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193 results on '"Zhao, Qingzhen"'

6. An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome

Author

Wang, Ruyi, You, Xiaoman, Zhang, Chongyang, Fang, Hong, Wang, Min, Zhang, Fan, Kang, Houxiang, Xu, Xiao, Liu, Zheng, Wang, Jiyang, Zhao, Qingzhen, Wang, Xuli, Hao, Zeyun, He, Feng, Tao, Hui, Wang, Debao, Wang, Jisong, Fang, Liang, Qin, Mengchao, Zhao, Tianxiao, Zhang, Pingping, Xing, Hefei, Xiao, Yunping, Liu, Wende, Xie, Qi, Wang, Guo-Liang, and Ning, Yuese

Published
2022
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9. Productivity characteristics and controlling factors of coalbed methane vertical well in a coal block of Qinshui Basin.

Author

Chen, Fengjie, Wu, Caifang, Huo, Zhanbo, and Zhao, Qingzhen

Abstract

Although a coal block in the Qinshui Basin is a key location for coalbed methane (CBM) exploration and development, the productivity of various vertical wells varies significantly. The productivity characteristics of 636 vertical wells were analyzed better to understand the effects of different variables on CBM productivity. Grey correlation analysis was used to identify the key determinants of CBM well productivity. The findings indicate that vertical well production is below average, with more than 50% serving as water wells. The production of the central well area is high in the west and south. Highly productive wells are significantly influenced by geological conditions, primarily located in areas with high gas content, moderate cover depth, high permeability, and elevated water head. The engineering factor that exerts the most significant influence on productivity is the rate of liquid level drop. Based on grey correlation analysis, the primary determinants of CBM vertical well production are permeability and cover depth. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Particle Swarm Optimizer Based on Small-World Topology and Comprehensive Learning

Author

Liu, Yanmin, Luo, Dongshen, Zhao, Qingzhen, Sui, Changling, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Huang, De-Shuang, editor, Zhao, Zhongming, editor, Bevilacqua, Vitoantonio, editor, and Figueroa, Juan Carlos, editor

Published
2010
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17. Particle Swarm Optimizer Based on Dynamic Neighborhood Topology

Author

Liu, Yanmin, Zhao, Qingzhen, Shao, Zengzhen, Shang, Zhaoxia, Sui, Changling, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Goebel, Randy, editor, Siekmann, Jörg, editor, Wahlster, Wolfgang, editor, Huang, De-Shuang, editor, Jo, Kang-Hyun, editor, Lee, Hong-Hee, editor, Kang, Hee-Jun, editor, and Bevilacqua, Vitoantonio, editor

Published
2009
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18. Prednisone lowers serum uric acid levels in patients with decompensated heart failure by increasing renal uric acid clearance

Author

Liu, Chao, Zhen, Yuzhi, Zhao, Qingzhen, Zhai, Jian-Long, Liu, Kunshen, and Zhang, Jian-Xin

Subjects
Uric acid -- Health aspects, Prednisone -- Dosage and administration, Heart failure -- Drug therapy, Biological sciences
Abstract

Clinical studies have shown that large doses of prednisone could lower serum uric acid (SUA) in patients with decompensated heart failure (HF); however, the optimal dose of prednisone and underlying mechanisms are unknown. Thirty-eight patients with decompensated HF were randomized to receive standard HF care alone (n = 10) or with low-dose (15 mg/day, n = 8), medium-dose (30 mg/day, n = 10), or high-dose prednisone (60 mg/day, n = 10), for 10 days. At the end of the study, only high-dose prednisone significantly reduced SUA, whereas low- and medium-dose prednisone and standard HF care had no effect on SUA. The reduction in SUA in high-dose prednisone groups was associated with a significant increase in renal uric acid clearance. In conclusion, prednisone can reduce SUA levels by increasing renal uric acid clearance in patients with decompensated HF. Key words: heart failure, uric acid, prednisone, renal uric acid clearance. Des etudes cliniques ont montre qu'une forte dose de prednisone pourrait permettre d'abaisser les taux d'acide urique seriques (AUS) chez les patients atteints d'insuffisance cardiaque (IC) decompensee. Toutefois, la dose optimale de prednisone et les mecanismes sous-jacents demeurent inconnus. Trente-huit patients atteints d'IC decompensee ont ete repartis aleatoirement pour recevoir la norme de soins standard seule (n = 10) ou de la prednisone a dose faible (a 15 mg/jour, n = 8), moderee (a 30 mg/jour, n = 10) ou elevee (a 60 mg/jour, n = 10) pendant 10 jours. A la fin de l'etude, seule la dose elevee de prednisone avait permis d'abaisser les taux d'AUS de facon notable, alors que ni les doses faible et moderee de prednisone ni la norme de soins standard pour l'IC n'ont eu d'effets sur les taux d'AUS. En fait, l'abaissement des taux d'AUS par la prednisone a dose elevee etait associe a une augmentation importante de la clairance renale de l'acide urique. En conclusion, la prednisone pourrait abaisser les taux d'AUS en augmentant la clairance renale de l'acide urique chez les patients atteints d'IC decompensee. [Traduit par la Redaction] Mots-cles: insuffisance cardiaque, acide urique, prednisone, clairance renale de l'acide urique., Uric acid (UA) is the final product of purine degradation with xanthine oxidase. Approximately two thirds of UA is excreted through the kidneys and the remainder through the gastrointestinal tract. [...]

Published
2016
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26. Additional file 1 of An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome

Author

Wang, Ruyi, You, Xiaoman, Zhang, Chongyang, Fang, Hong, Wang, Min, Zhang, Fan, Kang, Houxiang, Xu, Xiao, Liu, Zheng, Wang, Jiyang, Zhao, Qingzhen, Wang, Xuli, Hao, Zeyun, He, Feng, Tao, Hui, Wang, Debao, Wang, Jisong, Fang, Liang, Qin, Mengchao, Zhao, Tianxiao, Zhang, Pingping, Xing, Hefei, Xiao, Yunping, Liu, Wende, Xie, Qi, Wang, Guo-Liang, and Ning, Yuese

Abstract

Additional file 1. Figure S1. Analysis of the ubiquitinated site-containing proteins in rice from published studies. Figure S2. Location of all E3 ligase encoding genes on the rice chromosome. Figure S3. Different types of ubiquitin E3 ligase-encoding genes in rice and the number of RT-PCR cloned and chemically synthesized E3 genes in this study. Figure S4. Confirmation of the interaction between OsUBC14 and its candidate E3s. Figure S5. E3 ubiquitin ligase activity of OsRING77, OsRING113, OsPUB28, OsPUB46, OsPUB49 and OsPUB69 in vitro. Figure S6. Ubiquitination assay of GST-OsSKIPa by MBP-OsPUB46. Figure S7. E3 ubiquitin ligase activity of OsRFPH2-10, P3IP1 and OsRING336 in vitro. Figure S8. The E3 ubiquitin ligase activity of OsRING116 in vitro and ubiquitination analysis of rTGA2.1. Figure S9. Transcript level of OPAL1 in individual overexpression lines and the editing types of OsFBK16. Figure S10. Degradation assay of OsPAL5 and OsPAL6 by OsFBK16 in vivo. Figure S11. Transcript level of OsPAL6 in individual overexpression lines.

Published
2022
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27. Additional file 7 of An ORFeome of rice E3 ubiquitin ligases for global analysis of the ubiquitination interactome

Author

Wang, Ruyi, You, Xiaoman, Zhang, Chongyang, Fang, Hong, Wang, Min, Zhang, Fan, Kang, Houxiang, Xu, Xiao, Liu, Zheng, Wang, Jiyang, Zhao, Qingzhen, Wang, Xuli, Hao, Zeyun, He, Feng, Tao, Hui, Wang, Debao, Wang, Jisong, Fang, Liang, Qin, Mengchao, Zhao, Tianxiao, Zhang, Pingping, Xing, Hefei, Xiao, Yunping, Liu, Wende, Xie, Qi, Wang, Guo-Liang, and Ning, Yuese

Abstract

Additional file 7. Review history.

Published
2022
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33. The Impact of Glucocorticoid Therapy on Guideline-Directed Medical Treatment Titration in Patients Hospitalized for Heart Failure with Low Blood Pressure: A Retrospective Study

Author

Li,Shuyu, Zhao,Qingzhen, Zhen,Yuzhi, Li,Lizhuo, Mi,Yiqing, Li,Tongxin, Liu,Kunshen, Liu,Chao, Li,Shuyu, Zhao,Qingzhen, Zhen,Yuzhi, Li,Lizhuo, Mi,Yiqing, Li,Tongxin, Liu,Kunshen, and Liu,Chao

Abstract

Shuyu Li,1,2 Qingzhen Zhao,1 Yuzhi Zhen,1 Lizhuo Li,1 Yiqing Mi,1 Tongxin Li,1 Kunshen Liu,1 Chao Liu1 1The First Cardiology Division, First Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050022, People’s Republic of China; 2The Second Cardiology Division, North China University of Science and Technology Affiliated Hospital, Tangshan, 063000, People’s Republic of ChinaCorrespondence: Chao LiuThe First Cardiology Division, First Affiliated Hospital of Hebei Medical University, Hebei Medical University, No. 89 of Donggang Road, Yuhua District, Shijiazhuang, Hebei, 050000, People’s Republic of ChinaTel +86 311 8591 7032Fax +86 311 8591 7290Email dr.liuchao@gmail.comBackground: Positive inotropic and renal protective actions of glucocorticoids have been observed clinically. Therefore, glucocorticoids may be used in patients with heart failure and low blood pressure (HF-LBP).Methods: The medical records of 144 consecutive patients with HF-LBP who received glucocorticoids as an adjunctive treatment to facilitate the up-titration of β-blocker and angiotensin-converting enzyme inhibitor were reviewed.Results: After four weeks of treatment, the metoprolol and captopril (or equivalent) dosages were progressively and consistently increased from 25 (interquartile range [IQR] = 12.5– 75 mg/day) to 100 mg/day (IQR = 50– 178.8 mg/day) and from 0 (IQR = 0– 25 mg/day) to 12.5 mg/day (IQR = 0– 50 mg/day), respectively. There was a remarkable beneficial hemodynamic response to the glucocorticoid treatment signified by an increase in blood pressure and decrease in heart rate. The average heart rate decreased by 6 beat per minute (bpm) (0.5– 16 bpm), and the mean arterial blood pressure increased from 74.06 ± 7.81 to 78.85 ± 7.91 mmHg. We also observed an improvement in renal function and an increased diuretic response following glucocorticoid treatment. As a result, the left ventricular ejection fraction increased from 28.92 ± 8.06% to 33.86 ± 8.76

Published
2021

37. Synthesis of Functional Hyperbranched Poly(methyltriazolylcarboxylate)s by Catalyst-free Click Polymerization of Butynoates and Azides

Author

Lang, Muning, Chi, Weiwen, Han, Ting, Zhao, Qingzhen, Li, Hongkun, Tang, Benzhong, Li, Yongfang, Lang, Muning, Chi, Weiwen, Han, Ting, Zhao, Qingzhen, Li, Hongkun, Tang, Benzhong, and Li, Yongfang

Abstract

Azide-alkyne click polymerization has become a powerful tool for polymer synthesis. However, the click polymerization between internal alkynes and azides is rarely utilized to prepare functional polymers. In this work, the polymerization reactions of activated internal alkyne monomers of tris(2-butynoate)s (1) with tetraphenylethene-containing diazides (2) were performed in dimethylformamide (DMF) under simple heating, affording four hyperbranched poly(methyltriazolylcarboxylate)s (hb-PMTCs) with high molecular weights (Mw up to 2.4 × 104) and regioregularities (up to 83.9%) in good yields. The hb-PMTCs are soluble in common organic solvents, and thermally stable with 5% weight loss temperatures up to 400 °C. They are non-emissive in dilute solution, but become highly emissive in aggregated state, exhibiting aggregation-induced emission characteristics. The polymers can generate fluorescent photopatterns with high resolution, and can work as fluorescent sensors to detect nitroaromatic explosive with high sensitivity. © 2020, Chinese Chemical Society Institute of Chemistry, Chinese Academy of Sciences Springer-Verlag GmbH Germany, part of Springer Nature.

Published
2020

46. Engineering Test of Gas Ablation Agent in Mine Gas Control

Author

Guo Aijun, Yang Haorui, Zhai Zhiwei, Sun Hanying, and Zhao Qingzhen

Subjects
Waste management, business.industry, Extraction (chemistry), Coal mining, Environmentally friendly, Decomposition, Methane, chemistry.chemical_compound, Adsorption, chemistry, Anaerobic oxidation of methane, Environmental science, Coal, business
Abstract

Gas is a major threat to the safety of coal mine production, Gas Ablation Agent is a major component of methane oxidation bacteria, added a special catalyst, used to eliminate the high concentration of gas biological solvents, gas reduction speed, low cost, non-toxic harmless characteristics. Gas Ablation Agent can quickly decompose or convert gas into other harmless substances, eliminate or reduce gas in coal seams, reduce gas pressure and gas content, so as to eliminate the prominent risk of coal and gas, is a new biochemical technology to control coal mine gas. After 24 hours, the gas content decreased by an average of 3.64m3/t and 2.24m3/t respectively. Gas ablation microorganisms, while breaking down methane, can promote the rapid decomposition of methane adsorbed in coal bodies. Compared with the conventional excavation method, the number of construction drilling holes decreased by about 92%, the total number of digging days decreased by 59 days, and the efficiency of coal extraction increased by 3.2 times. Gas Ablation Agent is an effective and environmentally friendly technical method to control gas, which is of great practical significance for the prevention and control of coal and gas, and the promotion of efficient and safe production.

Published
2021

48. Smart drug carrier based on polyurethane material for enhanced and controlled DOX release triggered by redox stimulus

Author

Zhao Qingzhen, Liang Zhong, Zhimin Wu, Tan Xing, Di Xiong, Guodian Zhu, Wenqi Teng, Xu Zhenzhu, and Yu Chao

Subjects
chemistry.chemical_classification, Aqueous solution, Polymers and Plastics, General Chemical Engineering, technology, industry, and agriculture, 02 engineering and technology, General Chemistry, Polymer, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Biochemistry, Micelle, 0104 chemical sciences, chemistry, Chemical engineering, Dynamic light scattering, Critical micelle concentration, Partition equilibrium, Micellar solutions, Materials Chemistry, Environmental Chemistry, 0210 nano-technology, Drug carrier
Abstract

A series of amphiphilic polymer mPEG-PUSS-mPEG were developed by a combination of ring opening polymerization (ROP) and polyaddition reaction and its self-assembled micelles were developed for hydrophobic anticancer drugs delivery. Polymeric critical micellar concentration (CMC) values in aqueous solution were about 2.8–5.5 mg/L. And the partition equilibrium constant (Kv) of pyrene in micellar solutions ranged from 1.52 × 105 to 2.20 × 105. The average sizes of the self-assembled blank and DOX-loaded micelles were 160–180 nm determined by dynamic light scattering (DLS). The morphology of the DOX-loaded micelles was spherical by transmission electron microscopy (TEM) and scanning electron microscopy (SEM).The in vitro drug release behaviors of DOX and PTX from mPEG-PUSS-mPEG micelles were investigated at different simulated conditions. We found that the PTX release was significantly accelerated by redox stimuli compared with DOX-loaded reduction-sensitive PU micelles. The change of the size of this system under different conditions was further evaluated by DLS. DOX-loaded mPEG-PUSS-mPEG micelles in 50% fetal bovine serum (FBS) were evaluated the hemocompatibility. In addition, the self-assembly process of polymers mPEG-PUSS-mPEG in aqueous solution for micellar formation was also investigated by means of dissipative particle dynamics (DPD) simulations.AndCCK-8 assays revealed that the mPEG-PUSS-mPEG materials had low toxicity, but the DOX-loaded micelles showed a high cytotoxicity against HepG2 tumor cells. All results demonstrate that mPEG-PUSS-mPEG self-assembled micelles are a very promising for hydrophobic anticancer drugs delivery.

Published
2020

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