1. Fast and sensitive recognition of enantiomers by electrochemical chiral analysis: Recent advances and future perspectives.
- Author
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Zou, Jiao, Zhao, Guo-Qing, Zhao, Guo-Ling, and Yu, Jin-Gang
- Subjects
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ELECTROCHEMICAL analysis , *CHIRAL recognition , *ENANTIOMERS , *MOLECULAR recognition , *LIFE sciences , *CHIRAL stationary phases , *ELECTRODE performance - Abstract
[Display omitted] • The basic principle of rational design of electrochemical chiral sensor for sensing is summarized. • Preparation of doped electrodes and their recognition performance for chiral enantiomers are summarized. • Construction of modified electrodes and their recognition performances are discussed. • The challenges and scientific prospects of new generation of modifiers in electrochemical chiral sensing are proposed. Chiral recognition, especially rendering specificity in biomolecular recognition, is a basic property of many biomolecules. Being closely related to the chirality of biomolecules, it has been regarded as one of the most important areas in biological and medical sciences due to the different effects in biological systems. Based on the possible interactions between chiral selectors and the enantiomers, various methods including chromatographic techniques such as gas or liquid chromatography, electromigration techniques such as capillary electrophoresis and so on were developed for the chiral separation and recognition of different optical isomers. Recently, chemical sensors and biosensors have been gradually designed and developed for the analysis of chiral compounds. Based on the difference in electrical response to different isomers, chiral identifications can be successfully implemented. Major successes in enantiomer recognition based on electrochemical analysis are reviewed. The research data available for highly enantio -selective recognition are categorized into several subgroups according to specific topics and critically discussed for the period since 1994, and the latest techniques for electrochemical chiral recognition of enantiomers were also reviewed. Simultaneously, a brief conclusive summary and future perspectives are presented, and the challenges and scientific prospects of the newest generation of electrode modifiers in electrochemical sensing are also proposed. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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