Search

Your search keyword '"Zheng, Jinxuan"' showing total 32 results
Start Over Author "Zheng, Jinxuan"
32 results on '"Zheng, Jinxuan"'

8. Parenchymal and stromal tissue regeneration of tooth organ by pivotal signals reinstated in decellularized matrix

Author

He, Ling, Zhou, Jian, Chen, Mo, Lin, Chyuan-Sheng, Kim, Sahng G, Zhou, Yue, Xiang, Lusai, Xie, Ming, Bai, Hanying, Yao, Hai, Shi, Changcheng, Coelho, Paulo G, Bromage, Timothy G, Hu, Bin, Tovar, Nick, Witek, Lukasz, Wu, Jiaqian, Chen, Kenian, Gu, Wei, Zheng, Jinxuan, Sheu, Tzong-Jen, Zhong, Juan, Wen, Jin, Niu, Yuting, Cheng, Bin, Gong, Qimei, Owens, David M, Stanislauskas, Milda, Pei, Jasmine, Chotkowski, Gregory, Wang, Sainan, Yang, Guodong, Zegarelli, David J, Shi, Xin, Finkel, Myron, Zhang, Wen, Li, Junyuan, Cheng, Jiayi, Tarnow, Dennis P, Zhou, Xuedong, Wang, Zuolin, Jiang, Xinquan, Romanov, Alexander, Rowe, David W, Wang, Songlin, Ye, Ling, Ling, Junqi, and Mao, Jeremy

Subjects
Biomedical and Clinical Sciences, Engineering, Biomedical Engineering, Regenerative Medicine, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Transplantation, 5.2 Cellular and gene therapies, 1.1 Normal biological development and functioning, Aetiology, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, Underpinning research, Adolescent, Animals, Female, Homeodomain Proteins, Humans, Incisor, Mice, Inbred Strains, Molar, Third, Organ Culture Techniques, Parenchymal Tissue, Pregnancy, Promoter Regions, Genetic, Regeneration, Stromal Cells, Swine, Tooth, Vascular Endothelial Growth Factor A, Wnt3A Protein, Nanoscience & Nanotechnology
Abstract

Cells are transplanted to regenerate an organs' parenchyma, but how transplanted parenchymal cells induce stromal regeneration is elusive. Despite the common use of a decellularized matrix, little is known as to the pivotal signals that must be restored for tissue or organ regeneration. We report that Alx3, a developmentally important gene, orchestrated adult parenchymal and stromal regeneration by directly transactivating Wnt3a and vascular endothelial growth factor. In contrast to the modest parenchyma formed by native adult progenitors, Alx3-restored cells in decellularized scaffolds not only produced vascularized stroma that involved vascular endothelial growth factor signalling, but also parenchymal dentin via the Wnt/β-catenin pathway. In an orthotopic large-animal model following parenchyma and stroma ablation, Wnt3a-recruited endogenous cells regenerated neurovascular stroma and differentiated into parenchymal odontoblast-like cells that extended the processes into newly formed dentin with a structure-mechanical equivalency to native dentin. Thus, the Alx3-Wnt3a axis enables postnatal progenitors with a modest innate regenerative capacity to regenerate adult tissues. Depleted signals in the decellularized matrix may be reinstated by a developmentally pivotal gene or corresponding protein.

Published
2019

10. 3D-printed cell-free PCL–MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration

Author

Guo, Weimin, Chen, Mingxue, Wang, Zhenyong, Tian, Yue, Zheng, Jinxuan, Gao, Shuang, Li, Yangyang, Zheng, Yufeng, Li, Xu, Huang, Jingxiang, Niu, Wei, Jiang, Shuangpeng, Hao, Chunxiang, Yuan, Zhiguo, Zhang, Yu, Wang, Mingjie, Wang, Zehao, Peng, Jiang, Wang, Aiyuan, Wang, Yu, Sui, Xiang, Xu, Wenjing, Hao, Libo, Zheng, Xifu, Liu, Shuyun, and Guo, Quanyi

Published
2021
Full Text
View/download PDF

11. Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

Author

Zheng, Jinxuan, primary, Yu, Rongcheng, additional, Tang, Yiqi, additional, Su, Sihui, additional, Wang, Sainan, additional, Liao, Chenxi, additional, Li, Xuecong, additional, Liao, Jiabin, additional, Yu, Dongsheng, additional, Ai, Tingting, additional, Zhao, Wei, additional, Yau, Vicky, additional, Liu, Chufeng, additional, Wu, Liping, additional, and Cao, Yang, additional

Published
2023
Full Text
View/download PDF

25. Mechanistic Insight of Platelet-Rich Plasma (PRP) in Mesenchymal and Vascular Progenitors

Author

He, Ling, primary, Gong, Qimei, additional, Ahn, Jeffrey A., additional, Chotkowski, Gregory, additional, Bai, Hanying, additional, Pei, Jasmine, additional, Zheng, Jinxuan, additional, Rodeo, Scott A., additional, Wang, Sainan, additional, Fortier, Lisa A., additional, Wen, Jin, additional, Liao, Zheting, additional, Guo, Weimin, additional, Shi, Xin, additional, Xu, Annie, additional, Ateshian, Gerard A., additional, Autz, Arthur J., additional, Ling, Junqi, additional, and Mao, Jeremy, additional

Published
2018
Full Text
View/download PDF

26. Treatment of Necrotic Teeth by Apical Revascularization: Meta-analysis

Author

He, Ling, primary, Zhong, Juan, additional, Gong, Qimei, additional, Kim, Sahng G., additional, Zeichner, Samuel J., additional, Xiang, Lusai, additional, Ye, Ling, additional, Zhou, Xuedong, additional, Zheng, Jinxuan, additional, Liu, Yongxing, additional, Guan, Chenyu, additional, Cheng, Bin, additional, Ling, Junqi, additional, and Mao, Jeremy J., additional

Published
2017
Full Text
View/download PDF

28. Exosomes Mediate Epithelium–Mesenchyme Crosstalk in Organ Development

Author

Jiang, Nan, primary, Xiang, Lusai, additional, He, Ling, additional, Yang, Guodong, additional, Zheng, Jinxuan, additional, Wang, Chenglin, additional, Zhang, Yimei, additional, Wang, Sainan, additional, Zhou, Yue, additional, Sheu, Tzong-Jen, additional, Wu, Jiaqian, additional, Chen, Kenian, additional, Coelho, Paulo G., additional, Tovar, Nicky M., additional, Kim, Shin Hye, additional, Chen, Mo, additional, Zhou, Yan-Heng, additional, and Mao, Jeremy J., additional

Published
2017
Full Text
View/download PDF

31. Relationship of Lane Width to Capacity for Urban Expressways

Author

Zheng, Jinxuan, Sun, Jian, and Yang, Jianhao

Abstract

To increase the capacity of urban expressways in Shanghai, China, additional lanes were created during the past decade through reconstruction. Field measurements indicate that maximum lane width is 3.97 m and minimum width is only 2.73 m. To investigate the relationship between lane width and capacity for urban expressways, 3 months of traffic flow data were extracted and filtered from the system to manage inductive detectors on Shanghai’s urban expressways. Analysis of all 440 segments of expressways in Shanghai showed that only 60 sites could reach their capacity; the characteristics of these 60 sites were further analyzed statistically. An analysis of a variance, a regression analysis, and a t-test were used to explore the relationship between lane width and capacity. The research showed that lane width had no statistically significant effect on capacity. Two causes that might account for this finding are discussed further: (a) free-flow speeds are similar for different lane widths according to the findings of a t-test that found no statistically significant differences and (b) the critical speed when capacity is reached for a Shanghai expressway is very low, only 45 km/h. Thus, drivers can deal with a narrow lane width at such a low critical speed. This finding suggests that geometric design policies for capacity purposes should provide substantial flexibility for use of narrower lane widths on urban expressways with low speed limits, although those lane widths must be subject to safety considerations.

Published
2015
Full Text
View/download PDF

32. Alkali-extracted proteins from the tooth dentin matrix as a mixture of bioactive molecules for cartilage repair and regeneration.

Author

Wang S, Mao S, Huang G, Jia P, Dong Y, and Zheng J

Abstract

Introduction: Dentin matrix extracted protein (DMEP) is a mixture of proteins extracted from the organic matrix of a natural demineralized dentin matrix that is rich in a variety of growth factors. However, the effect of DMEP on cartilage regeneration is unclear. The aim of this study was to investigate the efficacy of DMEP extracted via a novel alkali conditioning method in promoting cartilage regeneration., Methods: Alkali-extracted DMEP (a-DMEP) was obtained from human dentin fragments using pH 10 bicarbonate buffer. The concentration of chondrogenesis-related growth factors in a-DMEP was measured via enzyme-linked immunosorbent assay (ELISA). Human bone marrow mesenchymal stem cells (hBMMSCs) in pellet form were induced with a-DMEP. Alcian blue and Safranin O staining were performed to detect cartilage matrix formation, and quantitative real-time polymerase chain reaction (qRT-PCR) was used to assess chondrogenic-related gene expression in the pellets. Rabbit articular osteochondral defects were implanted with collagen and a-DMEP. Cartilage regeneration was assessed with histological staining 4 weeks after surgery., Results: Compared with traditional neutral-extracted DMEP, a-DMEP significantly increased the levels of transforming growth factor beta 1(TGF-β1), insulin-like growth factor-1(IGF-1) and basic fibroblast growth factor (bFGF). After coculture with hBMMSC pellets, a-DMEP significantly promoted the expression of the collagen type II alpha 1(COL2A1) and aggrecan (ACAN) genes and the formation of cartilage extracellular matrix in cell pellets. Moreover, compared with equivalent amounts of exogenous human recombinant TGF-β1, a-DMEP had a stronger chondrogenic ability. In vivo, a-DMEP induced osteochondral regeneration with hyaline cartilage-like structures., Conclusions: Our results showed that a-DMEP, a compound of various proteins derived from natural tissues, is a promising material for cartilage repair and regeneration., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Author(s).)

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results