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3 results on '"Zhangyue Wei"'

1. Adult onset haemophagocytic lymphohistiocytosis prognosis is affected by underlying disease: analysis of a single-institution series of 174 patients

Author

Qiaolei Zhang, Li Li, Lixia Zhu, Jingjing Zhu, Xiudi Yang, De Zhou, Yanglong Zheng, Mingyu Zhu, Mixue Xie, Jianai Sun, Xueying Li, Ying Wu, Zhangyue Wei, Wanzhuo Xie, and Xiujin Ye

Subjects
haemophagocytic lymphohistiocytosis, adults, criteria, clinical manifestation, Prognosis, Medicine
Abstract

BACKGROUND Haemophagocytic lymphohistiocytosis (HLH) is a rare clinical syndrome characterised by activation of the mononuclear phagocytic system, and often leads to progressive multiple organ failure. The diagnosis of HLH is made late by most physicians. METHODS To confirm the diagnosis of acquired HLH made in a single-institution series of adult patients with HLH-04 criteria, we applied the HScore and evaluated prognostic factors associated with clinical outcome. RESULTS A total of 174 patients with a median age of 51 years (range 17–90) were included. Male/female ratio was 111/63. In 92/174 (52.9%) patients, there were potential haematological diseases (4 acute leukaemia, 1 thrombotic thrombocytopenic purpura, 3 Hodgkin’s lymphoma [HL], 17 B-cell non-Hodgkin’s lymphoma [NHL], 67 T-cell NHL including 22 natural killer / T-cell NHL [NK/t-cell NHL). Six (3.4%) patients had autoimmune disease and 76 (43.7%) undiagnosed underlying disease. There were 44 (25.3%) patients with Epstein-Barr virus infection, 11 (6.3%) with cytomegalovirus, 1 (0.5%) syphilis, 9 (5.2%) hepatitis B virus and 3 (1.7%) human immunodeficiency virus. More than 95% of patients had hyperferritinaemia, high lactate dehydrogenase, fever and low albumin, whereas 89.1% of patients had bone marrow phagocytosis. By the HScore, 4/174 patients had a >50% and 16/174 patients had a >90% probability of not having HLH. All 174 patients fulfilled more than five of the HLH-04 diagnostic criteria, but 16 of them had a low probability of HLH by the HScore. In a multivariate analysis, lymphopenia and hypofibrinogenaemia were independent prognostic factors for death. CONCLUSION In our study, viral infection was not an independent prognostic factor. NK/T-cell -NHL was associated with worse prognosis compared with B-cell NHL and T-cell NHL (p = 0.036) and similar to other aetiologies.

Published
2018
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2. In vivo production of psilocybin in E. coli

Author

John D. Brinton, Chantal S. Monnier, Alexis L. Enacopol, Alexandra M. Adams, J. Andrew Jones, Nicholas A. Kaplan, Zhangyue Wei, and Theresa Ramelot

Subjects
0106 biological sciences, Hallucinogen, Bioengineering, Biology, Pharmacology, 01 natural sciences, Applied Microbiology and Biotechnology, Psilocybin, Metabolic engineering, 03 medical and health sciences, chemistry.chemical_compound, 010608 biotechnology, Escherichia coli, medicine, 030304 developmental biology, 0303 health sciences, Norbaeocystin, Bioproduction, Baeocystin, Titer, Metabolic Engineering, chemistry, Batch Cell Culture Techniques, Psilocin, Biotechnology, medicine.drug
Abstract

Psilocybin, the prodrug of the psychoactive molecule psilocin, has demonstrated promising results in clinical trials for the treatment of addiction, depression, and post-traumatic stress disorder. The development of a psilocybin production platform in a highly engineerable microbe could lead to rapid advances towards the bioproduction of psilocybin for use in ongoing clinical trials. Here, we present the development of a modular biosynthetic production platform in the model microbe, Escherichia coli. Efforts to optimize and improve pathway performance using multiple genetic optimization techniques were evaluated, resulting in a 32-fold improvement in psilocybin titer. Further enhancements to this genetically superior strain were achieved through fermentation optimization, ultimately resulting in a fed-batch fermentation study, with a production titer of 1.16 g/L of psilocybin. This is the highest psilocybin titer achieved to date from a recombinant organism and a significant step towards demonstrating the feasibility of industrial production of biologically-derived psilocybin.

Published
2019
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3. Risk factors and clinical characteristics of non-promyelocytic acute myeloid leukemia of intracerebral hemorrhage: A single center study in China

Author

Lixia Zhu, De Zhou, Qiaolei Zhang, Mixue Xie, Li Li, Xiujin Ye, Jingjing Zhu, Mingyu Zhu, Yanlong Zheng, Xiudi Yang, Wanzhuo Xie, Zhangyue Wei, Xueying Li, and Jianai Sun

Subjects
Adult, Male, China, medicine.medical_specialty, Single Center, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Physiology (medical), Internal medicine, White blood cell, Humans, Medicine, cardiovascular diseases, Leukocytosis, Aged, Intracerebral hemorrhage, Acute leukemia, business.industry, Incidence, Myeloid leukemia, General Medicine, Middle Aged, medicine.disease, Peripheral blood, Blood Cell Count, nervous system diseases, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Neurology, 030220 oncology & carcinogenesis, Anesthesia, Female, Surgery, Neurology (clinical), medicine.symptom, business, Intracranial Hemorrhages, 030217 neurology & neurosurgery
Abstract

Although high mortality in patients with acute leukemia (AL) is associated with intracranial hemorrhage (ICH), the clinical features and pathogenesis of AL patients with cerebral hemorrhage are not well known.We diagnosed 90 patients with ICH from a total of 1467 patients with non-promyelocytic AL who had been hospitalized in the First Affiliated Hospital of Medical School of Zhejiang University from January 2010 to October 2015. Moreover, the risk factors of ICH death were evaluated.Median age at ICH was 51years old, in which men accounted for 52.2%. They also accounted for 85.6% of acute myeloid leukemia. The relative incidence of ICH was the highest in M2 and M5 (60.1%). ICH presented with higher peripheral blood white blood cell count (WBC) (P0.001), lower peripheral platelet counts (P0.001), lower albumin (P0.001), lower fibrous protein (P0.001) and prolongation of prothrombin time (P0.001) compared to those observed in the patients of NICH group; multivariate analysis, independent risk factors for death in patients with ICH include: WBC≥30.00×109/l and prothrombin time≥12.91 s.Leukocytosis and coagulation dysfunctions might be the main pathogenesis of acute leukemia complicated with cerebral hemorrhage.

Published
2017
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