Search

Small cell lung cancer (SCLC) rarely metastasizes to the ovary, and is difficult to diagnose given its overlapping clinical features and histological characteristics with primary ovarian cancer. Since therapies for SCLC and primary ovarian cancer differ, it is important to determine the original site of ovarian lesions. This report describes the differential diagnosis of metastatic from primary ovarian cancer. A 46-year-old Chinese woman with a history of SCLC, confirmed by transbronchial lung biopsy in August 2018, presented with abdominal distension in December 2018. Ultrasound examination and whole abdomen computed tomography showed one mass in each ovary. A provisional diagnosis of ovarian tumor was given. A palliative total abdominal hysterectomy and bilateral salpingo-oophorectomy was performed; and three postoperative courses of chemotherapies. The patient died from multiple organ failure in May 2019. Metastatic ovarian cancer from SCLC was determined based on characteristic histological and immunohistochemical staining.

BackgroundAs a multi-ethnic and economically underdeveloped region, Xinjiang faces severe challenges coming with an aging population. To promote active aging under the circumstances of unsatisfied comprehensive strength and imperfect home care system, it is important for Xinjiang to give priority to groups with disabilities, improve family resilience via enhancing family functions, and gradually develop a family-centered home care system with community support.ObjectiveTo explore the mechanism of mediating action of family function between disability severity and family resilience in home-living older adults with disability in Xinjiang's minority areas, offering new ideas for relevant departments to improve family resilience of this population.MethodsFrom July to August 2020, a household survey was conducted with older adults with disability, and their primary caregivers and core family members of 431 Uygur or Kazak households selected from Xinjiang's Bortala Mongol Autonomous Prefecture by use of stratified multistage sampling. Questionnaires including demographic questionnaire developed by our research team, Katz Index of Independence in Activities of Daily Living (Katz ADL) , Mini-mental State Examination (MMSE) , Family Resilience Assessment Scale (FRAS) , and the Family Concern Index Questionnaire (APGAR) were used in the survey to collect information regarding degree of disability, family resilience, and family functions of the older adults with disability. Spearman correlation analysis was used to explore the relationship of family resistance with disability severity, family function and its five functional components (adaptability, partnership, growth, affection, and resolve) . Multiple linear regression analysis and Bootstrap test were used to verify and examine the medicating effect of family function and its five components between disability severity and family resilience.ResultsFrom the 431 households, older adults with disability, primary family caregivers, and core family members were selected at a ratio of 1∶1∶1 (each group contained 431 cases) . Among the older adults with disability, the prevalence of mild, moderate and severe disability was 46.9% (202/431) , 40.1% (173/431) , and 13.0% (56/431) , respectively. The prevalence of intact family function, moderate and severe family dysfunction in the households was 46.4% (200/431) , 43.6% (188/431) , and 10.0% (43/431) , respectively. The prevalence of low and high family resilience in the households was 51.7% (223/431) , and 48.3% (208/431) , respectively. Spearman correlation analysis revealed that disability severity of the older adults reduced with the increase of family function and its five components as well as family resilience (P

Fumarate hydratase （FH）-deficient uterine leiomyoma is a rare pathological type of uterine leiomyoma, which is caused by FH gene germ-line or system mutations, primarily the latter cause. Although this disease is rare, when it is a sentinel manifestation of hereditary leiomyomatosis and renal cell carcinoma （HLRCC） syndromes, its severe symptoms and signs lead to early surgery and post-operative pathology that offers the possibility of early diagnosis of the aggressive consequences of this hereditary disease. Systematic diagnosis is the main diagnostic methods. Morphological and immunohistochemical staining are helpful to improve the detection rate, whereas their values are limited. Although the biological potential of FH-deficient uterine leiomyoma is low, the treatment and prognosis of patients significantly vary due to different sources of mutations. Therefore, how to distinguish sporadic and hereditary uterine fibroids is a great challenge for clinicians. In this article, clinical manifestations, morphological features, diagnosis and differential diagnosis, treatment and prognosis of FH-deficient uterine leiomyoma were reviewed.

The objective of this study was to explore the expression of EpCAM and EGFR in human epithelial ovarian cancer (EOC) and their correlation with clinicopathological parameters.