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ObjectiveTo develop a hand flexibility assessment system based on pneumatic actuation and sensing, and validate its accuracy and reliability. The system aims to provide a scientific basis for solving the problem of hand flexibility assessment and developing hand rehabilitation training plans.MethodsA pneumatic-driven assessment system consisting of pneumatic actuation modules, circuit boards, data feedback modules, and human-computer interaction modules is designed. The system uses air pressure as a quantitative indicator to assess hand flexibility. Based on the data collection needs of patients with varying degrees of hand dysfunction, four impedance evaluation modes with different intensities (mild, moderate, severe, and very severe) are designed. The soft actuator produces unilateral bending or relaxation through air inflation and deflation. During multiple finger flexions by the user, an opposing effect is generated between the user and the system. The air pressure inside the soft actuator is recorded in real time, providing data for hand flexibility assessment. Hand flexibility is quantified by combining the Brunnstrom hand function stage scale and the Total Active Motion (TAM) assessment method. Healthy subjects' test data are recorded and used as a template. The air pressure data of eight patients with hand dysfunction are collected for hand flexibility evaluation and compared with the results of three attending physicians from a rehabilitation center to verify the system’s accuracy in assessing hand flexibility.ResultsThe average air pressure change was maintained around 10 kPa for healthy subjects performing group impedance flexion tests. In 10 repeated experiments, the standard deviations of test results for the four intensity levels (mild, moderate, severe, very severe) were 0.37535, 0.27961, 0.39354, and 0.32010, respectively. During group impedance extension tests, the average air pressure change was maintained around 6 kPa, with standard deviations for the four intensity levels of 0.40442, 0.26102, 0.22012, and 0.13050, respectively, in 10 repeated experiments. For patients 1 and 2, based on the Brunnstrom evaluation scale, their finger recovery stages were determined to be Stage I and Stage II, respectively. For patients 3 and 4, the air pressure change was around 1 kPa. Patient 3 demonstrated better finger flexibility than patient 4. Patients 5 to 8 were evaluated using the TAM method, and patient 8 was classified with good hand flexibility, while the others were rated as poor.ConclusionThe system shows high accuracy and reliability in assessing hand flexibility and has the potential to replace rehabilitation physicians in quantitatively evaluating hand flexibility.

To investigate the effect of dietary addition of Bacillus subtilis on the antioxidant capacity, meat color, protein oxidation, lipid oxidation and sensory quality of pork during storage in high-oxygen modified atmosphere packaging, 12 Duroc × Landrace × Yorkshire pigs were equally allocated into 2 groups that were fed a basal diet alone and in combination with B. subtilis, respectively. Following slaughter, the longissimus dorsi muscle was taken and cut into two parts: one part was used to measure the activity of antioxidant enzymes; the other part was packaged under high oxygen conditions and stored at 4 ℃. The meat color and the contents of malondialdehyde (MDA), carbonyl, and sulfhydryl were measured after 0, 5, 10, 15, and 20 d, and sensory evaluation was performed. The results demonstrated that the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) significantly increased in the B. subtilis supplementation group compared with those in the control group (P < 0.05). Furthermore, dietary supplementation with B. subtilis significantly improved the color of pork stored in high-oxygen modified atmosphere packaging (P < 0.05). During low-temperature storage, dietary supplementation with B. subtilis decreased the MDA content (P < 0.05) and inhibited the lipid oxidation of pork stored in high-oxygen modified packaging. In addition, it significantly inhibited the formation of carbonyl compounds and the loss of sulfhydryl compounds (P < 0.05), and significantly increased the sensory color score of high-oxygen modified atmosphere packaged pork and the overall preference score after opening the package (P < 0.05). In summary, dietary addition of B. subtilis could improve the antioxidant capacity of pork, thereby maintaining the color and inhibiting protein and lipid oxidation in pork stored in high-oxygen modified atmosphere packaging, ultimately enhancing the eating quality of pork.

[Objective] To explore the characteristics of lifestyle behaviors and mental health status among blood donors in Guangzhou, and to investigate the correlation between donation frequency and these factors. [Methods] A cross-sectional study was conducted among 13 042 whole blood donors from 17 street blood donation sites of Guangzhou Blood Center from May to August 2020. Descriptive analysis was used to describe the characteristics of lifestyle behaviors and mental health status among blood donors in Guangzhou. Ordinal multinomial logistic regression model was used to analyze the correlation between donation frequency and these factors. [Results] It was found that some of 13 042 blood donors had unhealthy habits, such as 6.8% (698/10 214，2 828 missing values) had severe tobacco dependence, 30.6% (3 997/13 042) had low exercise levels, 38.8%（5 056/13 042）had poor sleep quality, and 2.2% (271/12 159，883 missing values) had alcohol dependence. In addition, 2.8% (364/13 042) and 1.3% (172/13 042) of the donors may have moderate to severe depression and anxiety symptoms, respectively. The results of the ordinal multinomial logistic regression model showed that exercise level was significantly negatively correlated with the degree of depression and anxiety among blood donors. With the decrease in exercise level, the possibility of depression and anxiety among donors increased significantly. BMI, household income, education level, marital status, donation frequency, alcohol consumption and smoking had no significant correlation with the mental health status of donors. [Conclusion] Improving the exercise habits of blood donors may help enhance their mental health level. It is recommended that blood station staff strengthen the content of exercise when providing health education to blood donors to maintain a healthy lifestyle. It also suggests that there may be a certain degree of under-diagnosis of mental health problems in the process of health consultation before blood donation, and conducting more comprehensive and effective mental health assessments for blood donors is recommended.

In order to explore the differences in the aroma components of baked green tea harvested in different seasons, the composition and content of volatile components in spring and autumn green tea processed from three major tea cultivars in Zhejiang province were systematically analyzed via stir bar sportive extraction (SBSE) combined with gas chromatography-mass spectrometry (GC-MS). Then, key differential volatile components and key aroma-active components were selected by multivariate statistics and odor activity value (OAV) analysis. Results showed that a total of 105 volatile components were identified in spring and autumn green tea, and alcohols, esters and ketones accounted for more than half of the total number. Through principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA) and significance analysis, 38 compounds such as phytol, 1-octanol and 1-octen-3-ol were found to be the key compounds with statistical differences in spring and autumn green tea (P 1). The concentration of phytol in autumn tea samples (967.65 ng/mL) was significantly higher than that in spring tea samples (370.82 ng/mL). It might be related to the sufficient chlorophyll reserve in fresh tea leaves harvested in autumn. However, the concentrations of hexanal and other components were generally higher in spring tea, which might be related to the seasonal changes of enzyme activities related to the formation of fatty acids or carotenoid derivatives.

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin’s lymphoma. Ferroptosis, an iron-dependent programmed cell death, is closely related to cancer prognosis. In this study, we established a model of ferroptosis related genes for prognostic evaluation of patients with MCL.

ObjectiveThis study aimed to investigate the impact of electroacupuncture (EA) on blood glucose levels, gut microbiota, short-chain fatty acids (SCFAs), and glucagon-like peptide-1 (GLP-1) in a rat model of type 2 diabetes mellitus (T2DM).MethodsForty Sprague–Dawley (SD) rats were randomly assigned to five groups (n = 8/group) using a random number table: normal control, T2DM model, electroacupuncture (EA), EA + antibiotics (EA + A), and antibiotics (A). The normal rats received a standard diet and saline gavage, while the other groups were fed a high-fat diet and emulsion. The EA + A and A groups received additional antibiotic solution gavage. The normal, model, and A groups were immobilized and restrained for 30 min, six times per week, for 4 weeks. The EA and EA + A groups received EA treatment at specific acupoints for 30 min, six times per week, for 4 weeks. EA parameters were continuous waves at 10 Hz and 1–2 mA. During the intervention, water and food consumption, body weight, fasting blood glucose (FBG), and oral glucose tolerance test (OGTT) were monitored. Pancreatic tissue was examined using hematoxylin and eosin (H&E) staining. Fecal microbial communities were analyzed by 16S rDNA sequencing, and short-chain fatty acids (SCFAs) were measured using gas chromatography–mass spectrometry (GC–MS). Serum levels of fasting insulin (FINS), glycated hemoglobin (HbA1c), and glucagon-like peptide-1 (GLP-1) were determined using enzyme-linked immunosorbent assay (ELISA).ResultsEA significantly improved daily water intake, food consumption, and body weight in T2DM rats (p

C19H17FINO4, triclinic, P1̄ (no. 2), a = 7.1158(2) Å, b = 11.1914(3) Å, c = 12.4974(3) Å, α = 73.015(2)°, β = 87.945(2)°, γ = 78.137(2)°, V = 931.19(4) Å3, Z = 2, R gt(F) = 0.0563, wRref (F 2) = 0.1639, T = 293(2) K.

To solve the mixing problem of the drill in the construction of cement-soil mixing pile in low moisture content silty loam in northern China, this paper carries out a feasibility field test study of the two construction schemes, namely, presoaking method and higher water-cement ratio method. They are conducted in the context of the ground treatment of the cement-soil mixing pile used for the foundation of the Dongci drainage culvert and sluice, a sub-project of the Heibei Baigou River governance project (Zhuozhou part). The feasibility of the two schemes under the site condition is compared and analyzed by measuring data regarding the construction speed and compressive strength of cement soil. It is found that both the schemes are applicable on an engineering basis in low moisture content silty loam, but the higher water-cement ratio method is superior to the presoaking method in terms of construction efficiency and effect. Furthermore, on the condition of silty loam, when the higher water-cement ratio method is applied, the optimal water-cement ratio is 1.5, which satisfies construction quality and economy at the same time. The research finding provides not only a new idea for selecting the construction scheme for cement-soil mixing piles in low moisture content silty loam but also reliable construction technical parameters for cement-soil mixing pile construction under similar conditions.

AIM: To evaluate the effect of capsular tension ring(CTR)on the stability and accuracy of Barrett universal Ⅱ intraocular lens(IOL)calculation formula in patients with high myopia and cataract.METHODS:Prospective study. A total of 40 cases(80 eyes)of high myopia and cataract that visited our hospital from January to June 2022 were selected. The patients were divided into CTR group and blank group by random number table method, with 40 eyes in each group. All patients were measured by IOL Master, and the actual implanted IOL power and predicted postoperative power were calculated according to Barrett universal Ⅱ formula. The uncorrected visual acuity(UCVA)and best corrected visual acuity(BCVA)at 6 mo after surgery were recorded, and the mean absolute error(MAE)was compared at 6 mo after surgery. Furthermore, the stability of postoperative refractive status and the relationship between the predicted postoperative diopter and CTR were evaluated.RESULTS:The UCVA and BCVA of the two groups were improved at 6 mo after operation(P>0.05), and there was no significant difference in UCVA and BCVA between the two groups at each time point(all P>0.05). After the implantation of IOL in 80 eyes based on the Barrett universal Ⅱ formula, the predicted postoperative diopter was -2.01±0.71 D, the actual postoperative diopter was -1.64±0.88 D, and the MAE was 0.37±0.98 D in the CTR group; in the blank group, the predicted diopter was -2.12±0.64 D, the actual diopter was -1.54±0.88 D, and the MAE was 0.58±0.31 D. The difference between the two groups was statistically significant(P0.05). With the grouth of axial length, the MAE value increased. The postoperative MAE value of patients with axial length ≥30 mm was statistically different between the two groups(P

Research on the stereochemistry of natural products, especially that of flexible macrocyclic molecules, has always been a huge challenge. Cembranes diterpenoids are a typical class of flexible macrocyclic molecules, whose configurations are often determined by coupling constant and nuclear Overhauser effect (NOE), both of which are nuclear magnetic resonance (NMR) parameters with local character. The development of methods such as residual dipolar coupling (RDC) and quantum chemical calculations has further expanded the toolbox for solving stereochemical problems. RDC, as an NMR parameter with non-local character, has not only been reported in the structure construction and function research of biomolecules such as proteins and nucleic acids, but has also gradually been applied to the configuration determination of natural products, contributing significantly to the stereochemical research on drug molecules. At present, there are few reports of RDC application in determining the configurations of cembranes diterpenoids. Here, the stereochemical configuration of sinulariol Z is investigated by RDC for the first time and confirmed by X-ray diffraction, further demonstrating the feasibility of RDC in the stereochemical study on cembranes diterpenoids.

Objective The main defects on metro tunnel inner wall are cracks and water seepage. Current detection methods based on manual and semi-automatic equipment have problems such as high intensity, low efficiency, and low reliability. The intelligence-based detection/identification algorithm and detection system should be studied to realize informative and intelligent detection for metro tunnel lining defects. Method The current status of metro tunnel defect inspection technology is analyzed, and a set of algorithms applicable to the identification of metro tunnel lining defects are put forward, mainly including image processing algorithm, defect category detection algorithm, and defect grading detection algorithm, etc. Four indexes are chosen to evaluate the detection effect of the identification algorithm. Furthermore, an intelligent detection system for metro tunnel lining defects based on deep learning method is established from both software and hardware aspects. Finally, the system is implemented on Beingjing Metro Line 3 to analyze the reliability of its on-site application. Result & Conclusion After the application of the intelligent detection system, the detection rate of metro tunnel lining crack defects reaches 91.95% with a false detection rate of 0.89%. The detection rate of seepage defect is 93.83% and the false detection rate 0.65%. This system can be used as the core intelligent detection platform of metro tunnel, effectively detecting various defects in metro tunnel.

Fermented foods are rich in protein and free amino acids, which are decarboxylated by microbial amino acid decarboxylase to produce biogenic amines. Excessive ingestion of biogenic amines poses a threat to human health. Tyramine, a biogenic amine having high toxicity, is present in fermented foods in large quantities, so developing safe and effective methods to control tyramine is of practical significance for improving the safety of fermented foods. In this article, the physiological functions, harms and limit standard of tyramine in fermented foods are described with an emphasis on the formation mechanism and control methods of tyramine, so as to provide theoretical references for further improving the safety of fermented foods.

Honey, as a natural sweet substance, has always been favored by consumers due to its various functional activities, such as regulating the gastrointestinal tract, antibacterial, anti-inflammatory, and antioxidant properties. However, the production of honey is far less than the market demand for it, so driven by interests, honey is often adulterated, leading to quality deterioration. The adulteration of honey seriously undermines its natural attributes, having a negative impact on the honey industry. To safeguard the interests of consumers and producers, uphold the industry’s reputation, and promote its sustainable development, it is crucial to establish and improve methods for assessing honey authenticity. This article reviews the major methods for identifying the authenticity of honey, including traditional analytical techniques, targeted and non-targeted analytical techniques. In particular, the characteristic components in honey have been used for the identification of honey authenticity in recent years, which is achieved directly by analyzing the overall properties and chemical characteristics of honey are consistent with each other or not, but not relying on any prior knowledge of the adulterants. This paper aims to provide theoretical references for the authenticity identification of honey.

In this article, we aim to establish the optimal time decay rates of strong solutions to a two-phase flow model derived from a type of coupled fluid-kinetic equation. It is proved that the strong solutions converge to the given constant states with algebraic time decay rates under some additional assumptions on the initial data.

[Objective] The aim of this study is to reveal the spatiotemporal patterns of soil organic carbon (SOC) content in terraced fields on the Loess Plateau and investigate the spatiotemporal distribution characteristics of soil carbon sequestration in these terraced fields. [Methods] Using the META analysis method, the variations characteristics of SOC content in terraced soil with soil depth and years of terraced construction were studied, and analyzed the spatiotemporal distribution features of soil carbon sequestration in terraced fields across different regions of the Loess Plateau. [Results] (1) SOC content and carbon sequeering benefits decreased with the increase of soil depth, SOC content in the 80-100 cm soil layer was 60.74% of that in 0-20 cm soil layer, carbon sequeering benefit in the 0-20 cm layer was 23.1% and that in 80-100 cm soil layer was 5.7%. (2) The carbon sequestration benefits of terrace increased nonlinearly with the construction years. The carbon sequestration benefits of 0-20 cm soil layer of terrace gradually increased from -8.29% in the first year of construction to 34% in the 24th year, and then remained stable. (3) During 1979 to 2023, the total carbon sequestration of terraces on the Loess Plateau was approximately 38.29 Mt C, and the average carbon sequestration was 38.49 t C/(km2·a). The Jinghe River upper and middle reaches exhibited the highest average sequestration rate at 50.14 t C/(km2·a), while the Helong interval showed the lowest at 29.04 t C/(km2·a). [Conclusion] Terraced field construction on the Loess Plateau can enhance SOC content, and terraced field carbon sequestration was a relatively lengthy process that requires scientific design and management to maximize its carbon sequestration benefits. Conducting terraced field construction, along with proper planning, design, and scientific management, proved to be an effective measure to enhance regional soil carbon sequestration benefits. The research findings can offer theoretical and methodological support for assessing the carbon sequestration benefits of soil and water conservation in the Loess Plateau region.

Objective To screen the risk factors of hydrocephalus after decompressive craniectomy in patients with cerebral hernia after traumatic brain injury (TBI), and construct a Bayesian network model based on the risk factors. Methods A total of 77 patients with cerebral hernia after TBI who underwent decompressive craniotomy in Nanjing Tongren Hospital Affiliated to Southeast University from March 2020 to January 2022 were included. They were divided into hydrocephalus group (n = 25) and non - hydrocephalus group (n = 52) according to whether hydrocephalus was complicated after surgery. The risk factors of hydrocephalus after decompressive craniectomy in patients with cerebral hernia after TBI were analyzed by univariate and multivariate Logistic regression analyses. The Bayesian network model was constructed based on the risk factors, and the receiver operating characteristic (ROC) curve and calibration curve were drawn and Hosmer-Lemeshow goodness-of-fit test was conducted. Results In hydrocephalus group, the Glasgow Coma Scale (GCS) score at admission (t = 2.178, P = 0.032), the ratio of cerebrospinal fluid replacement after lumbar puncture (χ2 = 8.675, P = 0.003), and the level of β2 -microglobulin after operation (t = 11.146, P = 0.000) were lower than those in non-hydrocephalus group, while subarachnoid hemorrhage (χ2 = 5.901, P = 0.015), bilateral operation (χ2 = 6.441, P = 0.011), the ratio of dural unstitched during operation (χ2 = 9.759, P = 0.002), postoperative intraventricular hemorrhage (χ2 = 8.938, P = 0.003), postoperative midline displacement > 10 mm (χ2 = 7.589, P = 0.006), and intracranial infection (χ2 = 4.519, P = 0.034), as well as postoperative coma time (t = 2.709, P = 0.008) were higher than those in non - hydrocephalus group. Logistic regression analysis showed that subarachnoid hemorrhage (OR = 1.885, 95%CI: 1.432-2.240; P = 0.012), dural unstitched during operation (OR = 1.468, 95%CI: 1.215-1.930; P = 0.006), long postoperative coma time (OR = 1.574, 95%CI: 1.358-1.926; P = 0.007), postoperative intraventricular hemorrhage (OR = 1.550, 95%CI: 1.254-1.768; P = 0.010), the level of β2- microglobulin increased after operation (OR = 1.622, 95%CI: 1.165-1.840; P = 0.004) were risk factors for hydrocephalus after decompressive craniectomy in patients with cerebral hernia after TBI. Based on these 5 factors, the Bayesian network model was constructed, and the area under ROC curve was 0.886 (95%CI: 0.823-0.925, P = 0.000). The calibration curve showed that there was a good consistency between the predicted probability and the actual probability, while the Hosmer-Lemeshow goodness-of-fit test showed no significant difference (χ2 = 8.760, P = 0.232), which indicated that the model had good discrimination, calibration and accuracy. Conclusions Subarachnoid hemorrhage, dural unstitched during operation, long postoperative coma time, postoperative intra ventricular hemorrhage, and elevated β2 - microglobulin level are the risk factors for hydrocephalus after decompressive craniectomy in patients with cerebral hernia after TBI.

Objective To reasonably evaluate the energy absorption reliability index of anti-climber devices, a reliability analysis method based on ISSSM (improved sinusoidal and surrogate model) is proposed. Method Firstly, a finite element model for anti-climber device collision is established. Secondly, the rationality of the finite element simulation model is verified based on the collision test data of the anti-climber device. Then, based on the principles of sum of sine function construction, the basic form of the force-displacement function for the anti-climber device collision process is clarified. According to the energy absorption consistency criterion, the anti-climber device energy absorption ISSSM is constructed. Combining reliability theory, a reliability analysis model for anti-climber device energy absorption is established. Finally, a specific model of anti-climber device is studied, and its energy absorption reliability index is evaluated. Result & Conclusion The constructed energy absorption ISSSM can reasonably reproduce the mechanical characteristics of the anti-climber device collision energy absorption process. When the coefficient of variation increases from 0.05 to 0.1, the energy absorption reliability index decreases from 3.07 to 1.53.

Objective To investigate the rehabilitation effects of vestibular rehabilitation in acute brainstem infarction patients with subjective visual vertical (SVV) tilting, and the correlation between the SVV, balance confidence, dizziness/vertigo and walking function. Methods All 45 acute brainstem infarction patients with SVV tilting who were hospitalized in Tianjin Huanhu Hospital from July 2022 to July 2023 were collected. Patients were divided into vestibular rehabilitation group (n = 25) and general rehabilitation group (n = 20), Bucket Test was used to test SVV tilting angle, Activities-Specific Balance Confidence Scale (ABC) was used to evaluate balance confidence, Visual Analog Scales (VAS) was used to evaluate dizziness/vertigo and Functional Ambulation Category Scale (FAC) was used to evaluate walking function before and after 2 weeks of treatment. Results The SVV tilting angle (F = 4.356, P = 0.043), ABC score (F = 4.389, P = 0.042), dizziness/vertigo VAS score (F = 4.138, P = 0.048) were significantly different between vestibular rehabilitation group and general rehabilitation group. After treatment, the SVV tilting angle (t = - 2.139, P = 0.038) and the dizziness/vertigo VAS score (t = - 2.952, P = 0.005) in vestibular rehabilitation group were lower than those in general rehabilitation group, and the ABC score was higher than that in general rehabilitation group (t = 2.920, P = 0.006). SVV tilting angle (F = 196.923, P = 0.000), ABC score (F = 89.050, P = 0.000), dizziness/vertigo VAS score (F = 81.803, P = 0.000), FAC grade (F = 72.866, P = 0.000) were statistically significant. The SVV tilting angle (t = 0.763, P = 0.000; t = 0.972, P = 0.000) and dizziness/vertigo VAS score (t = 8.815, P = 0.000; t = 5.107, P = 0.000) after treatment were lower than those before treatment of 2 groups, and the ABC score (t = 0.689, P = 0.001; t = 0.703, P = 0.001) and FAC grade (t = - 6.721, P = 0.000; t = - 5.772, P = 0.000) were higher than those before treatment of 2 groups. Correlation analysis showed a positive correlation between SVV tilting angle and dizziness/vertigo VAS score in acute brainstem infarction patients with SVV tilting (r = 0.627, P = 0.000). Conclusions Vestibular rehabilitation can effectively improve the SVV tilting, balance confidence and dizziness/vertigo symptoms of acute brainstem infarction patients with SVV tilting, and the SVV tilting angle is closely related to the degree of dizziness/vertigo.

ObjectiveTo investigate the impact of acute respiratory infections in children under 12 years old in Pudong New Area， Shanghai from 2019 to 2023.MethodsAcute respiratory infection samples of children under 12 years old from three sentinel hospitals in Pudong New Area， Shanghai from 2019 to 2023 were collected， and 42 respiratory infection pathogens， including influenza virus， adenovirus， parainfluenza virus， respiratory syncytial virus， human enterovirus/rhinovirus， human pulmonary virus， human bokavirus， coronavirus （229E， HKU1， NL63 and OC43）， and novel coronavirus， were detected with microfluidic chips. The situation of acute respiratory infections among outpatient and inpatient children in this area was analyzed for the before the implementation of non pharmacological intervention measures （2019.12‒2020.1）， during the period of non pharmacological intervention measures （2020.2‒2022.12）， and after non pharmacological intervention measures （2023.1‒2023.6）.ResultsFrom 2019 to 2023， a total of 1 770 samples were collected， and 445 pathogens were detected， with a detection rate of 25.14% （445/1 770）. The main pathogens detected during the study period were influenza virus： 8.70% （154/1 770）， respiratory syncytial virus： 4.41% （78/1 770）， human enterovirus/rhinovirus： 2.66% （47/1 770）， human adenovirus： 2.49% （44/1 770）， and parainfluenza virus： 2.20% （39/1 770）. Before the implementation of non pharmacological intervention measures， outpatients were primarily infected with influenza， parainfluenza virus， and respiratory syncytial virus， with detection rates of 8.09%， 4.49%， and 4.04%， respectively； inpatients were mainly infected with influenza， respiratory syncytial virus， and parainfluenza virus， with detection rates of 4.49%， 3.82%， and 3.15%， respectively. During the period of non pharmacological intervention measures， influenza， rhinovirus and respiratory syncytial virus were the main viruses detected in the samples of outpatient children， with detection rates of 4.04%， 3.60%， and 2.47%， respectively； inpatient samples mainly detected respiratory syncytial virus， rhinovirus， and influenza virus， with detection rates of 3.60%， 2.02%， and 1.80%， respectively. After non pharmacological intervention measures， influenza， rhinovirus and respiratory syncytial virus were the main pathogens detected in the outpatients， with detection rates of 9.89%， 2.92% and 2.02%， respectively； influenza， respiratory syncytial virus， and rhinovirus were the main pathogens detected in inpatient children， with detection rates of 6.29%， 1.57%， and 1.35%， respectively.ConclusionThe prevalence of pathogens related to acute respiratory infections in children is influenced by non pharmacological preventive measures.

Objective To explore the effect of esketamine on working memory impairment in neuropathic mice and its underlying mechanism. Methods Fifty clean grade male C57BL/6J mice (2 months) were divided into 5 groups by random number table method: sham+saline (SN group), CCI+saline (CN group), CCI+esketamine(CE group), CCI+ANA-12 (CA group), CCI+ANA-12+esketamine (CAE group), with 10 mice in each group. Chronic constriction injury (CCI) was employed to establish a neuropathic pain model. On the 16th day after modeling, CE group and CAE group were administered ketamine (10 mg/kg), CAE group received ANA-12 (0.5 mg/kg) half an hour before ketamine injection, CA group was only given ANA-12, and SN group and CN group received an equivalent volume of saline. The administration was done through intraperitoneal injection for 5 consecutive days. The open-field test (OFT), paw withdrawal threshold (PWT), paw withdrawal latency (PWL) and Y-maze test were performed from day 21 after surgery. Bromo-2-deoxyUridine (BrdU) was dissolved in saline and intraperitoneally injected into the mice on days 21 to 23 after the surgery. Western blot was performed to determine the expression of Brain-derived neurotrophic factor(BDNF) in hippocampus, the immunofluorescence was performed to determine the number of BrdU and doublecortxin (DCX) positive cells in the dentate gyrus (DG) area of hippocampal. Results Compared with SN group, the other four groups showed significant reductions in both PWT and PWL on day 21 after surgery (all P

[Objective]The daylily, a perennial herb in the lily family, boasts a rich nutritional profile. Given its economic importance, enhancing its yield is a crucial objective. However, current research on daylily cultivation is limited, especially regarding three-dimensional dynamic growth simulation of daylily plants. In order to establish a technological foundation for improved cultivation management, growth dynamics prediction, and the development of plant variety types in daylily crops, this study introduces an innovative three-dimensional dynamic growth and yield simulation model for daylily plants.[Methods]The open-source GroIMP software platform was used to simulate and visualize three-dimensional scenes. With Datong daylily, the primary cultivated variety of daylily in the Datong area, as the research subject, a field experiment was conducted from March to September 2022, which covered the growth season of daylily. Through actual cultivation experiment measurements, morphological data and leaf photosynthetic physiological parameters of daylily leaves, flower stems, flower buds, and other organs were collected. The functional-structural plant model (FSPM) platform's three-dimensional modeling technology was employed to establish the Cloud Cover-based solar radiation models (CSRMs) and the Farquhar, von Camerer, and Berry model (FvCB model) suitable for daylily. Moreover, based on the source-sink relationship of daylily, the carbon allocation model of daylily photosynthetic products was developed. By using the β growth function, the growth simulation model of daylily organs was constructed, and the daily morphological data of daylily during the growth period were calculated, achieving the three-dimensional dynamic growth and yield simulation of daylily plants. Finally, the model was validated with measured data.[Results and Discussions]The coefficient of determination (R2) between the measured and simulated outdoor surface solar radiation was 0.87, accompanied by a Root Mean Squared Error (RMSE) of 28.52 W/m2. For the simulated model of each organ of the daylily plant, the R2 of the measured against the predicted values ranged from 0.896 to 0.984, with an RMSE varying between 1.4 and 17.7 cm. The R2 of the average flower bud yield simulation was 0.880, accompanied by an RMSE of 0.5 g. The overall F-value spanned from 82.244 to 1 168.533, while the Sig. value was consistently below the 0.05 significance level, suggesting a robust fit and statistical significance for the aforementioned models. Subsequently, a thorough examination of the light interaction, temperature influences, and photosynthetic attributes of daylily leaves throughout their growth cycle was carried out. The findings revealed that leaf nutrition growth played a pivotal role in the early phase of daylily's growth, followed by the contribution of leaf and flower stem nutrition in the middle stage, and finally the growth of daylily flower buds, which is the crucial period for yield formation, in the later stages. Analyzing the photosynthetic traits of daylily leaves comprehensively, it was observed that the photosynthetic rate was relatively low in the early spring as the new leaves were initially emerging and reached a plateau during the summer. Considering real-world climate conditions, the actual net photosynthetic rate was marginally lower than the rate verified under optimal conditions, with the simulated net assimilation rate typically ranging from 2 to 4 μmol CO2/(m2·s).[Conclusions]The three-dimensional dynamic growth model of daylily plants proposed in this study can faithfully articulate the growth laws and morphological traits of daylily plants across the three primary growth stages. This model not only illustrates the three-dimensional dynamic growth of daylily plants but also effectively mimics the yield data of daylily flower buds. The simulation outcomes concur with actual conditions, demonstrating a high level of reliability.

This paper takes Dongzhaigang National Nature Reserve and 1 km peripheral zone as the study area, selects Sentinel-2 remote sensing image data from 2017—2021, decodes landscape types using human-computer interaction, calculates landscape pattern index, and then compares and analyzes the landscape pattern changes inside and outside the reserve during the 5-year period and its main driving forces. The results show that (1) within the protected area, the mangrove wetland area shows an increasing trend, the woodland area decreases, and the cultured water area decreases significantly; the protected area has better landscape connectivity and lower fragmentation, among which mangrove is the dominant landscape. (2) In the peripheral zone, the area of mangrove wetlands has increased, the area of woodland has decreased, the area of cultured water surface and construction area have decreased, but the area of cultivated land has increased; compared with the protected area, the landscape fragmentation is higher and the connectivity and integrity are poor. (3) Mangrove ecological conservation and restoration activities were the main drivers of significant changes in the landscape pattern of the protected area, while human activities such as farming and construction were the main factors that changed the landscape pattern of the peripheral zone. The results of the study are of reference value for optimizing the conservation management of the reserve and strengthening the control of human activities in the peripheral zone.

Objective To use the Plan-Do-Check-Action(PDCA) cycle management model to reduce the number of nursing adverse events in home-based nursing of patients with indwelling gastric tubes. Methods A total of 14 patients who chose to have indwelling gastric tube at home from January to June of 2021 were enrolled. With the informed consent of the patient and his family, indwelling gastric tube placement was performed at home. The PDCA cycle management model was implemented for the home indwelling gastric tube nursing of patients. The occurrence of indwelling gastric tube-associated nursing adverse events and the nursing quality of nursing staff before and after the implementation of PDCA mode were compared. Results After implementation of the PDCA cycle management model, six indicators were regularly monitored daily: the number of nasal strips that were not measured for deep replacement of gastric tubes, residual volume before nasogastric feeding, gastric tube use for more than 28 days, self-extubation, no oral care and other nursing problems. After observation, the number of gastric tubes-associated nursing problems were significantly reduced, with as significant difference (P＜0. 01). Nursing staff had significant improvements in PDCA skills, team spirit, brain development, communication and coordination, activity confidence, responsibility in the PDCA cycle mode. Conclusion The use of PDCA cycle management mode in the home-based nursing of patients with indwelling gastric tubes can reduce the incidence of nursing adverse events, and effectively improve the nursing quality. (目的 运用PDCA循环管理模式减少留置胃管相关护理问题, 提升患者居家护理安全。方法 选取2021年1月—6月共14例接受居家护理的留置胃管患者为研究对象。在患者及其家属知情同意下, 于家中实施留置胃管。运用PDCA循环管理模式开展居家护理, 对比实施PDCA模式前和实施PDCA模式后留置胃管相关护理问题发生情况与护理人员的护理质量。结果 运用PDCA循环管理模式后, 每日定期观察6项指标: 未测量胃管深度更换鼻贴、鼻饲前未回抽检查残余量、胃管使用超过28 d、自行拔管、无口腔护理和其他护理问题的发生数量。实施PDCA循环管理模式后, 留置胃管相关护理问题较实施前减少, 差异有统计学意义(P＜0. 01), 护理人员PDCA循环工具、团队精神、脑力开发、沟通协调、活动信心, 责任荣誉感方面均较改善前有明显改善。结论 对于居家留置胃管患者, 运用PDCA循环管理模式能够减少留置胃管相关护理问题, 有效提升护理人员的护理质量。)

Micro-devices fabrication has led to extensive scientific research on microfluidics and microelectromechanical systems. These devices are used for a wide range of technological applications, but research on microfluidic devices for nanofluids is relatively scarce. In response to this problem, the electrokinetic energy conversion (EKEC) efficiency of nanofluids is provided under the coupling effect of pressure gradient and magnetic field through porous microtubes using the Debye–Hückel linearization and the Green’s function method. The results show that the periodic excitation of the square waveform is more effective in increasing the EKEC efficiency. In addition, compared with previous studies, the average velocity is in good agreement with the cosine waveform at R = 0.2. It is worth noting that compared to cosine waves, the average velocity reaches 47% in triangular waves and 85% in square waves.

Using a high temperature solid state reaction at 1600 ℃ for 6 h, (Nd1－xCax)(Al1－xFex)O3－x/2(x=0, 0.1, 0.2, 0.3) was synthesized by introducing Ca2+ and Fe3+ into NdAlO3, and spark plasma sintering (SPS) ceramic samples were used to investigate the effects of Ca2+ and Fe3+ addition on the phase composition, emissivity and ferroelasticity of NdAlO3. The results show that a solid solution can be successfully fabricated through the high temperature solid state reaction. The doping of Ca2+ and Fe3+ in NdAlO3 increases oxygen vacancies and slight lattice distortion occurs, emissivity of NdAlO3 within the wavelength range of 2.5-10 μm increases the maximum to 0.9. The introduction of impurity ions makes the phase gradually transform from rhombohedral to cubic, leading to the ferroelastic domains vanish. However, the fracture toughness of ceramic samples remains at a high level.

To summerize the effect of moxibustion therapy and nursing interventions on the peripheral neuropathic pain of lower limbs caused by oxaliplatin. A comprehensive pain assessment was conducted for the establishment of following nursing plan. The combination treatment of moxibustion and acupoint massage was carried out to relive the peripheral neuropathic pain of lower limbs and ensure the completion of chemotherapy. (本文总结1例艾灸疗法缓解奥沙利铂致下肢周围神经病变性疼痛的护理经验。评估患者疼痛程度, 明确干预方案, 先用生姜涂擦, 再用艾灸条艾灸下肢, 并进行穴位按摩。通过肿瘤绿色调护, 有效减轻患者下肢周围神经病变性疼痛, 保障化疗的顺利进行, 对提高患者生存质量具有积极意义。)

Objective: The objective of this study was to develop high-quality non-fried whole shiitake (Lentinus edodes) crisps due to having high oil content of vacuum fried L. edodes crisps which inevitably pose health risks after long-term use. Methods: Based on uniform design, instant controlled pressure drop (DIC) was used to investigate the influences of moisture content after heat pump pre-drying, puffing temperature and vacuum drying temperature on the puffing degree, rehydration ratio, total color difference, hardness and crispness of L. edodes crisps. The polynomial regression model was established by using a weighted comprehensive score method, and it was optimized and verified accordingly. Results: The optimum parameter combinations of L. crisps during DIC processing were moisture content after heat pump pre-drying of 35.63%, puffing temperature of 100 ℃, vacuum drying temperature of 64.17 ℃. Under the control of these optimal parameter combinations, the puffing degree of L. crisps was 69.34%, total color difference was 20.68, hardness was 108.16 N, and crispness was 75.79. Conclusion: Uniform design combined with response surface methodology can be used to optimize processing parameters of DIC crisps and obtain high quality non-fried L. crisps.

C16H9BrINO2, triclinic, P1̄ (no. 2), a = 7.9305(12) Å, b = 8.2051(10) Å, c = 11.3141(13) Å, α = 85.384(10)°, β = 85.619(11)°, γ = 87.745(11)°, V = 731.27(17) Å3, Z = 2, Rgt(F) = 0.0397, wRref(F2) = 0.0819, T = 293(2) K.

This paper reports the first case of myelodysplastic syndromes combined with myeloid sarcoma for which the department of radiotherapy used total marrow and lymphoid irradiation (TMLI) to assist in myeloablating. Radiotherapy localization and target area delineation were carried out before treatment and the entire process of TMLI treatment was designed using the TOMO therapy. Radiotherapy was performed successfully for targeted irradiation of the total bone marrow and lymph nodes. The patient felt comfortable during the treatment process and good pretreatment effects were achieved. The treatment time (45 min-1 h per session) was significantly shorter than that during total body irradiation (TBI)(3-4 h per session), the irradiation dose rate (800 cGy/min) was significantly increased compared to TBI (5-30 cGy/min), and oral mucosal inflammation and gastrointestinal reactions were mild after treatment. This article discusses the treatment process of this case and TMLI technology, to provide reference for the whole process design and important parameters for further treatment of more patients.

The completion of the Hong Kong-Zhuhai-Macao Bridge makes the Guangdong-Hong Kong-Macao Bay Area a closed-loop traffic system that provides the basis and possibility for tourism integration. From the spatial perspective of tourism supply and demand, this study examines the pattern of tourism competitiveness and residents' travel potential of cities in the Bay Area before and after the opening of the bridge, using the Geographic Information System and an improved gravity model of the tourism system. The development trend of regional tourism integration under bridge impact was also analyzed. The results show that: (1) the opening of the Hong Kong-Zhuhai-Macao Bridge has facilitated a more balanced distribution of tourist flows on the east and west sides of the Pearl River Estuary, which will benefit balanced development and promote the integrated development of regional tourism in the Guangdong-Hong Kong-Macao Greater Bay Area. (2) The bridge impact index on tourism competitiveness and residents' travel potential in 11 cities in the Greater Bay Area was significantly correlated with traffic accessibility change following the opening of the bridge, presenting an obvious attenuation effect of the bridge's impact on tourism with distance to the bridge. The opening of the bridge has reduced tourism resistance between the two sides of the estuary and greatly strengthened tourism cooperation between cities on both sides of the estuary, especially the complementary resource advantages between the east and west bank city clusters (Hong Kong, Shenzhen, Macao, and Zhuhai). (3) The impact on tourism competitiveness and residents' travel potential in the Greater Bay Area shows a significant spatial clustering pattern. The high-value clustering areas are mainly located in Hong Kong, Macao, and Zhuhai, which are directly connected by the bridge. Some areas of Zhongshan and Zhuhai are surrounded by high-value neighbors and are more likely to be diffused. Some areas of Guangzhou-Foshan and Shenzhen-Dongguan are low-value clustering areas, showing a marginalization trend. The bridge significantly strengthens the advantages of the core city agglomerations of Hong Kong and Macao. The relative status of Guangzhou and nearby areas has been weakened; however, the bridge does not affect Guangzhou's leading position in the tourism industry in the Guangdong-Hong Kong-Macao Greater Bay Area.

This study aims to assess the capability of monocyte-to-lymphocyte ratio (MLR) and C-reactive protein (CRP) to diagnose and differentiate diagnosis various types of lung diseases, including non-small-cell lung cancer (NSCLC), small-cell lung cancer (SCLC) and benign pulmonary diseases (BPD).

Argonaute (Ago) proteins are conserved programmable nucleases present in eukaryotes and prokaryotes and provide defense against mobile genetic elements. Almost all characterized pAgos prefer to cleave DNA targets. Here, we describe a novel pAgo from Verrucomicrobia bacterium (VbAgo) that can specifically cleave RNA targets rather than DNA targets at 37°C and function as a multiple-turnover enzyme showing prominent catalytic capacity. VbAgo utilizes DNA guides (gDNAs) to cleave RNA targets at the canonical cleavage site. Meanwhile, the cleavage activity is remarkably strengthened at low concentrations of NaCl. In addition, VbAgo presents a weak tolerance for mismatches between gDNAs and RNA targets, and single-nucleotide mismatches at positions 11‒12 and dinucleotide mismatches at positions 3‒15 dramatically reduce target cleavage. Moreover, VbAgo can efficiently cleave highly structured RNA targets at 37°C. These properties of VbAgo broaden our understanding of Ago proteins and expand the pAgo-based RNA manipulation toolbox.

Pharmacoeconomic evaluation is the essential supporting information for the inclusion of rare disease drugs into medical insurance in China. The accurate measurement of the health state utility of rare diseas is of practical significance to the development of rare disease pharmacoeconomic evaluation. Based on the review of pharmacoeconomic evaluation requirements for rare diseases in some countries/regions, we systematically retrieved the published studies on the measurement of health state utility for 121 rare diseases in China and other countries and regions. We identified 17 591 papers in the initial review, and later selected 230 after screening. We also made a comprehensive analysis of the quality of literature, evaluation content and use of tools for measuring health state utility in rare diseases in China. Finally, we analyzed the challenges in measurement in terms of population, instruments use, and application of results and made recommendations based on analysis, hoping to provide reference for the development of rare disease health state utility measurement studies in China.

Since the prognosis of patients with pancreatic cancer is very poor and there is a lack of treatment methods, this study is performed to investigate the function of PITX2 in pancreatic stellate cells (PSCs) in the progression of pancreatic cancer. Scientific hypotheses are proposed according to bioinformatics analysis and tissue microarray analysis. Stable knockdown of PITX2 in PSCs is achieved through lentiviral infection. The relative expressions of PITX2, α-SMA, vimentin, CTNNB1, AXIN1 and LEF1 are measured in wild-type PSCs and PITX2-knockdown PSCs. Proliferative capacity is measured by EdU assay. After coculture with PSCs, the proliferation, invasion and migration capacity of pancreatic cancer cells are tested. EMT and Wnt/β-catenin downstream genes of pancreatic cancer cells are investigated to reveal the potential mechanism. Bioinformatics analysis reveals that the PITX2 gene is highly expressed in stromal cells in pancreatic cancer and is correlated with squamous-type PDAC. Analysis of PDAC tissue microarray further demonstrates that high PITX2 level in stromal cells is correlated with poor prognosis in PDAC. After stable knockdown of PITX2 in PSCs, the relative protein levels of α-SMA, vimentin, CTNNB1, AXIN1 and LEF1 are decreased, and the proliferative capacity of PSCs is also decreased. After coculture with PSCs, in which PITX2 expression is downregulated, the proliferation, invasion and migration capacities of pancreatic cancer cells are inhibited. Thus, our results show that PITX2-silenced PSCs inhibit the growth, migration and invasion of pancreatic cancer cells via reduced EMT and Wnt/β-catenin signaling.

Patients with castration-resistant prostate cancer (CRPC) often develop drug resistance after treatment with enzalutamide. The goal of our study was to identify the key genes related to enzalutamide resistance in CRPC and to provide new gene targets for future research on improving the efficacy of enzalutamide. Differential expression genes (DEGs) associated with enzalutamide were obtained from the GSE151083 and GSE150807 datasets. We used R software, the DAVID database, protein–protein interaction networks, the Cytoscape program, and Gene Set Cancer Analysis for data analysis. The effect of RAD51 knockdown on prostate cancer (PCa) cell lines was demonstrated using Cell Counting Kit-8, clone formation, and transwell migration experiments. Six hub genes with prognostic values were screened (RAD51, BLM, DTL, RFC2, APOE, and EXO1), which were significantly associated with immune cell infiltration in PCa. High RAD51, BLM, EXO1, and RFC2 expression was associated with androgen receptor signaling pathway activation. Except for APOE, high expression of hub genes showed a significant negative correlation with the IC50 of Navitoclax and NPK76-II-72-1. RAD51 knockdown inhibited the proliferation and migration of PC3 and DU145 cell lines and promoted apoptosis. Additionally, 22Rv1 cell proliferation was more significantly inhibited with RAD51 knockdown than without RAD51 knockdown under enzalutamide treatment. Overall, six key genes associated with enzalutamide resistance were screened (RAD51, BLM, DTL, RFC2, APOE, and EXO1), which are potential therapeutic targets for enzalutamide-resistant PCa in the future.

The effect of specimen thickness on the very high cycle fatigue （VHCF） properties of DD6 nickel-based single crystal superalloys for turbine blades with hollow air-cooled structure was investigated. Based on the finite element method （FEM）, a thin-walled vibration fatigue specimen with a thickness of 0.5 mm was designed with a natural frequency of 1425 Hz, which was a suitable test efficiency for VHCF test. The VHCF test was carried out by electrodynamic shaker at room temperature, and a VHCF S-N curve up to 109 cycles was obtained. Comparing with the rotational bending fatigue and vibration fatigue test data of conventional size specimens, the results show that the fatigue strength of DD6 single crystal superalloy continues to decrease after 107 cycles and the fatigue strength is decreased about 25%，from 107 to 109 cycles; The high cycle fatigue strength of the thin-walled specimen is basically the same as the standard rotary bending fatigue strength of the same material, and slightly lower than the conventional vibration fatigue strength. The cracks in the thin-walled specimen initiate on the surface of the dangerous section, showing the characteristics of line source. There are two propagation planes in the fatigue growth zone, showing the characteristics of cleavage like.

Now that UAVs （unmanned aerial vehicles） have been widely used for power inspection， the UAV image analysis method based on computer vision technology can provide auxiliary means for pole tilt detection and risk assessment. This paper proposes a method of pole tilt detection and risk assessment based on semantic segmentation and evidence theory. The pole image segmentation method based on U-Net and connected component labeling algorithm is used to classify the images pixel by pixel according to semantic categories， and non-pole regions are eliminated by using the connected component labeling algorithm. By the construction of pole tilt criterion， a method for pole tilt detection based on evidence theory is proposed to fuse the conclusions of multiple criteria by using synthetic rules. The tilt risk assessment method is given， and the tilt level is taken as the assessment result. The experimental results show that the proposed method can improve detection accuracy.

Immune cells are indispensable defenders of the human body, clearing exogenous pathogens and toxicities or endogenous malignant and aging cells. Immune cell dysfunction can cause an inability to recognize, react, and remove these hazards, resulting in cancers, inflammatory diseases, autoimmune diseases, and infections. Immune cells regulation has shown great promise in treating disease, and immune agonists are usually used to treat cancers and infections caused by immune suppression. In contrast, immunosuppressants are used to treat inflammatory and autoimmune diseases. However, the key to maintaining health is to restore balance to the immune system, as excessive activation or inhibition of immune cells is a common complication of immunotherapy. Nanoparticles are efficient drug delivery systems widely used to deliver small molecule inhibitors, nucleic acid, and proteins. Using nanoparticles for the targeted delivery of drugs to immune cells provides opportunities to regulate immune cell function. In this review, we summarize the current progress of nanoparticle-based strategies for regulating immune function and discuss the prospects of future nanoparticle design to improve immunotherapy.

Abstract Background The changes in demographic and family structures have weakened the traditional norms of filial piety and intergenerational relationships dramatically. This study aims to examine the dynamic association between financial support of adult children to their parents and informal care provision in China and its differences in household registration, residence arrangement and community-based care services. Methods Data was derived from the 2008–2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS), which is a longitudinal survey of a nationally representative sample of individuals aged 60 and over. Random effects model was used to assess the association between financial support and informal care provision of adult children to their parents. Results It was found that financial support showed an upward trend while informal care provision showed a download trend from 2008 to 2018. The result indicated a significant and negative association between financial support and informal care provision of adult children to their parents (B = -0.500, 95% confidence interval (CI) = -0.761 to -0.239). And the association was significant among elderly people who were from urban areas (B = -0.628, 95% CI = -0.970 to -0.287), co-resided with adult children (B = -0.596, 95% CI = -0.939 to -0.253), and had community-based services (B = -0.659, 95% CI = -1.004 to -0.315). Conclusion Financial support was negatively associated with informal care provision of adult children to their parents in China, and the association has differences in household registration, residence arrangement and community-based care services. It is suggested that policymakers should prioritize planning interventions for elderly care services and establish a family caregiver support system.

Our purpose was to devise a radiomics model using preoperative computed tomography angiography (CTA) images to differentiate new from old emboli of acute lower limb arterial embolism. 57 patients (95 regions of interest; training set: n = 57; internal validation set: n = 38) with femoral popliteal acute lower limb arterial embolism confirmed by pathology and with preoperative CTA images were retrospectively analyzed. We selected the best prediction model according to the model performance tested by area under the curve (AUC) analysis across 1,000 iterations of prediction from three most common machine learning methods: support vector machine, feed-forward neural network (FNN), and random forest, through several steps of feature selection. Then, the selected best model was also validated in an external validation dataset (n = 24). The established radiomics signature had good predictive efficacy. FNN exhibited the best model performance on the training and validation groups: its AUC value was 0.960 (95% CI, 0.899–1). The accuracy of this model was 89.5%, and its sensitivity and specificity were 0.938 and 0.864, respectively. The AUC of external validation dataset was 0.793. Our radiomics model based on preoperative CTA images is valuable. The radiomics approach of preoperative CTA to differentiate new emboli from old is feasible.

Objective·To explore the effect of continuous positive urine ketone body in pregnant women with gestational diabetes mellitus (GDM) on the maternal and infant outcomes.Methods·A total of 168 GDM pregnant women who attended the Nutrition Clinic of the International Peace Maternal & Child Health Hospital, Shanghai Jiao Tong University School of Medicine from January 2021 to January 2022 and gave birth in the hospital were selected as the study subjects. According to the difference of urine ketone body test results in prenatal examination, they were divided into ketone body-positive group (56 cases, the pregnant women had ketone body test positive for three times or more after the diagnosis of GDM) and ketone body-negative group (112 cases, the ketone body test was continuously negative after the diagnosis of GDM). The general information included clinical data and laboratory indicators of pregnant women and clinical outcomes of pregnant women and their newborns were collected and compared.Results·There were no statistically significant differences in clinical data and laboratory indicators of pregnant women between the two groups, among which the body mass index before pregnancy, weight change before diagnosis of GDM, family history of diabetes mellitus, history of GDM, total cholesterol and triacylglycerol levels in the early pregnancy, fasting blood glucose and insulin levels in the middle pregnancy had no significant correlation with the production of urine ketone body. The results of clinical outcome indicators of pregnant women showed that there were statistically significant differences in weight change (P=0.000; RR=6.000, 95% CI 1.251‒28.777) and rate of weight gain (P=0.000; RR=1.829, 95% CI 1.132‒2.953) after diagnosis of GDM between the two groups. The results of neonatal clinical outcome indicators showed that there was statistically significant difference in the neonatal hospitalization rate (P=0.023; RR=2.167, 95% CI 1.059‒4.434) between the two groups; among them, there were 4 adverse events in the ketone body positive group and no such adverse events in the ketone body negative group.Conclusion·The continuous positive urine ketone body of pregnant women with GDM may increase the risk of insufficient weight gain in pregnant women and neonatal hospitalization. It is recommended to timely detect and intervene in clinical practice.

This paper summarized the nursing management of constipation in a patient with Chest Stuffiness and Pains treated with Traditional Chinese Medicine (TCM) external treatment. Based on the nursing evaluation, a combination of TCM external treatment including acupoint application, auricular acupoint pressing therapy and abdominal massage were carried out to relieve the clinical symptoms. The TCM external treatment may provide new ideas for treating constipation in patients with chest stuffiness and pains, and promote its clinical practice. (本文总结中医外治法治疗1例胸痹心痛病患者便秘的护理体会。通过护理评估, 选用穴位贴敷、耳穴贴压和便秘推拿技术, 改善患者便秘的症状。中医外治法联合为治疗胸痹便秘提供了新的思路, 从而促进中医外治法的临床应用与推广。)

During postharvest storage, spinach is prone to problems such as oxidation, dehydration, wilting and decay, causing severe losses. In view of this, postharvest spinach was treated with 1 μL/L 1-methylcyclopropene (1-MCP), 0.1% phytic acid (PA) or their combination to explore the effects of preservatives on the physiology and storage quality of spinach. Spinach not treated with preservatives was used as a control. All samples were stored at room temperature (20 ± 1) ℃ and a relative humidity between 80% and 90%. The decay index, mass loss percentage, chlorophyll content, soluble solid content, ethylene release, peroxidase (POD) activity and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity were measured. In addition, sensory evaluation was performed in terms of appearance, morphology and smell. The results showed that all three treatments were effective in maintaining spinach quality. Specifically, compared with the other three groups, combined treatment with 1-MCP and PA significantly enhanced peroxidase (POD) activity and DPPH radical-scavenging capacity, thereby delaying the increase in decay index, mass loss percentage and ethylene release and increasing the chlorophyll content of spinach and maintaining high soluble solid content and sensory evaluation score during storage. As a result, 1 μL/L 1-MCP + 0.1% PA composite treatment had the best preservation effect, which could effectively delay the postharvest senescence and quality deterioration of spinach.

The cone-beam oral CT requires high transmission accuracy, and harmonic reducers with smooth operation, high precision efficiency and safety factor are mostly used. Its flexspline is prone to failure due to periodic deformation under alternating load when rotating. The tooth profile of the flexspline is designed, modeled by SolidWorks, and imported into the Ansys Workbench for the static analysis, modal analysis, and transient dynamic analysis. The results show that the flexural strain is mainly located at the long and short axes of the wave generator, and the axial strain decreases gradually along the cylinder. The maximum stress is located at the contact between the wave generator and the flexspline, and the maximum stress is located at the connection between the tooth root and the cylinder during the transient dynamic analysis. At the same time, the stress and strain of the flexspline are also affected by tooth width, barrel length and barrel thickness.

There are numerous applications of terahertz (THz) imaging in many fields. However, current THz imaging is generally based on scanning technique due to the limited intensity of the THz sources. Thus, it takes a long time to obtain a frame image of the target and cannot meet the requirement of fast THz imaging. Here, we demonstrate a single-shot direct THz imaging strategy based on a broadband intense THz source with a frequency range of 0.1~23 THz and a THz camera with a frequency response range of 1~7 THz. This THz source was generated from the laser–plasma interaction, with its central frequency at ~12 THz. The frame rate of this imaging system was 8.5 frames per second. The imaging resolution reached 146.2 μm. With this imaging system, a single-shot THz image for a target object with a size of more than 7 cm was routinely obtained, showing a potential application for fast THz imaging. Furthermore, we proposed and tested an image enhancement algorithm based on an improved dark channel prior (DCP) theory and multi-scale retinex (MSR) theory to optimize the image brightness, contrast, entropy and peak signal-to-noise ratio (PSNR).

C17H12INO3, monoclinic, P21/n (no. 14), a = 7.5319(5) Å, b = 7.9745(5) Å, c = 25.1313(17) Å, β = 98.459(7)°, V = 1493.04(17) Å3, Z = 4, Rgt(F) = 0.0272, wRref(F2) = 0.0595, T = 199.98(10) K.

Faster-than-Nyquist (FTN) technology can improve the spectral efficiency of Optical Wireless Communications (OWC). However, it is affected by the artificially introduced Inter-Symbol Interference (ISI) and atmospheric turbulence, which leads to the degradation of Bit Error Rate (BER) performance. To deal with this issue, a PAM modulated Multiple Input Multiple Output (MIMO)-FTN-OWC system is proposed, and MIMO technology is utilized to suppress the influence of atmospheric turbulence. Furthermore, the theoretical BER in log-normal fading channel is deduced, and the influence of channel correlation on the BER performance is analyzed. The simulation results show that the BER performance of 2×2 MIMO-FTN system is 9.5 dB higher than that of Single-Input Single-Output (SISO)-FTN system when BER is 10-4. In addition, the MIMO-FTN system has better BER performance than that of SISO-FTN system when the channel spatial correlation coefficient is lower than 0.6.