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Background: As the fight against the COVID-19 epidemic continues, medical workers may have allostatic load. Objective: During the reopening of society, medical and nonmedical workers were compared in terms of allostatic load. Methods: An online study was performed; 3,590 Chinese subjects were analyzed. Socio-demographic variables, allostatic load, stress, abnormal illness behavior, global well-being, mental status, and social support were assessed. Results: There was no difference in allostatic load in medical workers compared to nonmedical workers (15.8 vs. 17.8%; p = 0.22). Multivariate conditional logistic regression revealed that anxiety (OR = 1.24; 95% CI 1.18–1.31; p < 0.01), depression (OR = 1.23; 95% CI 1.17–1.29; p < 0.01), somatization (OR = 1.20; 95% CI 1.14–1.25; p < 0.01), hostility (OR = 1.24; 95% CI 1.18–1.30; p < 0.01), and abnormal illness behavior (OR = 1.49; 95% CI 1.34–1.66; p < 0.01) were positively associated with allostatic load, while objective support (OR = 0.84; 95% CI 0.78–0.89; p < 0.01), subjective support (OR = 0.84; 95% CI 0.80–0.88; p < 0.01), utilization of support (OR = 0.80; 95% CI 0.72–0.88; p < 0.01), social support (OR = 0.90; 95% CI 0.87–0.93; p < 0.01), and global well-being (OR = 0.30; 95% CI 0.22–0.41; p < 0.01) were negatively associated. Conclusions: In the post-COVID-19 epidemic time, medical and nonmedical workers had similar allostatic load. Psychological distress and abnormal illness behavior were risk factors for it, while social support could relieve it. [ABSTRACT FROM AUTHOR]

C13H18N4O12Zn, triclinic, P1̄ (no. 2), a = 9.0311(3) Å, b = 9.4464(3) Å, c = 12.6951(5) Å, α = 109.2790(11)°, β = 92.6348(12)°, γ = 116.2514(10)°, V = 892.97(5) Å3, Z = 2, Rgt(F) = 0.0263, wRref(F2) = 0.0712, T = 293(2) K. [ABSTRACT FROM AUTHOR]

Objective: To compare the effect of conventional mechanical caries removal treatment, atraumatic restorative treatment (ART) and Carisolv chemical caries removal treatment applied in the dental caries treatment of primary teeth. Methods: 96 pediatric patients diagnosed of mild/moderate dental caries in deciduous teeth from January 2011 to June 2012 were randomly divided into conventional mechanical removal treatment group, atraumatic restorative treatment (ART) group and Carisolv chemical caries removal treatment group with 60 dentals each. Then operative reaction, operation time and long-term efficacy were recorded and analyzed. Results: The efficacy of dental removal in conventional mechanical caries removal group and Carisolv chemical caries removal treatment group were significantly better than ART group (P<0.05). There was no significant difference in the operation time spent among all treatment groups (P>0.05). The number of intraoperative pain occurs in ART group and Carisolv chemical caries removal treatment group were lower than that on the conventional mechanical caries removal group (P<0.05). In one-year post-treatment, secondary caries incidence in conventional mechanical caries removal group and Carisolv chemical caries removal treatment group were significantly lower than that in ART group(P<0.05). However, there was no significant difference in the incidence of break/loss dental filling among all treatment groups (P>0.05). Conclusions: Carisolv chemical caries removal treatment can effectively relieve intraoperative pain and recurrence rate after operation, which is worthy of promotion and application in clinical treatment of deciduous teeth. Caries removal effects and long-term efficacy ofART may limit its widespread application. [ABSTRACT FROM AUTHOR]

PURPOSE: To study the definitive surgical timing and indications in clinical comprehensive management of oral and maxillofacial trauma patients associated with multiple systemic injuries. METHODS: A total of 4869 patients with oral and maxillofacial trauma treated over a 20-year period in four general hospitals were retrospectively reviewed. The clinical conditions of associated multiple systemic injuries with oral and maxillofacial trauma and the specific definitive surgical timing were analyzed. RESULTS: 3364 patients had facial fractures, 1505 patients had soft tissue injuries. 1524 (31.3%) patients had injuries in other parts of the body, among which 570 (37.4%) were cranio-cerebral injuries, 545(35.8%) were orthopedic injuries, 170(11.2%) were thoracic injuries, 151(9.9%) were ophthalmic injuries, 54 (3.3%) were spinal injuries and 34 (2.2%) were abdominal injuries. There were 422 (74%) patients associated cranio-cerebral injuries in whom maxillofacial fractures surgery within 4 weeks after trauma, 115(76.2%) patients had associated ophthalmic injuries in whom maxillofacial fractures surgery was performed within the first 7 days after trauma. The maxillofacial definitive surgical treatment in some other associated patients including orthopedic, thoracic, abdominal and spinal injuries was delayed in different times. CONCLUSION: Clinical comprehensive management in maxillofacial trauma patients associated with multiple systemic injuries needs cooperation within multiple specialties and departments. A large number of oral and maxillofacial trauma patients with multiple systemic injuries are amenable to definitive maxillofacial surgery in early time after trauma, or surgical management of other injuries of the body, if the conditions of respiratory and circulatory system were stable. [ABSTRACT FROM AUTHOR]

Background: Transcranial alternating current stimulation (tACS) offers a new approach for adult patients with major depressive disorder (MDD). The study is to evaluate the efficacy and safety of tACS treating MDD., Methods: This is an 8-week, double-blind, randomized, placebo-controlled study. Ninety-two drug-naive patients with MDD aged 18 to 65 years will receive 20 daily 40-min, 77.5-Hz, 15-mA sessions of active or sham tACS targeting the forehead and both mastoid areas on weekdays for 4 consecutive weeks (week 4), following a 4-week observation period (week 8). The primary outcome is the remission rate defined as the 17-item Hamilton depression rating scale (HDRS-17) score ≤7 at week 8. Secondary outcomes are the rates of response at weeks 4 and 8 and rate of remission at week 4 based on HDRS-17, the proportion of participants having improvement in the clinical global impression-improvement, the change in HDRS-17 score (range, 0-52, with higher scores indicating more depression) over the study, and variations of brain imaging and neurocognition from baseline to week 4. Safety will be assessed by vital signs at weeks 4 and 8, and adverse events will be collected during the entire study., Discussion: The tACS applied in this trial may have treatment effects on MDD with minimal side effects., Trial Registration: Chinese Clinical Trial Registry, ChiCTR1800016479; http://www.chictr.org.cn/showproj.aspx?proj=22048.

Objective: To discuss the influence of intensive insulin therapy on insulin resistance of patients with severe burn or trauma., Methods: Sixty patients with severe burn or trauma hospitalized in the Third People's Hospital of Chongqing or Southwest Hospital of the Third Military Medical University from January 2010 to December 2011 were randomly divided into intensive insulin therapy group (IT, treated with intensive insulin therapy to control the blood glucose to the level of 6.0-8.0 mmol/L) and control group (C, treated with routine therapy) according to the paired grouping method, with 30 patients in each group. Before treatment and on post treatment day (PTD) 1, 3, 7, 10, 14, the levels of fasting blood glucose and fasting plasma insulin were determined. Insulin resistance index and β-cell function index were calculated using homeostasis model assessment. Data were processed with t test, analysis of variance, and LSD test., Results: On PTD 1, 3, 7, 10, levels of fasting blood glucose in group IT [(6.8 ± 1.4), (6.7 ± 1.3), (5.8 ± 1.9), (5.4 ± 1.6) mmol/L] were significantly lower than those of group C [(14.8 ± 4.9), (12.7 ± 3.7), (7.7 ± 1.9), (6.6 ± 1.3) mmol/L, with t values respectively 12.453, 11.386, 5.563, 4.731, P < 0.05 or P < 0.01]. On PTD 3, 7, levels of fasting insulin in group IT [(14 ± 5), (10 ± 3) mU/L] were significantly lower than those of group C [(16 ± 4), (13 ± 4) mU/L, with t values respectively 4.212, 4.364, P values below 0.05]. Levels of fasting blood glucose and fasting insulin in the two groups at each time point were statistically significantly different from those before treatment (with P values below 0.01), except for the level of fasting blood glucose on PTD 3. On PTD 1, 3, 7, 10, levels of insulin resistance index in group IT (1.60 ± 0.80, 1.46 ± 0.70, 0.96 ± 0.21, 0.90 ± 0.23) were significantly lower than those in group C (2.15 ± 1.35, 2.21 ± 1.21, 1.50 ± 0.95, 1.17 ± 0.66, with t values respectively 8.316, 10.607, 7.825, 5.217, P < 0.05 or P < 0.01). Levels of insulin resistance index of patients in the two groups at each time point after treatment were significantly lower than those before treatment (with P values below 0.01). On PTD 1, 3, 7, levels of β-cell function index in group IT (4.6 ± 2.9, 4.5 ± 3.3, 4.5 ± 3.6) were significantly higher than those in group C (3.4 ± 2.5, 3.6 ± 2.2, 4.2 ± 2.5, with t values respectively 8.243, 7.914, 4.338, P < 0.05 or P < 0.01). Levels of β-cell function index in group C on PTD 1 and 3 were significantly lower than that before therapy (with P values below 0.05)., Conclusions: Intensive insulin therapy can alleviate insulin resistance of patients with severe burn or trauma.

Objective: To study the correlation between prostate volume and body mass index, blood pressure, blood lipid and glucose in 30-50 year-old males., Methods: Prostate volume (PV), body mass index (BMI), blood pressure(BP), blood glucose (BG), blood cholesterol (CHOL), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) were measured in 1 002 30-50 year-old males. The correlation of PV with BMI, BP, BG, CHOL, TG, LDL, and HDL were analyzed with SPSS 13.0 statistical software., Results: The subjects' average age was (43.66 ± 0.17) years, and their mean prostate volume (14.28±0.02) mL. The statistical analyses regarding the age (P=0.000, r=0.62), BMI (P=0.013,r=0.57), BG (P=0.032, r=0.52), CHOL (P=0.040,r=0.51), LDL (P=0.032, r=-0.50), HDL (P=0.017,r=-0.48) were significantly associated with PV. Adjusted for age factors, PV still had a strong correlation with BMI and LDL, P values were 0.029, 0.001, r values were 0.53, -0.49., Conclusion: In the 30-50 year-old males, BMI and dyslipidemia could be risk factors in the way of the enlargement of prostate volume. Weight control and therapy of blood lipid abnormalities may delay the increase of prostate volume.

Objective: To investigate the association of the serum testosterone (T) level with metabolic syndrome (MS)., Methods: We enrolled in this investigation 1,006 men aged 30-60 years in Beijing and obtained the data on their blood pressure (BP), waist circumference (WC), fasting blood glucose (FBG), serum triglycerides (TG), high density lipoprotein-cholesterol (HDL-C) and serum testosterone (T). The men were divided into an MS group and a non-MS (NMS) group based on The Chinese Adult Dyslipidemia Prevention Guide 2007. The results were compared and analyzed., Results: There was no statistically significant difference between the ages of the two groups (P >0.05). Systolic BP (SBP), diastolic BP (DBP), WC, FBG and TG were significantly higher, while serum T and HDL-C remarkably lower in the MS than in the NMS group (P <0.001). The serum T level was markedly decreased with the increase of MS components (P <0.01). Both Pearson's correlation coefficients and multiple linear regression analyses showed that the serum T level was negatively correlated with age, WC, SBP and TG (P < 0.05)., Conclusion: Low serum T level may predict the development of MS in men.

In order to control the ion density and energy distribution in the vicinity of plasma sheath independently, the inductively coupled plasma and its glow discharge mechanism in the vicinity of plasma sheath were studied by means of optical emission spectroscopy (OES) under different RF power, different discharge and different substrate DC bias voltage. It was shown that the ion density is higher and the electron temperature is lower in the vicinity of inductively coupled plasma sheath according to the ionic line and atomic line. With changing the discharge pressure and RF power, the spectral characteristics analysis shows that the ion density in the vicinity of plasma sheath linearly increases with the RF power and rises with the pressure under the low pressure. The atomic spectral intensity of low excitation states increases rapidly. The atomic spectral intensity of high excitation states rises slowly and the intensity of ion spectrum increases not obviously. By applying the DC bias voltage to substrate, the intensity of emission spectroscopy was analyzed. The result shows that the intensity of spectra rises with the increase in positive bias voltage, while first reduces then increases with the increase in negative bias voltage, and is the weakest in the case of DC bias at -30 V. This shows that the fast ions and the electrons are the main source of energy for Ar ionization and excitation.

Objective: To investigate the effects of intensive insulin therapy on inflammatory response and prognosis of patients with severe trauma., Methods: Eighty severely injured patients were divided into intensive insulin therapy group (n = 40, IT) and routine therapy group (n = 40, RT) in random pair. At the time of admission, a continuous infusion of insulin (2-4 U/h) was pumped into the patients of IT group to maintain blood glucose level at 6-8 mmol/L. Patients in RT group were given routine treatment without administration of insulin. Fever, organ injury, and mortality of patients in 2 groups were recorded. Venous blood was drawn from patients of 2 groups on the morning of post treatment day (PTD) 1, 3, 5, and 7. Values of TNF-alpha, C-reactive protein (CRP), IL-2, and IL-10 in plasma were assayed., Results: High fever appeared in 9 patients in IT group, and WBC exceeded 10.0 x 10(9) for more than 3 days in 17 patients in this group, versus 20 and 29 patients respectively in RT group. Dysfunction of 1 organ appeared in 31 patients in IT group and 30 patients in RT group. Dysfunction of 3 organs appeared in 10 patients in IT group and 19 patients in RT group. Dysfunction of 4 organs appeared in 7 patients in IT group and 12 patients in RT group. In IT group, 4 patients died within 3 post-injury day (PID), and 1 patient died after PID 3 (total case fatality: 12.5%). In RT group, 5 patients died within 3 PID, and 4 patient died after PID 3 (total case fatality: 22.5%). Plasma levels of TNF-alpha and CRP of patients in IT group were significantly lower than those of patients in RT group on PID 3-7 ( P < 0.05 or P < 0.01), while levels of IL-2 and IL-10 of patients in IT group were significantly higher than those of patients in RT group (P < 0.05 or P < 0.01). Plasma levels of TNF-alpha (1.3 +/- 0.6 microg/L) and CRP (55 +/- 16 mg/L) of patients in IT group on PTD 7 were lowered to the trough level, and they were significantly lower than those of patients in RT group (3.0 +/- 0.8 microg/L, 89 +/- 20 mg/L, respectively, P < 0.01)., Conclusions: Intensive insulin therapy can mitigate systemic inflammatory response and improve prognosis of patients with severe trauma.