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5 results on '"Zhangting Xu"'

1. Role of Rubus chingii BBX gene family in anthocyanin accumulation during fruit ripening

Author

Zhangting Xu, Guihua Zhang, Junyu Chen, Yuxin Ying, Lingtiao Yao, Xiaoxian Li, Jaime A. Teixeira da Silva, and Zhenming Yu

Subjects
Rubus chingii, BBX, anthocyanidin, expression analysis, fruit ripening, Plant culture, SB1-1110
Abstract

The B-box (BBX) family, which is a class of zinc finger transcription factors, exhibits special roles in plant growth and development as well as in plants’ ability to cope with various stresses. Even though Rubus chingii is an important traditional medicinally edible plant in east Asia, there are no comprehensive studies of BBX members in R. chingii. In this study, 32 RcBBX members were identified, and these were divided into five groups. A collinearity analysis showed that gene duplication events were common, and when combined with a motif analysis of the RcBBX genes, it was concluded that group V genes might have undergone deletion of gene fragments or mutations. Analysis of cis-acting elements revealed that each RcBBX gene contained hormone-, light-, and stress-related elements. Expression patterns of the 32 RcBBX genes during fruit ripening revealed that highest expression occurred at the small green fruit stage. Of note, the expression of several RcBBX genes increased rapidly as fruit developed. These findings, combined with the expression profiles of anthocyanin biosynthetic genes during fruit ripening, allowed us to identify the nuclear-targeted RcBBX26, which positively promoted anthocyanin production in R. chingii. The collective findings of this study shed light on the function of RcBBX genes in different tissues, developmental stages, and in response to two abiotic stresses.

Published
2024
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2. Genome-Wide Identification and Characterization of the Salvia miltiorrhiza Histone Deacetylase (HDAC) Family in Response to Multiple Abiotic Stresses

Author

Junyu Chen, Yuxin Ying, Lingtiao Yao, Zhangting Xu, Zhenming Yu, and Guoyin Kai

Subjects
phytohormone, histone deacetylase (HDAC), expression profiles, genome-wide identification, phenolic acids, Salvia miltiorrhiza, Botany, QK1-989
Abstract

Salvia miltiorrhiza is a plant commonly used in traditional Chinese medicine. Its material bases for treating diseases are tanshinones and phenolic acids, including salvianolic acids. Histone deacetylase proteins (HDACs) are a class of specific functional enzymes that interact with acetylation groups on the N-terminal lysine of histone proteins further regulate gene transcription through structural changes at the chromatin level. HDACs involved in the growth and development of various plants, and induced by plant hormones to regulate the internal environment of plants to resist stress, at the same time affect the accumulation of some secondary metabolites. However, the role of SmHDACs on the accumulation of salvianolic acid in S. miltiorrhiza remains unclear. In this study, 16 SmHDACs genes were identified from the high-quality S. miltiorrhiza genome, their physicochemical properties were predicted. In phylogenetic trees co-constructed with HDACs proteins from other plants, SmHDACs was divided into three subfamilies, each with similar motif and conserved domain composition. The distribution of the three subfamilies is similar to that of dicotyledonous plants. Chromosome localization analysis showed that SmHDACs genes were randomly located. Cis-acting element analysis predicted that SmHDACs gene expression may be related to and induced by various phytohormones, such as MeJA and ABA. By combining the expression pattern and co-expression network induced by phytohormones, we speculate that SmHDACs may further influence the synthesis of salvianolic acid, and identified SmHDA5, a potential functional gene, then speculate its downstream target based on the co-expression network. In summary, we analyzed the SmHDACs gene family of S. miltiorrhiza and screened out the potential functional gene SmHDA5. From the perspective of epigenetics, we proposed the molecular mechanism of plant hormone promoting salvianolic acid synthesis, which filled the gap in the subdivision of histone deacetylase in S. miltiorrhiza research, provided a theoretical basis for the culture and transformation of S. miltiorrhiza germplasm resources.

Published
2024
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3. Fabrication of glucose-responsive and biodegradable copolymer membrane for controlled release of insulin at physiological pH

Author

Xiaoyun Xie, Yi Shen, Ming Luo, Zhangting Xu, Lulin Li, and Weizhong Yuan

Subjects
Atom-transfer radical-polymerization, Insulin, medicine.medical_treatment, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Controlled release, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Membrane, chemistry, Polymerization, Chemical engineering, Materials Chemistry, Copolymer, medicine, Molecule, Phenylboronic acid, 0210 nano-technology
Abstract

A glucose-responsive and biodegradable copolymer, poly(e-caprolactone)-b-poly(2-phenylboronic ester-1,3-dioxane-5-ethyl)methylacrylate (PCL-b-PPBDEMA), was synthesized by the combination of ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). The diblock copolymer could be easily prepared as a membrane containing insulin via a solution casting approach. The crystalline behaviour and thermal properties were investigated by POM and DSC. The results indicated that the PPBDEMA segments could destroy the crystallizability of the PCL segments. Glucose molecules could react with PPBDEMA, which led to the breakage of the phenylboronic acid molecules from the PBDEMA groups. PCL-b-PPBDEMA copolymer membranes as intelligent carriers could realize controlled insulin release via adjusting the glucose concentration. At the physiological pH, the membrane revealed a higher release rate of insulin after immersion in glucose solutions with high concentrations than that in glucose solutions with lower concentrations. In vitro cytotoxicity assays showed that the membrane is almost noncytotoxic.

Published
2019

4. Reduction and temperature dually-triggered size-shrinkage and drug release of micelles for synergistic photothermal-chemotherapy of cancer

Author

Xiaoyun Xie, Zhangting Xu, Weizhong Yuan, Danfeng Wu, Hai-Quan Wang, and Zhihong Li

Subjects
Polymers and Plastics, Atom-transfer radical-polymerization, Organic Chemistry, General Physics and Astronomy, 02 engineering and technology, Photothermal therapy, 010402 general chemistry, 021001 nanoscience & nanotechnology, Methacrylate, Photochemistry, 01 natural sciences, Micelle, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Polymerization, Materials Chemistry, Copolymer, medicine, Doxorubicin, 0210 nano-technology, Ethylene glycol, medicine.drug
Abstract

Reduction and temperature dually responsive poly(2-(2-methoxyethoxy)ethylmethacrylate-co-oligo(ethylene glycol) methacrylate)-b-poly(e-caprolactone)-SS-poly(e-caprolactone)-b-poly(2-(2-methoxyethoxy)ethylmethacrylat-co-oligo(ethylene glycol) methacrylate) (P(MEO2MA-co-OEGMA)-b-PCL-SS-PCL-b-P(MEO2MA-co-OEGMA)) was synthesized by the combination of ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). The copolymer can self-assemble into spherical micelles. After loading doxorubicin (DOX) and photothermal agent Indocyanine green (ICG), the micelles were endowed with synergistic effect of chemotherapy and photothermal therapy to cancer through reduction and temperature dually triggered size-shrinkage and drug release. The micelles showed good reduction and temperature responsiveness due to the presence of disulfide bond and thermoresponsive segments in copolymer. Under reducing conditions, the disulfide bond broke and the micelles were converted into micelles with half the original size, which was conducive to drug release. Near Infrared light (NIR) promoted the photothermal conversion of ICG, so that the micelle underwent a temperature response transition and further promoted the release of drugs. The micelles showed drug release rate, high photothermal conversion efficiency, highly cytotoxic to cancer cells and excellent synergistic photothermal-chemotherapy effect.

Published
2021

5. Cellulosic sponges with pH responsive wettability for efficient oil-water separation

Author

Zhiping Mao, Liduo Rong, Hong Xu, Xueling Feng, Jinying Yuan, Bijia Wang, Zhangting Xu, Shanqiu Liu, Xiaofeng Sui, and Lijie Li

Subjects
Polymers and Plastics, Organic Chemistry, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Chemical engineering, Superhydrophilicity, Covalent bond, Cellulosic ethanol, Desorption, Materials Chemistry, Wetting, Cellulose, 0210 nano-technology, Porous medium, Porosity
Abstract

To obtain efficient oil-water separation materials with responsiveness, cellulosic porous materials with switchable wettability in response to pH changes were developed by reacting cellulose acetoacetate sponges with alkylamines of varying carbon chain length via dynamic covalent enamine bonds. The resulting sponges reversibly changed between being superhydrophilic (θwater = 0°) and highly hydrophobic (maximal θwater = 146°) under suitable pH conditions while maintained the favorable porous structures. Notably, the functionalized sponges exhibited high and selective oil absorption capacity (40–80 g/g) and satisfying desorption ability of 80%, and could efficiently separate oil-water mixtures and emulsions with extremely high efficiency (> 99%) in a controllable manner. With the three-dimensional micro/nano porous structure, switchable wettability and intrinsic environmentally friendliness, the pH responsive cellulosic sponges developed here hold great potential in controllable oil-water separation and oily wastewater purification.

Published
2020

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