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Chronic coronary disease (CCD) refers to chronic heart or vascular disease caused by insufficient blood flow into or out of the heart. The incidence and mortality rates of CCD are high, resulting in significant personal, economic, and societal burdens. In July 2023, the American Heart Association (AHA) and the American College of Cardiology (ACC), along with other academic organizations, jointly released the 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients with Chronic Coronary Disease. This guideline provides a on the evidence-based and patient-centered approach to comprehensive management of patients with CCD. It covers the epidemiology of CCD, patient assessment, diagnosis, risk stratification, treatment, management of special populations, patient follow-up, and related considerations. The guideline emphasizes the importance of a healthy diet, regular physical exercise, and tobacco avoidance for cardiovascular health. It also updates the recommendations for the use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) and provides the latest evidence-based recommendations for clinical practice. This article provides a key interpretation of the management strategies outlined in the guideline, aiming to provide a basis for the development and update of relevant guidelines in China. The goal is to standardize and improve the specialized diagnosis and care for patients with CCD, with the ultimate aim of providing evidence-based guidance for clinical practice and improving the prognosis of patients with CCD.

Background and objective: Cardio-oncology that focuses on the management of cardiovascular toxicity associated with cancer therapy, has grown rapidly worldwide as an emerging interdisciplinary discipline over the past decade. This study aimed to summarize the hot spots and development trends of cardio-oncology to provide a reference for scientific researchers in related fields based on bibliometrics. Methods: CiteSpace was employed to conduct the visualized analysis of annual publications, authors, countries, citations and keywords of the related papers from 2012 to 2022 in the Web of Science Core Collection and China National Knowledge Infrastructure (CNKI). Results: A total of 4 287 English articles and 1 165 Chinese articles were included after screening. At present, the number of foreign literature in the field of cardio-oncology, showed a trend of rapid growth, while our country has "slow development period" and "rapid development period" with 2016 as the boundary. The United States is the country with the largest number of publications in Web of Science, accounting for about 34.21% of the total, followed by China, Italy and other countries. The institutions with the largest number of publications at home and abroad are the University of Texas MD Anderson Cancer Center and the First Affiliated Hospital of Dalian Medical University. Bonnie KY, Ana Barac, Paaladinesh Thavendiranathan are the main contributors abroad, and Xia Yunlong, Zhang Yuhui and Cheng Leilei are the main contributors in China. The most frequently cited literature is the position statement on cancer treatment and cardiovascular toxicity from the European Society of Cardiology. The most frequently used keywords abroad were "heart failure", "breast cancer" and "cardiotoxicity", while the most frequently used keywords in China were "cardiotoxicity", "cardiac tumor" and "doxorubicin". Keywords with the strongest citation bursts at home and abroad in recent three years are "immune checkpoint inhibitors". Conclusion: The research hotspots mainly focus on cardiotoxicity caused by antineoplastic therapy, prevention and treatment, screening and diagnosis of cardiovascular toxicity associated with cancer therapy, etc. Establishing a multidisciplinary diagnosis and treatment model and paying attention to the immune checkpoint inhibitor-related myocarditis and whole process management of cardio-oncology are the directions of future development.

Geopolymers assume an irreplaceable position in the engineering field on account of their numerous merits, such as durability and high temperature resistance. Nevertheless, geopolymers also demonstrate brittleness. In this study, geotextiles with different layers were added to geopolymer to study its compressive strength and stability. Laboratory materials such as alkali activators, geotextiles and granite residual soil (GRS) were utilized. The samples were characterized via XRD, TG-DTG, SEM-EDS and FT-IR. The results indicate that the toughness of geopolymer is significantly enhanced by adding geotextiles, and the strength increase is most obvious when adding one layer of geotextile: the strength increased from 2.57 Mpa to 3.26 Mpa on the 14th day, an increase of 27%. Additionally, the D-W cycle has a great influence on geotextile polymers. On the 14th day, the average strength of the D-W cyclic sample (1.935 Mpa) was 1.305 Mpa smaller than that of the naturally cured sample (3.24 Mpa), and the strength decreased by 40%. These discoveries offer a novel approach for further promoting the application of geopolymers, especially in the field of foundation reinforcement. [ABSTRACT FROM AUTHOR]

Background: As a chronic skin disease, psoriasis often affects the physical, psychological and social status of the patient, which in turn impacts on their experience of illness and needs. However, there is no review of qualitative research that integrates and analyses the experiences and needs of these three influences from a holistic perspective. Methods: This review follows the ENTREQ guidelines. Six English databases (JBI, Cochrane Library, PubMed, PsyINFO, CINAHL and Embase) and three Chinese databases (CNKI, VIP and Wanfang) were searched from January 2012 to October 2022. Literature was included if it was relevant to the experience of illness and caring needs of patients with psoriasis. The JBI‐QARI was used to rate the quality of included studies. Results: Eleven studies were included in the meta‐synthesis. Four analytical themes were identified for analysis: physical challenges, psychological discomfort, social phenomena and caring needs. Conclusions: The combined physical, psychological and social effects of psoriasis and the consequent caring needs should be emphasised. Health professionals, including doctors and nurses, should be aware of the multiple changes in patients and their coping strategies, provide information about psoriasis, monitor and follow‐up regularly over time and obtain feedback to inform further treatment and care so as to develop high‐quality therapeutic interventions to help and guide patients with their coping strategies. Relevance to Clinical Practice: These findings describe the physical, psychological and social experiences of illness and caring needs of patients with psoriasis. Healthcare professionals should be more aware of patients' easily overlooked psychological and social distress, providing prompt attention and recognition of patients' experiences and needs, offering relevant assistance and support and enhancing daily, regular follow‐up to help them improve their understanding of and ability to manage their illness. No Patient or Public Contribution: This is a meta‐synthesis without direct patient involvement. [ABSTRACT FROM AUTHOR]

The modulus of compressibility of muddy soil in Dawan District is low, and the equivalent value of modulus of compressibility within the calculated depth range of foundation settlement is generally less than 2.5MPa, which exceeds the value range of empirical coefficient calculation basis for settlement calculation in the specification, and has the characteristics of large settlement. This time, according to the measured data of a coastal foundation settlement in Dawan District, the maximum settlement is fitted with the hyperbolic method, and the theoretical value of the total settlement is calculated according to the Code for Design of Building Foundation (GB50007-2011). Based on this analysis, the fitting curve equation of the empirical coefficient of settlement calculation when the equivalent value of the compression modulus is 2.5~4.15MPa is given, and the recommended value of the empirical coefficient of settlement calculation when the equivalent value of the compression modulus is 1.5~2.5MPa is calculated, so as to improve the calculation deviation of the original formula.

Endogenous reference genes (ERGs) provide vital information regarding genetically modified organisms (GMOs). The successful detection of ERGs can identity GMOs and the source of genes, verify stability and reliability of the detection system, and calculate the level of genetically modified (GM) ingredients in mixtures. The reported ERGs in rice include sucrose-phosphate synthase (SPS), phospholipase D (PLD), RBE4 and rice root-specific GOS9 genes. Based on the characteristics of ERGs, a new ERG gene, phosphoenolpyruvate carboxylase (PEPC), was selected, and further compared with the four existing genes. A total of 18 rice varieties and 29 non-rice crops were used to verify the interspecies specificity, intraspecies consistency, sensitivity, stability and reliability of these five ERGs using qualitative and quantitative PCR. Qualitative detection indicated that SPS and PEPC displayed sufficient specificity, and the detection sensitivity was 0.05% and 0.005%, respectively. Although the specificity of both RBE4 and GOS9 were adequate, the amplicons were small and easily confused with primer dimers. Non-specific amplification of the PLD gene was present in maize and potato. Real-time quantitative PCR detection indicated that PLD, SPS and PEPC displayed good specificity, with R2 of the standard curve greater than 0.98, while the amplification efficiency ranged between 90% and 110%. Both the detection sensitivities of PLD and PEPC were five copies and that of SPS was ten copies. RBE4 showed typical amplification in maize, beet and Arabidopsis, while GOS9 was found in maize, tobacco and oats. PEPC exhibited excellent detection sensitivity and species specificity, which made it a potentially useful application in GM-rice supervision and administration. Additionally, SPS and PLD are also suitable for GM-rice detection. This study effectively established a foundation for GMO detection, which not only provides vital technical support for GMO identification, but also is of great significance for enhancing the comparability of detection results, and the standardization of ERG testing in GM-rice. Keywords: Endogenous reference gene, Rice, Genetically modified crop, Phosphoenolpyruvate carboxylase gene, Sucrose-phosphate synthase gene, Phospholipase D gene, Starch branching enzyme 4 gene, Rice root-specific GOS9 gene

Problem Early detection of syphilis-infected people followed by effective treatment is essential for syphilis prevention and control. Approach Starting in 2010 the local health authority in Yunnan province, China, developed a network of 670 service sites for syphilis testing, diagnosis and treatment or for testing-only with referral for further diagnosis and treatment. Point-of-care tests for syphilis and syphilis Interventions were integrated into the existing human immunodeficiency virus (HIV) prevention and control programme. To improve the syphilis services, a pay-for-performance scheme was introduced in which providers were paid for testing and treating patients. Local setting Yunnan province is the region hardest hit by HIV infection and disproportionately burdened with syphilis cases In China. Relevant changes The proportion of attendees at voluntary counselling and testing clinics who were tested for syphilis increased from 46.2% (32 877/71 162) in 2010 to 98.2% (68 012/69 259) in 2015. Syphilis-infected cases treated with the recommended therapy Increased from 26.6% (264/993) In 2010 to 82.5% (453/549) in 2015 at designated testing, diagnosis and treatment sites. Lessons learnt The strategy greatly increased the uptake of syphilis testing and treatment among people at risk. Introduction of point-of-care tests for syphilis increased coverage of the testing services. Introduction of a pay-for-performance scheme seemed to motivate health-care providers to undertake syphilis intervention services. Probleme Le depistage precoce de la syphilis, suivi par un traitement efficace des personnes atteintes, est essentiel pour prevenir et controler cette maladie. Approche A partir de 2010, l'administration sanitaire locale de la province du Yunnan, en Chine, a developpe un reseau de 670 centres de services pour le depistage, le diagnostic et le traitement de la syphilis ou pour le deplstage uniquement, le diagnostic et le traitement etant alors effectues dans un autre etablissement. Des tests de depistage de la syphilis sur les lieux des soins et des interventions ciblant la syphilis ont ete integres au programme existant de prevention et de controle du virus de l'immunodeficience humaine (VIH). Afin d'ameliorer les services lies a la syphilis, un systeme de remuneration aux resultats a ete mis en place; les prestataires etaient done remuneres pour proceder au depistage et soigner les patients. Environnement local La province du Yunnan est la region de Chine la plus durement touchee par l'infection a VIH et est confrontee a un nombre disproportionne de cas de syphilis. Changements sigriificatlfs La proportion des personnes qui se sont rendues dans des centres de consultation et de depistage volontaire et qui ont beneficie d'un depistage de la syphilis est passee de 46,2% (32 877/71 162) en 2010 a 98,2% (68 012/69 259) en 2015. Le nombre de personnes infectees par la syphilis qui ont recu le traitement recommande est passe de 26,6% (264/993) en 2010 a 82,5% (453/549) en 2015 dans les centres de depistage, de diagnostic et de soins prealablement mentionnes. Lecons tirees La strategie a permis d'accroitre considerablement le recours au depistage et au traitement de la syphilis par les personnes vulnerables. L'utilisation de tests de depistage de la syphilis sur les lieux des soins a permis d'augmenter le nombre de beneficiaires des services de depistage. La mise en place d'un systeme de remuneration aux resultats a semble inciter les prestataires de soins de sante a pratiquer des interventions ciblant la syphilis. Situacion La deteccion temprana de las personas infectadas por la sifilis seguida de un tratamiento efectivo es esencial para la prevencion y el control de la enfermedad. Enfoque Desde 2010, la autoridad sanitaria local de la provincia de Yunnan, China, desarrollo una red de 670 puntos de servicio para llevar a cabo las pruebas, el diagnostico y el tratamiento de la sifilis o solo para llevar a cabo las pruebas con derivacion a diagnostico y tratamiento posteriores. Las pruebas en el punto de atencion para la sifilis y sus intervenciones se integraron en el programa de prevencion y control del virus de la inmunodeficiencia humana (VIH) existente. Para mejorar los servicios relativos a la sifilis, se introdujo un programa de pago por desempeno en el que los profesionales recibian un pago por hacer pruebas y tratar a pacientes. Marco regional La provincia de Yunnan es la region mas afectada por la infeccion por VIH y una cantidad desproporcionada de casos de sifilis en China. Cambios importantes La proporcion de atendidos en clinicas de pruebas y asesoramiento voluntario a los que se les realizaron pruebas de la sifilis aumento del 46,2% (32 877/71 162) en 2010 al 98,2% (68012/69 259) en 2015. Los casos de infeccion por la sifilis tratados con la terapia recomendada aumentaron del 26,6% (264/993) en 2010 al 82,5% (453/549) en 2015 en los puntos de pruebas, diagnostico y tratamiento designados. Lecciones aprendidas La estrategia aumento de forma considerable la aceptacion de las pruebas y el tratamiento de la sifilis entre las personas en riesgo. La introduccion de las pruebas de la sifilis en el punto de atencion aumento la cobertura de los servicios de pruebas. La introduccion de un programa de pago por desempeno parecio motivara los profesionales sanitarios a realizar servicios de intervencion para la sifilis., Introduction Syphilis is a sexually transmitted disease caused by the bacterium Treponema pallidum subspecies pallidum. Approximately 3 million people aged 15-49 years were infected with syphilis in China in 2011, [...]

Background: It is significant for the healthy outcome of patients with psoriasis (PSO) to improve their self-management efficacy. A standardized assessment tool, however, was lacking. Therefore, we aimed to develop a self-management efficacy questionnaire for patients with PSO (SMEQ-PSO) and evaluate its psychometric properties. Methods: A cross-sectional study developing clinical evaluation tool was conducted from October 2021 to August 2022. In the process of developing SMEQ-PSO, three phases were involved: item generation, item evaluation, and psychometric evaluation. Results: The SMEQ-PSO with five dimensions and 28 items was developed. The questionnaire's content validity index was 0.976. Exploratory factor analysis indicated a five-factor structure (self-efficacy of psychosocial adaptation, self-efficacy of daily life management, self-efficacy of skin management, self-efficacy of disease knowledge management and self-efficacy of disease treatment management) that explained 62.039% of the total variance. Confirmatory factor analysis indicated appropriate fit of the five-factor model. The overall Cronbach'α coefficient was 0.930, the test-retest reliability was 0.768 and the split half reliability coefficients was 0.952. Conclusions: The 28-item SMEQ-PSO is a reliable and valid tool that can be used to assess the self-management efficacy among patients with PSO and provide personalized interventions based on their individual circumstances to improve their health outcomes. [ABSTRACT FROM AUTHOR]