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179 results on '"Zhang, Yingang"'

23. Boosting MRSA Infectious Osteoporosis Treatment: Mg‐Doped Nanofilm on Vacancy‐Enriched TiO2 Coating for Providing In Situ Sonodynamic Bacteria‐Killing and Osteogenic Alkaline Microenvironment.

Author

Chen, Shimeng, Liu, Fuwei, Xin, He, Wen, Dan, Zhang, Yingang, Li, Bo, and Han, Yong

Subjects
OSTEOPOROSIS, HYDROXYAPATITE coating, METHICILLIN-resistant staphylococcus aureus, SURFACE coatings, OSSEOINTEGRATION, NANORODS
Abstract

To effectively combat infectious osteoporosis, Ti‐based implants with enhanced antibacterial and osseointegrative properties are urgently required. Herein, a one‐step method involving Mg thermal‐reduction is employed to modify a hydroxyapatite (HA) array on Ti, which comprises an inner TiO2 layer and an outer nanorod‐like HA layer. This process introduces oxygen vacancies (OVs) into the TiO2 layer and deposits a Mg─O‐contained amorphous nanolayer on each HA nanorod. The introduced OVs enhance reactive oxygen species (ROS) yield by the array during ultrasound treatment via narrowing TiO2 bandgap and improving H2O molecules absorption. The produced ROS, combined with a weak alkaline microenvironment created by the degraded Mg─O nanolayer, endows the array with potent bacterial‐killing and biofilm‐eradicating efficacies within a 5 min ultrasound treatment via the combination of proton‐consumption and cell envelop‐detriment effects. Moreover, due to the alkaline microenvironment and the released Mg2+, the array hinders osteoclastogenesis by activating the inflammation‐related FAK‐PI3K‐AKT signaling pathway in macrophages, as revealed by transcriptomic analysis, resulting in robust osseointegration in rat femoral shaft with concurrent bacterial‐infection and osteoporosis. This work paves a new way for simultaneously endowing a sonosensitive coating on Ti with sonodynamic treatment‐derived high antibacterial ability and alkaline microenvironment‐mediated strong osseointegration for infectious osteoporosis treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Ti6Al4V biomimetic scaffolds for bone tissue engineering:Fabrication, biomechanics and osseointegration

Author

Liu, Jiantao, primary, Wang, Runqing, additional, Gong, Xi, additional, Zhu, Yihan, additional, Shen, Chengyu, additional, Zhu, Zhixian, additional, Li, Yiming, additional, Li, Zhuoyue, additional, Ren, Zhiwei, additional, Chen, Xiaopeng, additional, Bian, Weiguo, additional, Wang, Dezhi, additional, Yang, Xiaobin, additional, and Zhang, Yingang, additional

Published
2023
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26. Co-downregulation of GRP78 and GRP94 induces apoptosis and inhibits migration in prostate cancer cells

Author

Lu Tong, Wang Yue, Xu Kang, Zhou Zhijun, Gong Juan, Zhang Yingang, Gong Hua, Dai Qiang, Yang Jun, Xiong Biao, Song Ze, and Yang Gang

Subjects
grp78, grp94, prostate cancer, apoptosis, migration, Biology (General), QH301-705.5
Abstract

Both glucose-regulated protein 78 kDa (GRP78) and glucose-regulated protein 94 kDa (GRP94) are important molecular chaperones that play critical roles in maintaining tumor survival and progression. This study investigated the effects in prostate cancer cells following the downregulation of GRP78 and GRP94.

Published
2019
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27. Study of Hydroxyapatite-coated High-strength Biodegradable Magnesium-based Alloy in Repairing Fracture Damage in Rats

Author

MA, DING, ZHANG, KUI, DONG, BINGCHEN, SHE, JIANG, and ZHANG, YINGANG

Subjects
Pharmacology, Cancer Research, General Biochemistry, Genetics and Molecular Biology, Research Article
Abstract

Background/Aim: Hydroxyapatite (HA) coating can improve the degradation rate and biological activity of metallic implants. This study aimed to fabricate a hydroxyapatite-coated ultrafine-grained biodegradable WE43 magnesium (HA/UFG–WE43 Mg) implant for repairing bone fractures. Materials and Methods: A hybrid approach, including parallel tubular-channel angular pressing (PTCAP) and physical vapour deposition (PVD) magnetron sputtering, was employed. The HA/UFG–WE43 Mg samples were tested in terms of their physicochemical and biological properties. Results: The processed tubes exhibited ultrafine structures and the uniformity of microstructures improved following the two-pass PTCAP. The phase composition of the coating formed on UFG–WE43 Mg implant at 250 W for 90 min after heat treatment at 500˚C for 60 min confirmed the presence of the HA characteristic peaks. Rat skeletal muscle cells were inoculated on the specimens and cultured for 1, 2, 6, 12, and 24 h, followed by evaluation of cell adhesion and morphology. The growth rates of cells were examined by the Cell Counting Kit8 (CCK-8) and cell survival was observed after 3 days of culture by fluorescence microscopy. The concentration of Mg ions in the blood of rats on 1, 3, 5, 7, and 15 days showed a reduction in Mg concentration after deposition of HA. Conclusion: Combination of PTCAP processing followed by surface modification led to tibial fracture healing, and histological analysis of implanted areas demonstrated an efficient biodegradation of the implanted material and a moderate inflammatory reaction.

Published
2023

49. MALAT1 promotes proliferation, migration, and invasion of MG63 cells by upregulation of TGIF2 via negatively regulating miR-129

Author

Liu, Kai, Zhang, Yingang, Liu, Liang, and Yuan, Qiling

Subjects
osteosarcoma, miR-129, TGIF2, prognosis, MALAT1, invasion, OncoTargets and Therapy, Original Research
Abstract

Kai Liu, Yingang Zhang, Liang Liu, Qiling Yuan Department of Orthopedics, The First Affliated Hospital of Xi’an Jiaotong University, Xi’an, China Purpose: This article aimed to investigate the mechanism by which MALAT1 and miR-129 affected the development of osteosarcoma.Methods: Tumor tissues and adjacent tissues of 23 osteosarcoma patients were collected. Normal osteoblasts hFOB1.19 and osteosarcoma cells MG63 were cultured. MG63 cells were transfected and grouped: si-negative control (NC) group, si-MALAT1 group, miR-129 NC group, miR-129 mimics group, p-Empty vector group, p-MALAT1 group, p-MALAT1+ miR-129 mimics group, and p-MALAT1+ si-TGIF2 group. Luciferase reporter assay, Cell Counting Kit-8 assay, Transwell assay, quantitative reverse transcription PCR, Western blot, and Pearson correlation analysis were performed.Results: MALAT1 expression in tumor tissues and MG63 cells was increased (P

Published
2018

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