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47 results on '"Zhao, Xianghai"'

3. The Genetic Risk Score with Variants at PDGFs and PDGFRB for the Risk of Major Cardiovascular Adverse Events in Patients with Coronary Artery Disease

Author

Xu, Xiaojuan, primary, Li, Wen, additional, Liu, Fangyuan, additional, Chen, Changying, additional, Xie, Hankun, additional, Wang, Feifan, additional, Han, Xu, additional, Zhuang, Qian, additional, Zhao, Xianghai, additional, Sun, Junxiang, additional, Yin, Yunjie, additional, Wei, Pengfei, additional, Chen, Yanchun, additional, Shen, Chong, additional, and Yang, Song, additional

Published
2024
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9. Dexmedetomidine alleviates hippocampal neuronal loss and cognitive decline in rats undergoing open surgery under sevoflurane anaesthesia by suppressing CCAAT/enhancer‐binding protein beta.

Author

Fu, Shanshan, Zhao, Xianghai, Li, Yingna, Fan, Xinwen, and Huang, Zeqing

Subjects
*DEXMEDETOMIDINE, *COGNITION disorders, *SEVOFLURANE, *HIPPOCAMPUS (Brain), *CENTRAL nervous system, *ANESTHESIA
Abstract

Dexmedetomidine (Dex) may exert neuroprotective effects by attenuating inflammatory responses. However, whether Dex specifically improves postoperative cognitive dysfunction (POCD) by inhibiting microglial inflammation through what pathway remains unclear. In this study, the POCD model was constructed by performing open surgery after 3 h of continuous inhalation of 3% sevoflurane to rats, which were intraperitoneally injected with 25 μg/kg Dex.5 h before anaesthesia. The results displayed that Dex intervention decreased rat escape latency, maintained swimming speed and increased the number of times rats crossed the platform and the time spent in the target quadrant. Furthermore, the rat neuronal injury was restored, alleviated POCD modelling‐induced rat hippocampal microglial activation and inhibited microglial M1 type polarization. Besides, we administered Dex injection and/or CCAAT/enhancer‐binding protein beta (CEBPB) knockdown on the basis of sevoflurane exposure and open surgery and found that CEBPB was knocked down, resulting in the inability of Dex to function, which confirmed CEBPB as a target for Dex treatment. To sum up, Dex improved POCD by considering CEBPB as a drug target to activate the c‐Jun N‐terminal kinase (JNK)/p‐38 signaling pathway, inhibiting microglial M1 polarization‐mediated inflammation in the central nervous system. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Gender Specificity and Local Socioeconomic Influence on Association of GHR fl/d3 Polymorphism With Growth and Metabolism in Children and Adolescents

Author

Chen, Xiaotian, primary, Liu, Chunlan, additional, Yang, Song, additional, Yang, Yaming, additional, Chen, Yanchun, additional, Zhao, Xianghai, additional, Zhu, Weiguang, additional, Zhao, Qihui, additional, Ni, Chuan, additional, Huang, Xiangyuan, additional, Yan, Weili, additional, Shen, Chong, additional, and Gu, Harvest F., additional

Published
2022
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16. Interaction Analysis of Abnormal Lipid Indices and Hypertension for Ischemic Stroke: A 10-Year Prospective Cohort Study

Author

Wei, Lai, Sun, Junxiang, Xie, Hankun, Zhuang, Qian, Wei, Pengfei, Zhao, Xianghai, Chen, Yanchun, Dong, Jiayi, Li, Mengxia, Chen, Changying, Yang, Song, and Shen, Chong

Subjects
Cardiology and Cardiovascular Medicine
Abstract

BackgroundDyslipidemia and hypertension are two important independent risk factors for ischemic stroke (IS); however, their combined effect on IS remains uncertain.ObjectivesThis present study aimed to evaluate the interaction effect of hypertension and abnormal lipid indices on IS in a 10-year prospective cohort in Chinese adults.MethodsThe cohort study of 4,128 participants was conducted in May 2009 and was followed up to July 2020. All qualified participants received a questionnaire survey, physical examination, and blood sample detection. Cox regression was used to evaluate the association of dyslipidemia and hypertension with IS, and calculate the hazard ratio (HR) and 95% confidence interval (CI). The relative excess risk of interaction (RERI) and the HR (95%CI) of interaction terms were used to examine additive and multiplicative interactions.ResultsIn the hypertensive population, Non-HDL-C ≥190 mg/dl, LDL-C/HDL-C ≥2 and HDL-C ≥60 mg/dl were statistically associated with IS, and after adjusting for covariates, HRs (95%CIs) were 1.565 (1.007–2.429), 1.414 (1.034–1.933) and 0.665 (0.450–0.983), respectively. While in the non-hypertension population, no significant association of Non-HDL-C ≥190 mg/dl, LDL-C/HDL-C ≥2, and HDL-C ≥60 was detected with IS (P > 0.05). There was a significant association between TC/HDL-C ≥ 3.6 and the decreased risk of IS in the non-hypertension population, and the HR (95%CI) was 0.479 (0.307–0.750). Whereas, a similar association was not observed in the hypertensive population. HDL-C ≥ 60 mg/dl, Non-HDL-C ≥ 190 mg/dl, TC/HDL-C ≥ 3.6, and TG/HDL-C ≥ 1 have additive and multiplicative interactions with hypertension (P < 0.05). The RERIs (95% CIs) of the additive interaction are −0.93 (−1.882–0.044), 1.394 (0.38–2.407), 0.752 (0.354–1.151) and 0.575 (0.086–1.065), respectively. The HRs (95% CIs) of the multiplicative interaction terms were 0.498 (0.272–0.911), 4.218 (1.230–14.464), 2.423 (1.437–4.086) and 1.701 (1.016–2.848), respectively.ConclusionHigh concentration of HDL-C reduces the impact of hypertension on IS, while the high concentration of Non-HDL-C, TC/HDL-C, and TG/HDL-C positively interact with hypertension affecting the incidence of IS. This study provides useful evidence for the combined effects of dyslipidemia and hypertension in predicting IS.

Published
2021

18. The Associations of Lipid Profiles With Cardiovascular Diseases and Death in a 10-Year Prospective Cohort Study

Author

Dong, Jiayi, primary, Yang, Song, additional, Zhuang, Qian, additional, Sun, Junxiang, additional, Wei, Pengfei, additional, Zhao, Xianghai, additional, Chen, Yanchun, additional, Chen, Xiaotian, additional, Li, Mengxia, additional, Wei, Lai, additional, Chen, Changying, additional, Fan, Yao, additional, and Shen, Chong, additional

Published
2021
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25. Common variants of ROCKs and the risk of hypertension, and stroke: Two case-control studies and a follow-up study in Chinese Han population

Author

Yang, Song, primary, Zhao, Yanping, additional, Tian, Yuanrui, additional, Chen, Yanchun, additional, Zhao, Xianghai, additional, Li, Ying, additional, Zhao, Hailong, additional, Chen, Xiaotian, additional, Zhu, Lijun, additional, Fang, Zhengmei, additional, Yao, YingShui, additional, Hu, Zhibing, additional, and Shen, Chong, additional

Published
2018
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30. Association study of IGFBP1 and IGFBP3 polymorphisms with hypertension and cardio-cerebral vascular diseases in a Chinese Han population

Author

Fang, Zhengmei, primary, Yang, Song, additional, Zhu, Lijun, additional, Li, Ying, additional, Chen, Yanchun, additional, Jin, Yuelong, additional, Zhao, Xianghai, additional, Zhao, Hailong, additional, Chen, Xiaotian, additional, Zhao, Yanping, additional, Shen, Chong, additional, and Yao, Yingshui, additional

Published
2017
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31. The variants at FLNAand FLNBcontribute to the susceptibility of hypertension and stroke with differentially expressed mRNA

Author

Liu, Chunlan, Tang, Wuzhuang, Zhao, Hailong, Yang, Song, Ren, Zhanyun, Li, Jie, Chen, Yanchun, Zhao, Xianghai, Xu, Donghua, Zhao, Yanping, and Shen, Chong

Abstract

Background: Filamin A and filamin B were involved in vascular development and remodeling. Herein, it is important to explore the associations of FLNAand FLNBvariants with hypertension and stroke. Methods: The associations of two single-nucleotide polymorphisms (SNPs) at FLNAand five SNPs at FLNBwith hypertension and stroke were examined in two case-control studies and a cohort study in Chinese Han population. Risks were estimated as odds ratio (OR) and hazard ratio (HR) by Logistic and Cox regression analysis respectively. In addition, filamin B, FLNAand FLNBmRNA expression were measured. Results: In the case-control study of hypertension, FLNArs2070816 (CT + TT vs. CC) and rs2070829 (CG + GG vs. CC) were significantly associated with hypertension in &lt;55 years group (OR = 1.338, P= 0.018; OR = 1.615, P= 0.005) and FLNBrs839240 (AG + GG vs. AA) was significantly associated with hypertension in females (OR = 0.828, P= 0.041) and nonsmokers (OR = 0.829, P= 0.020). In the follow-up study, rs2070829 GG genotype carriers presented a higher risk of hypertension than CC/CG in males (HR = 1.737, P= 0.014) and smokers (HR = 1.949, P= 0.012). In the case-control study of stroke, FLNBrs1131356 variation was significantly associated with ischemic stroke (IS) and intracerebral hemorrhage (ICH), ORsof additive model were 1.342 and 1.451, with Pvalues of 0.001 and 0.007. The FLNA transcript 2, FLNB transcript 3, transcript 4 mRNA, and filamin B expression levels were significantly different between IS cases and hypertension controls and among the genotypes of rs839240 in hypertensive individuals (P&lt; 0.05). Conclusions: Our findings support the genetic contribution of FLNAand FLNBto hypertension, and stroke with differentially mRNA expression.

Published
2021
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33. The variant at TGFBRAP1 is significantly associated with type 2 diabetes mellitus and affects diabetes‐related miRNA expression.

Author

Yang, Song, Chen, Xiaotian, Yang, Mengyao, Zhao, Xianghai, Chen, Yanchun, Zhao, Hailong, Liu, Chunlan, and Shen, Chong

Subjects
TRANSFORMING growth factors, TYPE 2 diabetes diagnosis, MICRORNA, INSULIN resistance, GLUCOSE tolerance tests
Abstract

While the transforming growth factor‐β1 (TGF‐β1) regulates the growth and proliferation of pancreatic β‐cells, its receptors trigger the activation of Smad network and subsequently induce the insulin resistance. A case‐control was conducted to evaluate the associations of the polymorphisms of TGF‐β1 receptor‐associated protein 1 (TGFBRAP1) and TGF‐β1 receptor 2 (TGFBR2) with type 2 diabetes mellitus (T2DM), and its genetic effects on diabetes‐related miRNA expression. miRNA microarray chip was used to screen T2DM‐related miRNA and 15 differential expressed miRNAs were further validated in 75 T2DM and 75 normal glucose tolerance (NGT). The variation of rs2241797 (T/C) at TGFBRAP1 showed significant association with T2DM in case‐control study, and the OR (95% CI) of dominant model for cumulative effects was 1.204 (1.060‐1.370), Bonferroni corrected P < 0.05. Significant differences in the fast glucose and HOMA‐β indices were observed amongst the genotypes of rs2241797. The expression of has‐miR‐30b‐5p and has‐miR‐93‐5p was linearly increased across TT, TC, and CC genotypes of rs2241797 in NGT, Ptrend values were 0.024 and 0.016, respectively. Our findings suggest that genetic polymorphisms of TGFBRAP1 may contribute to the genetic susceptibility of T2DM by mediating diabetes‐related miRNA expression. [ABSTRACT FROM AUTHOR]

Published
2019
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34. Evaluation of common variants in MG53 and the risk of type 2 diabetes and insulin resistance in Han Chinese

Author

Yang, Song, primary, Zhao, Hailong, additional, Xu, Kuangfeng, additional, Qian, Yun, additional, Wu, Ming, additional, Yang, Tao, additional, Chen, Yanchun, additional, Zhao, Xianghai, additional, Chen, Jinfeng, additional, Wen, Jinbo, additional, Hu, Zhibing, additional, Gu, Harvest F., additional, Shen, Hongbing, additional, and Shen, Chong, additional

Published
2016
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41. Common Variants in TGFBR2 and miR-518 Genes Are Associated With Hypertension in the Chinese Population

Author

Chen, Jinfeng, primary, Zhao, Xianghai, additional, Wang, Hairu, additional, Chen, Yanchun, additional, Wang, Wen, additional, Zhou, Wei, additional, Wang, Xuecai, additional, Tang, Junming, additional, Zhao, Yanping, additional, Lu, Xiangfeng, additional, Chen, Shufeng, additional, Wang, Laiyuan, additional, Shen, Chong, additional, and Yang, Song, additional

Published
2014
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42. A nonlinear model predictive control strategy based on dynamic fuzzy model using two-step optimization method

Author

Rong Gang, Wang Shuqing, Wang Yin, and Zhao Xianghai

Subjects
Model predictive control, Nonlinear system, Linear programming, Resist, Robustness (computer science), Control theory, Fuzzy set, Fuzzy control system, Robust control, Mathematics
Abstract

The dynamic fuzzy model implements a set of local dynamic models, identified by the least square method, to approximate the dynamics of a nonlinear process. The nonlinear predictive controller consists of a multi-step predictor based on a dynamic fuzzy model, an output optimizer and a robust filter. The output is optimized by two steps, the descent-gradient method first, and then a linear optimization. The robust filter with one adjustable parameter can resist the model mis-match and improve the transient performance. The simulation of pH neutralization process is given to demonstrate the better performance of the proposed control scheme compared with a conventional DMC controller.

Published
2002

43. Association study of CRP gene polymorphism and hypertension in Han Chinese population

Author

Zhao, Yanping, primary, Wang, Hairu, additional, Liu, Sijun, additional, Zhao, Xianghai, additional, Chen, Yanchun, additional, Yang, Yichun, additional, Wang, Wen, additional, Wu, Yiming, additional, Chen, Aiqin, additional, Tang, Junming, additional, Yao, Yingshui, additional, Li, Yun, additional, Chen, Jinfeng, additional, Shen, Chong, additional, and Yang, Song, additional

Published
2013
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45. HMGB1 gene polymorphism is associated with hypertension in Han Chinese population.

Author

Yao, Yingshui, Guo, Daoxia, Yang, Song, Jin, Yuelong, He, Lianping, Chen, Jinfeng, Zhao, Xianghai, Chen, Yanchun, Zhou, Wei, and Shen, Chong

Subjects
GENETIC polymorphisms, HYPOTENSION, CYTOKINE receptors, INFLAMMATION, TOLL-like receptors, PULMONARY hypertension, BLOOD pressure, PATIENTS
Abstract

Background: High-mobility group box 1 protein (HMGB1) acts as a proinflammatory cytokine by activating pattern recognition receptors (PRRs), including Toll-like receptor 4 (TLR4) and the receptor of AGE (AGER) with oxidative injury. Animal study proved that HMGB1 contributed to the pathogenesis of experimental pulmonary hypertension (HT) via activation of TLR4. The aim of this study is to test whether HMGB1 harbor genetic susceptibility to HT in a Chinese population. Methods: A case-control study comprising 2012 HT cases and 2210 controls was used to evaluate the association of three tagging single nucleotide polymorphism (tagSNPs) in HMGB1 gene with HT and blood pressure. Logistic regression model was used to adjust confounding factor for HT and general linear model (GLM) was applied to compare blood pressure levels between genotypes in cases and controls. Results: Single locus analysis showed that there was no statistical association of three tagSNPs with HT after adjustment for the covariates. Further stratification analysis found that rs2249825 was significantly associated with HT in ≥55 years groups, ORs (95% CI) of additive model and dominant model were 1.208 (1.029-1.417) and 1.212 (1.020-1.441), and p values were 0.021 and 0.029, respectively. Quantitative trait analysis indicated that DBP had a linear decrease with the variations of rs2249825 in both untreated HT group ( p = 0.002) and control group ( p = 0.034) respectively. Conclusions: Our finding suggests that rs2249825 of HMGB1 genetic polymorphisms are significantly associated with HT and diastolic blood pressure, and the genetic effect on HT is modulated by age. [ABSTRACT FROM AUTHOR]

Published
2015
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47. Insulin-Like Growth Factor-1 and Receptor Contribute Genetic Susceptibility to Hypertension in a Han Chinese Population.

Author

Yao Y, Zhu L, Fang Z, Yang S, Chen Y, Jin Y, Zhao X, Zhao H, Zhuang Q, Chen X, and Shen C

Subjects
Adolescent, Adult, Age Factors, Aged, Asian People genetics, Body Mass Index, Case-Control Studies, Child, China epidemiology, Female, Follow-Up Studies, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Hypertension diagnosis, Hypertension ethnology, Hypertension physiopathology, Incidence, Male, Middle Aged, Obesity diagnosis, Obesity ethnology, Phenotype, Receptor, IGF Type 1, Risk Assessment, Risk Factors, Sex Factors, Hypertension genetics, Insulin-Like Growth Factor I genetics, Polymorphism, Single Nucleotide, Receptors, Somatomedin genetics
Abstract

Background: Insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) have been suggested to mediate the pathophysiological response to elevated blood pressure. This study aims to evaluate the association of IGF-1 and IGF-1R with hypertension., Methods: Overall, 2,012 hypertensive cases and 2,210 controls were included in a case-control study, and 10 tagging single nucleotide polymorphisms (tagSNPs) were selected. The association of these SNPs with hypertension was further evaluated in a follow-up analysis and in an adolescent population., Results: A case-control study indicated that rs1815009 and rs2654981 in IGF-1R were significantly associated with hypertension, with odds ratios of 0.89 (P = 0.009) and 1.19 (P = 0.034), respectively, after adjusting for covariates. Stratification analyses revealed significant associations with hypertension (P < 0.05) for rs35767 in normal weight and obese populations; for rs2229765 in individuals <55 years of age and in overweight and nondrinking populations; and for rs2002880 in overweight and drinking populations. In a follow-up study, rs13379905 in IGF-1R was associated with hypertension incidence (hazard ratio, HR = 1.24, P = 0.042). This association was more significant in individuals with a hypertensive family history (HR = 2.10, P = 0.001). The association of rs13379905 with prehypertension and hypertension was further replicated in adolescent males (P = 0.005). Significant associations with hypertension incidence (P < 0.05) were observed for rs6219 in individuals <55 years of age and among those with obesity and a hypertensive family history as well as rs2002880 in obese individuals., Conclusions: Our findings suggest that IGF-1R may contribute to the genetic susceptibility to hypertension, with BMI, age, and family history of hypertension all potentially modulating the genetic effects of IGF-1 on hypertension.

Published
2018
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