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This study aimed to analyze counter-movement jump (CMJ) performance in time and frequency domains. Fortyfour Division I American football players participated in the study. Kinetic variables were collected from both dominant and non-dominant legs using two force plates. Normalized peak power, normalized net impulse, and normalized peak force significantly correlated with jump height (r = .960, r = .998, r = .725, respectively with p < .05). The mean frequency component was significantly correlated with CMJ performance (r = .355 with p < .05). The reliability of the frequency variables was higher than the time domain variables. Frequency domain variables showed weaker correlations with jump height compared with time domain variables. Frequency domain analysis provides frequency components, which represent the rate of energy transmission from the eccentric phase to the end of the push-off phase. Frequency component information may provide additional information for the analyses of CMJ performance for athletes.

Purpose The study examined the associations of multiple psychiatric and chronic conditions with the self-reported history of major depressive disorder (MDD) among patients with opioid use disorder (OUD) and tested whether the associations differed by gender. Methods We conducted a secondary data analysis of baseline data from a clinical trial including 1,646 participants with OUD, of which 465 had MDD. A variable cluster analysis was used to classify chronic medical and psychiatric conditions. Multivariable logistic regression analyses were used to estimate their associations with MDD in subjects with OUD. Results Nine variables were divided into three clusters: cluster 1 included heart condition, hypertension, and liver problems; cluster 2 included gastrointestinal (GI) problems and head injury, and cluster 3 included anxiety disorder, bipolar disorder, and schizophrenia. The overall prevalence of MDD in participants with OUD was 28.3% (22.8% for males and 39.5% for females). Gender, anxiety disorder, schizophrenia, liver problems, heart condition, GI problems, and head injury were significantly associated with MDD. Gender-stratified analyses showed that bipolar disorder, liver problems and individuals with one chronic condition were associated with MDD only in males, whereas heart condition, hypertension, and GI problems were associated with MDD only in females. In addition, anxiety disorder, head injury, individuals with one or more than two psychiatric conditions, and individuals with more than two chronic conditions were associated with MDD regardless of gender. Conclusions Treatment plans in patients with OUD should not only address MDD but also co-morbid psychiatric and chronic medical conditions that occur with MDD.

Dai, B, Layer, J, Vertz, C, Hinshaw, T, Cook, R, Li, Y, and Sha, Z. Baseline assessments of strength and balance performance and bilateral asymmetries in collegiate athletes. J Strength Cond Res 33(11): 3015-3029, 2019-Injuries to upper and lower extremities comprise more than 70% of the total injuries in collegiate athletes. Establishing normative data of upper and lower extremity strength and balance may help guide postinjury rehabilitation and return-to-play decisions. The purposes of the current study were to develop the normative data of performance and bilateral asymmetries during 4 upper and lower extremity strength and balance tests in collegiate athletes and to quantify the correlations between strength and balance performance and bilateral asymmetries. A total of 304 male and 195 female Division I athletes from 14 sports performed a maximum push-up test to assess upper extremity strength, a countermovement jump test to assess lower extremity strength, an upper extremity reaching test to assess upper extremity balance, and a lower extremity reaching test to assess lower extremity balance. Bilateral ground reaction forces were collected for the push-up and jump tests. Reaching distances were measured for the 2 balance tests. Bilateral asymmetries were generally less than 10%. Significant sports effects were observed for all 5 performance variables (p < 0.001) but not for asymmetry variables (p ≥ 0.36). Weak correlations were found between strength and balance performance and asymmetries (r < 0.3). Normative data are sex and sports specific in collegiate athletes. Increased asymmetries could be more individualized rather than sex and sports specific. When return-to-play decisions are made, athletes following injuries need to demonstrate less than 10% of asymmetries to be consistent with the normative data. Strength and balance should be evaluated and improved with specific focuses.

Hinshaw, TJ, Stephenson, ML, Sha, Z, and Dai, B. Effect of external loading on force and power production during plyometric push-ups. J Strength Cond Res 32(4): 1099-1108, 2018-One common exercise to train upper-body strength and power is the push-up. Training at the loads that would produce the greatest power is an effective way to increase peak power. The purpose of the current study was to quantify the changes in peak force, peak power, and peak velocity among a modified plyometric push-up and plyometric push-ups with or without external loading in physically active young adults. Eighteen male and 17 female participants completed 4 push-ups: (a) modified plyometric push-up on the knees, (b) plyometric push-up without external loading, (c) plyometric push-up with an external load of 5% of body weight, and (d) plyometric push-up with an external load of 10% of body weight. Two force platforms were set up to collect vertical ground reaction forces at the hands and feet. The modified plyometric push-up demonstrated the lowest force, power, and velocity (5.4≥ Cohen's dz ≥1.2). Peak force and force at peak velocity increased (3.8≥ Cohen's dz ≥0.3) and peak velocity and velocity at peak power decreased (1.4≥ Cohen's dz ≥0.8) for the push-up without external loading compared with the 2 push-ups with external loading. No significant differences were observed for peak power among the push-ups with or without external loading (0.4≥ Cohen's dz ≥0.1). Although peak power is similar with or without external loading, push-ups without external loading may be more beneficial for a quick movement, and push-ups with external loading may be more beneficial for a greater force production.

In this paper, we introduce an experiment evaluating performance of football players in countermovement jumps (CMJs). Three methods including time domain, frequency domain, and machine learning algorithms are proposed for performance evaluation. Correlation coefficients and p-values are given for time domain and frequency domain methods, and prediction errors are given for different machine learning algorithms.

Objective: Screening for colorectal cancer (CRC) can reduce disease incidence, morbidity, and mortality. However, few studies have investigated the urban-rural differences in social and behavioral factors influencing CRC screening. The objective of the study was to investigate the potential factors across urban-rural groups on the usage of CRC screening. Methods: A total of 38,505 adults (aged ≥40 years) were selected from the 2009 California Health Interview Survey (CHIS) data - the latest CHIS data on CRC screening. The weighted generalized linear mixed-model (WGLIMM) was used to deal with this hierarchical structure data. Weighted simple and multiple mixed logistic regression analyses in SAS ver. 9.4 were used to obtain the odds ratios (ORs) and their 95% confidence intervals (CIs). Results: The overall prevalence of CRC screening was 48.1% while the prevalence in four residence groups - urban, second city, suburban, and town/rural, were 45.8%, 46.9%, 53.7% and 50.1%, respectively. The results of WGLIMM analysis showed that there was residence effect (p

The associations of nutrition factors and physical activities with adult diabetes are inconsistent; while most of these factors are inter correlated. The aims of this study are to overcome the disturbance of the multicollinearity of the risk factors and examine the associations of these factors with diabetes using the principal component analysis (PCA) and regression analysis with principal component scores (PCS). Totally, 659 adults with diabetes and 2827 non-diabetic were selected from the 2012 Health Information National Trends Survey (HINTS 4, Cycle 2). PCA was utilized to deal with multicollinearity of the risk factors. Weighted univariate and multiple logistic regression analyses were used to estimate the associations of potential factors and PCS with diabetes. The odds ratios (ORs) with 95% confidence intervals (CIs) were estimated. The first 3 PCs for nutrition factors and physical activities could explain 70% variances. The first principal component (PC1) is a measure of nutrition factors (fruit and vegetables consumption), PC2 is a measure for physical activities (moderate exercise and strength training), and PC3 is about calorie information use and soda use. Weighted multiple logistic regression showed that African Americans, middle aged adults (45-64 years), elderly (65+), never married, and with lower education were associated with increased odds of diabetes. After adjusting for others factors, the PC1 showed marginal association with diabetes (OR=0.84, 95% CI=0.70-1.01); while PC2 and PC3 revealed significant associations with diabetes (OR=0.73, 95% CI=0.61-0.86 and OR=0.85, 95% CI=0.74-0.99, respectively). In conclusion, PCA can be used to reduce the indicators in complex survey data. The first 3 PCs of nutrition factors and physical activities were associated with diabetes. Promotion of health food and physical activities should be encouraged to help decrease the prevalence of diabetes.

Background Toll‐like receptors ( TLR s) have been shown to be involved in cerebral ischemia/reperfusion (I/R) injury. TLR 9 is located in intracellular compartments and recognizes CpG‐ DNA . This study examined the effect of CpG‐ ODN on cerebral I/R injury. Methods and Results C57BL/6 mice were treated with CpG‐ ODN by i.p. injection 1 hour before the mice were subjected to cerebral ischemia (60 minutes) followed by reperfusion (24 hours). Scrambled‐ ODN served as control‐ ODN . Untreated mice, subjected to cerebral I/R, served as I/R control. The effect of inhibitory CpG‐ ODN ( iCpG ‐ODN) on cerebral I/R injury was also examined. In addition, we examined the therapeutic effect of CpG‐ ODN on cerebral I/R injury by administration of CpG‐ ODN 15 minutes after cerebral ischemia. CpG‐ ODN administration significantly decreased cerebral I/R‐induced infarct volume by 69.7% (6.4±1.80% vs 21.0±2.85%, P ODN also significantly reduced infarct volume by 44.7% (12.6±2.03% vs 22.8±2.54%, P ODN , nor iCpG ‐ODN altered I/R‐induced cerebral injury or neurological deficits. Nissl staining showed that CpG‐ ODN treatment preserved neuronal morphology in the ischemic hippocampus. Immunoblot showed that CpG‐ ODN administration increased Bcl‐2 levels by 41% and attenuated I/R‐increased levels of Bax and caspase‐3 activity in ischemic brain tissues. Importantly, CpG‐ ODN treatment induced Akt and GSK ‐3β phosphorylation in brain tissue and cultured microglial cells. PI 3K inhibition with LY 294002 abolished CpG‐ ODN ‐induced protection. Conclusion CpG‐ ODN significantly reduces cerebral I/R injury via a PI 3K/Akt‐dependent mechanism. Our data also indicate that CpG‐ ODN may be useful in the therapy of cerebral I/R injury.