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32. Bisabolane-type sesquiterpenoids with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Morinda citrifolia

Author

Zhao, Ying-Ying, Li, Yu-Jie, Yu, Xiao-Mei, Su, Qin-Ting, Wang, Li-Wen, Zhu, Yu-Shu, Fu, Yan-Hui, Chen, Guang-Ying, and Liu, Yan-Ping

Subjects
Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry
Abstract

The phytochemical study on the stems and leaves of Morinda citrifolia L. resulted in the isolation of a new naturally occurring bisabolane-type sesquiterpenoid, morincitrinoid A (1), together with five known analogues (2–6). The chemical structure of 1 was elucidated by comprehensive spectral analyses. The known compounds 2–6 were identified by comparing their spectral data with those reported in the literature, which were isolated from M. citrifolia for the first time. In addition, the anti-inflammatory and anti-HIV activities of compounds 1–6 were evaluated in vitro. Compounds 1–6 displayed significant inhibitory activities on NO (nitric oxide) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells with IC50 values ranging from 0.98 ± 0.07 to 6.32 ± 0.11 μM, which was comparable to hydrocortisone. Meanwhile, compounds 1–6 showed remarkable anti-HIV-1 reverse transcriptase (RT) effects with the EC50 values ranging from 0.16 to 6.29 μM.

Published
2022

40. Population total and unbound pharmacokinetics and pharmacodynamics of ciprofol and M4 in subjects with various renal functions

Author

Liu, Shuai‐bing, primary, Yao, Xia, additional, Tao, Jun, additional, Yang, Jian‐jun, additional, Zhao, Ying‐ying, additional, Liu, Dong‐wei, additional, Wang, Su‐yun, additional, Sun, Su‐ke, additional, Wang, Xu, additional, Yan, Pang‐ke, additional, Wu, Nan, additional, Liu, Xiao, additional, Zhang, Xiao‐jian, additional, Tian, Xin, additional, and Liu, Zhang‐suo, additional

Published
2022
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43. Anthraquinones with potential antiproliferative activities from the fruits of Morinda citrifolia

Author

Shen, Zhang-Yang, Zhao, Ying-Ying, Qiao, Ze-Hua, Xie, Zhen, Guan, Ruo-Qing, Liu, Ze-Yu, Liu, Yan-Ping, Chen, Guang-Ying, and Fu, Yan-Hui

Subjects
Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry
Abstract

The phytochemical investigation on the fruits of Morinda citrifolia led to the isolation and characterization of a new anthraquinone, moricitrifone (1), along with seven known anthraquinones (2–8). The chemical structure of 1 was elucidated by extensive spectral analyses. The known compounds (2–8) were identified by comparing their spectral data with those reported in the literature. The antiproliferative activities of all isolated anthraquinones (1–8) against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 were evaluated in vitro. Compounds 1–8 exhibited remarkable antiproliferative activities with IC50 values ranging from 0.26 ± 0.05 to 16.58 ± 0.18 μM, which were comparable to those of doxorubicin.

Published
2021

44. Bisabolane-type sesquiterpenoids with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Morinda citrifolia.

Author

Zhao, Ying-Ying, Li, Yu-Jie, Yu, Xiao-Mei, Su, Qin-Ting, Wang, Li-Wen, Zhu, Yu-Shu, Fu, Yan-Hui, Chen, Guang-Ying, and Liu, Yan-Ping

Subjects
MORINDA citrifolia, SESQUITERPENES, ANTI-inflammatory agents, REVERSE transcriptase, CHEMICAL structure
Abstract

The phytochemical study on the stems and leaves of Morinda citrifolia L. resulted in the isolation of a new naturally occurring bisabolane-type sesquiterpenoid, morincitrinoid A (1), together with five known analogues (2–6). The chemical structure of 1 was elucidated by comprehensive spectral analyses. The known compounds 2–6 were identified by comparing their spectral data with those reported in the literature, which were isolated from M. citrifolia for the first time. In addition, the anti-inflammatory and anti-HIV activities of compounds 1–6 were evaluated in vitro. Compounds 1–6 displayed significant inhibitory activities on NO (nitric oxide) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells with IC50 values ranging from 0.98 ± 0.07 to 6.32 ± 0.11 μM, which was comparable to hydrocortisone. Meanwhile, compounds 1–6 showed remarkable anti-HIV-1 reverse transcriptase (RT) effects with the EC50 values ranging from 0.16 to 6.29 μM. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Association between internal migration experience and depressive symptoms: analysis of PSID data.

Author

Liao, Zi-Xuan, Tan, Xiao-Min, Zhao, Ying-Ying, Sun, Xiao-Cui, and Yi, Fa-Ling

Abstract

Background: Depression is on the rise globally. Additionally, the United States has a high level of population mobility. The main aim of this study was to provide a reference for improving the mental health of internal migrants by investigating the relationship between internal migration experience and depressive symptoms. Methods: We analysed data from the Panel Study of Income Dynamics (PSID). We included PSID data from the 2005 to 2019 waves in which all respondents were asked about their internal migration experience and depressive symptoms. This study included 15,023 participants. T tests, chi-square tests, multiple logistic regression methods were performed and fixed effects model. Results: In the sample, the prevalence of depressive symptoms was 4.42%. The risk of depression in internal migrants was 1.259 times (OR = 1.259, 95% CI = (1.025–1.547, p < 0.05) that of nonmigrants. Internal migration experience was significantly positively associated with female depressive episodes (OR = 1.312, 95% CI = 1.010–1.704, p < 0.05) and increased risk of becoming depressed at a young age (OR = 1.304, 95% CI = 1.010–1.684, p < 0.05). The association between internal migration experience and depressive symptoms was more significant for participants who might move (OR = 1.459, 95% CI = 1.094–1.947, p < 0.05). In addition, different internal migratory causes are associated with depressive symptoms to varying degrees. Conclusions: Our findings highlight the need for greater policy attention to mental health inequalities between Internal migrants and those who never move away from their hometown in the United States. Our study provides a foundation for further research. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Anthraquinones with potential antiproliferative activities from the fruits of Morinda citrifolia.

Author

Shen, Zhang-Yang, Zhao, Ying-Ying, Qiao, Ze-Hua, Xie, Zhen, Guan, Ruo-Qing, Liu, Ze-Yu, Liu, Yan-Ping, Chen, Guang-Ying, and Fu, Yan-Hui

Subjects
MORINDA citrifolia, ANTHRAQUINONES, CHEMICAL structure, CELL lines, CANCER cells
Abstract

The phytochemical investigation on the fruits of Morinda citrifolia led to the isolation and characterization of a new anthraquinone, moricitrifone (1), along with seven known anthraquinones (2–8). The chemical structure of 1 was elucidated by extensive spectral analyses. The known compounds (2–8) were identified by comparing their spectral data with those reported in the literature. The antiproliferative activities of all isolated anthraquinones (1–8) against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 were evaluated in vitro. Compounds 1–8 exhibited remarkable antiproliferative activities with IC50 values ranging from 0.26 ± 0.05 to 16.58 ± 0.18 μM, which were comparable to those of doxorubicin. [ABSTRACT FROM AUTHOR]

Published
2023
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