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Your search keyword '"Zhangyuan, Guangyan"' showing total 21 results
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21 results on '"Zhangyuan, Guangyan"'

7. lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway

Author

Luo, Tianping, Gao, Yuan, Zhangyuan, Guangyan, Xu, Xiaoliang, Xue, Cailin, Jin, Lei, Zhang, Wenjie, Zhu, Chunfu, Sun, Beicheng, and Qin, Xihu

Subjects
PCBP1-AS1, long non-coding RNA, Cancer Management and Research, AKT, hepatocarcinogenesis, metastasis, hepatocellular carcinoma, poly(C)-binding protein 1, Original Research
Abstract

Tianping Luo,1 Yuan Gao,1 Guangyan Zhangyuan,2 Xiaoliang Xu,3 Cailin Xue,1 Lei Jin,1 Wenjie Zhang,3 Chunfu Zhu,1 Beicheng Sun,3 Xihu Qin1 1Department of Hepatobiliary Surgery, The Affiliated Changzhou NO. 2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu Province 213164, People’s Republic of China; 2Liver Transplantation Center of the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu Province 210029, People’s Republic of China; 3Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province 210008, People’s Republic of ChinaCorrespondence: Xihu QinDepartment of Hepatobiliary Surgery, The Affiliated Changzhou NO. 2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu Province 213164, People’s Republic of ChinaEmail qinxihu@126.comBackground: Hepatocellular carcinoma (HCC) is a very belligerent primary liver tumor with high metastatic potential. Aberrant expression of lncRNAs drives tumorous invasion and metastasis. Whether lncRNAs engage mechanisms of liver cancer metastasis remains largely unexplored.Patients and Methods: We collected HCC tissues from the tumors and their adjacent normal samples in the Chinese population and analyzed the levels of lncRNAs by microarray analysis. The gain- and loss-of-function analysis demonstrated that PCBP1-AS1 accelerated tumorous growth and metastasis in vivo and in vitro. Moreover, we used RNA-pulldown assay to show that PCBP1-AS1 physically interacted with polyC-RNA-binding protein 1 (PCBP1); meanwhile, PCBP1-AS1 was indeed detected in RIP with the PCBP1 antibody. Mechanistically, we first explored the relationship between PCBP1‐AS1 and PCBP1 in HCC cell lines.Results: Here we show that PCBP1-AS1, identified by microarray analysis on pre- and post-operative HCC plasma specimens, was highly expressed in human HCC, clinically verified as a prometastatic factor and markedly associated with poor prognosis in patients with hepatocellular carcinoma. PCBP1‐AS1 was negatively related with PCBP1 at the messenger RNA and protein expression levels. PCBP1-AS1 triggered PRL-3 and AKT in HCC tumor cells. Additionally, the double knockout of PCBP1 and PCBP1-AS1 abolished the PCBP1-AS1-induced PRL-3-AKT signalling pathway activation.Conclusion: The upregulation of PCBP1-AS1 enhances proliferation and metastasis in HCC, thus regulating the PCBP1-PRL-3-AKT signalling pathway.Keywords: hepatocellular carcinoma, long non-coding RNA, PCBP1-AS1, poly(C)-binding protein 1, AKT, hepatocarcinogenesis, metastasis

Published
2020

8. PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis: Erratum

Author

Jin, Kangpeng, primary, Liu, Yang, additional, Shi, Yuze, additional, Zhang, Haitian, additional, Sun, YuanYuan, additional, Zhangyuan, Guangyan, additional, Wang, Fei, additional, Yu, Weiwei, additional, Wang, Jincheng, additional, Tao, Xuewen, additional, Chen, Xin, additional, Zhang, Wenjie, additional, and Sun, Beicheng, additional

Published
2022
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9. The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation

Author

Zhang, Wenjie, primary, Zhangyuan, Guangyan, additional, Wang, Fei, additional, Jin, Kangpeng, additional, Shen, Haiyuan, additional, Zhang, Liansheng, additional, Yuan, Xiang, additional, Wang, Jincheng, additional, Zhang, Haitian, additional, Yu, Weiwei, additional, Huang, Ruyi, additional, Xu, Xiaoliang, additional, Yin, Yin, additional, Zhong, Guisheng, additional, Lin, Anning, additional, and Sun, Beicheng, additional

Published
2021
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10. PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis

Author

Jin, Kangpeng, primary, Liu, Yang, additional, Shi, Yuze, additional, Zhang, Haitian, additional, Sun, YuanYuan, additional, Zhangyuan, Guangyan, additional, Wang, Fei, additional, Yu, Weiwei, additional, Wang, Jincheng, additional, Tao, Xuewen, additional, Chen, Xin, additional, Zhang, Wenjie, additional, and Sun, Beicheng, additional

Published
2020
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11. Correction: VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway

Author

Zhangyuan, Guangyan, primary, Wang, Fei, additional, Zhang, Haitian, additional, Jiang, Runqiu, additional, Tao, Xuewen, additional, Yu, Decai, additional, Jin, Kangpeng, additional, Yu, WeiWei, additional, Liu, Yang, additional, Yin, Yin, additional, Shen, Jintao, additional, Xu, Qinfeng, additional, Zhang, Wenjie, additional, and Sun, Beicheng, additional

Published
2019
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12. VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway

Author

Zhangyuan, Guangyan, primary, Wang, Fei, additional, Zhang, Haitian, additional, Jiang, Runqiu, additional, Tao, Xuewen, additional, Yu, Decai, additional, Jin, Kangpeng, additional, Yu, WeiWei, additional, Liu, Yang, additional, Yin, Yin, additional, Shen, Jintao, additional, Xu, Qinfeng, additional, Zhang, Wenjie, additional, and Sun, Beicheng, additional

Published
2019
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14. Effect of lymph nodes count in node-positive gastric cancer

Author

Zhang, Wenjie, primary, Zhangyuan, Guangyan, additional, Wang, Jincheng, additional, Jin, Kangpeng, additional, Liu, Yang, additional, Wang, Fei, additional, Yu, Weiwei, additional, Zhang, Haitian, additional, Li, Guoqiang, additional, Yu, Decai, additional, Chen, Huihui, additional, Xu, Qingxiang, additional, and Sun, Beicheng, additional

Published
2019
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