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19 results on '"Zhang, Xiangheng"'

2. Integrated analyses of multi-omic data derived from paired primary lung cancer and brain metastasis reveal the metabolic vulnerability as a novel therapeutic target

Author

Duan, Hao, Ren, Jianlan, Wei, Shiyou, Yang, Zhenyu, Li, Chuan, Wang, Zhenning, Li, Meichen, Wei, Zhi, Liu, Yu, Wang, Xiuqi, Lan, Hongbin, Zeng, Zhen, Xie, Maodi, Xie, Yuan, Wu, Suwen, Hu, Wanming, Guo, Chengcheng, Zhang, Xiangheng, Liang, Lun, Yu, Chengwei, Mou, Yanhao, Jiang, Yu, Li, Houde, Sugarman, Eric, Deek, Rebecca A., Chen, Zexin, Li, Tao, Chen, Yaohui, Yao, Maojin, Chen, Likun, Liu, Lunxu, Zhang, Gao, and Mou, Yonggao

Published
2024
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3. Latent Association Between Diets and Glioma Risk: A Mendelian Randomization Analysis.

Author

Zhao, Jixiang, He, Changjia, Xie, Haoqun, Zou, Yunzhi, Yan, Zeming, Deng, Jingen, Du, Yizhi, Yang, Wenzhuo, and Zhang, Xiangheng

Abstract

Background: Gliomas, particularly high-grade gliomas such as glioblastoma, represent a major challenge due to their poor prognosis. While dietary factors have been proposed as potential modulators of glioma risk, causal inference has been hindered by confounding and reverse causality in observational studies. This study employs Mendelian randomization to investigate the causal relationship between dietary factors and glioma risk. Methods: A two-sample MR framework was applied, utilizing genome-wide association study data for 22 dietary exposures and glioma risks, including both GBM and non-GBM subtypes. Instrumental variables (genetic variants) were identified for each dietary factor to address confounding and pleiotropy. Causal inference was conducted using inverse-variance weighted regression, complemented by MR-Egger and MR-PRESSO analyses to assess and correct for potential pleiotropy. Results: A positive causal association was observed between the intake of cooked vegetables and the GBM risk (OR = 6.55, 95% CI: 1.86–23.12, p = 0.00350). While alcohol intake demonstrated a protective effect for non-GBM risk (OR = 0.770, 95% CI: 0.61–0.97, p = 0.029), beer was substantially linked to an increased risk of non-GBM gliomas (OR = 4.82, 95% CI: 1.84–12.59, p = 0.0014). Other dietary factors did not exhibit significant causal associations. Conclusions: These findings suggest that certain dietary factors, including cooked vegetable intake, beer consumption, and alcohol intake, may exert a causal influence on glioma risk. This study provides new insights into the potential dietary determinants of glioma and underscores the need for further investigation into modifiable risk factors for glioma prevention. [ABSTRACT FROM AUTHOR]

Published
2025
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7. Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

Author

Duan, Hao, primary, Ren, Jianlan, additional, Wei, Shiyou, additional, Li, Chuan, additional, Wang, Zhenning, additional, Li, Meichen, additional, Wei, Zhi, additional, Yang, Zhenyu, additional, Liu, Yu, additional, Xie, Yuan, additional, Wu, Suwen, additional, Hu, Wanming, additional, Guo, Chengcheng, additional, Zhang, Xiangheng, additional, Liang, Lun, additional, Yu, Chengwei, additional, Mou, Yanhao, additional, Jiang, Yu, additional, Li, Houde, additional, Sugarman, Eric, additional, Deek, Rebecca A., additional, Chen, Zexin, additional, Chen, Likun, additional, Chen, Yaohui, additional, Yao, Maojin, additional, Liu, Lunxu, additional, Zhang, Gao, additional, and Mou, Yonggao, additional

Published
2024
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10. Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas

Author

Guo, Chengcheng, primary, Yang, Qunying, additional, Xu, Pengfei, additional, Deng, Meiling, additional, Jiang, Taipeng, additional, Cai, Linbo, additional, Li, Jibin, additional, Sai, Ke, additional, Xi, Shaoyan, additional, Ouyang, Hui, additional, Liu, Mingfa, additional, Li, Xianming, additional, Li, Zihuang, additional, Ni, Xiangrong, additional, Cao, Xi, additional, Li, Cong, additional, Wu, Shaoxiong, additional, Du, Xiaojing, additional, Su, Jun, additional, Xue, Xiaoying, additional, Wang, Yiming, additional, Li, Gang, additional, Qin, Zhiyong, additional, Yang, Hui, additional, Zhou, Tao, additional, Liu, Jinquan, additional, Hu, Xuefeng, additional, Wang, Jian, additional, Jiang, Xiaobing, additional, Lin, Fuhua, additional, Zhang, Xiangheng, additional, Ke, Chao, additional, Lv, Xiaofei, additional, Lv, Yanchun, additional, Hu, Wanming, additional, Zeng, Jing, additional, Chen, Zhenghe, additional, Zhong, Sheng, additional, Wang, Hairong, additional, Chen, Yinsheng, additional, Zhang, Ji, additional, Li, Depei, additional, Mou, Yonggao, additional, and Chen, Zhongping, additional

Published
2023
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12. Computational study on new natural compound agonists of dopamine receptor

Author

Li, Hui, primary, Yang, Wenzhuo, additional, Xi, Jianxin, additional, Wang, Zhenhua, additional, Lu, Han, additional, Du, Zhishan, additional, Li, Weihang, additional, Wu, Bo, additional, Jiang, Shanshan, additional, Peng, Yida, additional, liu, Jingyi, additional, liu, Luwei, additional, Zhang, Xiangheng, additional, and Feng, Jiachun, additional

Published
2021
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13. Effective natural inhibitors targeting poly ADP-ribose polymerase by computational study

Author

Zhong, Sheng, primary, Wu, Bo, additional, Yang, Wenzhuo, additional, Ge, Junliang, additional, Zhang, Xiangheng, additional, Chen, Zhenghe, additional, Duan, Hao, additional, He, Zhenqiang, additional, Liu, Yibing, additional, Wang, Hongyu, additional, Jiang, Yuting, additional, Zhang, Zhiyun, additional, Wang, Xinhui, additional, Li, Weihang, additional, Liu, Naimeng, additional, Guo, Xiaoyu, additional, and Mou, Yonggao, additional

Published
2021
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14. Utilizing phenotypic characteristics of metastatic brain tumors to predict the probability of circulating tumor DNA detection from cerebrospinal fluid.

Author

Li, Meichen, primary, Li, Delan, additional, Hou, Xue, additional, Zhang, Xiangheng, additional, Wang, Na, additional, Liang, Jianzhong, additional, Chen, Jing, additional, Wang, Kaicheng, additional, Wang, Fufeng, additional, Chen, Yedan, additional, Zhang, Xian, additional, Bao, Hua, additional, Wu, Xue, additional, Wang, Xiaonan, additional, Shao, Yang, additional, and Chen, Likun, additional

Published
2020
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15. SURG-06. FOLLOWING INTRAOPERATIVE TUMOR-FREE PRINCIPLES IS AN EFFECTIVE APPROACH TO IMPROVE SURVIVAL OF PATIENTS WITH GLIOBLASTOMA

Author

Mou, Yonggao, primary, Fuad, Al-Nahari, additional, Duan, Hao, additional, He, Zhenqiang, additional, Zhang, Guanhua, additional, Zhang, Xiangheng, additional, Sai, Ke, additional, Ke, Chao, additional, Zhang, Ji, additional, Jiang, Xiaobing, additional, Lin, Fuhua, additional, Chen, Zhenghe, additional, and Chen, Yinsheng, additional

Published
2019
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16. Phase 2 clinical trial of VAL-083 as first-line treatment in newly-diagnosed MGMT-unmethylated glioblastoma multiforme (GBM): Halfway report

Author

Brown, Dennis, primary, Chen, Zhong-ping, primary, Guo, Chengcheng, additional, Yang, Qunying, additional, Li, Jiawei, additional, Wu, Shaoxiong, additional, Deng, Meiling, additional, Du, Xiaojing, additional, Sai, Ke, additional, Jiang, Xiaobing, additional, Chen, Zhenghe, additional, Zhang, Ji, additional, Lin, Fuhua, additional, Wang, Jian, additional, Chen, Yinsheng, additional, Ke, Chao, additional, Zhang, Xiangheng, additional, Ju, Xue, additional, Mou, Yonggao, additional, Bacha, Jeffrey, additional, Steino, Anne, additional, Kanekal, Sarath, additional, Kwan, Claire, additional, Johnson, Gregory, additional, Schwartz, Richard, additional, and Langlands, John, additional

Published
2019
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17. Real-world management and survival outcomes of patients with newly diagnosed gliomas from a single institution in China: A retrospective cohort study

Author

Chen, Zhongping, primary, Li, Depei, additional, Chen, Yinsheng, additional, Guo, Chengcheng, additional, Zhang, Xiangheng, additional, Sai, Ke, additional, Ke, Chao, additional, Zhang, Ji, additional, Jiang, Xiaobing, additional, Chen, Zhenghe, additional, Lin, Fuhua, additional, Yang, Qunying, additional, Wang, Jian, additional, and Mu, Yonggao, additional

Published
2019
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18. Outcome of surgical resection for brain metastases and radical treatment of the primary tumor in Chinese non–small-cell lung cancer patients

Author

Li,Zhenye, Zhang,Xiangheng, Jiang,Xiaobing, Guo,Chengcheng, Sai,Ke, Yang,Qunying, He,Zhenqiang, Wang,Yang, Chen,Zhongping, Li,Wei, Mou,Yonggao, Li,Chuzhong, Wu,Dan, Li,Zhenye, Zhang,Xiangheng, Jiang,Xiaobing, Guo,Chengcheng, Sai,Ke, Yang,Qunying, He,Zhenqiang, Wang,Yang, Chen,Zhongping, Li,Wei, Mou,Yonggao, Li,Chuzhong, and Wu,Dan

Abstract

Zhenye Li,1,3,* Xiangheng Zhang,1,* Xiaobing Jiang,1 Chengcheng Guo,1 Ke Sai,1 Qunying Yang,1 Zhenqiang He,1 Yang Wang,1 Zhongping Chen,1 Wei Li,2 Yonggao Mou1 1Department of Neurosurgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 2Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China; 3Beijing Neurosurgical Institute, Capital Medical University, Beijing, People’s Republic of China *These authors have contributed equally to this work Purpose: Brain metastasis is the most common complication of brain cancer; nevertheless, primary lung cancer accounts for approximately 20%–40% of brain metastases cases. Surgical resection is the preferred treatment for brain metastases. However, no studies have reported the outcome of surgical resection of brain metastases from non–small-cell lung cancer (NSCLC) in the People’s Republic of China. Moreover, the optimal treatment for primary NSCLC in patients with synchronous brain metastases is hitherto controversial. Patients and methods: We retrospectively analyzed the cases of NSCLC patients with brain metastases who underwent neurosurgical resection at the Sun Yat-sen University Cancer Center, and assessed the efficacy of surgical resection and the necessity of aggressive treatment for primary NSCLC in synchronous brain metastases patients. Results: A total of 62 patients, including 47 men and 15 women, with brain metastases from NSCLC were enrolled in the study. The median age at the time of craniotomy was 54 years (range 29–76 years). At the final follow-up evaluation, 50 patients had died. The median OS time was 15.1 months, and the survival rates were 70% and 37% a

Published
2015

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