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This study investigates the effectiveness of fusion-based appreciative curriculum moral education through non-experimental research methods involving college students from Hong Kong, Macau, Taiwan, and mainland China who took the Ethics and Life course. The findings indicate that: (1) moral education based on integrated appreciation significantly enhances students’ moral cognition and demonstrates a positive but nonsignificant impact on moral behaviour. (2) Both classroom reflection and course papers reveal that integrative appreciation-based moral education promotes moral cognition and fosters value cultivation. (3) Gender can influence the effectiveness of curriculum moral education, warranting attention to the active utilization of this subgroup characteristic in practice. (4) College students’ moral cognition and behaviour are not significantly correlated with their academic performance.

The most pronounced neuropathological feature of Parkinson's disease (PD) is the loss of dopamine (DA) neurons in the substantia nigra compacta (SNc), which depletes striatal DA. Hypothalamic oxytocin is found to be reduced in PD patients and closely interacts with the DA system, but the role of oxytocin in PD remains unclear. Here, the disturbances of endogenous oxytocin level and the substantia nigra (SN) oxytocin receptor expression in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced PD mouse model is observed, correlated with the striatal tyrosine hydroxylase (TH) expression reduction. Killing/silencing hypothalamic oxytocin neurons aggravates the vulnerability of nigrostriatal DA signal to MPTP, whereas elevating oxytocin level by intranasal delivery or microinjecting into the SN promotes the resistance. In addition, knocking out SN oxytocin receptors induces the time‐dependent reductions of SNc DA neurons, striatal TH expression, and striatal DA level by increasing neuronal excitotoxicity. These results further uncover that oxytocin dampens the excitatory synaptic inputs onto DA neurons via activating oxytocin receptor‐expressed SN GABA neurons, which target GABA(B) receptors expressed in SNc DA neuron‐projecting glutamatergic axons, to reduce excitotoxicity. Thus, besides the well‐known prosocial effect, oxytocin acts as a key endogenous factor in protecting the nigrostriatal DA system. [ABSTRACT FROM AUTHOR]

AbstractLarge Language Models (LLMs) excel in natural language-relevant tasks like text generation and question answering Q&A. To further expand their application, efforts focus on enabling LLMs to utilize real-world tools. However, their tool-use ability in professional GIS remains under explored due to two main challenges. Firstly, LLMs are usually trained on general-domain corpora, lacking sufficient and comprehensive GIS-specific data to align with professional knowledge, including understanding the functions of GIS tools. Secondly, researchers often need to combine multiple GIS tools to solve geospatial tasks. To address these challenges, we propose a trainable method to enable LLMs to master GIS tools. We curated a comprehensive set of resources: instruction-response data (GeoTool, 1950 instructions) to enhance the understanding of LLMs for GIS tools, instruction-solution data (GeoSolution, 3645 instructions) to improve their ability to generate tool-use solutions for geospatial tasks, and annotated instruction-solution evaluation data (GeoTask, 300 instructions) for evaluating LLMs’ GIS tool-use proficiency. Using the collected training data (GeoTool and GeoSolution), we fine-tuned a professional-domain LLM called GeoTool-GPT based on an open-source general-domain LLM, the LLaMA-2-7b model. The experiment based on evaluation data validates our method’s effectiveness in enhancing the tool-use ability of general-domain LLMs in the professional GIS domain, with the performance of our model closely approaching that of GPT-4. [ABSTRACT FROM AUTHOR]