Search

Your search keyword '"Zhao, Shasha"' showing total 745 results
Start Over Author "Zhao, Shasha"
745 results on '"Zhao, Shasha"'

2. Advances in Metabolic Reprogramming of Osteoblasts with the Development of Early Renal Bone Disease

Author

WANG Zuoyu, ZHOU Yang, XIONG Mingxia, ZHAO Shasha, YANG Junwei

Subjects
chronic kidney disease-mineral and bone disorder, renal bone disease, cellular reprogramming, fibroblast growth factor-23, Medicine
Abstract

Chronic kidney disease-mineral and bone disorder (CKD-MBD) has a direct impact on patients' quality of life, hospitalization rates and fracture risk. In recent years, osteoblasts and osteoclasts have become central to the pathophysiology of CKD-MBD. Osteoblasts interact with other organs by synthesizing fibroblast growth factor-23 (FGF-23) and sclerostin (SOST), making the skeleton an endocrine organ. Therefore, dysregulation of osteoblast differentiation is an important early event in the pathogenesis of CKD. In this paper, we systematically discuss the metabolic pathways of osteoblasts and the mechanisms related to the altered metabolic reprogramming of osteoblasts in the early CKD-MBD pathology. This paper shows that abnormalities in signaling pathways and metabolites such as Wnt/β-catenin, FGF-23, uremic toxins, metabolic acidosis, can alter the metabolic activity of osteoblasts, causing impaired maturation of the osteogenic spectrum, which in turn affects bone remodeling, which will provide a new way of thinking for explaining the pathological changes in renal bone disease and developing clinical treatment options.

Published
2024
Full Text
View/download PDF

41. Reducing the Impact of Time Evolution on Source Code Authorship Attribution via Domain Adaptation.

Author

Li, Zhen, Zhao, Shasha, Chen, Chen, and Chen, Qian

Subjects
ATTRIBUTION of authorship, DEEP learning, LEARNING ability, PHYSIOLOGICAL adaptation
Abstract

Source code authorship attribution is an important problem in practical applications such as plagiarism detection, software forensics, and copyright disputes. Recent studies show that existing methods for source code authorship attribution can be significantly affected by time evolution, leading to a decrease in attribution accuracy year by year. To alleviate the problem of Deep Learning (DL)-based source code authorship attribution degrading in accuracy due to time evolution, we propose a new framework called TimeDomain Adaptation (TimeDA) by adding new feature extractors to the original DL-based code attribution framework that enhances the learning ability of the original model on source domain features without requiring new or more source data. Moreover, we employ a centroid-based pseudo-labeling strategy using neighborhood clustering entropy for adaptive learning to improve the robustness of DL-based code authorship attribution. Experimental results show that TimeDA can significantly enhance the robustness of DL-based source code authorship attribution to time evolution, with an average improvement of 8.7% on the Java dataset and 5.2% on the C++ dataset. In addition, our TimeDA benefits from employing the centroid-based pseudo-labeling strategy, which significantly reduced the model training time by 87.3% compared to traditional unsupervised domain adaptive methods. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

43. Block type Lie algebras and their representations

Author

Tang, Xiaomin and Zhao, Shasha

Subjects
Mathematics - Representation Theory, 17B10, 17B65, 17B68
Abstract

Block type Lie algebras have been studied by many authors in the latest twenty years. In this paper, we will study a class of more general Block type Lie algebra $\mathcal{B}(p,q)$, which is a class of infinite-dimensional Lie algebra by using the generalized Balinskii-Novikov's construction method to Witt type Novikov algebra. We study the representation theory for $\mathcal{B}(p,q)$. We classify quasifinite irreducible highest weight $\mathcal{B}(p,q)$-module. We also prove that any quasifinite irreducible module of Block type Lie algebras $\mathcal{B}(p,q)$ is either a highest or lowest weight module, or else a uniformly bounded module. This paper can be considered as a generalization of the related literatures., Comment: 14 pages. arXiv admin note: substantial text overlap with arXiv:1102.5187 by other authors

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results