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Objective To investigate the correlation between serum creatinine（Scr），high-sensitivity troponin T（hs-cTnT），N-terminal pro-B-type natriuretic peptide（NT-proBNP），and in-hospital major adverse cardiovascular events（MACE）in burn patients and evaluate their predictive value. Methods In this retrospective study，254 burn patients were enrolled and divided into the MACE group（n = 85）and non-MACE group（n = 169）according to whether MACE occurred during hospital stay. Clinical baseline data and laboratory indexes were statistically compared between the two groups. The predictive values of Scr，hs-cTnT，and NT-proBNP for in-hospital MACE in burn patients were assessed by the receiver operating characteristic（ROC）curve. Results Compared with the non-MACE group，older age，larger total area of burns，and higher levels of Scr，hs-cTnT，NT-proBNP，and cystatin C were observed in the MACE group（all P < 0.05）. There were significant differences in gender，history of hypertension，sepsis，and smoking history between the two groups（all P < 0.05）. Multivariate analysis showed that Scr，hs-cTnT，and NT-proBNP were the independent risk factors for nosocomial MACE in burn patients（all P < 0.05）. The area under the curve（AUC）values of Scr，hs-cTnT，NT-proBNP，and their combined prediction of MACE were 0.743，0.802，0.733，and 0.801 by ROC curve analysis. According to the DeLong test results，the AUC value of MACE predicted by the three combined was more significant than the value indicated by Scr alone（Z value = 2.897，P = 0.003）. The predictive value of Scr，hs-cTnT，and NT-proBNP for MACE was not significantly different（Z values were 1.398，0.202，and 1.900，and P values were 0.162，0.840，and 0.057，respectively）. Subgroup analysis showed that the incidence of MACE in burn patients in the hs-cTnT≥0.014 5 μg/L group was higher than in their counterparts in the hs-cTnT < 0.014 5 μg/L group（P < 0.05）. Spearman correlation analysis showed a positive correlation between hs-cTnT level and the severity of burns（P < 0.05）. Conclusions Scr，hs-cTnT，and NT-proBNP are the independent risk factors for nosocomial MACE in burn patients and have good predictive values. In addition，hs-cTnT level is correlated with the severity of burns.

A three‐dimensional alginate‐coated scaffold (GAIS) was constructed in the present study to showcase the multidifferentiation potential of peripheral blood mesenchymal stem cells (PBMSCs) and to investigate the role and mechanism by which Icariin (ICA)/stromal cell‐derived factor (SDF‐1α)/PBMSCs promote damaged articular repair. In addition, the ability of ICA, in combination with SDF‐1α, to promote the migration and proliferation of stem cells was validated through the utilization of CCK‐8 and migration experiments. The combination of ICA and SDF‐1α inhibited the differentiation of PBMSCs into cartilage, as demonstrated by in vivo experiments and histological staining. Both PCR and western blot experiments showed that GAIS could upregulate the expression of particular genes in chondrocytes. In comparison to scaffolds devoid of alginate (G0), PBMSCs seeded into GAIS scaffolds exhibited a greater rate of proliferation, and the conditioned medium derived from scaffolds containing SDF‐1α enhanced the capacity for cell migration. Moreover, after a 12‐week treatment period, GAIS, when successfully transplanted into osteochondral defects of mice, was found to promote cartilage regeneration and repair. The findings, therefore, demonstrate that GAIS enhanced the in vitro capabilities of PBMSCs, including proliferation, migration, homing and chondrogenic differentiation. In addition, ICA and SDF‐1α effectively collaborated to support cartilage formation in vivo. Thus, the ICA/SDF‐1α/PBMSC‐loaded biodegradable alginate‐gelatin scaffolds showcase considerable potential for use in cartilage repair. [ABSTRACT FROM AUTHOR]

We study first nonzero eigenvalues for the p-Laplacian on Kähler manifolds. Our first result is a lower bound for the first nonzero closed (Neumann) eigenvalue of the p-Laplacian on compact Kähler manifolds in terms of dimension, diameter, and lower bounds of holomorphic sectional curvature and orthogonal Ricci curvature for p\in (1, 2]. Our second result is a sharp lower bound for the first Dirichlet eigenvalue of the p-Laplacian on compact Kähler manifolds with smooth boundary for p\in (1, \infty). Our results generalize corresponding results for the Laplace eigenvalues on Kähler manifolds proved by Li and Wang [Trans. Amer. Math. Soc. 374 (2021), pp. 8081–8099]. [ABSTRACT FROM AUTHOR]

Background The histologically complete resection (CR) rate of small rectal neuroendocrine tumors (RNETs) is unsatisfactory at the first endoscopy. Risk factors and clinical outcomes associated with incomplete resection (IR) have not been explicitly elucidated. This study aims to explore the relevant factors of IR. Methods This retrospective study reviewed patients with small RNETs (≤10 mm) in eight centers from January 2013 to December 2021. Clinicopathological characteristics and clinical outcomes were compared between the CR and IR groups, and the polypectomy and advanced treatment groups. Results Of the 326 patients included, 83 (25.5%) were diagnosed with IR. Polypectomy (odds ratio [OR]   =   16.86), a central depression (OR = 7.50), and treatment in the early period (OR = 2.60) were closely associated with IR. Further analysis revealed that an atypical hyperemic appearance (OR = 7.49) and treatment in the early period (OR = 2.54) were significantly associated with the inappropriate use of polypectomy (both P  <   0.05). In addition, a total of 265 (81.3%) were followed up with a median follow-up period of 30.9 months. No death, metastasis, or recurrence was found during the follow-up period. Conclusions Polypectomy, a central depression, and treatment in the early period were risk factors for IR. Further, an atypical hyperemic appearance and treatment in the early period were significant predisposing factors for inappropriate choice of polypectomy. For histologically incompletely resected small RNETs, follow-up may be a safe and feasible alternative to rigorous salvage therapy. [ABSTRACT FROM AUTHOR]

In this paper, for a class of nonlinear implicit ordinary differential equation with variable coefficients, a new approach to get the analytical singular solutions are given both for first order and higher order equations. Sufficient conditions on singular solutions are strengthened into necessary and sufficient conditions in specific case. Finally, the new results are verified by practical examples and MATLAB illustrations compared with traditional methods. [ABSTRACT FROM AUTHOR]