risk loci of nonobstructive azoospermia. For the teratozoospermia, the application of whole-exome sequencing (WES) revealed a series of disease-causing genes, greatly enriching our knowledge of teratozoospermia including multiple morphological abnormalities of the flagella (MMAF). The discovery of lots of disease genes helped the characterization of the pathological mechanisms of male infertility. Therefore, a comprehensive and in-depth understanding of genetic factors in spermatogenesis abnormalities will play important roles in the clinical diagnosis, treatment and genetic counseling of male infertility.

Influence of biological activated carbon (BAC) on simultaneous nitrification and denitrification (SND) in inflow with different C/N ratios was investigated with continuous operation of BAC reactor and SBR. Methanol was added as carbon source and the inflow C/N ratio was set to 3, 5, 8 and 10 to run for about 120 cycles, under conditions of indoor temperature (15-27℃), initial DO 2-3mg·L -1 . The TN removal efficiency and stability of two reactors were compared. The results showed that, BAC reactor had a higher TN removal efficiency than SBR at different C/N ratios. TN removal rate of BAC reactor was 44.88%, 58.07% and 66.64%, when the C/N ratio was 3, 5 and 8 respectively. After increasing the C/N ratio to 10, the BAC reactor could maintain TN removal rate of 63.65%, but the SBR showed sludge bulking. BAC provided various DO environments for microorganisms in a vessel, which was beneficial to SND. BAC could reduce the influence of excessive carbon source on the nitrification system, enlarge the application range and improve the stability of reactor at different C/N ratios, and increase the nitrogen removal capacity of organic matter. BAC provided condition for efficient nitrogen removal.

Objective: To observed efficacy differences of acupuncture at "Zusanli" (ST 36) in rats with asthma and asthma with spleen-deficency, so as to investigate the therapeutic mechanism., Methods: Sixty SD rats were randomly divided into 5 groups according to their weight, named as an asthma with spleen-deficency group (group A), an acupuncture on asthma with spleen-deficency group (group B), an asthma group (group C), an acupuncture on asthma group (group D) and a control group. The rat models with spleen-deficiency in the first two groups were set up by TCM, then the rats of asthma model in the first four groups were induced by egg albumin, but the control group was treated by the same dose of saline. The group B and the group D were both treated with acupuncture at "Zusanli" (ST 36), once each day for 8 days, and the other groups remained unhandled. The mRNA expressions of Fas and Bcl-2 in the lung tissues were detected by hybridization in situ and apoptosis was detected by TUNEL (terminal dexynucleotidyl transferase-mediated dutp nick end labeling)., Results: Compared with the control group, in both the group A and the group C, the expression of Fas mRNA significantly decreased, but the expression of Bcl-2 mRNA significantly increased (all P < 0.01), and eosinophils (EOS) counts significantly increased, but EOS apoptosis rate significantly decreased (all P < 0.01). Compared with the group C, in the group A, the expressions of Fas mRNA significantly decreased, but the expressions of Bcl-2 mRNA and EOS counts significantly increased (all P < 0.01). At the same time, compared with the corresponding asthma groups, in both acupuncture groups, Fas mRNA expression obviously increased, Bcl-2 mRNA expression was significantly reduced (all P < 0.01), EOS counts remarkably decreased and EOS apoptosis rate significantly increased (all P < 0.01). There were no significant differences in the expressions of Fas mRNA and Bcl-2 mRNA between the two acupuncture groups (both P > 0.05), but compared with group B,in the group D, EOS counts significantly decreased and EOS apoptosis rate significantly increased (both P < 0.01)., Conclusion: Acupuncture at "Zusanli" (ST 36) can regulate the disorders of Fas mRNA and Bcl-2 mRNA expression in the state of both asthma and asthma with spleen-deficency, promote EOS apoptosis so as to inhibit the development of inflammatory reaction of asthma, showing that acupuncture at "Zusanli" (ST 36) has certain advantages on regulation of related gene of EOS in asthma with spleen-deficency.

Objective: To summarize the clinical experiences of treating intracranial aneurysms associated with Moyamoya disease by endovascular approach., Methods: A total of 13 patients were admitted into our hospital because of subarachnoid hemorrhage. Cerebral angiography revealed the evidence of Moyamoya disease and intracranial aneurysms. Endovascular embolization was performed for these aneurysms with coils, balloon-assisted coils placement and stent plus coils., Results: All operations were successful. Total occlusion was achieved in 11 patients and over 90% in 2. The patients recovered well with a patency of parent arteries., Conclusion: Endovascular therapy is a valid and suitable approach for the treatment of intracranial aneurysms associated with Moyamoya disease.

In this paper, English translation of JUN, CHEN, ZUO, and SHI in science of prescription of traditional Chinese medicine were discussed by hunting the headstream, analyzing and explaining their implication, discriminating and selecting the relative English terms.