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Objective To investigate the expression levels of thyroid transcription factor-1 （TTF-1） and CyclinD1 in ovarian cancer and analyze their relationship with lymphangiogenesis. Methods The ovarian cancer tissue samples were collected from 60 patients with ovarian cancer and corresponding ovarian tissue samples from 20 patients pathologically diagnosed with benign ovarian tumors and normal ovarian tissue were collected as the control group. Tissue sections were prepared for immunohistochemical staining of TTF-1， CyclinD1 and D2-40. The staining results of TTF-1 and CyclinD1 were evaluated based on semi-quantitative integration method. D2-40 staining results were assessed according to Weidner evaluation method. Lymphatic vessel density （LVD） was calculated. Results The positive expression rates of TTF-1 and CyclinD1 were 58% and 83% in the ovarian cancer tissues， which were higher than 5% and 10% in the normal cancer tissues（all P < 0.001）， respectively. The positive expression rates of TTF-1 and CyclinD1 were significantly increased in the ovarian cancer tissues with pathological stageⅢ-Ⅳ， lymph node metastasis， peritoneal metastasis， T3-T4 stage， N1 stage and M1 stage （all P < 0.05）. Age and histological type were not correlated with the positive expression rates of TTF-1 and CyclinD1 （all P > 0.05）. The LVD of ovarian cancer tissues with pathological stageⅢ-Ⅳ， lymph node metastasis and peritoneal metastasis was significantly increased （all P < 0.05）. The LVD of ovarian cancer tissues with positive expression of TTF-1 and CyclinD1 was significantly higher than that of ovarian cancer tissues with negative expression （both P < 0.05）. Conclusions TTF-1 and CyclinD1 are highly expressed in ovarian cancer tissues. Patients with severe ovarian cancer， lymphangiogenesis and metastasis have high expression of TTF-1 and CyclinD1， which may be potential new targets for ovarian cancer interventions.

Problem: Pregnancy complications such as spontaneous abortion, preeclampsia, and preterm birth persist, despite current interventions aimed at their prevention and treatment largely proving unsuccessful. Interleukin‐27 (IL‐27), composed of p28 and EBI3 subunits, binds to IL‐27R, which consists of gp130 and IL‐27Rα (also known as WSX‐1 or TCCR), and plays a pivotal role in tumor development and inflammation regulation. At the maternal‐fetal interface, IL‐27 expression has been detected in trophoblasts, endometrial stromal cells, and decidual cells. Abnormal levels of IL‐27/IL‐27R have been linked to adverse pregnancy outcomes, including spontaneous miscarriage, preeclampsia, and preterm birth. This review aims to explore the expression of IL‐27 at the maternal‐fetal interface and its signaling pathway, uncovering the complex role of IL‐27 in pregnancy complications. Method of Study: A comprehensive literature review was conducted using PubMed/Medline, Scopus, and Embase databases, analyzing studies on IL‐27 expression and its signaling pathways at the maternal‐fetal interface. The review focused on identifying the presence of IL‐27 in various cell types and linking abnormal IL‐27/IL‐27R expression to pregnancy complications such as spontaneous miscarriage, preeclampsia, and preterm birth. Discussion and Conclusion: IL‐27 plays a complex role at the maternal‐fetal interface, with abnormal expression linked to several pregnancy complications. These findings highlight the need for further research to elucidate IL‐27's mechanisms and develop targeted interventions. Future studies should aim to develop targeted interventions and improve therapeutic strategies for managing pregnancy complications. [ABSTRACT FROM AUTHOR]

In this study, a targeted nanocarrier was developed by functionalizing graphene oxide with polyethyleneimine and folic acid, intended for loading oridonin. The nanocarrier was successfully synthesized and characterized using an ultraviolet spectrum, Fourier transform infrared spectroscopy and scanning electron microscopy. The nanocarrier demonstrated a remarkable oridonin loading capacity, reaching 424.8 μg/mg, as determined by ultra‐high performance liquid chromatography. In vitro drug release experiments exhibited a pH‐dependent release profile, with a higher cumulative release in an acidic environment. The release mechanism followed the Ritger–Peppas equation model. Cytotoxicity assays indicated minimal toxicity of the nanocarrier. Enhanced cellular uptake by MCF7 cells was observed for carriers functionalized with folate and polyethyleneimine. These findings highlight the potential of functionalized graphene oxide as a promising carrier for oridonin delivery in biomedical applications. [ABSTRACT FROM AUTHOR]

This paper is concerned with optimizing the configuration of a set of platform products and the associated supply chain consisting of one manufacturer and multiple suppliers using a three-move dynamic game-theoretic approach. The variants in the product family share a common platform for developing/configuring variant modules which are substitutable in the sense that high-end module options can functionally replace low-end ones at higher prices. As the customer in the supply chain, the manufacturer takes its leading role by making the first move to give decisions on platform products development (PPD) and supplier selection. The concerned suppliers make the second move to optimize their decisions including price discounts and their ordering policies. The manufacturer finishes the game by taking the last move to make his ordering decisions. The ranges of the rational reactions for the players are derived from the analyses of their payoff models, and an enumerative algorithm is developed to find the subgame perfect equilibrium of the game through the technique of backward induction. The game model and the proposed solution procedure are illustrated through a series of simulation experiments and sensitivity analyses using a numerical example. The results have allowed us to draw some meaningful interpretations and useful managerial insights. The use of platform commonality and modularity has been found generally beneficial not only to the supply chain as a whole but also to individual players that are eventually configured into the game. Flexibility of the suppliers' capability is also found to affect the PPD decisions. Index Terms--Commonality, configuration game, game theory, mass customization, modularity, platform product, supply chain.