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432 results on '"Zhang, Tianci"'

3. Age of Information in a Multisource Ber/Geo/1/1 Preemptive Queueing System

Author

Zhang, Tianci and Chen, Zhengchuan

Subjects
Computer Science - Information Theory, Computer Science - Networking and Internet Architecture
Abstract

This work studies the information freshness of the vehicle-to-infrastructure status updating in Internet of vehicles, which is modeled as a multi-source Ber/Geo/1/1 preemptive queueing system with heterogeneous service time. We pay attention to both the distribution and average of AoI. To fully track the per-source AoI evolution, a Markov two-dimensional (2D) age process is introduced. The first element of the 2D age process stands for the instantaneous per-source AoI, while the second represents whether an update of the concerned source is being served and its current age. A complete framework and detailed analyses on the per-source AoI are presented based on the Markovity of the 2D age process. By studying the state transition probabilities, stationary equations, and stationary distribution of the 2D age process, analytical expressions of the probability mass function and average of per-source AoI are derived. Numerical results validate the accuracy of the theoretical analyses.

Published
2023

4. Violation Probabilities of AoI and PAoI and Optimal Arrival Rate Allocation for the IoT-based Multi-Source Status Update System

Author

Zhang, Tianci, Chen, Shutong, Chen, Zhengchuan, Tian, Zhong, Jia, Yunjian, Wang, Min, and Wu, Dapeng Oliver

Subjects
Computer Science - Performance
Abstract

Lots of real-time applications over Internet of things (IoT)-based status update systems have imperative demands on information freshness, which is usually evaluated by age of information (AoI). Compared to the average AoI and peak AoI (PAoI), violation probabilities and distributions of AoI and PAoI characterize the timeliness in more details. This paper studies the timeliness of the IoT-based multi-source status update system. By modeling the system as a multi-source M/G/1/1 bufferless preemptive queue, general formulas of violation probabilities and probability density functions (p.d.f.s) of AoI and PAoI are derived with a time-domain approach. For the case with negativeexponentially distributed service time, the violation probabilities and p.d.f.s are obtained in closed form. Moreover, the maximal violation probabilities of AoI and PAoI are proposed to characterize the overall timeliness. To improve the overall timeliness under the resource constraint of IoT-device, the arrival rate allocation scheme is used to minimize the maximal violation probabilities. It is proved that the optimal arrival rates can be found by convex optimization algorithms. In addition, it is obtained that the minimum of maximal violation probability of AoI (or PAoI) is achieved only if all violation probabilities of AoI (or PAoI) are equal. Finally, numerical results verify the theoretical analysis and show the effectiveness of the arrival rate allocation scheme.

Published
2022

5. Minimizing Age-upon-Decisions in Bufferless System: Service Scheduling and Decision Interval

Author

Chen, Shutong, Zhang, Tianci, Chen, Zhengchuan, Dong, Yunquan, Wang, Min, Jia, Yunjian, and Quek, Tony Q. S.

Subjects
Computer Science - Information Theory
Abstract

In Internet of Things (IoT), the decision timeliness of time-sensitive applications is jointly affected by the statistics of update process and decision process. This work considers an update-and-decision system with a Poisson-arrival bufferless queue, where updates are delivered and processed for making decisions with exponential or periodic intervals. We use age-upon-decisions (AuD) to characterize timeliness of updates at decision moments, and the missing probability to specify whether updates are useful for decision-making. Our theoretical analyses 1) present the average AuDs and the missing probabilities for bufferless systems with exponential or deterministic decision intervals under different service time distributions; 2) show that for service scheduling, the deterministic service time achieves a lower average AuD and a smaller missing probability than the uniformly distributed and the negative exponentially distributed service time; 3) prove that the average AuD of periodical decision system is larger than and will eventually drop to that of Poisson decision system along with the increase of decision rate; however, the missing probability in periodical decision system is smaller than that of Poisson decision system. The numerical results and simulations verify the correctness of our analyses, and demonstrate that the bufferless systems outperform the systems applying infinite buffer length.

Published
2022

12. Sequestration of Intestinal Acidic Toxins by Cationic Resin Attenuates Pancreatic Cancer Progression through Promoting Autophagic Flux for YAP Degradation.

Author

Zhao, Guangfu, Zhang, Tianci, Liu, Wei, Edderkaoui, Mouad, Hu, Richard, Li, Jun, Pandol, Stephen, Fu, Xiangsheng, and Han, Yuan-Ping

Subjects
autophagy, bile acid, cystatin A, endotoxin, lysosome, pancreatic cancer, yes-associated protein
Abstract

Pancreatic cancer is driven by risk factors such as diabetes and chronic pancreatic injury, which are further associated with gut dysbiosis. Intestinal toxins such as bile acids and bacterial endotoxin (LPS), in excess and persistence, can provoke chronic inflammation and tumorigenesis. Of interest is that many intestinal toxins are negatively charged acidic components in essence, which prompted us to test whether oral administration of cationic resin can deplete intestinal toxins and ameliorate pancreatic cancer. Here, we found that increased plasma levels of endotoxin and bile acids in Pdx1-Cre: LSL-KrasG12D/+ mice were associated with the transformation of the pancreatic ductal carcinoma (PDAC) state. Common bile-duct-ligation or LPS injection impeded autolysosomal flux, leading to Yap accumulation and malignant transformation. Conversely, oral administration of cholestyramine to sequestrate intestinal endotoxin and bile acids resumed autolysosomal flux for Yap degradation and attenuated metastatic incidence. Conversely, chloroquine treatment impaired autolysosomal flux and exacerbated malignance, showing jeopardization of p62/ Sqxtm1 turnover, leading to Yap accumulation, which is also consistent with overexpression of cystatin A (CSTA) in situ with pancreatic cancer cells and metastatic tumor. At cellular levels, chenodeoxycholic acid or LPS treatment activated the ligand-receptor-mediated AKT-mTOR pathway, resulting in autophagy-lysosomal stress for YAP accumulation and cellular dissemination. Thus, this work indicates a potential new strategy for intervention of pancreatic metastasis through sequestration of intestinal acidic toxins by oral administration of cationic resins.

Published
2022

15. Design and Development of an Unmanned Excavator System for Autonomous Mining

Author

Fu, Tao, Zhang, Tianci, Li, Guang, Qiao, Jianqiang, Sun, Gang, Yue, Haifeng, Song, Xueguan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Hu, Cungang, editor, and Cao, Wenping, editor

Published
2023
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26. Programmable DNA Scaffolds Enable Orthogonal Engineering of Cell Membrane-Based Nanovesicles for Therapeutic Development

Author

Li, Wei, primary, Liu, Shuyun, additional, Wang, Zhenghao, additional, Gou, Liping, additional, Ou, Yiran, additional, Zhu, Xinyue, additional, Zhou, Ye, additional, Zhang, Tianci, additional, Liu, Jiaye, additional, Zheng, Xiaowei, additional, Berggren, Per-Olof, additional, Liu, Jingping, additional, and Zheng, Xiaofeng, additional

Published
2024
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27. Hepatitis B Virus X Protein (HBx) Suppresses Transcription Factor EB (TFEB) Resulting in Stabilization of Integrin Beta 1 (ITGB1) in Hepatocellular Carcinoma Cells

Author

Zhang, Chunyan, Yang, Huan, Pan, Liwei, Zhao, Guangfu, Zhang, Ruofei, Zhang, Tianci, Xiao, Zhixiong, Tong, Ying, Zhang, Yi, Hu, Richard, Pandol, Stephen J, and Han, Yuan-Ping

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Hepatitis - B, Liver Cancer, Liver Disease, Chronic Liver Disease and Cirrhosis, Infectious Diseases, Rare Diseases, Hepatitis, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, HBx, TFEB, lysosome biogenesis, ITGB1, cysteine protease, hepatocellular carcinoma, Oncology and carcinogenesis
Abstract

Hepatitis B virus (HBV) infection is a major etiological risk for the incidence of hepatocellular carcinoma (HCC), and HBV X protein (HBx) is essential for oncogenic transformation. It is not known that if HBx can sabotage the lysosomal system for transformation and tumorigenesis, or its mechanism if it does have an effect. Examining clinical data, we observed that the downregulation of lysosomal components and transcription factor EB (TFEB) was associated with a poor prognosis of HCC patients. In HCC cells, we found that expression of HBx suppressed TFEB, impaired biogenesis of autophagic-lysosome, and promoted cellular dissemination. HBx mediated downregulation of TFEB led to impairment of autophagic/lysosomal biogenesis and flux, and consequently, accumulation of integrin beta 1 (ITGB1) for motility of HCC cells. Conversely, TFEB, in a steady-state condition, through induction of lysosomal biogenesis restrained ITGB1 levels and limited mobility of HCC cells. Specifically, overexpression of TFEB upregulated and activated the cysteine proteases including cathepsin L (CTSL) to degrade ITGB1. Conversely, expression of cystatin A (CSTA) or cystatin B (CSTB), the cellular inhibitors of lysosomal cysteine proteinases, spared ITGB1 from degradation and promoted dissemination of HCC cells. Taken together, this study suggests a potential mechanism for HBV-mediated malignancy, showing that HBx mediated downregulation of TFEB leads to accumulation of ITGB1 for HCC cell migration.

Published
2021

34. A Denoising Method by Low-Rank and Sparse Representations and Its Application in Tunnel Boring Machine

Author

Wang, Yitang, Fu, Tau, Zhang, Tianci, Song, Xueguan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Cao, Wenping, editor, Hu, Cungang, editor, Huang, Xiaoyan, editor, Chen, Xiangping, editor, and Tao, Jun, editor

Published
2022
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35. Dynamic Cutterhead Torque Prediction of Tunnel Boring Machines Based on a Hybrid Transfer Learning Framework

Author

Fu, Tao, Zhang, Tianci, Song, Xueguan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Cao, Wenping, editor, Hu, Cungang, editor, Huang, Xiaoyan, editor, Chen, Xiangping, editor, and Tao, Jun, editor

Published
2022
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