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The purpose of this retrospective study was to investigate the risk factors associated with progressive hemorrhagic injury (PHI) in patients with isolated traumatic brain injury (TBI) and develop prognostic models for predicting patient outcomes. A total of 137 patients with isolated TBI who underwent additional CT scans were included in the study. Single-factor analysis and multivariate logistic regression analysis were performed to identify significant risk factors associated with PHI development. Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the diagnostic value of certain markers in predicting PHI. The single-factor analysis revealed statistically significant differences between the PHI group (62 patients) and the non-PHI group (75 patients) in various factors, including gender, etiology, pupillary size and reflex, midline shift, hematoma type, associated brain contusion, D-dimer levels, neutrophil-to-lymphocyte ratio (NLR), platelet count, blood glucose levels, and Glasgow Coma Scale (GCS) score. Multivariate logistic regression analysis identified NLR, blood glucose level, and GCS score as significant risk factors for PHI occurrence in isolated TBI patients. ROC curve analysis showed that NLR had a significant auxiliary diagnostic value in predicting PHI. This study concluded that NLR, blood glucose level, and GCS score are significant risk factors for PHI development in isolated TBI patients. NLR demonstrated potential as an auxiliary diagnostic marker for identifying the risk of PHI. The constructed prognostic model incorporating age, GCS score, NLR, and platelet-to-lymphocyte ratio (PLR) can provide valuable predictive capabilities for patient outcomes in isolated TBI cases. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to detect the expression pattern of SPZ1 in glioma samples and to clarify its biological functions in the malignant progression of glioma. Our results provide a novel molecular target for glioma., Methods: SPZ1 levels in 40 pairs of glioma and non-tumoral ones were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The differences in clinical indicators and prognosis between glioma patients expressing high and low levels of SPZ1 were compared. After knockdown of SPZ1 by transfection of sh-SPZ1, migratory and invasive abilities of A172 and U251 cells were examined by transwell migration and invasion assays. The interaction between SPZ1 and its target gene CXXC4 was finally explored by Western blot and dual-luciferase reporter assay., Results: SPZ1 was upregulated in glioma tissues than non-tumoral ones, and the difference was statistically significant. Cell function experiments showed that knockdown of SPZ1 weakened the migratory and invasive abilities of A172 and U251 cells. CXXC4 was identified as the target gene binding to SPZ1. Knockdown of CXXC4 abolished the role of SPZ1 knockdown in inhibiting glioma progression., Conclusions: SPZ1 stimulates glioma's malignant progression via targeting CXXC4.