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14 results on '"Zheng, Jin Guang"'

4. A Semantic Portal for Next Generation Monitoring Systems

Author

Wang, Ping, Zheng, Jin Guang, Fu, Linyun, Patton, Evan W., Lebo, Timothy, Ding, Li, Liu, Qing, Luciano, Joanne S., McGuinness, Deborah L., Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Aroyo, Lora, editor, Welty, Chris, editor, Alani, Harith, editor, Taylor, Jamie, editor, Bernstein, Abraham, editor, Kagal, Lalana, editor, Noy, Natasha, editor, and Blomqvist, Eva, editor

Published
2011
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9. Provenance Representation for the National Climate Assessment in the Global Change Information System

Author

Tilmes, Curt, Fox, Peter, Ma, Xiaogang, Xiaogang, McGuinness, Deborah L., Privette, Ana Pinheiro, Smith, Aaron, Waple, Anne, Zednik, Stephan, and Zheng, Jin Guang

Abstract

The important topic of global climate change builds on a huge collection of scientific research. It is common for agencies releasing climate change information to be served with requests for all supporting materials resulting in a particular conclusion. Capturing and presenting global change provenance, linking to the research papers, data sets, models, analyses, observations, satellites, etc., that support the key research findings in this domain can increase understanding and aid in reproducibility of results and conclusions. The U.S. Global Change Research Program is now coordinating the production of a national climate assessment (NCA) that presents our best understanding of global change. We are now developing a global change information system that will present the content of that report and its provenance, including the scientific support for the findings of the assessment. We are using an approach that will present this information both through a human accessible Web site as well as a machine-readable interface for automated mining of the provenance graph. We plan to use the developing World Wide Web Consortium (W3C) PROV data model and ontology for this system. This paper will describe an overview of the process of developing the NCA and how the provenance trail of the report and each of the technical inputs can be captured and represented using the W3C PROV ontology. This will improve the visibility into the assessment process, increase understanding and possibility of reproducibility, and ultimately increase the credibility and trust of the resulting report.

Published
2013

11. Entity Linking for Biomedical Literature

Author

Zheng, Jin Guang, primary, Howsmon, Daniel, additional, Zhang, Boliang, additional, Hahn, Juergen, additional, McGuinness, Deborah, additional, Hendler, James, additional, and Ji, Heng, additional

Published
2014
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13. TWC LOGD: A portal for linked open government data ecosystems

Author

Ding, Li, primary, Lebo, Timothy, additional, Erickson, John S., additional, DiFranzo, Dominic, additional, Williams, Gregory Todd, additional, Li, Xian, additional, Michaelis, James, additional, Graves, Alvaro, additional, Zheng, Jin Guang, additional, Shangguan, Zhenning, additional, Flores, Johanna, additional, McGuinness, Deborah L., additional, and Hendler, James A., additional

Published
2011
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14. Dimethyl sulfoxide inhibits zymosan-induced intestinal inflammation and barrier dysfunction.

Author

Li YM, Wang HB, Zheng JG, Bai XD, Zhao ZK, Li JY, and Hu S

Subjects
Amine Oxidase (Copper-Containing) blood, Animals, Apoptosis drug effects, Enteritis chemically induced, Enteritis metabolism, Enteritis pathology, Interleukin-10 metabolism, Intestinal Mucosa blood supply, Intestinal Mucosa pathology, Male, Malondialdehyde metabolism, Multiple Organ Failure chemically induced, Rats, Rats, Sprague-Dawley, Regional Blood Flow drug effects, Superoxide Dismutase metabolism, Systemic Inflammatory Response Syndrome chemically induced, Tight Junctions drug effects, Tumor Necrosis Factor-alpha metabolism, Zonula Occludens-1 Protein metabolism, Zymosan, Dimethyl Sulfoxide pharmacology, Enteritis drug therapy, Free Radical Scavengers pharmacology, Intestinal Mucosa drug effects, Intestinal Mucosa metabolism
Abstract

Aim: To investigate whether dimethyl sulfoxide (DMSO) inhibits gut inflammation and barrier dysfunction following zymosan-induced systemic inflammatory response syndrome and multiple organ dysfunction syndrome., Methods: Sprague-Dawley rats were randomly divided into four groups: sham with administration of normal saline (SS group); sham with administration of DMSO (SD group); zymosan with administration of normal saline (ZS group); and zymosan with administration of DMSO (ZD group). Each group contained three subgroups according to 4 h, 8 h, and 24 h after surgery. At 4 h, 8 h, and 24 h after intraperitoneal injection of zymosan (750 mg/kg), the levels of intestinal inflammatory cytokines [tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-10] and oxides (myeloperoxidase, malonaldehyde, and superoxide dismutase) were examined. The levels of diamine oxidase (DAO) in plasma and intestinal mucosal blood flow (IMBF) were determined. Intestinal injury was also evaluated using an intestinal histological score and apoptosis of intestinal epithelial cells was determined by deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. The intestinal epithelial tight junction protein, ZO-1, was observed by immunofluorescence., Results: DMSO decreased TNF-α and increased IL-10 levels in the intestine compared with the ZS group at the corresponding time points. The activity of intestinal myeloperoxidase in the ZS group was higher than that in the ZD group 24 h after zymosan administration (P < 0.05). DMSO decreased the content of malondialdehyde (MDA) and increased the activity of superoxide dehydrogenase (SOD) 24 h after zymosan administration. The IMBF was lowest at 24 h and was 49.34% and 58.26% in the ZS group and ZD group, respectively (P < 0.05). DMSO alleviated injury in intestinal villi, and the gut injury score was significantly lower than the ZS group (3.6 ± 0.2 vs 4.2 ± 0.3, P < 0.05). DMSO decreased the level of DAO in plasma compared with the ZS group (65.1 ± 4.7 U/L vs 81.1 ± 5.0 U/L, P < 0.05). DMSO significantly preserved ZO-1 protein expression and localization 24 h after zymosan administration. The TUNEL analysis indicated that the number of apoptotic intestinal cells in the ZS group was much higher than the ZD group (P < 0.05)., Conclusion: DMSO inhibited intestinal cytokines and protected against zymosan-induced gut barrier dysfunction.

Published
2015
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