Search

This study aimed to determine the prognostic value and microenvironmental crosstalk of exosome-related signatures in human epidermal growth factor receptor 2 positive breast cancer (HER2+ BC). Transcriptome sequencing and clinicopathological data were downloaded from the Cancer Genome Atlas. The 10X single cell sequencing dataset was downloaded from the National Center for Biotechnology Information Gene Expression Omnibus. Exosomes-Related Genes were extracted from the ExoCarta and Gene Set Enrichment Analysis databases. FGF9, SF3B4, and EPCAM were found and deemed the most accurate predictive signatures. Patients with HER2+ BC were subtyped into three groupings by exosome prognostic gene (EPGs). The expression of SF3B4 was positively linked with the infiltration of macrophages, neutrophils, and CD4+ T cells. The expression characteristics of EPGs were associated with the biological process of “response to xenobiotic stimuli.” Interactions were relatively high between malignant epithelial cells and fibroblasts, endothelial cells, monocytes, and macrophages. Malignant epithelial cells interact more with fibroblasts and endothelial cells. The migration inhibitory factor pathway was the primary outgoing signaling pattern, while the C-C motif chemokine ligand pathway was the primary incoming signaling pattern for communication between malignant epithelial cells and macrophages. This study described the role of exosome signatures in the prognosis and microenvironment of HER2+ BC and provided a basis for future research.

C40H46CoN4O4, monoclinic, P21/n (no. 14), a = 12.0084(5) Å, b = 28.1263(10) Å, c = 12.0351(5) Å, β = 110.800(1)°, V = 3800.0(3) Å3, Z = 4, Rgt(F) = 0.0575, wRref(F2) = 0.1150, T = 173(2) K.

Baicalin has been shown to promote spatial learning and neural regeneration, which might increase the differentiation of neural stem cells in Alzheimer’s disease (AD) rat models. We aimed to study the role of baicalin on neuronal pentraxin-1 (NPTX-1), neuronal pentraxin-2 (NPTX-2), and C-reactive protein (CRP) in AD model rats.

C30H22F2N2O4Zn, monoclinic, P2/c (no. 13), a = 9.5936(8) Å, b = 11.2561(10) Å, c = 11.9682(10) Å, β = 104.598(3)°, V = 1250.68(19) Å3, Z = 2, Rgt(F) = 0.0661, wRref(F2) = 0.1259, T = 173(2) K.

The informatization and intelligence of wind farm lock and key management is the key to further improve the level of wind farm operation and maintenance management. This paper designs a smart key security management and control architecture for wind farms. Combined with the proposed short-range wireless communication anti-jamming technology, key encryption, and dynamic attack detection technology, a set of wind farm smart key security management and control system has been developed. The system can realize the functions of opening and closing information traceability and risk prevention, etc., which improves the network, digital and intelligent level of wind farm operation and maintenance.

C20H24N2O2, monoclinic, P21/c (no. 14), a = 14.5088(4) Å, b = 17.4849(6) Å, c = 7.1398(2) Å, β = 97.933(1)°, Z = 4, V = 1793.93(9) Å3, R gt(F) = 0.0561, wRref (F 2) = 0.1596, T = 173 K.

C40H46N4O4Zn, monoclinic, P21/n (no. 14), a = 12.0198(4) Å, b = 28.0212(9) Å, c = 12.0655(4) Å, β = 110.727(2)°, V = 3800.8(2) Å3, Z = 4, Rgt(F) = 0.0442, wRref(F2) = 0.1076, T = 173(2) K.

C21H26N2O2, monoclinic, P21 (no. 4), a = 7.1425(7) Å, b = 9.2733(8) Å, c = 14.3161(13) Å, β = 93.592(4)°, V = 946.36(15) Å3, Z = 2, Rgt (F) = 0.0461, wRref (F 2) = 0.1148, T = 173(2) K.

In order to reveal the microstructure transformation mechanism of the process of depositing dissimilar material on the surface of mold steel containing Cr, the 316L stainless steel was deposited on two kinds of mold steel. The microstructure and hardness were characterized by SEM, EPMA, XRD etc, moreover, the mechanism of microstructure transformation in the interface and deposition zone was analyzed by the combination of melting-solidification dynamic process and Schaeffler diagram. The results show that the microstructure near the deposition interface shows obviously different characters due to the difference of matrix element composition and phase distribution. The thickness of transition zone of high Cr ledeburite steel is 200 μm, the transition zone is obviously different from other areas of the deposition layer in terms of its morphology and phase; the carbides in the transition zone undergo complex changes, such as local aggregation and growth at first, and then uniform distribution among dendrites. However, the thickness of microstructure transition zone of the deposition layer in P20 steel is less than 20 μm, the microstructure grows in the form of dendrite and is connected with the non transition zone of the deposition layer, meanwhile, dispersed granular carbides are found in the dendrites. Under the action of the dynamic changes of C, Cr, Ni and other elements in the molten pool, the composition phase of the non transition zone in the two kinds of steel deposition layers is also obviously different;the matrix phases of deposition layers in high Cr ledeburite steel and P20 steel are austenite phase and martensite phase respectively, as a result, the range of hardness variation is 295-325HV0.2 and 500-575HV0.2,respectively.

C20H20F2N2O4Zn, triclinic, P1‾ $P\overline{1}$ (no. 2), a = 8.4062(2) Å, b = 10.9987(3) Å, c = 11.8247(3) Å, α = 97.969(1)°, β = 103.217(1)°, γ = 110.601(1)°, V = 967.04(4) Å3, Z = 2, Rgt (F) = 0.0415, wRref (F 2) = 0.1167, T = 173(2) K.

C20H22F2N2O4, triclinic, P1‾ $P\overline{1}$ (no. 2), a = 4.7005(2) Å, b = 10.2279(3) Å, c = 10.9917(3) Å, α = 63.1510(10)°, β = 83.369(2)°, γ = 83.014(2)°, V = 466.88(3) Å3, Z = 1, Rgt (F) = 0.0361, wRref (F 2) = 0.1018, T = 173.0 K.

C30H26CoN4O4, monoclinic, C2/c (no. 15), a = 16.0520(5) Å, b = 19.1890(5) Å, c = 16.7292(4) Å, β = 93.064(1)°, Z = 8, V = 5145.6(2) Å3, Rgt(F) = 0.0400, wRref(F2) = 0.0932, T = 173(2) K.

C16H15FN2O2, monoclinic, P21/c (no. 14), a = 6.0573(3) Å, b = 13.8341(6) Å, c = 33.0876(15) Å, β = 92.837(2)°, Z = 8, V = 2769.3(2) Å3, Rgt(F) = 0.0581, wRref(F2) = 0.1605, T = 173(2) K.

C33H32F2N4O5Zn, triclinic, P1̄ (no. 2), a = 9.5132(5) Å, b = 13.0781(6) Å, c = 14.0448(6) Å, α = 63.0950(10)°, β = 73.5640(10)°, γ = 78.870(2)°, V = 1490.24(12) Å3, Z = 2, Rgt(F) = 0.0459, wRref(F2) = 0.1004, T = 173(2) K.

C68H68Cu2N8O8, monoclinic, P21/c, a = 16.241(3) Å, b = 12.1604(19) Å, c = 15.531(3) Å, β = 96.364(3)°, Z = 2, V = 3048.3(9) Å3, Rgt(F) = 0.0497, wRref(F2) = 0.1263, T = 296(2)K.

C92H84Cu2N8O8, monoclinic, P21/c (no. 14), a = 18.315(2) Å, b = 12.1533(12) Å, c = 17.518(2) Å, β = 105.289(4)°, Z = 2, V = 3761.3(7) Å3, Rgt(F) = 0.0658, wRref(F2) = 0.1809, T = 173(2)K.

C44H38CuN4O4, monoclinic, P21/n (no. 14), a = 8.0172(13) Å, b = 10.9003(17) Å, c = 42.154(8) Å, β = 94.749(6)°, Z = 4, V = 3671.2(11) Å3, Rgt(F) = 0.0483, wRref(F2) = 0.1072, T = 173(2)K.

C34H36CoN4O5, triclinic, P1̅ (no. 2), a = 8.7040(5) Å, b = 12.7375(9) Å, c = 14.2626(9) Å, α = 99.054(2)°, β = 95.727(2)°, γ = 92.477(2)° V = 1550.96(17) Å3, Z = 2, Rgt(F) = 0.0554, wRref(F2) = 0.1369, T = 296(2) K.

C15H12FNO2, monoclinic, C2/c (no. 15), a = 17.9898(8) Å, b = 4.6412(2) Å, c = 30.3832(15) Å, β = 93.072(3)°, Z = 8, V = 2533.2(2) Å3, Rgt(F) = 0.0568, wRref(F2) = 0.1399, T = 173(2) K.

C15H12BrNO2, monoclinic, P21/c (no. 14), a = 11.7848(3) Å, b = 10.0857(3) Å, c = 12.2695(4) Å, β = 111.2020(10)°, Z = 4, V = 1359.61(7) Å3, Rgt(F) = 0.0306, wRref(F2) = 0.0745, T = 173(2) K.

C15H12BrNO2, monoclinic, P21/c (no. 14), a = 8.0970(3) Å, b = 12.7315(4) Å, c = 12.8542(4) Å, β = 93.785(1)°, Z = 4, V = 1322.21(8) Å3, Rgt(F) = 0.0210, wRref(F2) = 0.0570, T = 173(2) K.

C32H28CuF2N4O4, monoclinic, P21/n (no. 14), a = 10.5489(3) Å, b = 6.2601(1) Å, c = 21.3299(7) Å, β = 99.401(1)°, V = 1389.65(6) Å3, Z = 2, Rgt(F) = 0.0312, wRref(F2) = 0.0849, T = 173(2) K.

C40H34N4NiO4, monoclinic, P21/c (no. 14), a = 21.443(7) Å, b = 13.862(5) Å, c = 11.733(4) Å, β = 103.690(5)°, Z = 4, V = 3388(2) Å3, Rgt(F) = 0.0484, wRref(F2) = 0.1411, T = 296(2) K.

C18H20N2O2, monoclinic, Pc (no. 7), a = 17.8843(15) Å, b = 7.1821(6) Å, c = 6.3086(6) Å, β = 98.487(3)°, Z = 2, V = 801.45(12) Å3, Rgt(F) = 0.0533, wRref(F2) = 0.1411, T = 296(2) K.

C36H38CuN4O4, triclinic, P1̄, a = 8.492(2) Å, b = 9.574(2) Å, c = 10.512(2) Å, α = 100.170(7)°, β = 103.421(7)°, γ = 95.055(8)°, Z = 1, V = 810.8(3) Å3, Rgt(F) = 0.0418, wRref(F2) = 0.1193, T = 296(2) K.

C32H30N4O4Zn, triclinic, P1̅ (no. 2), a = 8.6632(8) Å, b = 12.7133(10) Å, c = 14.2719(12) Å, α = 98.585(3)°, β = 94.985(3)°, γ = 92.916(3)°, Z = 2, V = 1545.1(2) Å3, Rgt(F) = 0.0714, wRref(F2) = 0.1740, T = 296(2) K.

C20H27ClN3O3, monoclinic, P21/n (no. 14), a = 10.7351(5) Å, b = 14.1177(6) Å, c = 14.3355(9) Å, β = 101.284(6)°, Z = 4, V = 2130.6(2) Å3, Rgt(F) = 0.0569, wRref(F2) = 0.1767, T = 293(2) K.

C19H23N3O2, monoclinic, P21/n (no. 14), a = 17.8421(15) Å, b = 9.4778(9) Å, c = 22.116(2) Å, β = 108.230(10)°, Z = 8, V = 3552.2(6) Å3, Rgt(F) = 0.0649, wRref(F2) = 0.1506, T = 293(2) K.

Objective To investigate the advantage and disadvantage between annular bone block embedded in maxillary sinus lift and conventional maxillary sinus lift.Methods =One hundred and twenty sinuses from 80 patients of serious insufficient of bone quantity (0-4 mm height of residual bone in the posterior maxilla) were divided into two groups randomly. Each group contained 60 sinuses. By preparing annular bone block at the alveolar ridge crest, 60 sinuses augmentation were carried out by repetitive knocking annular bone block under light force in the group of route from the crest of alveolar bone and 60 mucosa of maxillary sinuses were lifted up by routine fenestration operation on the maxillary lateral wall in the conventional sinus lifting group. Implants were implanted after six months. The perpetual prosthesis was made in 6 months. Misery index of patients, lifting height of sinus floor, the perforating rate of sinus mucosa and the success rate of implantation were compared between two methods. Lifting height of sinus floor was examined through x-ray imaging.Results No nostril hemorrhage was found in the group of route from crest sinus lifting whereas two patients occurred nostril hemorrhage in the conventional group; the mean operation time of route group from the crest of alveolar bone and the route group form the lateral wall was (42.82 ± 3.46) min, (88.38 ± 4.37) min, the difference was statistically significant (t = 35.237, P = 0.001) ; misery index of route group from the crest of alveolar bone and the route group form the lateral wall was (4.20 ± 0.68), (6.34 ± 0.45), the difference was statistically significant (t = 3.056, P = 0.003) ; lifting height of sinus floor of route group from the crest of alveolar and the route group form the lateral wall was (12.44 ± 2.48) mm, (12.28 ± 2.87) mm , and there was no statistical significance (t = 0.908, P = 0.390).Conclusion The route from the crest of alveolar bone could obviously reduce operative wound and postoperative complications, shorten operative time, lessen the trauma of operation, the difference was statistically significant between two methods. Two groups had no significant difference on lifting height of sinus floor, the perforating rate of sinus mucosa and the success rate of implantation.

C40H40Br4Cl4Mn4O16, triclinic, P1̄, a = 9.3724(9) Å, b = 11.7867(16) Å, c = 12.3994(18) Å, α = 70.650(13)°, β = 75.462(10)°, γ = 81.085(10)°, V = 1247.1(3) Å3, Z = 1, Rgt(F) = 0.0618, wRref(F2) = 0.1201, T = 294 K.

C34H34CuN4O6, Monoclinic, P21/c, a = 10.4018(4) Å, b = 6.1634(2) Å, c = 24.2227(15) Å, β = 101.820(5)°, Z = 2, V = 1520.01(13) Å3, Rgt(F) = 0.0565, wRref(F2) = 0.1455, T = 292 K.