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3. SubGraph Networks based Entity Alignment for Cross-lingual Knowledge Graph

Author

Yu, Shanqing, Zhang, Shihan, Zhang, Jianlin, Zhou, Jiajun, Xuan, Qi, Li, Bing, and Hu, Xiaojuan

Subjects
Computer Science - Computation and Language
Abstract

Entity alignment is the task of finding entities representing the same real-world object in two knowledge graphs(KGs). Cross-lingual knowledge graph entity alignment aims to discover the cross-lingual links in the multi-language KGs, which is of great significance to the NLP applications and multi-language KGs fusion. In the task of aligning cross-language knowledge graphs, the structures of the two graphs are very similar, and the equivalent entities often have the same subgraph structure characteristics. The traditional GCN method neglects to obtain structural features through representative parts of the original graph and the use of adjacency matrix is not enough to effectively represent the structural features of the graph. In this paper, we introduce the subgraph network (SGN) method into the GCN-based cross-lingual KG entity alignment method. In the method, we extracted the first-order subgraphs of the KGs to expand the structural features of the original graph to enhance the representation ability of the entity embedding and improve the alignment accuracy. Experiments show that the proposed method outperforms the state-of-the-art GCN-based method., Comment: 15 pages, 4 figures,conference

Published
2022

24. Nectin2 influences cell apoptosis by regulating ANXA2 expression in neuroblastoma

Author

Zhang Shihan, Jiang Chiyi, Su Yan, Gui Jingang, Yue Zhixia, Jian Binglin, He Sidou, and Ma Xiaoli

Subjects
neuroblastoma, Nectin2, apoptosis, ANXA2, Biochemistry, QD415-436, Genetics, QH426-470
Abstract

Neuroblastoma (NB) is a pediatric cancer of the peripheral sympathetic nervous system and represents the most frequent solid malignancy in infants. Nectin2 belongs to the immunoglobulin superfamily and has been shown to play a role in tumorigenesis. In the current study, we demonstrate that serum Nectin2 level is increased in NB patients compared with that in healthy controls and Nectin2 level is correlated with neuroblastoma international neuroblastoma staging system (INSS) classification. There is a positive correlation between Nectin2 level and shorter overall survival in NB patients. Knockdown of Nectin2 reduces the migration of SH-SY5Y and SK-N-BE2 cells and induces their apoptosis and cell cycle arrest. RNA-seq analysis demonstrates that Nectin2 knockdown affects the expressions of 258 genes, including 240 that are upregulated and 18 that are downregulated compared with negative controls. qRT-PCR and western blot analysis confirm that ANXA2 expression is decreased in Nectin2-knockdown SH-SY5Y cells, consistent with the RNA-seq results. ANXA2 overexpression rescues the percentage of apoptotic NB cells induced by Nectin2 knockdown and compensates for the impact of Nectin2 knockdown on cleaved caspase3 and bax expressions. In addition, western blot analysis results show that ANXA2 overexpression rescues the effect of Nectin2 knockdown on MMP2 and MMP9 expressions. The current data highlight the importance of Nectin2 in NB progression and the potential of Nectin2 as a novel candidate target for gene therapy.

Published
2023
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