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[Objective] In the context of the diminishing marginal effect of income quantity on diet quality, exploring the effect of income quality on the diet quality of farming households helps to address the bottleneck issue in the effect of income quality on diet quality improvement and provides a basis for the formulation of diet quality improvement measures. [Methods] Using the survey data of 510 farming households in Shaanxi Province in 2022, this study first measured the income quality of farming households by using the entropy value method from five dimensions: income quantity, structure, stability, cost involved, and contribution of knowledge. Second, the diet quality of farming households was evaluated by examining the deviation of actual food intake from recommended intake. On this basis, the impact of income quality on the diet quality of farming households and its heterogeneity were analyzed empirically. [Results] The improvement of income quality significantly improved the diet quality of farming households, reduced the deviation of cereals and potatoes, eggs, aquatic products, legumes, and nuts intake from the recommended intake of dietary pagoda, optimized the dietary structure, and significantly improved the diet quality of farming households, and the effect of income quality on the diet quality of low-income farming households was more obvious. [Conclusion] Enhancing the income quality of farming households is an important way to break through the bottleneck of improving the diet quality. It is recommended to improve the income quality of farming households by increasing income sources, strengthening skills training, promoting agricultural insurance and improving the medical insurance system, so as to improve the diet quality of farming households. And in the process of policy formulation, it is necessary to favor low-income groups and establish a more diversified food supply system.

Aims: The aim of this study was to explore the influence and possible mechanisms of pharmacokinetics‐related gene polymorphisms, especially CYP2C19 polymorphisms, and non‐genetic factors combined with the inflammatory status on the voriconazole (VRC) metabolism of the Chinese population. Methods: Clinical studies were performed by collecting more than one VRC trough concentration and C‐reactive protein (CRP) level. A total of 265 blood samples were collected from 120 patients. Results: Results of multiple regression analyses demonstrated that CYP2C19 genotypes and albumin (Alb) level remained predictors of Cminss/D in patients with no to mild inflammation (R2 = 0.12, P <.001). In addition, in patients with moderate to severe inflammation, it resulted in a significant model containing factors of CRP and total bilirubin (T‐Bil) levels (R2 = 0.19, P <.001). In non‐clinical studies, 32 rats were divided into control and inflammatory groups, and it was found that the mean residence time (MRT(0–t)) of VRC in the inflammatory group was significantly longer than that in the control group (P <.001), which may be due to down‐regulation of mRNA and protein expression of CYP2C19 (CYP2C6 in rats) through interleukin (IL)‐6/signal transducer and activator of transcription (STAT) 3 pathway. Conclusions: Therefore, the effect of CYP2C19 polymorphisms on VRC metabolism may be masked by inflammatory status, which should be of more concern than CYP2C19 polymorphisms in patients with moderate to severe inflammation. Additionally, the impact of Alb and T‐Bil on VRC metabolism should not be disregarded. [ABSTRACT FROM AUTHOR]

Traditional hydrogels, as wound dressings, usually exhibit poor mechanical strength and slow drug release performance in clinical biomedical applications. Although various strategies have been investigated to address the above issues, it remains a challenge to develop a simple method for preparing hydrogels with both toughness and controlled drug release performance. In this study, a tannic acid-reinforced poly (sulfobetaine methacrylate) (TAPS) hydrogel was fabricated via free radical polymerization, and the TAPS hydrogel was subjected to a simple electrophoresis process to obtain the hydrogels with a gradient distribution of copper ions. These gradient hydrogels showed tunable mechanical properties by changing the electrophoresis time. When the electrophoresis time reached 15 min, the hydrogel had a tensile strength of 368.14 kPa, a tensile modulus of 16.17 kPa, and a compressive strength of 42.77 MPa. It could be loaded at 50% compressive strain and then unloaded for up to 70 cycles and maintained a constant compressive stress of 1.50 MPa. The controlled release of copper from different sides of the gradient hydrogels was observed. After 6 h of incubation, the hydrogel exhibited a strong bactericidal effect on Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, with low toxicity to NIH/3T3 fibroblasts. The high toughness, controlled release of copper, and enhanced antimicrobial properties of the gradient hydrogels make them excellent candidates for wound dressings in biomedical applications. [ABSTRACT FROM AUTHOR]

Resveratrol in the aqueous extraction of Polygonum cuspidatum was separated and purified by liquid extraction assistance macroporous adsorption resin mixed bed. Firstly, petroleum ether and ethyl acetate were used to replace diethyl ether that was an effective solvent for separate Resveratrol from aqueous extract. Then, Resveratrol was further separated by macroporous adsorption resin-mixed bed. Finally, the experimental conditions were optimized. When the volume ratio of water and organic mixture was 2/3, extraction time interval was 60 min and extraction times was 5 times, the recovery rate of Resveratrol was 81.10% and the purity was 87.12%. [ABSTRACT FROM AUTHOR]

A complete demand system is estimated separately for urban and rural residents using a two‐stage almost ideal demand system–quadratic almost ideal demand system model and pooled provincial and time‐series data from 2000 to 2012. The estimated demand elasticities with respect to income and demographic variables are then used to predict the changes in the structure of food demand in China for the year 2030. Results of this study suggest that, as per capita incomes grow further while both urbanization and population aging continue their upward trends, the shares of expenditures on foods away from home are expected to rise while the shares of spending on foods at home would decline, and that at‐home food budget shares of grains are expected to continue decreasing whereas at‐home food budget shares of foods with animal origins and fruits would be on the rise. Thus, food security in China has been transformed into feed grain security. [ABSTRACT FROM AUTHOR]

Over the past 4 decades, China has experienced a nutritional transition and has developed the largest population of internet users. In this study, we evaluated the impacts of internet access on the nutritional intake in Chinese rural residents. An IV-Probit-based propensity score matching method was used to determine the impact of internet access on nutritional intake. The data were collected from 10,042 rural households in six Chinese provinces. The results reveal that rural residents with internet access have significantly higher energy, protein, and fat intake than those without. Chinese rural residents with internet access consumed 1.35% (28.62 kcal), 5.02% (2.61 g), and 4.33% (3.30 g) more energy, protein, and fat, respectively. There was heterogeneity in regard to the intake of energy, protein, and fat among those in different income groups. Moreover, non-staple food consumption is the main channel through which internet access affects nutritional intake. The results demonstrate that the local population uses the internet to improve their nutritional status. Further studies are required to investigate the impact of internet use on food consumed away from home and micronutrient intake. [ABSTRACT FROM AUTHOR]

Voriconazole (VRC) displays highly variable pharmacokinetics impacting treatment efficacy and safety. To provide evidence for optimizing VRC therapy regimens, the authors set out to determine the factors impacting VRC steady-state trough concentration (C min ) in patients with various albumin (Alb) level. A total of 275 blood samples of 120 patients and their clinical characteristics and genotypes of CYP2C19 , CYP3A4 , CYP3A5 , CYP2C9 , FMO3 , ABCB1 , POR , NR1I2 and NR1I3 were included in this study. Results of multivariate linear regression analysis demonstrated that C-reactive protein (CRP) and total bilirubin (T-Bil) were predictors of the VRC C min adjusted for dose in patients with hypoalbuminemia (Alb < 35 g/L) ( R 2 = 0.16, P < 0.001). Additionally, in patients with normal albumin level (Alb ≥ 35 g/L), it resulted in a significant model containing factors of the poor metabolizer (PM) CYP2C19 genotype and CRP level ( R 2 = 0.26, P < 0.001). Therefore, CRP and T-Bil levels ought to receive greater consideration than genetic factors in patients with hypoalbuminemia.