Author: "Zheng, Q" - Searchworks@Jio Institute Digital Library Search Results

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9,693 results on '"Zheng, Q"'

1. Turing instability and pattern formation induced by noise in the modified SIR model

Author: Zheng, Q. Q., Shen, J. W., and Guan, L. N.
Published: 2024
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2. Study on six agricultural wastes as additional carbon source of low C/N ratio sewage

Author: Long, Y., Ma, Y., Wan, J., Wang, Y., Zheng, Q., and Ma, Y.
Published: 2024
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3. Performance of FPGA controller in ISAC-1 accelerator chain

Author: Fong, K., Fu, X., Zheng, Q. W., Au, T., Leewe, R., TRIUMF, V6T2A3, Vancouver, and Canada
Subjects: Physics - Accelerator Physics
Abstract: The LLRF of five of TRIUMF's ISAC-1 accelerator cavities have been replaced by 3 similar FPGA based system with different operating frequencies. These LLRF use internal digital phase locked loops for frequency generation and synchronization, feedback control using Amplitude/Phase regulations. These FPGAs also have internal stepper motor controller for resonance control. Various modes of resonance control are possible, including phase comparison and minimum seeking slide-mode control. Operational performances including frequency generation and synchronization, amplitude and phase noises, tuning speeds, compatibility to original remote controls, are reported., Comment: Poster presented at LLRF Workshop 2023 (LLRF2023, arXiv: 2310.03199)
Published: 2023

4. STCF Conceptual Design Report: Volume 1 -- Physics & Detector

Author: Achasov, M., Ai, X. C., Aliberti, R., An, L. P., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X. F., Chen, X., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gradl, W., Gu, J. L., Escalante, A. G., Gui, L. C., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X. H., Li, X. Q., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, N., Lü, Q. F., Lu, Y., Lv, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Dias, J. M., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P. W., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.
Subjects: High Energy Physics - Experiment, High Energy Physics - Phenomenology, Physics - Instrumentation and Detectors
Abstract: The Super $\tau$-Charm facility (STCF) is an electron-positron collider proposed by the Chinese particle physics community. It is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of $0.5\times 10^{35}{\rm cm}^{-2}{\rm s}^{-1}$ or higher. The STCF will produce a data sample about a factor of 100 larger than that by the present $\tau$-Charm factory -- the BEPCII, providing a unique platform for exploring the asymmetry of matter-antimatter (charge-parity violation), in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions, as well as searching for exotic hadrons and physics beyond the Standard Model. The STCF project in China is under development with an extensive R\&D program. This document presents the physics opportunities at the STCF, describes conceptual designs of the STCF detector system, and discusses future plans for detector R\&D and physics case studies.
Published: 2023
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5. Effect of Consultation Number on the Assessment and Treatment of Polycystic Ovary Syndrome

Author: Wang Y, Chen J, Dong H, Ma RL, Zou Y, Wang W, Zheng Q, Feng Y, Tan Z, Zeng X, Zhao Y, Deng Y, Gu B, and Sun A
Subjects: polycystic ovary syndrome, consultation number, lifelong learning, insulin resistance, obesity, hyperandrogenemia, metformin., Gynecology and obstetrics, RG1-991
Abstract: Yue Wang,1 Jie Chen,1 Han Dong,2 Rui-Lin Ma,1 Ying Zou,3 Wei Wang,4 Qingmei Zheng,5 Ying Feng,6 Zhangyun Tan,7 Xiaoqin Zeng,8 Yinqing Zhao,7 Yan Deng,1 Yanfang Wang,1 Bei Gu,9 Aijun Sun1,10 1National Clinical Research Center for Obstetric & Gynecologic Diseases Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, People’s Republic of China; 2Department of Obstetrics and Gynecology, Women and Children’s Hospital of Jinzhou, Jinzhou, Liaoning, 121000, People’s Republic of China; 3Department of Obstetrics and Gynecology, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, Hunan, 410008, People’s Republic of China; 4Department of Reproductive Medicine, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China; 5Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266500, People’s Republic of China; 6Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China; 7Department of Obstetrics and Gynecology, Xinhui Maternity and Children’s Hospital, Nanning, Guangxi, 529100, People’s Republic of China; 8Department of Gynecology, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong, 510000, People’s Republic of China; 9Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, Capital Medical University, Peking University Ninth School of Clinical Medicine, Beijing, 100038, People’s Republic of China; 10Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, 100010, People’s Republic of ChinaCorrespondence: Aijun Sun, Email saj@pumch.cnBackground: The basic medical education stage is not enough to support physicians to fully diagnose and evaluate polycystic ovary syndrome (PCOS). The study aims to discover the difference in treatment choice between participants with different annual consultation number of PCOS, to promote lifelong learning, and drive balanced development within healthcare.Methods: This is a multicenter cross-sectional survey. Participants’ basic information, knowledge of PCOS and treatment options were collected online. According to the annual consultation number of patients with PCOS, physicians were divided into three groups: 0– 50 people/yr, 50– 200 people/yr, and > 200 people/yr, and the results were derived from χ2 test, Fisher exact test, and multivariate logistic regression analysis.Results: The study analyzed 1689 questionnaires, and 1206 physicians (71.4%) received less than 50 women per year, 388 physicians (30.0%) with an annual number of 50– 200 women, and 95 physicians (5.6%) with patient turnover for more than 200 people. Reproductive endocrinologists generally have higher access to the clinic. As the number of visits increases, more and more physicians would perceive patients as more likely to have abnormal blood glucose and heavy weight. Physicians with large numbers of consultations are more likely to use Asian or Chinese standards to assess obesity. The multivariate analysis involved variables such as age, hospital level, specialty, and patient turnover annually, and more young doctors actively assessed lipid profile (odds ratio (OR) 1.56, 95% confidence interval (CI) (1.16, 2.16)), and primary hospitals (OR 0.65 CI (0.44, 0.89)) chose OGTT for blood glucose assessment less than tertiary hospitals. Physicians in secondary hospitals are more aggressive in evaluating androgens.Conclusion: Our survey found differences in endocrine assessment, metabolic screening, and treatment in PCOS women in terms of the number of obstetrician-gynecologists who received different patient consultation numbers. The importance of continuing education for physicians is emphasized, to promote lifelong learning.Keywords: polycystic ovary syndrome, consultation number, lifelong learning, insulin resistance, obesity, hyperandrogenemia, metformin
Published: 2024

6. STCF conceptual design report (Volume 1): Physics & detector

Author: Achasov, M., Ai, X. C., An, L. P., Aliberti, R., An, Q., Bai, X. Z., Bai, Y., Bakina, O., Barnyakov, A., Blinov, V., Bobrovnikov, V., Bodrov, D., Bogomyagkov, A., Bondar, A., Boyko, I., Bu, Z. H., Cai, F. M., Cai, H., Cao, J. J., Cao, Q. H., Cao, X., Cao, Z., Chang, Q., Chao, K. T., Chen, D. Y., Chen, H., Chen, H. X., Chen, J. F., Chen, K., Chen, L. L., Chen, P., Chen, S. L., Chen, S. M., Chen, S., Chen, S. P., Chen, W., Chen, X., Chen, X. F., Chen, X. R., Chen, Y., Chen, Y. Q., Cheng, H. Y., Cheng, J., Cheng, S., Cheng, T. G., Dai, J. P., Dai, L. Y., Dai, X. C., Dedovich, D., Denig, A., Denisenko, I., Dias, J. M., Ding, D. Z., Dong, L. Y., Dong, W. H., Druzhinin, V., Du, D. S., Du, Y. J., Du, Z. G., Duan, L. M., Epifanov, D., Fan, Y. L., Fang, S. S., Fang, Z. J., Fedotovich, G., Feng, C. Q., Feng, X., Feng, Y. T., Fu, J. L., Gao, J., Gao, Y. N., Ge, P. S., Geng, C. Q., Geng, L. S., Gilman, A., Gong, L., Gong, T., Gou, B., Gradl, W., Gu, J. L., Guevara, A., Gui, L. C., Guo, A. Q., Guo, F. K., Guo, J. C., Guo, J., Guo, Y. P., Guo, Z. H., Guskov, A., Han, K. L., Han, L., Han, M., Hao, X. Q., He, J. B., He, S. Q., He, X. G., He, Y. L., He, Z. B., Heng, Z. X., Hou, B. L., Hou, T. J., Hou, Y. R., Hu, C. Y., Hu, H. M., Hu, K., Hu, R. J., Hu, W. H., Hu, X. H., Hu, Y. C., Hua, J., Huang, G. S., Huang, J. S., Huang, M., Huang, Q. Y., Huang, W. Q., Huang, X. T., Huang, X. J., Huang, Y. B., Huang, Y. S., Hüsken, N., Ivanov, V., Ji, Q. P., Jia, J. J., Jia, S., Jia, Z. K., Jiang, H. B., Jiang, J., Jiang, S. Z., Jiao, J. B., Jiao, Z., Jing, H. J., Kang, X. L., Kang, X. S., Ke, B. C., Kenzie, M., Khoukaz, A., Koop, I., Kravchenko, E., Kuzmin, A., Lei, Y., Levichev, E., Li, C. H., Li, C., Li, D. Y., Li, F., Li, G., Li, G., Li, H. B., Li, H., Li, H. N., Li, H. J., Li, H. L., Li, J. M., Li, J., Li, L., Li, L., Li, L. Y., Li, N., Li, P. R., Li, R. H., Li, S., Li, T., Li, W. J., Li, X., Li, X. H., Li, X. Q., Li, X. H., Li, Y., Li, Y. Y., Li, Z. J., Liang, H., Liang, J. H., Liang, Y. T., Liao, G. R., Liao, L. Z., Liao, Y., Lin, C. X., Lin, D. X., Lin, X. S., Liu, B. J., Liu, C. W., Liu, D., Liu, F., Liu, G. M., Liu, H. B., Liu, J., Liu, J. J., Liu, J. B., Liu, K., Liu, K. Y., Liu, K., Liu, L., Liu, Q., Liu, S. B., Liu, T., Liu, X., Liu, Y. W., Liu, Y., Liu, Y. L., Liu, Z. Q., Liu, Z. Y., Liu, Z. W., Logashenko, I., Long, Y., Lu, C. G., Lu, J. X., Lu, N., Lü, Q. F., Lu, Y., Lu, Y., Lu, Z., Lukin, P., Luo, F. J., Luo, T., Luo, X. F., Lyu, H. J., Lyu, X. R., Ma, J. P., Ma, P., Ma, Y., Ma, Y. M., Maas, F., Malde, S., Matvienko, D., Meng, Z. X., Mitchell, R., Nefediev, A., Nefedov, Y., Olsen, S. L., Ouyang, Q., Pakhlov, P., Pakhlova, G., Pan, X., Pan, Y., Passemar, E., Pei, Y. P., Peng, H. P., Peng, L., Peng, X. Y., Peng, X. J., Peters, K., Pivovarov, S., Pyata, E., Qi, B. B., Qi, Y. Q., Qian, W. B., Qian, Y., Qiao, C. F., Qin, J. J., Qin, J. J., Qin, L. Q., Qin, X. S., Qiu, T. L., Rademacker, J., Redmer, C. F., Sang, H. Y., Saur, M., Shan, W., Shan, X. Y., Shang, L. L., Shao, M., Shekhtman, L., Shen, C. P., Shen, J. M., Shen, Z. T., Shi, H. C., Shi, X. D., Shwartz, B., Sokolov, A., Song, J. J., Song, W. M., Song, Y., Song, Y. X., Sukharev, A., Sun, J. F., Sun, L., Sun, X. M., Sun, Y. J., Sun, Z. P., Tang, J., Tang, S. S., Tang, Z. B., Tian, C. H., Tian, J. S., Tian, Y., Tikhonov, Y., Todyshev, K., Uglov, T., Vorobyev, V., Wan, B. D., Wang, B. L., Wang, B., Wang, D. Y., Wang, G. Y., Wang, G. L., Wang, H. L., Wang, J., Wang, J. H., Wang, J. C., Wang, M. L., Wang, R., Wang, R., Wang, S. B., Wang, W., Wang, W. P., Wang, X. C., Wang, X. D., Wang, X. L., Wang, X. L., Wang, X. P., Wang, X. F., Wang, Y. D., Wang, Y. P., Wang, Y. Q., Wang, Y. L., Wang, Y. G., Wang, Z. Y., Wang, Z. Y., Wang, Z. L., Wang, Z. G., Wei, D. H., Wei, X. L., Wei, X. M., Wen, Q. G., Wen, X. J., Wilkinson, G., Wu, B., Wu, J. J., Wu, L., Wu, P., Wu, T. W., Wu, Y. S., Xia, L., Xiang, T., Xiao, C. W., Xiao, D., Xiao, M., Xie, K. P., Xie, Y. H., Xing, Y., Xing, Z. Z., Xiong, X. N., Xu, F. R., Xu, J., Xu, L. L., Xu, Q. N., Xu, X. C., Xu, X. P., Xu, Y. C., Xu, Y. P., Xu, Y., Xu, Z. Z., Xuan, D. W., Xue, F. F., Yan, L., Yan, M. J., Yan, W. B., Yan, W. C., Yan, X. S., Yang, B. F., Yang, C., Yang, H. J., Yang, H. R., Yang, H. T., Yang, J. F., Yang, S. L., Yang, Y. D., Yang, Y. H., Yang, Y. S., Yang, Y. L., Yang, Z. W., Yang, Z. Y., Yao, D. L., Yin, H., Yin, X. H., Yokozaki, N., You, S. Y., You, Z. Y., Yu, C. X., Yu, F. S., Yu, G. L., Yu, H. L., Yu, J. S., Yu, J. Q., Yuan, L., Yuan, X. B., Yuan, Z. Y., Yue, Y. F., Zeng, M., Zeng, S., Zhang, A. L., Zhang, B. W., Zhang, G. Y., Zhang, G. Q., Zhang, H. J., Zhang, H. B., Zhang, J. Y., Zhang, J. L., Zhang, J., Zhang, L., Zhang, L. M., Zhang, Q. A., Zhang, R., Zhang, S. L., Zhang, T., Zhang, X., Zhang, Y., Zhang, Y. J., Zhang, Y. X., Zhang, Y. T., Zhang, Y. F., Zhang, Y. C., Zhang, Y., Zhang, Y., Zhang, Y. M., Zhang, Y. L., Zhang, Z. H., Zhang, Z. Y., Zhang, Z. Y., Zhao, H. Y., Zhao, J., Zhao, L., Zhao, M. G., Zhao, Q., Zhao, R. G., Zhao, R. P., Zhao, Y. X., Zhao, Z. G., Zhao, Z. X., Zhemchugov, A., Zheng, B., Zheng, L., Zheng, Q. B., Zheng, R., Zheng, Y. H., Zhong, X. H., Zhou, H. J., Zhou, H. Q., Zhou, H., Zhou, S. H., Zhou, X., Zhou, X. K., Zhou, X. P., Zhou, X. R., Zhou, Y. L., Zhou, Y., Zhou, Y. X., Zhou, Z. Y., Zhu, J. Y., Zhu, K., Zhu, R. D., Zhu, R. L., Zhu, S. H., Zhu, Y. C., Zhu, Z. A., Zhukova, V., Zhulanov, V., Zou, B. S., and Zuo, Y. B.
Published: 2024
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7. Molecular Characteristics and Antimicrobial Susceptibility Profiles of blaKPC-Producing Escherichia Coli Isolated from a Teaching Hospital in Shanghai, China

Author: Cao S, Jiang X, Suo J, Lu Y, Ju M, Zeng Q, Zheng Q, Zhang Z, and Tang W
Subjects: escherichia coli, blakpc, carbapenemases, plasmids typing, Infectious and parasitic diseases, RC109-216
Abstract: Shuaijun Cao,1,&ast; Xiaoying Jiang,2,&ast; Jinshan Suo,3 Yanyan Lu,2 Mohan Ju,2 Qixiang Zeng,1 Qingru Zheng,1 Zuoyan Zhang,1 Wenqi Tang1 1Department of Critical Care Medicine, Shanghai Sixth People’s Hospital, Shanghai, People’s Republic of China; 2Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 3Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zuoyan Zhang; Wenqi Tang, Department of Critical Care Medicine, Shanghai Sixth People’s Hospital, No. 600 Yishan Road, Shanghai, 200000, People’s Republic of China, Tel +86 021-24058331, Email 18930177049@189.cn; zhang_zy1969@163.comIntroduction: Carbapenem-Resistant Enterobacteriaceae (CRE) has posed a significant threat to humans.The aim of this study was to investigate the molecular characteristics of blaKPC-producing Escherichia coli in a university-affiliated tertiary hospital.Methods: Polymerase chain reaction (PCR) and BLAST+ software were used to detect the prevalence of blaKPC in E. coli and Klebsiella pneumoniae. Whole-genome sequencing was performed for the blaKPC-harboring clinical E. coli isolates. Antimicrobial resistance genes, MLSTs, KPC-carrying plasmid typing and genetic environment of blaKPC were analyzed. A maximum likelihood core single nucleotide polymorphism (SNP)-based phylogeny tree was constructed to determine the evolutionary relationships within this ST131 collection. Conjugation experiments were performed to determine the mobilization of blaKPC. The minimal inhibitory concentrations of the common antimicrobial agents were determined using the broth microdilution method.Results: The prevalence of blaKPC in 424 clinical E. coli isolates and 1636 E. coli strains from GenBank database were 2.2% (45/2060) whereas the detection rate of blaKPC in K. pneumoniae from the GenBank database was 29.8% (415/1394). The blaKPC-harboring conjugants exhibited resistance to multiple β-lactams, except for cefepime-zidebactam and ceftazidime-avibactam. All blaKPC-carring E. coli isolates were susceptible to tigecycline and polymyxin B. ST131 was the dominant sequence type of blaKPC-carring E. coli, accounting for 40.0% (18/45). Most of the blaKPC-producing ST131 E. coli (89.5%,17/19) belonged to clade C ST131 lineage. Genetic environment analysis revealed that 57.8% (26/45) of blaKPC gene was linked to Tn 4401-associated structure ISKpn6-blaKPC-ISKpn7. IncN was the most common plasmid type in KPC-producing E. coli whereas IncFII was the dominant plasmid type in KPC-producing K. pneumoniae.Conclusion: The detection rate of blaKPC was lower in E. coli compared with K. pneumoniae. The dominant sequence and plasmid types of blaKPC-harboring isolates differed between E. coli and K. pneumoniae. Further studies about the role of the defense system in acquisition of KPC-plasmids in E. coli will be performed to provide new insights into the low prevalence of blaKPC.Keywords: Escherichia coli, blaKPC, carbapenemases, plasmids typing
Published: 2024

8. Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy

Author: Zheng Q, Chen C, Liu Y, Gao J, Li L, Yin C, and Yuan X
Subjects: metal nanoparticles, wound healing, diabetic wound, drug delivery, antibacterial activity, Medicine (General), R5-920
Abstract: Qinzhou Zheng,1,&ast; Cuimin Chen,2,&ast; Yong Liu,3 Jie Gao,2,&ast; Luxin Li,1 Chuan Yin,4 Xiaohuan Yuan1 1College of Life Science, Mudanjiang Medical University, Mudanjiang, People’s Republic of China; 2Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China; 3Center for Comparative Medicine, Mudanjiang Medical University, Mudanjiang, People’s Republic of China; 4Department of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, 200003, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chuan Yin, Department of Gastroenterology, Shanghai Changzheng Hospital, Naval Medical, University, Shanghai, 200003, People’s Republic of China, Email ilse1225@163.com Xiaohuan Yuan, College of Life Science, Mudanjiang Medical University, Mudanjiang, 157001, Heilongjiang, People’s Republic of China, Tel/Fax +86-453-6984647, Email yuanxiaohuan@mdjmu.edu.cnAbstract: Diabetic wounds pose a significant challenge to public health, primarily due to insufficient blood vessel supply, bacterial infection, excessive oxidative stress, and impaired antioxidant defenses. The aforementioned condition not only places a significant physical burden on patients’ prognosis, but also amplifies the economic strain on the medical system in treating diabetic wounds. Currently, the effectiveness of available treatments for diabetic wounds is limited. However, there is hope in the potential of metal nanoparticles (MNPs) to address these issues. MNPs exhibit excellent anti-inflammatory, antioxidant, antibacterial and pro-angiogenic properties, making them a promising solution for diabetic wounds. In addition, MNPs stimulate the expression of proteins that promote wound healing and serve as drug delivery systems for small-molecule drugs. By combining MNPs with other biomaterials such as hydrogels and chitosan, novel dressings can be developed and revolutionize the treatment of diabetic wounds. The present article provides a comprehensive overview of the research progress on the utilization of MNPs for treating diabetic wounds. Building upon this foundation, we summarize the underlying mechanisms involved in diabetic wound healing and discuss the potential application of MNPs as biomaterials for drug delivery. Furthermore, we provide an extensive analysis and discussion on the clinical implementation of dressings, while also highlighting future prospects for utilizing MNPs in diabetic wound management. In conclusion, MNPs represent a promising strategy for the treatment of diabetic wound healing. Future directions include combining other biological nanomaterials to synthesize new biological dressings or utilizing the other physicochemical properties of MNPs to promote wound healing. Synthetic biomaterials that contain MNPs not only play a role in all stages of diabetic wound healing, but also provide a stable physiological environment for the wound-healing process.Keywords: metal nanoparticles, wound healing, diabetic wound, drug delivery, antibacterial activity
Published: 2024

9. Quercetin is a Potential Therapy for Rheumatoid Arthritis via Targeting Caspase-8 Through Ferroptosis and Pyroptosis

Author: Zheng Q, Wang D, Lin R, Chen Y, Xu Z, and Xu W
Subjects: rheumatoid arthritis, ferroptosis, pyroptosis, caspase-8, quercetin, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Qingcong Zheng,1,&ast; Du Wang,2,&ast; Rongjie Lin,3,&ast; Yuchao Chen,4 Zixing Xu,1 Weihong Xu1 1Department of Orthopedics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China; 2Arthritis Clinical and Research Center, Peking University People’s Hospital, Beijing, People’s Republic of China; 3Department of Orthopedic Surgery, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 4Department of Paediatrics, Fujian Provincial Hospital South Branch, Fuzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zixing Xu; Weihong Xu, Email xuzixing@fjmu.edu.cn; xuweihong815@126.comBackground: Rheumatoid arthritis (RA) is one of the most common chronic inflammatory autoimmune diseases. However, the underlying molecular mechanisms of its pathogenesis are unknown. This study aimed to identify the common biomarkers of ferroptosis and pyroptosis in RA and screen potential drugs.Methods: The RA-related differentially expressed genes (DEGs) in GSE55235 were screened by R software and intersected with ferroptosis and pyroptosis gene libraries to obtain differentially expressed ferroptosis-related genes (DEFRGs) and differentially expressed pyroptosis-related genes (DEPRGs). We performed Gene Ontology (GO), Kyoto Encyclopedia of the Genome (KEGG), ClueGO, and Protein-Protein Interaction (PPI) analysis for DEFRGs and DEPRGs and validated them by machine learning. The microRNA/transcription factor (TF)-hub genes regulatory network was further constructed. The key gene was validated using the GSE77298 validation set, cellular validation was performed in in vitro experiments, and immune infiltration analysis was performed using CIBERSORT. Network pharmacology was used to find key gene-targeting drugs, followed by molecular docking and molecular dynamics simulations to analyze the binding stability between small-molecule drugs and large-molecule proteins.Results: Three hub genes (CASP8, PTGS2, and JUN) were screened via bioinformatics, and the key gene (CASP8) was validated and obtained through the validation set, and the diagnostic efficacy was verified to be excellent through the receiver operating characteristic (ROC) curves. The ferroptosis and pyroptosis phenotypes were constructed by fibroblast-like synoviocytes (FLS), and caspase-8 was detected and validated as a common biomarker for ferroptosis and pyroptosis in RA, and quercetin can reduce caspase-8 levels. Quercetin was found to be a potential target drug for caspase-8 by network pharmacology, and the stability of their binding was further verified using molecular docking and molecular dynamics simulations.Conclusion: Caspase-8 is an important biomarker for ferroptosis and pyroptosis in RA, and quercetin is a potential therapy for RA via targeting caspase-8 through ferroptosis and pyroptosis.Keywords: rheumatoid arthritis, ferroptosis, pyroptosis, caspase-8, quercetin
Published: 2023

10. Anti-Glioma Effects of Ligustilide or n-Butylphthalide on Their Own and the Synergistic Effects with Temozolomide via PI3K/Akt Signaling Pathway

Author: Li ZQ, Zhang GS, Liu RQ, Shuai SY, Hu PY, Zheng Q, and Xiao SH
Subjects: ligustilide, n-butylphthalide, glioma, synergistic effect, pi3k/akt signaling pathway, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Zi-Qi Li,&ast; Guo-Song Zhang,&ast; Ri-Qun Liu, Shu-Yuan Shuai, Peng-Yi Hu, Qin Zheng, Shu-Hua Xiao Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, 330004, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Peng-Yi Hu; Qin Zheng, Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, 330004, People’s Republic of China, Tel/Fax +86 0791 87118658, Email hpy820515@126.com; zhengqin912006@163.comBackground: Ligustilide (LIG) and n-butylphthalide (NBP) have neuroprotective effects in cerebral ischemia; however, their roles in gliomas are not well-known.This study aimed to explore the anti-glioma effects of LIG and NBP individually and the synergistic effects of temozolomide (TMZ) via the PI3K/Akt Signaling Pathway.Materials and Methods: Cytotoxicity of LIG and NBP alone and in combination with TMZ in U251 cells was determined using the CCk-8. The effect of compounds alone or in combination on cell migration was detected using the wound healing assay, and the invasion was evaluated by transwell assays, respectively. Cell apoptosis was quantified by flow cytometry and the changed expressions of proteins were detected by Western blotting.Results: The results showed that LIG and NBP significantly inhibited the growth of U251 cells at concentrations of 4– 10 μg/mL and 1.5– 6 μg/mL in a dose-dependent manner (p< 0.05, p< 0.01). The combination of 20 μg/mL TMZ with LIG in the concentration range of 4– 10 μg/mL or with NBP of 0.5– 6 μg/mlachieved synergistic effect towardsU251 cells. LIG and NBP, alone or in combination with TMZ, markedly inhibited cell invasion (p< 0.001) and enhanced apoptosis (p< 0.05). The combination of TMZ with LIG or NBP markedly inhibited cell migration (p< 0.001). Western blot analysis showed that LIG, NBP, and TMZ, alone and in combination, significantly decreased the expression of Bcl-2, p-PI3K, and p-Akt, and increased the expression of Bax.Conclusion: Both LIG and NBP exert anti-glioma effects on their own through the PI3K/Akt pathway and enhance TMZ-mediated anti-glioma efficiency via the same pathway. Keywords: ligustilide, n-butylphthalide, glioma, synergistic effect, PI3K/Akt signaling pathway
Published: 2023

11. Epoch of Reionization Power Spectrum Limits from Murchison Widefield Array Data Targeted at EoR1 Field

Author: Rahimi, M., Pindor, B., Line, J. L. B., Barry, N., Trott, C. M., Webster, R. L., Jordan, C. H., Wilensky, M., Yoshiura, S., Beardsley, A., Bowman, J., Byrne, R., Chokshi, A., Hazelton, B. J., Hasegawa, K., Howard, E., Greig, B., Jacobs, D., Joseph, R., Kolopanis, M., Lynch, C., McKinley, B., Mitchell, D. A., Murray, S., Morales, M. F., Pober, J. C., Takahashi, K., Tingay, S. J., Wayth, R. B., Wyithe, J. S. B., and Zheng, Q.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: Current attempts to measure the 21cm Power Spectrum of neutral hydrogen during the Epoch of Reionization are limited by systematics which produce measured upper limits above both the thermal noise and the expected cosmological signal. These systematics arise from a combination of observational, instrumental, and analysis effects. In order to further understand and mitigate these effects, it is instructive to explore different aspects of existing datasets. One such aspect is the choice of observing field. To date, MWA EoR observations have largely focused on the EoR0 field. In this work, we present a new detailed analysis of the EoR1 field. The EoR1 field is one of the coldest regions of the Southern radio sky, but contains the very bright radio galaxy Fornax-A. The presence of this bright extended source in the primary beam of the interferometer makes the calibration and analysis of EoR1 particularly challenging. We demonstrate the effectiveness of a recently developed shapelet model of Fornax-A in improving the results from this field. We also describe and apply a series of data quality metrics which identify and remove systematically contaminated data. With substantially improved source models, upgraded analysis algorithms and enhanced data quality metrics, we determine EoR power spectrum upper limits based on analysis of the best $\sim$14-hours data observed during 2015 and 2014 at redshifts 6.5, 6.8 and 7.1, with the lowest $2\sigma$ upper limit at z=6.5 of $\Delta^2 \leq (73.78 ~\mathrm{mK)^2}$ at $k=0.13~\mathrm{h~ Mpc^{-1}}$, improving on previous EoR1 measurement results., Comment: 18 pages, 17 figures, Accepted for publication in MNRAS
Published: 2021
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12. Constraining the 21cm brightness temperature of the IGM at $z$=6.6 around LAEs with the Murchison Widefield Array

Author: Trott, Cathryn M., Jordan, C. H., Line, J. L. B., Lynch, C. R., Yoshiura, S., McKinley, B., Dayal, P., Pindor, B., Hutter, A., Takahashi, K., Wayth, R. B., Barry, N., Beardsley, A., Bowman, J., Byrne, R., Chokshi, A., Greig, B., Hasegawa, K., Hazelton, B. J., Howard, E., Jacobs, D., Kolopanis, M., Mitchell, D. A., Morales, M. F., Murray, S., Pober, J. C., Rahimi, M., Tingay, S. J., Webster, R. L., Wilensky, M., Wyithe, J. S. B., and Zheng, Q.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The locations of Ly-$\alpha$ emitting galaxies (LAEs) at the end of the Epoch of Reionisation (EoR) are expected to correlate with regions of ionised hydrogen, traced by the redshifted 21~cm hyperfine line. Mapping the neutral hydrogen around regions with detected and localised LAEs offers an avenue to constrain the brightness temperature of the Universe within the EoR by providing an expectation for the spatial distribution of the gas, thereby providing prior information unavailable to power spectrum measurements. We use a test set of 12 hours of observations from the Murchison Widefield Array (MWA) in extended array configuration, to constrain the neutral hydrogen signature of 58 LAEs, detected with the Subaru Hypersuprime Cam in the \textit{Silverrush} survey, centred on $z$=6.58. We assume that detectable emitters reside in the centre of ionised HII bubbles during the end of reionization, and predict the redshifted neutral hydrogen signal corresponding to the remaining neutral regions using a set of different ionised bubble radii. A prewhitening matched filter detector is introduced to assess detectability. We demonstrate the ability to detect, or place limits upon, the amplitude of brightness temperature fluctuations, and the characteristic HII bubble size. With our limited data, we constrain the brightness temperature of neutral hydrogen to $\Delta{\rm T}_B<$30 mK ($<$200 mK) at 95% (99%) confidence for lognormally-distributed bubbles of radii, $R_B =$ 15$\pm$2$h^{-1}$cMpc., Comment: 9 pages, 6 figures, accepted for publication in MNRAS
Published: 2021
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13. The GLEAM 200 MHz Local Radio Luminosity Function for AGN and Star-forming Galaxies

Author: Franzen, T. M. O., Seymour, N., Sadler, E. M., Mauch, T., White, S. V., Jackson, C. A., Chhetri, R., Quici, B., Bell, M. E., Callingham, J. R., Dwarakanath, K. S., For, B., Gaensler, B. M., Hancock, P. J., Hindson, L., Hurley-Walker, N., Johnston-Hollitt, M., Kapinska, A. D., Lenc, E., McKinley, B., Morgan, J., Offringa, A. R., Procopio, P., Staveley-Smith, L., Wayth, R. B., Wu, C., and Zheng, Q.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: The GaLactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) is a radio continuum survey at 76-227 MHz of the entire southern sky (Declination $<+30\deg$) with an angular resolution of $\approx 2$ arcmin. In this paper, we combine GLEAM data with optical spectroscopy from the 6dF Galaxy Survey to construct a sample of 1,590 local (median $z \approx 0.064$) radio sources with $S_{200\,\mathrm{MHz}} > 55$ mJy across an area of $\approx 16,700~\mathrm{deg}^{2}$. From the optical spectra, we identify the dominant physical process responsible for the radio emission from each galaxy: 73 per cent are fuelled by an active galactic nucleus (AGN) and 27 per cent by star formation. We present the local radio luminosity function for AGN and star-forming galaxies at 200 MHz and characterise the typical radio spectra of these two populations between 76 MHz and $\sim 1$ GHz. For the AGN, the median spectral index between 200 MHz and $\sim 1$ GHz, $\alpha_{\mathrm{high}}$, is $-0.600 \pm 0.010$ (where $S \propto \nu^{\alpha}$) and the median spectral index within the GLEAM band, $\alpha_{\mathrm{low}}$, is $-0.704 \pm 0.011$. For the star-forming galaxies, the median value of $\alpha_{\mathrm{high}}$ is $-0.650 \pm 0.010$ and the median value of $\alpha_{\mathrm{low}}$ is $-0.596 \pm 0.015$. Among the AGN population, flat-spectrum sources are more common at lower radio luminosity, suggesting the existence of a significant population of weak radio AGN that remain core-dominated even at low frequencies. However, around 4 per cent of local radio AGN have ultra-steep radio spectra at low frequencies ($\alpha_{\mathrm{low}} < -1.2$). These ultra-steep-spectrum sources span a wide range in radio luminosity, and further work is needed to clarify their nature., Comment: 28 pages, 18 figures, accepted for publication in PASA
Published: 2021
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14. A new MWA limit on the 21 cm Power Spectrum at Redshifts $\sim$ 13 $-$ 17

Author: Yoshiura, S., Pindor, B., Line, J. L. B., Barry, N., Trott, C. M., Beardsley, A., Bowman, J., Byrne, R., Chokshi, A., Hazelton, B. J., Hasegawa, K., Howard, E., Greig, B., Jacobs, D., Jordan, C. H., Joseph, R., Kolopanis, M., Lynch, C., McKinley, B., Mitchell, D. A., Morales, M. F., Murray, S. G., Pober, J. C., Rahimi, M., Takahashi, K., Tingay, S. J., Wayth, R. B., Webster, R. L., Wilensky, M., Wyithe, J. S. B., Zhang, Z., and Zheng, Q.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Observations in the lowest MWA band between $75-100$ MHz have the potential to constrain the distribution of neutral hydrogen in the intergalactic medium at redshift $\sim 13-17$. Using 15 hours of MWA data, we analyse systematics in this band such as radio-frequency interference (RFI), ionospheric and wide field effects. By updating the position of point sources, we mitigate the direction independent calibration error due to ionospheric offsets. Our calibration strategy is optimized for the lowest frequency bands by reducing the number of direction dependent calibrators and taking into account radio sources within a wider field of view. We remove data polluted by systematics based on the RFI occupancy and ionospheric conditions, finally selecting 5.5 hours of the cleanest data. Using these data, we obtain two sigma upper limits on the 21 cm power spectrum in the range of $0.1\lessapprox k \lessapprox 1 ~\rm ~h~Mpc^{-1}$ and at $z$=14.2, 15.2 and 16.5, with the lowest limit being $6.3\times 10^6 ~\rm mK^2$ at $\rm k=0.14 \rm ~h~Mpc^{-1}$ and at $z=15.2$ with a possibility of a few \% of signal loss due to direction independent calibration., Comment: 17 pages, 18 figures, accepted to MNRAS
Published: 2021
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15. Role and Therapeutic Targeting Strategies of Neutrophil Extracellular Traps in Inflammation

Author: Li X, Xiao S, Filipczak N, Yalamarty SSK, Shang H, Zhang J, and Zheng Q
Subjects: neutrophil extracellular traps, inflammation, targeted inhibition, nanotherapy, herbal medicine, Medicine (General), R5-920
Abstract: Xiang Li,1,&ast; Shanghua Xiao,2,&ast; Nina Filipczak,3 Satya Siva Kishan Yalamarty,3 Hongming Shang,4 Jing Zhang,2 Qin Zheng2 1National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People’s Republic of China; 2Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, People’s Republic of China; 3Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USA; 4Department of Biochemistry & Chemical Biology, Vanderbilt University, Nashville, TN, USA&ast;These authors contributed equally to this workCorrespondence: Jing Zhang; Qin Zheng, Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, 330004, People’s Republic of China, Email jing.zhang@jxutcm.edu.cn; 20060903@jxutcm.edu.cnAbstract: Neutrophil extracellular traps (NETs) are large DNA reticular structures secreted by neutrophils and decorated with histones and antimicrobial proteins. As a key mechanism for neutrophils to resist microbial invasion, NETs play an important role in the killing of microorganisms (bacteria, fungi, and viruses). Although NETs are mostly known for mediating microbial killing, increasing evidence suggests that excessive NETs induced by stimulation of physical and chemical components, microorganisms, and pathological factors can exacerbate inflammation and organ damage. This review summarizes the induction and role of NETs in inflammation and focuses on the strategies of inhibiting NETosis and the mechanisms involved in pathogen evasion of NETs. Furthermore, herbal medicine inhibitors and nanodelivery strategies improve the efficiency of inhibition of excessive levels of NETs.Graphical Abstract: Keywords: neutrophil extracellular traps, inflammation, targeted inhibition, nanotherapy, herbal medicine
Published: 2023

16. Parametric study of solid-solid translucent phase change materials in building windows

Author: Gao, Y, Zheng, Q, Jonsson, JC, Lubner, S, Curcija, C, Fernandes, L, Kaur, S, and Kohler, C
Subjects: Phase change material, PCM window, Building simulation, EnergyPlus, Building energy, Energy, Engineering, Economics
Abstract: Thermal energy storage and solar radiation management are crucial to improve the sustainability and energy efficiency of buildings. Compared with the implementation of phase change materials (PCMs) in opaque components, the energy saving potential of incorporating PCMs in transparent glazing windows is much less studied and not well understood. Here we present a comprehensive parametric study of novel PCM windows for building energy saving with a focus on optimizing and quantitatively distinguishing the contributions from the optical and thermal properties of the PCM, which is particularly useful for the design of solid-solid PCM windows. We investigate a reference commercial office building using EnergyPlus by developing an equivalent model of our PCM window that is compatible with EnergyPlus's modeling capabilities. Compared with a clear-clear double-pane window, the integration of 3 mm solid-solid PCMs with optimal properties in warm, mixed, and cold climates can respectively save up to 17.2%, 14.0%, and 5.8% energy for the HVAC (heating, ventilation, and air conditioning) system, and 9.4%, 6.7%, and 3.2% energy for the whole building. We also demonstrate that these energy savings are most sensitive to the solar absorptance of PCMs for all three climates. The optimal transition temperature varies with climate and is related to the climate and solar radiation heat gain. Other issues are also briefly discussed, such as hysteresis, window orientations, and the effect of interior lighting. Although the optimal PCM windows show energy saving performance comparable with low-emissivity windows, the PCM windows provide a unique advantage in terms of shifting HVAC loads which can provide benefits to the electrical grid.
Published: 2021

17. Deep multi-redshift limits on Epoch of Reionisation 21cm Power Spectra from Four Seasons of Murchison Widefield Array Observations

Author: Trott, Cathryn M., Jordan, C. H., Midgley, S., Barry, N., Greig, B., Pindor, B., Cook, J. H., Sleap, G., Tingay, S. J., Ung, D., Hancock, P., Williams, A., Bowman, J., Byrne, R., Chokshi, A., Hazelton, B. J., Hasegawa, K., Jacobs, D., Joseph, R. C., Li, W., Line, J. L. B, Lynch, C., McKinley, B., Mitchell, D. A., Morales, M. F., Ouchi, M., Pober, J. C., Rahimi, M., Takahashi, K., Wayth, R. B., Webster, R. L., Wilensky, M., Wyithe, J. S. B., Yoshiura, S., Zhang, Z., and Zheng, Q.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: We compute the spherically-averaged power spectrum from four seasons of data obtained for the Epoch of Reionisation (EoR) project observed with the Murchison Widefield Array (MWA). We measure the EoR power spectrum over $k= 0.07-3.0~h$Mpc$^{-1}$ at redshifts $z=6.5-8.7$. The largest aggregation of 110 hours on EoR0 high-band (3,340 observations), yields a lowest measurement of (43~mK)$^2$ = 1.8$\times$10$^3$ mK$^2$ at $k$=0.14~$h$Mpc$^{-1}$ and $z=6.5$ (2$\sigma$ thermal noise plus sample variance). Using the Real-Time System to calibrate and the CHIPS pipeline to estimate power spectra, we select the best observations from the central five pointings within the 2013--2016 observing seasons, observing three independent fields and in two frequency bands. This yields 13,591 2-minute snapshots (453 hours), based on a quality assurance metric that measures ionospheric activity. We perform another cut to remove poorly-calibrated data, based on power in the foreground-dominated and EoR-dominated regions of the two-dimensional power spectrum, reducing the set to 12,569 observations (419 hours). These data are processed in groups of 20 observations, to retain the capacity to identify poor data, and used to analyse the evolution and structure of the data over field, frequency, and data quality. We subsequently choose the cleanest 8,935 observations (298 hours of data) to form integrated power spectra over the different fields, pointings and redshift ranges., Comment: 19 pages, 29 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society
Published: 2020
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18. First Season MWA Phase II EoR Power Spectrum Results at Redshift 7

Author: Li, W., Pober, J. C., Barry, N., Hazelton, B. J., Morales, M. F., Trott, C. M., Lanman, A., Wilensky, M., Sullivan, I., Beardsley, A. P., Booler, T., Bowman, J. D., Byrne, R., Crosse, B., Emrich, D., Franzen, T. M. O., Hasegawa, K., Horsley, L., Johnston-Hollitt, M., Jacobs, D. C., Jordan, C. H., Joseph, R. C., Kaneuji, T., Kaplan, D. L., Kenney, D., Kubota, K., Line, J., Lynch, C., McKinley, B., Mitchell, D. A., Murray, S., Pallot, D., Pindor, B., Rahimi, M., Riding, J., Sleap, G., Steele, K., Takahashi, K., Tingay, S. J., Walker, M., Wayth, R. B., Webster, R. L., Williams, A., Wu, C., Wyithe, J. S. B., Yoshiura, S., and Zheng, Q.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The compact configuration of Phase II of the Murchison Widefield Array (MWA) consists of both a redundant subarray and pseudo-random baselines, offering unique opportunities to perform sky-model and redundant interferometric calibration. The highly redundant hexagonal cores give improved power spectrum sensitivity. In this paper, we present the analysis of nearly 40 hours of data targeting one of the MWA's EoR fields observed in 2016. We use both improved analysis techniques presented in Barry et al. (2019) as well as several additional techniques developed for this work, including data quality control methods and interferometric calibration approaches. We show the EoR power spectrum limits at redshift 6.5, 6.8 and 7.1 based on our deep analysis on this 40-hour data set. These limits span a range in $k$ space of $0.18$ $h$ $\mathrm{Mpc^{-1}}$ $
Published: 2019
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19. Bibliometric Analysis of Acupuncture Therapy for Cancer Pain Over the Past 10 Years

Author: Ling F, Qi W, Li X, Zhou J, Xiong J, Zhao Y, Zheng Q, and Liang F
Subjects: acupuncture analgesia, cancer, pain, bibliometric analysis, citespace, Medicine (General), R5-920
Abstract: Fayang Ling,1,&ast; Wenchuan Qi,1,&ast; Xiao Li,1,&ast; Jun Zhou,1 Jian Xiong,1 Yi Zhao,1 Qianhua Zheng,1 Fanrong Liang2 1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine/Clinical Research Center for Acupuncture and Moxibustion in Sichuan Province, Chengdu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Fanrong Liang, Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine/Clinical Research Center for Acupuncture and Moxibustion in Sichuan Province, Chengdu, People’s Republic of China, Tel +86 136 0805 8216, Fax +86-028-87683962, Email acuresearch@126.com Qianhua Zheng, Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China, Tel +86 189 0870 5127, Fax +86-028-87683962, Email zhengqianhua@cdutcm.edu.cnPurpose: Cancer pain is a common symptom of cancer patients and greatly affects quality of life. Acupuncture has certain curative effects on cancer pain. The aim of this study was to analyze and visualize the current status and research trend of acupuncture treatment for cancer pain over the last 10 years and provide directions for future development.Methods: A search of the Web of Science Core Collection from 2012– 01-01 to 2022– 08-20 was performed to collect studies related to acupuncture therapy for cancer pain. CiteSpace was used to conduct bibliometric analysis and visualization from the perspective of the volume of annual publications, journals, nations, institutions, authors, keywords, and references.Results: A total of 302 studies were included in the analysis. The number of publications increased steadily with some fluctuations over the past decade. Integrative Cancer Therapies was the journal with the most relevant publications, and the Journal of Clinical Oncology was the most frequently cited journal. China had the highest volume of publications, and the USA contributed most to international collaboration. The most prolific institution was Memorial Sloan Kettering Cancer Center. The most productive author was Mao JJ, and the most influential author was Lu WD. “Acupuncture” was the top keyword in frequency and centrality. The references with the highest frequency and centrality were published by HE, Y, and Ting Bao, respectively.Conclusion: A stable development trend has formed in this field. The overall collaborative network needs to be strengthened. Breast cancer and multiple myeloma, electroacupuncture and bee venom acupuncture, postoperative pain, peripheral neuropathic pain syndrome, and aromatase inhibitors-associated arthralgia syndrome are research hotspots in this field. Randomized controlled trials (RCTs), evidence-based evaluations and mechanisms (cancer-induced bone pain) are research trends and frontiers.Keywords: acupuncture analgesia, cancer, pain, bibliometric analysis, CiteSpace
Published: 2023

20. Preoperative Vitamin D Deficiency is Associated with Increased One-Year Mortality in Chinese Geriatric Hip Fracture Patients – A Propensity Score Matching Study

Author: Fu G, Wu R, Zhang R, Chen D, Li H, Zheng Q, and Ma Y
Subjects: vitamin d deficiency, mortality, hip fracture, propensity score match, chinese population, Geriatrics, RC952-954.6
Abstract: Guangtao Fu,1,&ast; Rongjie Wu,1,2,&ast; Ruiying Zhang,1,&ast; Duanyong Chen,1 Haotao Li,1 Qiujian Zheng,1,3 Yuanchen Ma1 1Department of Orthopedics, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China; 2Shantou University Medical College, Shantou, People’s Republic of China; 3The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yuanchen Ma, Tel +86-18688889132, Email myc998@qq.com; Qiujian Zheng, Tel +86-13802740561, Email zhengqiujian@gdph.org.cnBackground: Vitamin D deficiency is a common comorbidity in geriatric hip fracture patients. However, there is still an ongoing debate regarding the influence of preoperative Vitamin D status on postoperative mortality in hip fracture patients.Methods: Elderly patients (≥ 60 years) who underwent surgical interventions for unilateral hip fracture from 2015 to 2020 in our center were included. We retrospectively retrieved the demographic data from the electronic medical database. Preoperative serum total 25-hydroxy-Vitamin D was set as the independent variable and patients were classified as the Vitamin D deficiency (< 20ng/mL) and the control groups consequently. Clinical outcomes include all-cause mortality, walking ability, and major postoperative complications in the first postoperative year. Propensity score matching (PSM) was performed in a ratio of 1:1 in the two groups for further comparison.Results: A total of 210 patients were included and 121 patients (57.6%) were diagnosed with Vitamin D deficiency. Patients in the Vitamin D deficiency group were much older and therefore preferred peripheral nerve block, and had significantly higher proportions of females, preoperative dementia, higher ASA grade, and lower baseline serum albumin level. Overall, 79 patients were identified in the Vitamin D deficiency and control groups after PSM, respectively. Patients diagnosed with Vitamin D deficiency showed a significantly higher one-year mortality (21.5% vs 6.3%, P=0.011) and a much lower one-year independent walking rate (67.1% vs.84.8%, P=0.016) after the matching. Regarding the dataset before PSM and after PSM, the AUC for serum Vitamin D for predicting one-year mortality was 0.656 (P=0.006) and 0.695 (P=0.002), respectively.Conclusion: Our retrospective PSM-design study provides new evidence that Vitamin D deficiency was associated with a significantly higher mortality and poor walking ability in the first year after surgical intervention based on southern Chinese populations.Keywords: vitamin D deficiency, mortality, hip fracture, propensity score match, Chinese population
Published: 2023

21. Design of support structure for spatially small-spaced four-tube tunnels: A case study of the He'ao tunnel in China

Author: Xiao, M.Q., primary, Xu, C., additional, Zheng, Q., additional, and Peng, C.S., additional
Published: 2023
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22. Magnetic order in single crystals of Na3Co2SbO6 with a honeycomb arrangement of 3d$^7$ Co$^{2+}$ ions

Author: Yan, J. -Q., Okamoto, S., Wu, Y., Zheng, Q., Zhou, H. D., Cao, H. B., and McGuire, M. A.
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract: We have synthesized single crystals of Na$_3$Co$_2$SbO$_6$ and characterized the structure and magnetic order by measuring anisotropic magnetic properties, heat capacity, x-ray and neutron single crystal diffraction. Magnetic properties and specific heat of polycrystalline Na$_3$Co$_2$SbO$_6$ were also measured for comparison. Na$_3$Co$_2$SbO$_6$ crystallizes in a monoclinic structure (space group $C2/m$) with [Co$_2$SbO$_6$]$^{3-}$ layers separated by Na$^+$ ions. The temperature dependence of magnetic susceptibility shows significant anisotropic behavior in the whole temperature range 2\,K-350\,K investigated in this work. An effective moment of about 5.5\,$\mu_B$/Co$^{2+}$ from a Curie-Weiss fitting of the magnetic susceptibility is larger than the spin only value and signals significant orbital contribution. Na$_3$Co$_2$SbO$_6$ single crystal undergoes a transition into a long-range antiferromagnetically ordered state below $T_N$=5\,K. Neutron single crystal diffraction confirmed the zigzag magnetic structure with a propagation vector k\,=\,(0.5, 0.5, 0). The ordered moment is found to be 0.9\,$\mu_B$ at 4\,K and align along the crystallographic \textit{b}-axis. Density functional theory calculations suggest that the experimentally observed zigzag order is energetically competing with the Neel order. It is also found that the covalency between Co $d$ and O $p$ is quite strong and competes with the local spin-orbit coupling, suggesting a $J_{eff}$=1/2 ground state may not be realized in this compound.
Published: 2019
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23. Gridded and direct Epoch of Reionisation bispectrum estimates using the Murchison Widefield Array

Author: Trott, Cathryn M., Watkinson, Catherine A., Jordan, Christopher H., Yoshiura, Shintaro, Majumdar, Suman, Barry, N., Byrne, R., Hazelton, B. J., Hasegawa, K., Joseph, R., Kaneuji, T., Kubota, K., Li, W., Line, J., Lynch, C., McKinley, B., Mitchell, D. A., Morales, M. F., Murray, S., Pindor, B., Pober, J. C., Rahimi, M., Riding, J., Takahashi, K., Tingay, S. J., Wayth, R. B., Webster, R. L., Wilensky, M., Wyithe, J. S. B., Zheng, Q., Emrich, David, Beardsley, A. P., Booler, T., Crosse, B., Franzen, T. M. O., Horsley, L., Johnston-Hollitt, M., Kaplan, D. L., Kenney, D., Pallot, D., Sleap, G., Steele, K., Walker, M., Williams, A., and Wu, C.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: We apply two methods to estimate the 21~cm bispectrum from data taken within the Epoch of Reionisation (EoR) project of the Murchison Widefield Array (MWA). Using data acquired with the Phase II compact array allows a direct bispectrum estimate to be undertaken on the multiple redundantly-spaced triangles of antenna tiles, as well as an estimate based on data gridded to the $uv$-plane. The direct and gridded bispectrum estimators are applied to 21 hours of high-band (167--197~MHz; $z$=6.2--7.5) data from the 2016 and 2017 observing seasons. Analytic predictions for the bispectrum bias and variance for point source foregrounds are derived. We compare the output of these approaches, the foreground contribution to the signal, and future prospects for measuring the bispectra with redundant and non-redundant arrays. We find that some triangle configurations yield bispectrum estimates that are consistent with the expected noise level after 10 hours, while equilateral configurations are strongly foreground-dominated. Careful choice of triangle configurations may be made to reduce foreground bias that hinders power spectrum estimators, and the 21~cm bispectrum may be accessible in less time than the 21~cm power spectrum for some wave modes, with detections in hundreds of hours., Comment: 19 pages, 10 figures, accepted for publication in PASA
Published: 2019
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24. Robust statistics toward detection of the 21 cm signal from the Epoch of Reionisation

Author: Trott, Cathryn M., Fu, Shih Ching, Murray, Steven, Jordan, Christopher, Line, Jack, Barry, N., Byrne, R., Hazelton, B. J., Hasegawa, K., Joseph, R., Kaneuji, T., Kubota, K., Li, W., Lynch, C., McKinley, B., Mitchell, D. A., Morales, M. F., Pindor, B., Pober, J. C., Rahimi, M., Takahashi, K., Tingay, S. J., Wayth, R. B., Webster, R. L., Wilensky, M., Wyithe, J. S. B., Yoshiura, S., Zheng, Q., and Walker, M.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: We explore methods for robust estimation of the 21 cm signal from the Epoch of Reionisation (EoR). A Kernel Density Estimator (KDE) is introduced for measuring the spatial temperature fluctuation power spectrum from the EoR. The KDE estimates the underlying probability distribution function of fluctuations as a function of spatial scale, and contains different systematic biases and errors to the typical approach to estimating the fluctuation power spectrum. Extraction of histograms of visibilities allows moments analysis to be used to discriminate foregrounds from 21 cm signal and thermal noise. We use the information available in the histograms, along with the statistical dis-similarity of foregrounds from two independent observing fields, to robustly separate foregrounds from cosmological signal, while making no assumptions about the Gaussianity of the signal. Using two independent observing fields to robustly discriminate signal from foregrounds is crucial for the analysis presented in this paper. We apply the techniques to 13 hours of Murchison Widefield Array (MWA) EoR data over two observing fields. We compare the output to that obtained with a comparative power spectrum estimation method, and demonstrate the reduced foreground contamination using this approach. Using the second moment obtained directly from the KDE distribution functions yields a factor of 2-3 improvement in power for k < 0.3hMpc^{-1} compared with a matched delay space power estimator, while weighting data by additional statistics does not offer significant improvement beyond that available for thermal noise-only weights., Comment: 19 pages, 18 figures, accepted for publication in MNRAS
Published: 2019
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25. Murchison Widefield Array and XMM-Newton observations of the Galactic supernova remnant G5.9+3.1

Author: Onić, D., Filipović, M. D., Bojičić, I., Hurley-Walker, N., Arbutina, B., Pannuti, T. G., Maitra, C., Urošević, D., Haberl, F., Maxted, N., Wong, G. F., Rowell, G., Bell, M. E., Callingham, J. R., Dwarakanath, K. S., For, B. -Q., Hancock, P. J., Hindson, L., Johnston-Hollitt, M., Kapińska, A. D., Lenc, E., McKinley, B., Morgan, J., Offringa, A. R., Porter, L. E., Procopio, P., Staveley-Smith, L., Wayth, R. B., Wu, C., and Zheng, Q.
Subjects: Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract: In this paper we discuss the radio continuum and X-ray properties of the so-far poorly studied Galactic supernova remnant (SNR) G5.9+3.1. We present the radio spectral energy distribution (SED) of the Galactic SNR G5.9+3.1 obtained with the Murchison Widefield Array (MWA). Combining these new observations with the surveys at other radio continuum frequencies, we discuss the integrated radio continuum spectrum of this particular remnant. We have also analyzed an archival XMM-Newton observation, which represents the first detection of X-ray emission from this remnant. The SNR SED is very well explained by a simple power-law relation. The synchrotron radio spectral index of G5.9+3.1, is estimated to be 0.42$\pm$0.03 and the integrated flux density at 1GHz to be around 2.7Jy. Furthermore, we propose that the identified point radio source, located centrally inside the SNR shell, is most probably a compact remnant of the supernova explosion. The shell-like X-ray morphology of G5.9+3.1 as revealed by XMM-Newton broadly matches the spatial distribution of the radio emission, where the radio-bright eastern and western rims are also readily detected in the X-ray while the radio-weak northern and southern rims are weak or absent in the X-ray. Extracted MOS1+MOS2+PN spectra from the whole SNR as well as the north, east, and west rims of the SNR are fit successfully with an optically thin thermal plasma model in collisional ionization equilibrium with a column density N_H~0.80x$10^{22}$ cm$^{-2}$ and fitted temperatures spanning the range kT~0.14-0.23keV for all of the regions. The derived electron number densities n_e for the whole SNR and the rims are also roughly comparable (ranging from ~$0.20f^{-1/2}$ cm$^{-3}$ to ~$0.40f^{-1/2}$ cm$^{-3}$, where f is the volume filling factor). We also estimate the swept-up mass of the X-ray emitting plasma associated with G5.9+3.1 to be ~$46f^{-1/2}M_{\odot}$., Comment: Accepted for publication in A&A
Published: 2019
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26. No woman left behind: achieving cervical cancer elimination among women living with HIV

Author: Sharma, Kirthana, Machalek, Dorothy A, Toh, Zheng Q, Amenu, Demisew, Muchengeti, Mazvita, Ndlovu, Andrew K, Mremi, Alex, Mchome, Bariki, Vallely, Andrew J, Denny, Lynette, Rees, Helen, and Garland, Suzanne M
Published: 2023
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27. Dynamic Covalent Synthesis of Crystalline Porous Graphitic Frameworks

Author: Li, X, Wang, H, Chen, H, Zheng, Q, Zhang, Q, Mao, H, Liu, Y, Cai, S, Sun, B, Dun, C, Gordon, MP, Zheng, H, Reimer, JA, Urban, JJ, Ciston, J, Tan, T, Chan, EM, and Zhang, J
Subjects: Macromolecular and Materials Chemistry
Abstract: Porous graphitic framework (PGF) is a two-dimensional (2D) material that has emerging energy applications. An archetype contains stacked 2D layers, the structure of which features a fully annulated aromatic skeleton with embedded heteroatoms and periodic pores. Due to the lack of a rational approach in establishing in-plane order under mild synthetic conditions, the structural integrity of PGF has remained elusive and ultimately limited its material performance. Here, we report the discovery of the unusual dynamic character of the C=N bonds in the aromatic pyrazine ring system under basic aqueous conditions, which enables the successful synthesis of a crystalline porous nitrogenous graphitic framework with remarkable in-plane order, as evidenced by powder X-ray diffraction studies and direct visualization using high-resolution transmission electron microscopy. The crystalline framework displays superior performance as a cathode material for lithium-ion batteries, outperforming the amorphous counterparts in terms of capacity and cycle stability. Insertion of well-defined, evenly spaced nanoscale pores into the two-dimensional (2D) layers of graphene invokes exciting properties due to the modulation of its electronic band gaps and surface functionalities. A bottom-up synthesis approach to such porous graphitic frameworks (PGFs) is appealing but also remains a great challenge. The current methods of building covalent organic frameworks rely on a small collection of thermodynamically reversible reactions. Such reactions are, however, inadequate in generating a fully annulated aromatic skeleton in PGFs. With the discovery of dynamic pyrazine formation, we succeeded in applying this linking chemistry to obtain a crystalline PGF material, which has displayed high electrical conductivity and remarkable performance as a cathode material for lithium-ion batteries. We envision that the demonstrated success will open the door to a wide array of fully annulated 2D porous frameworks, which hold immense potential for clean energy applications. We report the unusual dynamic characteristics of the C=N bonds in the pyrazine ring promoted under basic aqueous conditions, which enables the successful synthesis of two-dimensional porous graphitic frameworks (PGFs) featuring fully annulated aromatic skeletons and periodic pores. The PGF displayed high electrical conductivity and remarkable performance as a cathode material for lithium-ion batteries, far outperforming the amorphous counterparts in terms of capacity and cycle stability.
Published: 2020

28. Analysis and improvement of the hot disk transient plane source method for low thermal conductivity materials

Author: Zheng, Q, Kaur, S, Dames, C, and Prasher, RS
Subjects: physics.app-ph, cond-mat.mtrl-sci, physics.ins-det, Mechanical Engineering & Transports, Mathematical Sciences, Physical Sciences, Engineering
Abstract: The hot disk transient plane source (TPS) method is a widely used standard technique (ISO 22007–2) for characterizing the thermal properties of materials, especially the thermal conductivity, k. Despite its well-established reliability for a wide variety of common materials, the hot disk TPS method is also known to suffer from substantial systematic errors when applied to low-k thermal insulation materials, because of the discrepancies between the idealized model used for data analysis and the actual heat transfer process. Here, we present a combined numerical and experimental study of the influence of the geometry of the hot disk sensor on the measured k value of low-k materials. We demonstrate that the error is strongly affected by the finite thickness and thermal mass of the sensor's insulation layer as well as the corresponding increase of the effective heater size beyond the radius of the embedded metal heater itself. We further numerically investigate the dependence of the error on the sample thermal properties, confirming that the errors are worse in low-k samples. A simple polynomial correction function is provided based on the numerical error analysis, which converts the apparent (erroneous) result from a standard hot disk TPS measurement to a more accurate value of k. To experimentally validate the conclusions from numerical simulations, standard polyimide (Kapton) sensors are systematically optimized (thinned) by etching and used to measure low-k materials, including a standard polystyrene foam, a commercial Airloy® x56 aerogel, and a commercial Hydrophobic Silica Disk aerogel from Aerogel Technologies, LLC. The experimental results clearly demonstrate the strong influence of the sensor thickness. The k results of these samples obtained using either the optimized sensor or the pristine sensor then corrected with the corresponding polynomial correction functions are in good agreement with the values measured independently using a steady-state heat flowmeter (HFM) method: whereas the raw values measured with the pristine sensor are in error by 35% and 40% compared to the HFM reference values for the Airloy® x56 and the hydrophobic aerogel, respectively, the correction function greatly reduces those errors to
Published: 2020

29. Clinical Feature, Lifestyle Behavior and Non-Communicable Diseases Comorbidities Among Psoriasis Patients in Shanghai: Gender Disparity Analysis Based on a Cross-Sectional Study

Author: Zheng Q, Kuai L, Jiang W, Qiang Y, Wei L, Chen S, Li B, and Wang R
Subjects: psoriasis, gender disparity, tobacco smoking, alcohol drinking, overweight, metabolic diseases, comorbidity, Dermatology, RL1-803
Abstract: Qi Zheng,1,&ast; Le Kuai,2,&ast; Wencheng Jiang,1,&ast; Yan Qiang,3 Lei Wei,2 Siting Chen,2 Bin Li,1 Ruiping Wang3,4 1Department of Traditional Chinese Medicine, Shanghai Skin Diseases Hospital, Tongji University, Shanghai, People’s Republic of China; 2Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3Clinical Research and Innovation Transformation Center, Shanghai Skin Diseases Hospital, Tongji University, Shanghai, People’s Republic of China; 4School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bin Li; Ruiping Wang, Email 18930568129@163.com; w19830901@126.comBackground: Gender difference is prevalent in clinical feature, disease severity for noncommunicable diseases (NCD), but studies on gender disparity in clinical feature, disease severity and NCD comorbidity among psoriasis patients are limited. This cross-sectional study explores gender differences in clinical feature, lifestyle behavior and NCD comorbidity among psoriasis patients.Methods: Psoriasis patients were recruited through cluster survey method in two hospitals, and questionnaire interviews were applied to collect the demographic feature, lifestyle habits, clinical feature and NCD among patients.Results: A total of 2102 psoriasis patients included 1332 males (63.4%), 70% were over 35 years old and approximately 50% of them were overweight or obesity. The median value for psoriasis initiation age and disease duration was 33 years old (34 for male and 32 for female) and 9 years (10 for male and 7 for female), respectively. The psoriasis recurrence was mainly in winter (73.4%) and autumn (34.2%) both for patients. The prevalence of tobacco smoking and alcohol drinking was 31.2% and 12.6%. Male patients had higher prevalence of tobacco smoking (odds ratio (OR) = 13.26, 95% confidence interval (CI): 9.54– 18.44) and alcohol drinking (OR = 14.44, 95% CI: 7.90– 26.40). The prevalence of diabetes, hypertension, hyperlipidemia, and metabolic syndrome were 13.2%, 28.5%, 23.4% and 21.5%, respectively. Male patients had higher prevalence of diabetes (OR = 1.53, 95% CI: 1.16– 2.02), hypertension (OR = 1.87, 95% CI: 1.52– 2.30), hyperlipidemia (OR = 2.34, 95% CI: 1.85– 2.95) and metabolic syndrome (OR = 2.06, 95% CI: 1.63– 2.62) than female patients. The proportions for 4 types of NCDs diagnosed after psoriasis onset were over 58%, which were also higher in males than females.Conclusion: Female patients had shorter disease duration and with less NCD, and male patients had more body weight issue, with fewer sleep time and higher prevalence of tobacco smoking and alcohol drinking and NCDs. We recommend that dermatologist should notice the gender disparity in psoriasis patients, which is helpful for the disease diagnosis and treatment.Keywords: psoriasis, gender disparity, tobacco smoking, alcohol drinking, overweight, metabolic diseases, comorbidity
Published: 2022

30. Leiomyoma with Bizarre Nuclei: A Current Update

Author: Guo E, Li C, Hu Y, Zhao K, Zheng Q, and Wang L
Subjects: diagnosis, histopathology, molecular genetics, imaging examination, treatment, prognosis, Gynecology and obstetrics, RG1-991
Abstract: Enhui Guo,1,2,&ast; Chengqian Li,2,3,&ast; Yanjiao Hu,4 Kongyuan Zhao,1,2 Qingmei Zheng,1,&ast; Liming Wang1,&ast; 1Department of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Qingdao Medical College, Qingdao University, Qingdao, People’s Republic of China; 3Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 4Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qingmei Zheng; Liming Wang, Department of Gynecology, The Affiliated Hospital of Qingdao University, No. 1677, Wutaishan Road, Huangdao District, Qingdao, Shandong, 266000, People’s Republic of China, Tel +86-18661806725 ; +86-18661807912, Email zhengqingmei0532@126.com; wlmqingyi@163.comAbstract: Leiomyoma with bizarre nuclei (LBN), also known as symplastic leiomyoma, is a histological subtype of benign leiomyoma with bizarre cells and nuclear atypia. Differentiating LBN from other benign leiomyoma subtypes, uterine smooth muscle tumors of uncertain malignant potential (STUMP), or leiomyosarcoma (LMS) can be diagnostically challenging owing to overlapping features in clinical presentation and pathologic morphological analysis. The difficulty of distinguishing LBN from other lesions, especially from LMS, and the potential of LBN for subsequent malignant transformation make LBN an important topic of research. Herein, we review the definition, diagnosis, treatment, and prognosis of LBN. Histopathological examination is essential for distinguishing LBN from other diseases. Pathology sampling and morphological examination remain the key to diagnosis. The newly established ancillary immunohistochemical (IHC) and molecular genetic analysis can be useful tools for differential diagnosis. Furthermore, serum biomarkers and imaging examination may also be useful diagnostic tools. Attention should be paid to the differentiation between LBN and LMS because morphological diagnosis may still be challenging in some cases. Some IHC markers of LBN have been identified, which may be helpful for differential diagnosis. Furthermore, the use of IHC panels as diagnostic markers may be advocated. Molecular genetic studies suggest that some genes can aid with the differential diagnosis between LBN and LMS. However, increasing evidence support the idea that LBN and LMS are molecularly related, indicating that LBN may represent a potentially malignant stage of precancerous progression. At present, conservative treatment is recommended for primary LBN, especially for patients desiring to retain fertility, but close follow-up with imaging examinations is required.Keywords: diagnosis, histopathology, molecular genetics, imaging examination, treatment, prognosis
Published: 2022

31. Machine Learning Models for Predicting the Risk of Hard-to-Heal Diabetic Foot Ulcers in a Chinese Population

Author: Wang S, Xia C, Zheng Q, Wang A, and Tan Q
Subjects: hard-to-heal, diabetic foot ulcers, machine learning, classification., Specialties of internal medicine, RC581-951
Abstract: Shiqi Wang,1 Chao Xia,2 Qirui Zheng,3 Aiping Wang,4 Qian Tan1 1Department of Burns and Plastic Surgery, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, People’s Republic of China; 2Department of Orthopedics, Air Force Hospital of Eastern Theater Command, Nanjing, People’s Republic of China; 3Software Institute, Nanjing University, Nanjing, People’s Republic of China; 4Department of Endocrinology, Air Force Hospital of Eastern Theater Command, Nanjing, People’s Republic of ChinaCorrespondence: Qian Tan, Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China, Tel +86 25 83106666, Email smmutanqian@sina.com Aiping Wang, Department of Endocrinology, Air Force Hospital of Eastern Theater Command, Nanjing, 210002, People’s Republic of China, Email wap454hospital@163.comBackground: Early detection of hard-to-heal diabetic foot ulcers (DFUs) is vital to prevent a poor prognosis. The purpose of this work was to employ clinical characteristics to create an optimal predictive model of hard-to-heal DFUs (failing to decrease by > 50% at 4 weeks) based on machine learning algorithms.Methods: A total of 362 DFU patients hospitalized in two tertiary hospitals in eastern China were enrolled in this study. The training dataset and validation dataset were split at a ratio of 7:3. Univariate logistic analysis and clinical experience were utilized to screen clinical characteristics as predictive features. The following six machine learning algorithms were used to build prediction models for differentiating hard-to-heal DFUs: support vector machine, the naïve Bayesian (NB) model, k-nearest neighbor, general linear regression, adaptive boosting, and random forest. Five cross-validations were employed to realize the model’s parameters. Accuracy, precision, recall, F1-scores, and AUCs were utilized to compare and evaluate the models’ efficacy. On the basis of the best model identified, the significance of each characteristic was evaluated, and then an online calculator was developed.Results: Independent predictors for model establishment included sex, insulin use, random blood glucose, wound area, diabetic retinopathy, peripheral arterial disease, smoking history, serum albumin, serum creatinine, and C-reactive protein. After evaluation, the NB model was identified as the most generalizable model, with an AUC of 0.864, a recall of 0.907, and an F1-score of 0.744. Random blood glucose, C-reactive protein, and wound area were determined to be the three most important influencing factors. A corresponding online calculator was created (https://predicthardtoheal.azurewebsites.net/).Conclusion: Based on clinical characteristics, machine learning algorithms can achieve acceptable predictions of hard-to-heal DFUs, with the NB model performing the best. Our online calculator can assist doctors in identifying the possibility of hard-to-heal DFUs at the time of admission to reduce the likelihood of a dismal prognosis.Keywords: hard-to-heal, diabetic foot ulcers, machine learning, classification
Published: 2022

32. Natural Products-Based Nanoformulations: A New Approach Targeting CSCs to Cancer Therapy

Author: Liao W, Li Y, Wang J, Zhao M, Chen N, Zheng Q, Wan L, Mou Y, Tang J, and Wang Z
Subjects: cancer, cancer stem cells, nanoformulations, natural products, targeted therapy, Medicine (General), R5-920
Abstract: Wenhao Liao,1,&ast; Yuchen Li,1,2,&ast; Jing Wang,3,&ast; Maoyuan Zhao,1 Nianzhi Chen,1 Qiao Zheng,1 Lina Wan,1 Yu Mou,1 Jianyuan Tang,1,4 Zhilei Wang1,4 1Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2College of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 3Department of Obstetrics and Gynecology, Bishan Hospital of Traditional Chinese Medicine, Chongqing, People’s Republic of China; 4TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jianyuan Tang; Zhilei Wang, Email tangjy@cdutcm.edu.cn; wangzl1993@outlook.comAbstract: Cancer stem cells (CSCs) lead to the occurrence and progression of cancer due to their strong tumorigenic, self-renewal, and multidirectional differentiation abilities. Existing cancer treatment methods cannot effectively kill or inhibit CSCs but instead enrich them and produce stronger proliferation, invasion, and metastasis capabilities, resulting in cancer recurrence and treatment resistance, which has become a difficult problem in clinical treatment. Therefore, targeting CSCs may be the most promising approach for comprehensive cancer therapy in the future. A variety of natural products (NP) have significant antitumor effects and have been identified to target and inhibit CSCs. However, pharmacokinetic defects and off-target effects have greatly hindered their clinical translation. NP-based nanoformulations (NPNs) have tremendous potential to overcome the disadvantages of NP against CSCs through site-specific delivery and by improving their pharmacokinetic parameters. In this review, we summarize the recent progress of NPNs targeting CSCs in cancer therapy, looking forward to transforming preclinical research results into clinical applications and bringing new prospects for cancer treatment.Keywords: cancer, cancer stem cells, nanoformulations, natural products, targeted therapy
Published: 2022

33. Outcomes Associated with 50 mg/d and 100 mg/d Aspirin for the Prevention and Management of Cardiovascular Disease in Chinese Elderly: Single-Center Interim Analysis of a Multicenter, Prospective, Observational Study

Author: Wang X, Wang H, Zheng Q, Geng H, Zhang J, Fan Y, Feng X, Chen X, and Liu M
Subjects: low-dose aspirin, effectiveness outcome, safety outcome, chinese elderly, Medicine (General), R5-920
Abstract: Xiting Wang, Hao Wang, Qin Zheng, Hui Geng, Jing Zhang, Yan Fan, Xueru Feng, Xiahuan Chen, Meilin Liu Department of Geriatrics, Peking University First Hospital, Beijing, People’s Republic of ChinaCorrespondence: Meilin Liu, Department of Geriatrics, Peking University First Hospital, Beijing, People’s Republic of China, Email liumeilin@hotmail.comPurpose: Although aspirin can effectively reduce the occurrence of atherothrombosis, it is significantly associated with increased bleeding, with elderly individuals being at increased risk of cardiovascular diseases (CVD) and hemorrhage. This study aims to evaluate the efficacy and safety of aspirin 50 mg/d and 100 mg/d for the prevention and management of CVD in Chinese elderly.Patients and Methods: The Low-dose Aspirin for Primary and Secondary Prevention of Cardiovascular Disease in the Elderly Study (LAPIS) is a multicenter, prospective, observational cohort study, this study was a single-center interim analysis of LAPIS. Patients aged ≥ 60 and required long-term aspirin for primary and secondary prevention of CVD were eligible. From Apr 1, 2019 to Feb 28, 2022, 165 patients who received 50 mg/d aspirin and 261 patients who received 100 mg/d aspirin were included in the study. The incidence of major cardiovascular events (MACEs), bleeding events, and gastrointestinal adverse events were compared between two groups.Results: After adjusting for patient characteristics using propensity score matching, aspirin 100 mg/d was associated with increased incidence rates of total bleeding events (28.34 vs.17.25 events/100 patient-years, HR 1.671, 95% CI 1.024– 2.712, P = 0.040) and minor bleeding events (27.63 vs.15.92 events/100 patient-years, HR 1.738, 95% CI 1.056– 2.861, P = 0.031), whereas the incidence of MACE (6.35 vs 6.65 events/100 patient-years, HR 0.921, 95% CI 0.399– 2.127, P = 0.848) and gastrointestinal adverse events (12.73 vs.10.42 events/100 patient-years, HR 1.206, 95% CI 0.623– 2.337, P = 0.578) were similar between the two groups. Multivariate Cox analysis identified that aspirin dose (100 mg/d vs. 50 mg/d, HR 1.918, 95% CI 1.137– 3.235, P = 0.015), concomitant use of other antiplatelets (HR 1.748, 95% CI 1.009– 3.028, P = 0.046) and anticoagulants (HR 2.501, 95% CI 1.287– 4.862, P = 0.007) were independently associated with bleeding events.Conclusion: 50 mg/d aspirin may be preferred to balance the safety and effectiveness in Chinese individuals over 60 years of age who need long-term aspirin for the prevention and management of CVD.Trial Registration: ChiCTR1900021980 (chictr.org.cn). Registered on 19 March 2019.Keywords: low-dose aspirin, effectiveness outcome, safety outcome, Chinese elderly
Published: 2022

34. Risk factors for gingival invagination: A retrospective study

Author: Han, M., primary, Li, S. H., additional, Yao, Y., additional, Zhao, Yijiao, additional, You, L. P., additional, Zheng, Q., additional, and Xu, X. M., additional
Published: 2024
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35. Simulation of microbial transport and petroleum hydrocarbon compound biodegradation in a fracture–matrix coupled system

Author: Li, J, primary, Feng, S J, additional, and Zheng, Q T, additional
Published: 2024
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36. Imaging the Photochemical Ring-Opening of 1,3-Cyclohexadiene by Ultrafast Electron Diffraction

Author: Wolf, T. J. A., Sanchez, D. M., Yang, J., Parrish, R. M., Nunes, J. P. F., Centurion, M., Coffee, R., Cryan, J. P., Gühr, M., Hegazy, K., Kirrander, A., Li, R. K., Ruddock, J., Shen, X., Veccione, T., Weathersby, S. P., Weber, P. M., Wilkin, K., Yong, H., Zheng, Q., Wang, X. J., Minitti, M. P., and Martínez, T. J.
Subjects: Physics - Chemical Physics
Abstract: The ultrafast photoinduced ring-opening of 1,3-cyclohexadiene constitutes a textbook example of electrocyclic reactions in organic chemistry and a model for photobiological reactions in vitamin D synthesis. Here, we present direct and unambiguous observation of the ring-opening reaction path on the femtosecond timescale and sub-{\AA}ngstr\"om length scale by megaelectronvolt ultrafast electron diffraction. We follow the carbon-carbon bond dissociation and the structural opening of the 1,3-cyclohexadiene ring by direct measurement of time-dependent changes in the distribution of interatomic distances. We observe a substantial acceleration of the ring-opening motion after internal conversion to the ground state due to steepening of the electronic potential gradient towards the product minima. The ring-opening motion transforms into rotation of the terminal ethylene groups in the photoproduct 1,3,5-hexatriene on the sub-picosecond timescale. Our work demonstrates the potential of megaelectronvolt ultrafast electron diffraction to elucidate photochemical reaction paths in organic chemistry.
Published: 2018
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37. Galactic synchrotron distribution derived from 152 HII region absorption features in the full GLEAM survey

Author: Su, H., Macquart, J. P., Hurley-Walker, N., McClure-Griffiths, N. M., Jackson, C. A., Tingay, S. J., Tian, W. W., Gaensler, B. M., McKinley, B., Kapińska, A. D., Hindson, L., Hancock, P., Wayth, R. B., Staveley-Smith, L., Morgan, J., Johnston-Hollitt, M., Lenc, E., Bell, M. E., Callingham, J. R., Dwarkanath, K. S., For, B. -Q., Offringa, A. R., Procopio, P., Wu, C., and Zheng, Q.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We derive the synchrotron distribution in the Milky Way disk from HII region absorption observations over -40{\deg} < l < 40{\deg} at six frequencies of 76.2, 83.8, 91.5, 99.2, 106.9, and 114.6 MHz with the GaLactic and Extragalactic All-sky Murchison widefield array survey (GLEAM). We develop a new method of emissivity calculation by taking advantage of the Haslam et al., (1981) map and known spectral indices, which enable us to simultaneously derive the emissivity and the optical depth of HII regions at each frequency. We show our derived synchrotron emissivities based on 152 absorption features of HII regions using both the method previously adopted in the literature and our improved method. We derive the synchrotron emissivity from HII regions to the Galactic edge along the line of sight and, for the first time, derive the emissivity from HII regions to the Sun. These results provide direct information on the distribution of the Galactic magnetic field and cosmic-ray electrons for future modelling., Comment: Accepted for publication in MNRAS, 20 pages, 9 figures, 2 tables
Published: 2018
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38. PandaX-II constraints on spin-dependent WIMP-nucleon effective interactions

Author: Xia, J, Abdukerim, A, Chen, W, Chen, X, Chen, Y, Cui, X, Fang, D, Fu, C, Giboni, K, Giuliani, F, Gu, L, Guo, X, Guo, Z, Han, K, He, C, He, S, Huang, D, Huang, X, Huang, Z, Ji, P, Ji, X, Ju, Y, Li, S, Lin, H, Liu, H, Liu, J, Ma, Y, Mao, Y, Ni, K, Ning, J, Ren, X, Shi, F, Tan, A, Wang, A, Wang, C, Wang, H, Wang, M, Wang, Q, Wang, S, Wang, X, Wang, Z, Wu, M, Wu, S, Xiao, M, Xie, P, Yan, B, Yang, J, Yang, Y, Yu, C, Yuan, J, Yue, J, Zhang, D, Zhang, H, Zhang, T, Zhao, L, Zheng, Q, Zhou, J, Zhou, N, Zhou, X, and Haxton, WC
Subjects: PandaX-II experiment, WIMP dark matter, Spin-dependent effective interactions, hep-ex, hep-ph, Nuclear & Particles Physics, Mathematical Physics, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics
Abstract: We present PandaX-II constraints on candidate WIMP-nucleon effective interactions involving the nucleon or WIMP spin, including, in addition to standard axial spin-dependent (SD) scattering, various couplings among vector and axial currents, magnetic and electric dipole moments, and tensor interactions. The data set corresponding to a total exposure of 54-ton-days is reanalyzed to determine constraints as a function of the WIMP mass and isospin coupling. We obtain WIMP-nucleon cross section bounds of 1.6×10 −41 cm 2 and 9.0×10 −42 cm 2 (90% c.l.) for neutron-only SD and tensor coupling, respectively, for a mass M WIMP ∼40GeV/c 2 . The SD limits are the best currently available for M WIMP >40GeV/c 2 . We show that PandaX-II has reached a sensitivity sufficient to probe a variety of other candidate spin-dependent interactions at the weak scale.
Published: 2019

39. Alkalized MXene-supported nanoscale zero-valent iron in situ derived from NH2-MIL-88B(Fe) for the highly efficient catalytic reduction of 4-nitrophenol

Author: Zhang, X., Sun, H., Huang, J., Zheng, Q., Zhang, F., Li, H., Zhang, M., Zeng, J., and Yan, Z.
Published: 2022
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40. Calibration and Stokes Imaging with Full Embedded Element Primary Beam Model for the Murchison Widefield Array

Author: Sokolowski, M., Colegate, T., Sutinjo, A. T., Ung, D., Wayth, R. B., Hurley-Walker, N., Lenc, E., Pindor, B., Morgan, J., Kaplan, D. L., Bell, M. E., Callingham, J. R., Dwarakanath, K. S., For, Bi-Qing, Gaensler, B. M., Hancock, P. J., Hindson, L., Johnston-Hollitt, M., Kapińska, A. D., McKinley, B., Offringa, A. R., Procopio, P., Staveley-Smith, L., Wu, C., and Zheng, Q.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The Murchison Widefield Array (MWA), located in Western Australia, is one of the low-frequency precursors of the international Square Kilometre Array (SKA) project. In addition to pursuing its own ambitious science program, it is also a testbed for wide range of future SKA activities ranging from hardware, software to data analysis. The key science programs for the MWA and SKA require very high dynamic ranges, which challenges calibration and imaging systems. Correct calibration of the instrument and accurate measurements of source flux densities and polarisations require precise characterisation of the telescope's primary beam. Recent results from the MWA GaLactic Extragalactic All-sky MWA (GLEAM) survey show that the previously implemented Average Embedded Element (AEE) model still leaves residual polarisations errors of up to 10-20 % in Stokes Q. We present a new simulation-based Full Embedded Element (FEE) model which is the most rigorous realisation yet of the MWA's primary beam model. It enables efficient calculation of the MWA beam response in arbitrary directions without necessity of spatial interpolation. In the new model, every dipole in the MWA tile (4 x 4 bow-tie dipoles) is simulated separately, taking into account all mutual coupling, ground screen and soil effects, and therefore accounts for the different properties of the individual dipoles within a tile. We have applied the FEE beam model to GLEAM observations at 200 - 231 MHz and used false Stokes parameter leakage as a metric to compare the models. We have determined that the FEE model reduced the magnitude and declination-dependent behaviour of false polarisation in Stokes Q and V while retaining low levels of false polarisation in Stokes U., Comment: 15 pages, 11 figures. Accepted for publication in PASA
Published: 2017
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41. The Spectral Energy Distribution of Powerful Starburst Galaxies I: Modelling the Radio Continuum

Author: Galvin, T J, Seymour, N, Marvil, J, Filipovic, M D, Tothill, N F H, McDermid, R M, Hurley-Walker, N, Hancock, P J, Callingham, J R, Cook, R H, Norris, R P, Bell, M E, Dwarakanath, K S, For, B, Gaensler, B M, Hindson, L, Johnston-Hollitt, M, Kapińska, A D, Lenc, E, McKinley, B, Morgan, J, Offringa, A R, Procopio, P, Staveley-Smith, L, Wayth, R B, Wu, C, and Zheng, Q
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We have acquired radio continuum data between 70\,MHz and 48\,GHz for a sample of 19 southern starburst galaxies at moderate redshifts ($0.067 < z < 0.227$) with the aim of separating synchrotron and free-free emission components. Using a Bayesian framework we find the radio continuum is rarely characterised well by a single power law, instead often exhibiting low frequency turnovers below 500\,MHz, steepening at mid-to-high frequencies, and a flattening at high frequencies where free-free emission begins to dominate over the synchrotron emission. These higher order curvature components may be attributed to free-free absorption across multiple regions of star formation with varying optical depths. The decomposed synchrotron and free-free emission components in our sample of galaxies form strong correlations with the total-infrared bolometric luminosities. Finally, we find that without accounting for free-free absorption with turnovers between 90 to 500\,MHz the radio-continuum at low frequency ($\nu < 200$\,MHz) could be overestimated by upwards of a factor of twelve if a simple power law extrapolation is used from higher frequencies. The mean synchrotron spectral index of our sample is constrained to be $\alpha=-1.06$, which is steeper then the canonical value of $-0.8$ for normal galaxies. We suggest this may be caused by an intrinsically steeper cosmic ray distribution.
Published: 2017
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42. Magnetism out of disorder in a J=0 compound Ba2YIrO6

Author: Chen, Q., Svoboda, C., Zheng, Q., Sales, B. C., Mandrus, D. G., Zhou, H. D., Zhou, J. -S., McComb, D., Randeria, M., Trivedi, N., and Yan, J. -Q.
Subjects: Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract: We systematically investigate the magnetic properties and local structure of Ba2YIrO6 to demonstrate that Y and Ir lattice defects in the form of antiphase boundary or clusters of antisite disorder affect the magnetism observed in this $d^4$ compound. We compare the magnetic properties and atomic imaging of (1) a slow cooled crystal, (2) a crystal quenched from 900\degree C after growth, and (3) a crystal grown using a faster cooling rate than the slow cooled one. Atomic imaging by scanning transmission electron microscopy (STEM) shows that quenching from 900oC introduces antiphase boundary to the crystals, and a faster cooling rate during crystal growth leads to clusters of Y and Ir antisite disorder. STEM study suggests the antiphase boundary region is Ir-rich with a composition of Ba2YIrO6. The magnetic measurements show that Ba2YIrO6 crystals with clusters of antisite defects have a larger effective moment and a larger saturation moment than the slow-cooled crystals. Quenched crystals with Ir-rich antiphase boundary shows a slightly suppressed saturation moment than the slow cooled crystals, and this seems to suggest that antiphase boundary is detrimental to the moment formation. Our DFT calculations suggest magnetic condensation is unlikely as the energy to be gained from superexchange is small compared to the spin-orbit gap. However, once Y is replaced by Ir in the antisite disordered region, the picture of local non-magnetic singlets breaks down and magnetism can be induced. This is because of (a) enhanced interactions due to increased overlap of orbitals between sites, and, (b) increased number of orbitals mediating the interactions. Our work highlights the importance of lattice defects in understanding the experimentally observed magnetism in Ba2YIrO6 and other J=0 systems.
Published: 2017
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43. Coupling of structure to magnetic and superconducting orders in quasi-one-dimensional $\text{K}_2\text{Cr}_3\text{As}_3$

Author: Taddei, K. M., Zheng, Q., Sefat, A. S., and de la Cruz, C.
Subjects: Condensed Matter - Superconductivity
Abstract: Quasi-one-dimensional $A_2\text{Cr}_3\text{As}_3$ (with $A = \text{K, Cs, Rb}$) is an intriguing new family of superconductors which exhibit many similar features to the cuprate and iron-based unconventional superconductor families. Yet in contrast to these systems, no charge or magnetic ordering has been observed which could provide the electronic correlations presumed necessary for an unconventional superconducting pairing mechanism - an absence which defies predictions of first principles models. We report the results of neutron scattering experiments on polycrystalline $\text{K}_2\text{Cr}_3\text{As}_3$ $(T_c \sim 7\text{K})$ which probed the low temperature dynamics near $T_c$ . Neutron diffraction data evidence a strong response of the nuclear lattice to the onset of superconductivity while inelastic scattering reveals a highly dispersive column of intensity at the commensurate wavevector $q = (00\frac{1}{2})$ which loses intensity beneath $T_c$ - indicative of short-range magnetic fluctuations. Using linear spin-wave theory we model the observed scattering and suggest a possible structure to the short-range magnetic order. These observations suggest that $\text{K}_2\text{Cr}_3\text{As}_3$ is in close proximity to a magnetic instability and that the incipient magnetic order both couples strongly to the lattice and competes with superconductivity - in direct analogy with the iron-based superconductors.
Published: 2017
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44. Diffuse galaxy cluster emission at 168 MHz within the Murchison Widefield Array Epoch of Reionization 0-hour field

Author: Duchesne, S. W., Johnston-Hollitt, M., Offringa, A. R., Pratt, G. W., Zheng, Q., and Dehghan, S.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: We detect and characterise extended, diffuse radio emission from galaxy clusters at 168 MHz within the Epoch of Reionization 0-hour field: a $45^\circ \times 45^\circ$ region of the southern sky centred on R.~A.${}= 0^\circ$, decl.${}=-27^\circ$. We detect 29 sources of interest; a newly detected halo in Abell 0141; a newly detected relic in Abell 2751; 4 new halo candidates and a further 4 new relic candidates; and a new phoenix candidate in Abell 2556. Additionally, we find 9 clusters with unclassifiable, diffuse steep-spectrum emission as well as a candidate double relic system associated with RXC J2351.0-1934. We present measured source properties such as their integrated flux densities, spectral indices ($\alpha$, where $S_\nu \propto \nu^\alpha$), and sizes where possible. We find several of the diffuse sources to have ultra-steep spectra including the halo in Abell 0141, if confirmed, showing $\alpha \leq -2.1 \pm 0.1$ with the present data making it one of the steepest-spectrum haloes known. Finally, we compare our sample of haloes with previously detected haloes and revisit established scaling relations of the radio halo power ($P_{1.4}$) with the cluster X-ray luminosity ($L_{\mathrm{X}}$) and mass ($M_{500}$). We find that the newly detected haloes and candidate haloes are consistent with the $P_{1.4}$-$L_{\mathrm{X}}$ and $P_{1.4}$-$M_{500}$ relations, and see an increase in scatter in the previously found relations with increasing sample size likely caused by inhomogeneous determination of $P_{1.4}$ across the full halo sample. We show that the MWA is capable of detecting haloes and relics within most of the galaxy clusters within the Planck catalogue of Sunyaev-Zel'dovich sources depending on exact halo or relic properties., Comment: Accepted for publication in PASA, 30 pages, 40 figures
Published: 2017
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45. A high resolution foreground model for the MWA EoR1 field: model and implications for EoR power spectrum analysis

Author: Procopio, P., Wayth, R. B., Line, J., Trott, C. M., Intema, H. T., Mitchell, D. A., Pindor, B., Riding, J., Tingay, S. J., Bell, M. E., Callingham, J. R., Dwarakanath, K. S., For, Bi-Qing, Gaensler, B. M., Hancock, P. J., Hindson, L., Hurley-Walker, N., Johnston-Hollitt, M., Kapińnska, A. D., Lenc, E., McKinley, B., Morgan, J., Offringa, A., Staveley-Smith, L., Wu, Chen, and Zheng, Q.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: The current generation of experiments aiming to detect the neutral hydrogen signal from the Epoch of Reionisation (EoR) is likely to be limited by systematic effects associated with removing foreground sources from target fields. In this paper we develop a model for the compact foreground sources in one of the target fields of the MWA's EoR key science experiment: the `EoR1' field. The model is based on both the MWA's GLEAM survey and GMRT 150 MHz data from the TGSS survey, the latter providing higher angular resolution and better astrometric accuracy for compact sources than is available from the MWA alone. The model contains 5049 sources, some of which have complicated morphology in MWA data, Fornax A being the most complex. The higher resolution data show that 13% of sources that appear point-like to the MWA have complicated morphology such as double and quad structure, with a typical separation of 33~arcsec. We derive an analytic expression for the error introduced into the EoR two-dimensional power spectrum due to peeling close double sources as single point sources and show that for the measured source properties, the error in the power spectrum is confined to high $k_\bot$ modes that do not affect the overall result for the large-scale cosmological signal of interest. The brightest ten mis-modelled sources in the field contribute 90% of the power bias in the data, suggesting that it is most critical to improve the models of the brightest sources. With this hybrid model we reprocess data from the EoR1 field and show a maximum of 8% improved calibration accuracy and a factor of two reduction in residual power in $k$-space from peeling these sources. Implications for future EoR experiments including the SKA are discussed in relation to the improvements obtained., Comment: 16 pages, 8 figures, 3 tables. Accepted for publication in PASA
Published: 2017
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46. Low frequency spectral energy distributions of radio pulsars detected with the Murchison Widefield Array

Author: Murphy, Tara, Kaplan, David L., Bell, Martin E., Callingham, J. R., Croft, Steve, Johnston, Simon, Dobie, Dougal, Zic, Andrew, Hughes, Jake, Lynch, Christene, Hancock, Paul, Hurley-Walker, Natasha, Lenc, Emil, Dwarakanath, K. S., For, B. -Q., Gaensler, B. M., Hindson, L., Johnston-Hollitt, M., Kapinska, A. D., McKinley, B., Morgan, J., Offringa, A. R., Procopio, P., Staveley-Smith, L., Wayth, R., Wu, C., and Zheng, Q.
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract: We present low-frequency spectral energy distributions of 60 known radio pulsars observed with the Murchison Widefield Array (MWA) telescope. We searched the GaLactic and Extragalactic All-sky MWA (GLEAM) survey images for 200-MHz continuum radio emission at the position of all pulsars in the ATNF pulsar catalogue. For the 60 confirmed detections we have measured flux densities in 20 x 8 MHz bands between 72 and 231 MHz. We compare our results to existing measurements and show that the MWA flux densities are in good agreement., Comment: 20 pages. Accepted for publication in PASA
Published: 2017
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47. Spectral energy distribution and radio halo of NGC 253 at low radio frequencies

Author: Kapinska, A. D., Staveley-Smith, L., Crocker, R., Meurer, G. R., Bhandari, S., Hurley-Walker, N., Offringa, A. R., Hanish, D. J., Seymour, N., Ekers, R. D., Bell, M. E., Callingham, J. R., Dwarakanath, K. S., For, B. -Q., Gaensler, B. M., Hancock, P. J., Hindson, L., Johnston-Hollitt, M., Lenc, E., McKinley, B., Morgan, J., Procopio, P., Wayth, R. B., Wu, C., Zheng, Q., Barry, N., Beardsley, A. P., Bowman, J. D., Briggs, F., Carroll, P., Dillon, J. S., Ewall-Wice, A., Feng, L., Greenhill, L. J., Hazelton, B. J., Hewitt, J. N., Jacobs, D. J., Kim, H. -S., Kittiwisit, P., Line, J., Loeb, A., Mitchell, D. A., Morales, M. F., Neben, A. R., Paul, S., Pindor, B., Pober, J. C., Riding, J., Sethi, S. K., Shankar, N. Udaya, Subrahmanyan, R., Sullivan, I. S., Tegmark, M., Thyagarajan, N., Tingay, S. J., Trott, C. M., Webster, R. L., Wyithe, S. B., Cappallo, R. J., Deshpande, A. A., Kaplan, D. L., Lonsdale, C. J., McWhirter, S. R., Morgan, E., Oberoi, D., Ord, S. M., Prabu, T., Srivani, K. S., Williams, A., and Williams, C. L.
Subjects: Astrophysics - Astrophysics of Galaxies
Abstract: We present new radio continuum observations of NGC253 from the Murchison Widefield Array at frequencies between 76 and 227 MHz. We model the broadband radio spectral energy distribution for the total flux density of NGC253 between 76 MHz and 11 GHz. The spectrum is best described as a sum of central starburst and extended emission. The central component, corresponding to the inner 500pc of the starburst region of the galaxy, is best modelled as an internally free-free absorbed synchrotron plasma, with a turnover frequency around 230 MHz. The extended emission component of the NGC253 spectrum is best described as a synchrotron emission flattening at low radio frequencies. We find that 34% of the extended emission (outside the central starburst region) at 1 GHz becomes partially absorbed at low radio frequencies. Most of this flattening occurs in the western region of the SE halo, and may be indicative of synchrotron self-absorption of shock re-accelerated electrons or an intrinsic low-energy cut off of the electron distribution. Furthermore, we detect the large-scale synchrotron radio halo of NGC253 in our radio images. At 154 - 231 MHz the halo displays the well known X-shaped/horn-like structure, and extends out to ~8kpc in z-direction (from major axis)., Comment: Accepted for publication in Astrophysical Journal on 06 February 2017
Published: 2017
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48. A study of halo and relic radio emission in merging clusters using the Murchison Widefield Array

Author: George, L. T., Dwarakanath, K. S., Johnston-Hollitt, M., Intema, H. T., Hurley-Walker, N., Bell, M. E., Callingham, J. R., For, Bi-Qing, Gaensler, B., Hancock, P. J., Hindson, L., Kapińska, A. D., Lenc, E., McKinley, B., Morgan, J., Offringa, A., Procopio, P., Staveley-Smith, L., Wayth, R. B., Wu, Chen, and Zheng, Q.
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: We have studied radio haloes and relics in nine merging galaxy clusters using the Murchison Widefield Array (MWA). The images used for this study were obtained from the GaLactic and Extragalactic All-sky MWA (GLEAM) Survey which was carried out at 5 frequencies, viz. 88, 118, 154, 188 and 215 MHz. We detect diffuse radio emission in 8 of these clusters. We have estimated the spectra of haloes and relics in these clusters over the frequency range 80-1400 MHz; the first such attempt to estimate their spectra at low frequencies. The spectra follow a power law with a mean value of $\alpha = -1.13\pm0.21$ for haloes and $\alpha = -1.2\pm0.19$ for relics where, $S \propto \nu^{\alpha}$. We reclassify two of the cluster sources as radio galaxies. The low frequency spectra are thus an independent means of confirming the nature of cluster sources. Five of the nine clusters host radio haloes. For the remaining four clusters, we place upper limits on the radio powers of possible haloes in them. These upper limits are a factor of 2-20 below those expected from the $L_{\rm X}-P_{\rm 1.4}$ relation. These limits are the lowest ever obtained and the implications of these limits to the hadronic model of halo emission are discussed., Comment: 15 pages, 4 figures, accepted to MNRAS
Published: 2017
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49. Extragalactic Peaked-Spectrum Radio Sources at Low Frequencies

Author: Callingham, J. R., Ekers, R. D., Gaensler, B. M., Line, J. L. B., Hurley-Walker, N., Sadler, E. M., Tingay, S. J., Hancock, P. J., Bell, M. E., Dwarakanath, K. S., For, B. -Q., Franzen, T. M. O., Hindson, L., Johnston-Hollitt, M., Kapinska, A. D., Lenc, E., McKinley, B., Morgan, J., Offringa, A. R., Procopio, P., Staveley-Smith, L., Wayth, R. B., Wu, C., and Zheng, Q.
Subjects: Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract: We present a sample of 1,483 sources that display spectral peaks between 72 MHz and 1.4 GHz, selected from the GaLactic and Extragalactic All-sky Murchison Widefield Array (GLEAM) survey. The GLEAM survey is the widest fractional bandwidth all-sky survey to date, ideal for identifying peaked-spectrum sources at low radio frequencies. Our peaked-spectrum sources are the low frequency analogues of gigahertz-peaked spectrum (GPS) and compact-steep spectrum (CSS) sources, which have been hypothesized to be the precursors to massive radio galaxies. Our sample more than doubles the number of known peaked-spectrum candidates, and 95% of our sample have a newly characterized spectral peak. We highlight that some GPS sources peaking above 5 GHz have had multiple epochs of nuclear activity, and demonstrate the possibility of identifying high redshift ($z > 2$) galaxies via steep optically thin spectral indices and low observed peak frequencies. The distribution of the optically thick spectral indices of our sample is consistent with past GPS/CSS samples but with a large dispersion, suggesting that the spectral peak is a product of an inhomogeneous environment that is individualistic. We find no dependence of observed peak frequency with redshift, consistent with the peaked-spectrum sample comprising both local CSS sources and high-redshift GPS sources. The 5 GHz luminosity distribution lacks the brightest GPS and CSS sources of previous samples, implying that a convolution of source evolution and redshift influences the type of peaked-spectrum sources identified below 1 GHz. Finally, we discuss sources with optically thick spectral indices that exceed the synchrotron self-absorption limit., Comment: Accepted for publication in ApJ on 2017 Jan 04. 28 pages, 24 figures. Data tables, and the appendix containing all of the SEDs, are available from the journal and on request to the author
Published: 2017
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50. Enhancing trainee performance in obstetric ultrasound through an artificial intelligence system: randomized controlled trial.

Author: Lei, T., Zheng, Q., Feng, J., Zhang, L., Zhou, Q., He, M., Lin, M., and Xie, H. N.
Subjects: *ARTIFICIAL intelligence, *CYCLING training, *RANDOMIZED controlled trials, *PREGNANT women, *TEST scoring
Abstract: ABSTRACT Objective Methods Results Conclusion Performing obstetric ultrasound scans is challenging for inexperienced operators; therefore, the prenatal screening artificial intelligence system (PSAIS) software was developed to provide real‐time feedback and guidance for trainees during their scanning procedures. The aim of this study was to investigate the potential benefits of utilizing such an artificial intelligence system to enhance the efficiency of obstetric ultrasound training in acquiring and interpreting standard basic views.A prospective, single‐center randomized controlled study was conducted at The First Affiliated Hospital of Sun Yat‐sen University. From September 2022 to April 2023, residents with no prior obstetric ultrasound experience were recruited and assigned randomly to either a PSAIS‐assisted training group or a conventional training group. Each trainee underwent a four‐cycle practical scan training program, performing 20 scans in each cycle on pregnant volunteers at 18–32 gestational weeks, focusing on acquiring and interpreting standard basic views. At the end of each cycle, a test scan evaluated trainees' ability to obtain standard ultrasound views without PSAIS assistance, and image quality was rated by both the trainees themselves and an expert (in a blinded manner). The primary outcome was the number of training cycles required for each trainee to meet a certain standard of proficiency (i.e. end‐of‐cycle test scored by the expert at ≥ 80%). Secondary outcomes included the expert ratings of the image quality in each trainee's end‐of‐cycle test and the discordance between ratings by trainees and the expert.In total, 32 residents and 1809 pregnant women (2720 scans) were recruited for the study. The PSAIS‐assisted trainee group required significantly fewer training cycles compared with the non‐PSAIS‐assisted group to meet quality requirements (P = 0.037). Based on the expert ratings of image quality, the PSAIS‐assisted training group exhibited superior ability in acquiring standard imaging views compared with the conventional training group in the third (P = 0.012) and fourth (P < 0.001) cycles. In both groups, the discordance between trainees' ratings of the quality of their own images and the expert's ratings decreased with increasing training time. A statistically significant difference in overall trainee–expert rating discordance between the two groups emerged at the end of the first training cycle and remained at every cycle thereafter (P < 0.013).By assisting inexperienced trainees in obtaining and interpreting standard basic obstetric scanning views, the use of artificial intelligence‐assisted systems has the potential to improve training effectiveness. © 2024 International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]
Published: 2024
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