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25 results on '"Zhang, Zhen‐Ye"'

11. Effects of Glucose Fluctuations on Electrocardiogram Readings and the Development of Ventricular Arrhythmia in Diabetic Rats

Author

Wu, Li-Da, primary, Li, Feng, additional, Wang, Chao, additional, Dang, Shi-Peng, additional, Xiao, Feng, additional, Zhang, Zhen-Ye, additional, Zhang, Jie, additional, Zhang, Yu-Min, additional, Lu, Cun-Yu, additional, Liu, Ying, additional, Zhong, Guo-Qiang, additional, Qian, Ling-Ling, additional, and Wang, Ru-Xing, additional

Published
2022
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13. Glucose Fluctuations Aggravate Myocardial Fibrosis via the Nuclear Factor-κB-Mediated Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Activation

Author

Zhang, Zhen-Ye, primary, Dang, Shi-Peng, additional, Li, Shan-Shan, additional, Liu, Ying, additional, Qi, Miao-Miao, additional, Wang, Ning, additional, Miao, Ling-Feng, additional, Wu, Ying, additional, Li, Xiao-Yan, additional, Wang, Chun-Xin, additional, Qian, Ling-Ling, additional, and Wang, Ru-Xing, additional

Published
2022
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18. A method to screen left ventricular dysfunction through ECG based on convolutional neural network

Author

Sun, Jin‐Yu, primary, Qiu, Yue, additional, Guo, Hong‐Cheng, additional, Hua, Yang, additional, Shao, Bo, additional, Qiao, Yu‐Cong, additional, Guo, Jin, additional, Ding, Han‐Lin, additional, Zhang, Zhen‐Ye, additional, Miao, Ling‐Feng, additional, Wang, Ning, additional, Zhang, Yu‐Min, additional, Chen, Yan, additional, Lu, Juan, additional, Dai, Min, additional, Zhang, Chang‐Ying, additional, and Wang, Ru‐Xing, additional

Published
2021
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23. Protective Mechanisms of Quercetin Against Myocardial Ischemia Reperfusion Injury.

Author

Zhang, Yu-Min, Zhang, Zhen-Ye, and Wang, Ru-Xing

Subjects
REPERFUSION injury, MYOCARDIAL reperfusion, REACTIVE oxygen species, CALCIUM-dependent potassium channels, QUERCETIN
Abstract

Quercetin has attracted more attention in recent years due to its protective role against ischemia/reperfusion injury. Quercetin can alleviate oxidative stress injury through the inhibition of NADPH oxidase and xanthine oxidase, blockage of the Fenton reaction, and scavenging of reactive oxygen species. Quercetin can also exert anti-inflammatory and anti-apoptotic effects by reducing the response to inflammatory factors and inhibiting cell apoptosis. Moreover, it can induce vasodilation effects through the inhibition of endothelin-1 receptors, the enhancement of NO stimulation and the activation of the large-conductance calcium-activated potassium channels. Finally, Quercetin can also antagonize the calcium overload. These multifaceted activities of Quercetin make it a potential therapeutic alternative for the treatment of ischemia/reperfusion injury. [ABSTRACT FROM AUTHOR]

Published
2020
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24. Glucose Fluctuations Promote Aortic Fibrosis through the ROS/p38 MAPK/Runx2 Signaling Pathway.

Author

Zhang, Zhen-Ye, Wang, Ning, Qian, Ling-Ling, Miao, Ling-Feng, Dang, Shi-Peng, Wu, Ying, and Wang, Ru-Xing

Subjects
*RUNX proteins, *MITOGEN-activated protein kinases, *GLUCOSE, *VASCULAR smooth muscle, *FIBROSIS
Abstract

Aim: Glucose fluctuations may be responsible for, or further the onset of arterial hypertension, but the exact mechanisms remain unclear. The purpose of this study was to investigate the mechanisms behind and related to aortic fibrosis and aortic stiffening induced by glucose fluctuations. Methods: Sprague-Dawley rats were injected with streptozotocin (STZ) and randomly divided into three treatment groups: controlled STZ-induced diabetes (C-STZ); uncontrolled STZ-induced diabetes (U-STZ); and STZ-induced diabetes with glucose fluctuations (STZ-GF). After 3 weeks, rat blood pressure (BP) was tested, and aortic fibrosis was detected by using the Masson trichrome staining technique. Levels of p38 mitogen-activated protein kinase (p38 MAPK), runt-related transcription factor 2 (Runx2), collagen type 1 (collagen I), and NADPH oxidases were determined by Western blot.Rat vascular smooth muscle cells in vitro were used to explore underlying mechanisms. Results: The systolic BP of diabetic rats in the C-STZ, U-STZ, and STZ-GF groups was 127.67 ± 6.53, 150.03 ± 5.24, and 171.63 ± 3.53 mm Hg, respectively (p< 0.05). The mean BP of diabetic rats in the three groups was 91.20 ± 10.07, 117.29 ± 4.28, and 140.58 ± 2.14 mm Hg, respectively (p< 0.05). The diastolic BP of diabetic rats in the three groups was 73.20 ± 12.63, 101.93 ± 5.79, and 125.37 ± 4.62 mm Hg, respectively (p< 0.05). The ratios of fibrosis areas in the aortas of the three groups were 11.85 ± 1.23, 29.00 ± 0.87, and 48.36 ± 0.55, respectively (p< 0.05). The expressions of p38 MAPK, Runx2, and collagen I were significantly increased in the STZ-GF group. In vitro, applications of inhibitors of reactive oxygen species (ROS) and p38 MAPK successfully reversed glucose fluctuations that would have possibly induced aortic fibrosis. Conclusions: Blood glucose fluctuations aggravate aortic fibrosis via affecting the ROS/p38 MAPK /Runx2 signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2020
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