Search

Your search keyword '"Zhao, Jin-Ping"' showing total 174 results
Start Over Author "Zhao, Jin-Ping"
174 results on '"Zhao, Jin-Ping"'

7. Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies

Author

Berard, Anick, Sheehy, Odile, Zhao, Jin-Ping, Gorgui, Jessica, Bernatsky, Sasha, de Moura, Cristiano Soares, and Abrahamowicz, Michal

Subjects
Fluconazole -- Dosage and administration, Mycoses -- Drug therapy, Pregnancy complications -- Risk factors, Pregnant women -- Health aspects, Antifungal agents, Infants, Pregnancy, Birth defects, Stillbirth, Menstruation, Genetic disorders, Infection, Abortion, Miscarriage, Health
Abstract

Background: While topical azoles are the first-line treatment for fungal infections, oral fluconazole is frequently used during pregnancy. We aimed to assess the effect of exposure to low and high doses of fluconazole during pregnancy on the occurrence of spontaneous abortions, major congenital malformations and stillbirths. Methods: Within the Quebec Pregnancy Cohort (1998-2015), we identified women exposed to low- ([less than or equal to] 150 mg) and high-dose (> 150 mg) fluconazole, and women who were not exposed. For each case of spontaneous abortion or stillbirth, up to 5 controls were randomly selected using an incidence density sampling method matched on gestational age at diagnosis of spontaneous abortion or stillbirth (index date) and the year of the last menstrual period. For cases of major congenital malformation, we considered all liveborn babies as controls. Generalized estimation equation models were used to analyze the 3 main outcomes separately. Results: Within a cohort of 441949 pregnancies, 320868 pregnancies were included in the analyses of spontaneous abortions, 226599 of major congenital malformations and 7832 of stillbirths. Most (69.5%) women exposed to fluconazole in pregnancy received the common single therapeutic dose of 150 mg (low dose); the remainder received a dose of > 150 mg (high dose). Use of oral fluconazole during early pregnancy was associated with an increased risk of spontaneous abortion compared with no exposure (adjusted odds ratio [OR] for 345 cases exposed to low-dose treatment 2.23, 95% confidence interval [CI] 1.96-2.54; adjusted OR for 249 cases exposed to high-dose treatment 3.20, 95% CI 2.73-3.75). Exposure to fluconazole during the first trimester did not increase the risk of overall major congenital malformations; however, exposure to a high dose during the first trimester was associated with an increased risk of cardiac septal closure anomalies (adjusted OR 1.81, 95% CI 1.04-3.14; 13 exposed cases) compared with no exposure. No association was found between exposure to fluconazole during pregnancy and the risk of stillbirth. Interpretation: Any maternal exposure to fluconazole during pregnancy may increase risk of spontaneous abortion and doses higher than 150 mg during the first trimester may increase risk of cardiac septal closure anomalies., Fluconazole is a triazole antifungal agent that inhibits the fungal cytochrome P451 (CYP51) enzyme, which is essential for synthesis of ergosterol and the formation of fungal cell walls. (1) In [...]

Published
2019
Full Text
View/download PDF

10. Expression and clinical significance of miR-139-5p in non-small cell lung cancer

Author

You Yong-hao, Wang Xian-guo, Xu Ming, and Zhao Jin-ping

Subjects
Medicine (General), R5-920
Abstract

Objective MiR-139-5p is a common tumor-associated microRNA (miRNA), which inhibits the occurrence and development of malignant tumors from various tissue sources. We detected miR-139-5p expression levels in tissues from patients with non-small cell lung cancer (NSCLC) to explore the relationship between miR-139-5p expression and clinicopathological parameters. Methods MiR-139-5p expression levels were detected in cancerous and normal tissues from 60 NSCLC patients by fluorescence quantitative polymerase chain reaction, using normal paracancerous tissue as a control. The relationships between miR-139-5p and clinicopathological parameters of NSCLC, including survival, were analyzed by t -tests and univariate analysis. Results MiR-139-5p expression levels were significantly reduced in NSCLC tissues compared with normal adjacent tissue. MiR-139-5p expression was not significantly associated with age, sex, or smoking history, but was related to clinical stage, pathological type, tumor size, and lymph node metastasis. Furthermore, low expression of miR-139-5p, clinical stage (II/III), adenocarcinoma, tumor ≥3 cm, and lymph node metastasis were all related to overall survival. Conclusion MiR-139-5p expression levels are down-regulated in NSCLC tissues, and low expression is associated with clinical stage, pathological type, tumor size, and lymph node metastasis in NSCLC patients. MiR-139-5p may act as a tumor suppressor gene in the occurrence and development of NSCLC.

Published
2019
Full Text
View/download PDF

13. The Impact of COVID-19 on Maternal Mental Health during Pregnancy: A Comparison between Canada and China within the CONCEPTION Cohort

Author

Pagès, Nicolas, primary, Gorgui, Jessica, additional, Wang, Chongjian, additional, Wang, Xian, additional, Zhao, Jin-Ping, additional, Tchuente, Vanina, additional, Lacasse, Anaïs, additional, Côté, Sylvana, additional, King, Suzanne, additional, Muanda, Flory, additional, Mufike, Yves, additional, Boucoiran, Isabelle, additional, Nuyt, Anne Monique, additional, Quach, Caroline, additional, Ferreira, Ema, additional, Kaul, Padma, additional, Winquist, Brandace, additional, O’Donnell, Kieran J., additional, Eltonsy, Sherif, additional, Chateau, Dan, additional, Hanley, Gillian, additional, Oberlander, Tim, additional, Kassai, Behrouz, additional, Mainbourg, Sabine, additional, Bernatsky, Sasha, additional, Vinet, Évelyne, additional, Brodeur-Doucet, Annie, additional, Demers, Jackie, additional, Richebé, Philippe, additional, Zaphiratos, Valerie, additional, and Bérard, Anick, additional

Published
2022
Full Text
View/download PDF

16. The COVID-19 Pandemic Impacted Maternal Mental Health Differently Depending on Pregnancy Status and Trimester of Gestation

Author

Bérard, Anick, primary, Gorgui, Jessica, additional, Tchuente, Vanina, additional, Lacasse, Anaïs, additional, Gomez, Yessica-Haydee, additional, Côté, Sylvana, additional, King, Suzanne, additional, Muanda, Flory, additional, Mufike, Yves, additional, Boucoiran, Isabelle, additional, Nuyt, Anne Monique, additional, Quach, Caroline, additional, Ferreira, Ema, additional, Kaul, Padma, additional, Winquist, Brandace, additional, O’Donnell, Kieran J., additional, Eltonsy, Sherif, additional, Chateau, Dan, additional, Zhao, Jin-Ping, additional, Hanley, Gillian, additional, Oberlander, Tim, additional, Kassai, Behrouz, additional, Mainbourg, Sabine, additional, Bernatsky, Sasha, additional, Vinet, Évelyne, additional, Brodeur-Doucet, Annie, additional, Demers, Jackie, additional, Richebé, Philippe, additional, and Zaphiratos, Valerie, additional

Published
2022
Full Text
View/download PDF

17. Reply

Author

Bérard, Anick, Zhao, Jin-Ping, and Sheehy, Odile

Published
2017
Full Text
View/download PDF

25. Meta-Analysis of the Prevalence of Giardia duodenalisin Cattle in China

Author

Meng, Xiang-Zhu, Kang, Chao, Wei, Jiaqi, Ma, He, Liu, Gang, Zhao, Jin-Ping, Zhang, Hong-Shun, Yang, Xin-Bo, Wang, Xiang-Yu, Yang, Li-Hua, Geng, Hong-Li, and Cao, Hongwei

Abstract

Giardia duodenum (G. duodenalis)can cause giardiasis and infect a variety of hosts. So far, there have been no detailed data regarding the positive rate of G. duodenalisin cattle in China. Here, a systematic literature review was carried out to investigate the epidemiology of bovine G. duodenalisin China. To perform the meta-analysis, the databases China National Knowledge Infrastructure, VIP Chinese Journal Databases, WanFang Databases, PubMed, and ScienceDirect were employed for screening studies related to the prevalence of G. duodenalisin cattle in China. The total prevalence of G. duodenalisin cattle was estimated to be 8.00% (95% confidence interval [CI]: 5.51–11.62). In the age subgroup, the prevalence of G. duodenalisin calves (11.72%; 95% CI: 7.75–17.73) was significantly higher than that in cattle of other age groups. An analysis based on seasons showed that the prevalence of G. duodenalisin cattle was higher in summer (9.69%; 95% CI: 2.66–35.30) than that in other seasons. The prevalence of G. duodenalisin cattle in 2016 or later was 11.62% (95% CI: 6.49–20.79), which was significantly higher than that before 2016 (3.65%; 95% CI: 2.17–6.12). The highest prevalence of G. duodenalisin cattle was 74.23% (95% CI: 69.76–78.45) recorded in South China. The NOAA's National Center for Environmental Information (https://gis.ncdc.noaa.gov/maps/ncei/cdo/monthly) was used to extract relevant geoclimatic data (latitude, longitude, elevation, temperature, precipitation, humidity, and climate). By analyzing the data of each subgroup, it was shown that age of cattle, sampling year, province, region, temperature, and climate were potential risk factors for giardiasis prevalence in cattle. Based on the analysis of common factors and geographical factors, it is recommended to strengthen effective management measures (e.g., ventilation and disinfection in warm and humid areas) and formulate relevant policies according to local conditions. Breeders should pay more attention to the detection of G. duodenalisin calves, to prevent giardiasis prevalence in cattle of different ages, thereby reducing the economic losses of animal husbandry in China.

Published
2023
Full Text
View/download PDF

27. Impact of the COVID-19 Pandemic on Maternal Mental Health During Pregnancy: The CONCEPTION Study – Phase I

Author

Berard, Anick, primary, Lacasse, Anaïs, additional, Gomez, Yessica-Haydee, additional, Gorgui, Jessica, additional, Côté, Sylvana M., additional, King, Suzanne, additional, Tchuente, Vanina, additional, Muanda, Flory, additional, Mufike Lumu, Yves, additional, Boucoiran, Isabelle, additional, Nuyt, Anne-Marie, additional, Quach, Caroline, additional, Ferreira, Ema, additional, Kaul, Padma, additional, Winquist, Brandace, additional, O'Donnell, Kieran John, additional, Eltonsy, Sherif, additional, Chateau, Dan, additional, Zhao, Jin-Ping, additional, Hanley, Gillian, additional, Oberlander, Tim, additional, Kassai, Behrouz, additional, Mainbourg, Sabine, additional, Bernatsky, Sasha, additional, Vinet, Évelyne, additional, Brodeur-Doucet, Annie, additional, Demers, Jackie, additional, Richebé, Philippe, additional, Zaphiratos, Valerie, additional, Wang, Chongjian, additional, and Wang, Xian, additional

Published
2021
Full Text
View/download PDF

43. Overexpression of Ulk2 inhibits proliferation and enhances chemosensitivity to cisplatin in non-small cell lung cancer.

Author

Cheng, Hong, Yang, Ze-Tian, Bai, Yu-Quan, Cai, Yan-Fei, and Zhao, Jin-Ping

Subjects
CISPLATIN, NON-small-cell lung carcinoma, WESTERN immunoblotting, ELECTRON-transfer catalysis, CANCER cell proliferation
Abstract

The aim of the present study was to examine the function of unc-51 like autophagy activating kinase 2 (Ulk2) in non-small cell lung cancer (NSCLC). Western blotting was used to analyze the protein expression of Ulk2 in seven pairs of cancerous and adjacent non-cancerous NSCLC specimens. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis was used to determine the mRNA expression of Ulk2 in 20 pairs of tumor and adjacent normal tissues. Two NSCLC cell lines, A549 and H460, were transfected with an Ulk2 overexpression plasmid or empty vector; cell proliferation and chemosensitivity were measured using an MTT assay, and flow cytometry and western blotting were used to evaluate apoptosis. A nude mouse tumorigenesis experiment was used to assess tumor volume in vivo, using A549 cells stably overexpressing Ulk2 and control cells. The protein expression levels of Ulk2 were significantly lower in 6/7 (85.7%) cases of NSCLC compared with in non-cancerous tissues, as determined by western blotting (P<0.05). The mRNA expression levels of Ulk2 were significantly lower in 16/20 (70.0%) NSCLC specimens compared with in non-cancerous tissues, as revealed by RT-qPCR (P<0.05). Overexpression of Ulk2 significantly inhibited the proliferation of A549 and H460 cells (P<0.05) and sensitized the NSCLC cell lines to cisplatin- and etoposide-induced inhibition of proliferation, and to cisplatin-induced apoptosis, with a significant difference identified compared with the control group (P<0.05). Overexpression of Ulk2 significantly increased basal autophagy levels in A549 and H460 cells (P<0.05). Thus, Ulk2-induced enhanced chemosensitivity was suggested to be partly mediated through increased autophagy. The overexpression of Ulk2 significantly suppressed tumor volume in vivo (P<0.05). Overexpression of Ulk2 inhibits cancer cell proliferation and enhances chemosensitivity to cisplatin in NSCLC. [ABSTRACT FROM AUTHOR]

Published
2019

44. Leflunomide use during pregnancy and the risk of adverse pregnancy outcomes.

Author

Bérard, Anick, Jin-Ping Zhao, Shui, Irene, Colilla, Susan, and Zhao, Jin-Ping

Abstract

Objectives: Leflunomide is known to be embryotoxic and teratogenic in rodents. However, there is less evidence in humans. We quantified the risk of major congenital malformation (MCM), prematurity, low birth weight (LBW) and spontaneous abortion associated with leflunomide exposure during pregnancy in humans.Methods: From a cohort of 289 688 pregnancies in Montreal, Quebec, Canada, from 1998 to 2015, first-trimester leflunomide exposure and other antirheumatic drug exposures were studied for their association with MCM and spontaneous abortions. Also second or third-trimester leflunomide exposures were examined for associations with prematurity and LBW. Logistic regression model-based generalised estimating equations were used.Results: 51 pregnancies were exposed to leflunomide during the first trimester, and 21 during the second/third trimesters. Adjusting for potential confounders, use of leflunomide during the first trimester of pregnancy was not associated with the risk of MCM (adjusted OR (aOR) 0.97, 95% CI 0.81 to 1.16; 5 exposed cases). No association was found between second/third-trimester exposure to leflunomide and the risk of prematurity (aOR 4.03, 95% CI 0.91 to 17.85; 7 exposed cases) nor LBW (aOR 1.06, 95%CI 0.90 to 1.25; 8 exposed cases). Pregnancy exposure to leflunomide was also not associated with the risk of spontaneous abortion (aOR 1.09, 95% CI 0.90 to 1.32; 11 exposed cases).Conclusions: Maternal exposure to leflunomide during pregnancy was not associated with statistically significant increased risk of MCMs, prematurity, LBW or spontaneous abortions. However, given that relatively few women were exposed to leflunomide during pregnancy in this cohort, caution remains warranted. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

49. Investigation of the distribution and changes of VLDLR subtype in fibrotic cardiac muscles

Author

Bao Li, Zhao Jin-ping, Yang Guangtian, and Qu Shen

Subjects
medicine.medical_specialty, Myocardium, Biology, medicine.disease, Fibrosis, Endocrinology, Real-time polymerase chain reaction, Biochemistry, Receptors, LDL, Management of Technology and Innovation, Medicine public health, Internal medicine, Myocardial cell, medicine, Distribution (pharmacology), Humans, Myocytes, Cardiac, Receptor, Lipoprotein
Abstract

Very low-density lipoprotein receptor (VLDLR) is the major receptor with which cells can uptake the triacylglycerol from blood. It is divided into two subtypes according to presence of O-linked sugar domain located in the VLDLR receptor immediately outside of the membrane. Type I VLDLR contains the O-link domain, while type II has no such domain. The type I VLDLR are mainly found on the surface of human myocardial cells. The result of our quantitative polymerase chain reaction on the normal and fibrotic cardiac muscles showed that both subtypes and expression level of VLDLR on the myocardial cell surface did not vary significantly between the normal and the fibrotic cardiac muscles despite the presence of malfunction due to fibrosis. This finding suggests that fibrosis doesn’t exert significant influence on the subtype and the expression of VLDLR on the surface of myocardial cells. Such inconsistence with the changes found in other fibrotic tissues is awaiting further studies.

Published
2003

Catalog

Books, media, physical & digital resources
See catalog results