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227 results on '"Zheng, Rong-Qin"'

7. Age-dependent Female Survival Advantage in Hepatocellular Carcinoma: A Multicenter Cohort Study

Author

Pang, Chuan, primary, Li, Jian-Ming, additional, Wang, Zhen, additional, Luo, Yan-Chun, additional, Cheng, Zhi-Gang, additional, Han, Zhi-Yu, additional, Liu, Fang-Yi, additional, Yu, Xiao-Ling, additional, Liang, Feng, additional, Xi, Hong-Qing, additional, Zheng, Rong-Qin, additional, Cheng, Wen, additional, Wei, Qiang, additional, Yu, Song-Yuan, additional, Li, Qin-Ying, additional, He, Guang-Zhi, additional, Yu, Jie, additional, and Liang, Ping, additional

Published
2023
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12. Contrast-enhanced ultrasound Liver Imaging Reporting and Data System (LI-RADS) in hepatocellular carcinoma ≤ 5cm: biological characteristics and patient outcomes

Author

Cai, Wen-jia, primary, Ying, Minghua, additional, Zheng, Rong-qin, additional, Liao, Jintang, additional, Luo, Baoming, additional, Tang, Lina, additional, Cheng, Wen, additional, Yang, Hong, additional, Wei, An, additional, Yang, Yilin, additional, Wang, Hui, additional, Luo, Yan-chun, additional, Liu, Cun, additional, Zhong, Hui, additional, Yang, Qi, additional, Yu, Jie, additional, and Liang, Ping, additional

Published
2023
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15. Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes.

Author

Cai, Wen-Jia, Ying, Minghua, Zheng, Rong-Qin, Liao, Jintang, Luo, Baoming, Tang, Lina, Cheng, Wen, Yang, Hong, Wei, An, Yang, Yilin, Wang, Hui, Luo, Yan-Chun, Liu, Cun, Zhong, Hui, Yang, Qi, Yu, Jie, and Liang, Ping

Subjects
CONTRAST-enhanced ultrasound, ULTRASONIC imaging, HEPATOCELLULAR carcinoma, KI-67 antigen, MEDIAN (Mathematics)
Abstract

Introduction: The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among different categories after radical resection. Methods: Between June 2017 and December 2020, standardized CEUS data of liver nodules were prospectively collected from multiple centers across China. We conducted a retrospective analysis of the prospectively collected data on HCCs measuring no more than 5 cm, as diagnosed by pathology. LI-RADS categories were assigned after thorough evaluation of CEUS features. Then, CEUS LI-RADS categories and major features were compared in different differentiation, Ki-67, and microvascular invasion (MVI) statuses. Differences in recurrence-free survival (RFS) among different LI-RADS categories were further analyzed. Results: A total of 293 HCC nodules in 293 patients were included. This study revealed significant differences in the CEUS LI-RADS category of HCCs among differentiation (p < 0.001) and levels of Ki-67 (p = 0.01) and that poor differentiation (32.7% in LR-M, 12% in LR-5, and 6.2% in LR-4) (p < 0.001) and high level of Ki-67 (median value 30%) were more frequently classified into the LR-M category, whereas well differentiation (37.5% in LR-4, 15.1% in LR-5, and 11.5% in LR-M) and low levels of Ki-67 (median value 11%) were more frequently classified into the LR-4 category. No significant differences were found between MVI and CEUS LI-RADS categories (p > 0.05). With a median follow-up of 23 months, HCCs assigned to different CEUS LI-RADS classes showed no significant differences in RFS after resection. Conclusions: Biological characteristics of HCC, including differentiation and level of Ki-67 expression, could influence major features of CEUS and impact the CEUS LI-RADS category. HCCs in different CEUS LI-RADS categories showed no significant differences in RFS after resection. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Period-Dependent Survival Benefit of Percutaneous Microwave Ablation for Hepatocellular Carcinoma: A 12-Year Real-World, Multicentric Experience

Author

Yu, Jie, primary, Cheng, Zhi-Gang, additional, Han, Zhi-Yu, additional, Liu, Fang-Yi, additional, Zheng, Rong-Qin, additional, Cheng, Wen, additional, Wei, Qiang, additional, Yu, Song-Yuan, additional, Li, Qin-ying, additional, He, Guang-zhi, additional, Luo, Yan-chun, additional, Yu, Xiao-Ling, additional, and Liang, Ping, additional

Published
2022
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26. Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Hepatocellular Carcinoma ≤5 cm: Biological Characteristics and Patient Outcomes

Author

Cai, Wen-Jia, Ying, Minghua, Zheng, Rong-Qin, Liao, Jintang, Luo, Baoming, Tang, Lina, Cheng, Wen, Yang, Hong, Wei, An, Yang, Yilin, Wang, Hui, Luo, Yan-Chun, Liu, Cun, Zhong, Hui, Yang, Qi, Yu, Jie, and Liang, Ping

Abstract

Introduction:The present study aimed to evaluate the influence of biological characteristics of hepatocellular carcinoma (HCC) on the Liver Imaging Reporting and Data System (LI-RADS) v2017 category of contrast-enhanced ultrasound (CEUS) in patients with high risk and compare the outcomes among different categories after radical resection. Methods:Between June 2017 and December 2020, standardized CEUS data of liver nodules were prospectively collected from multiple centers across China. We conducted a retrospective analysis of the prospectively collected data on HCCs measuring no more than 5 cm, as diagnosed by pathology. LI-RADS categories were assigned after thorough evaluation of CEUS features. Then, CEUS LI-RADS categories and major features were compared in different differentiation, Ki-67, and microvascular invasion (MVI) statuses. Differences in recurrence-free survival (RFS) among different LI-RADS categories were further analyzed. Results:A total of 293 HCC nodules in 293 patients were included. This study revealed significant differences in the CEUS LI-RADS category of HCCs among differentiation (p< 0.001) and levels of Ki-67 (p= 0.01) and that poor differentiation (32.7% in LR-M, 12% in LR-5, and 6.2% in LR-4) (p< 0.001) and high level of Ki-67 (median value 30%) were more frequently classified into the LR-M category, whereas well differentiation (37.5% in LR-4, 15.1% in LR-5, and 11.5% in LR-M) and low levels of Ki-67 (median value 11%) were more frequently classified into the LR-4 category. No significant differences were found between MVI and CEUS LI-RADS categories (p> 0.05). With a median follow-up of 23 months, HCCs assigned to different CEUS LI-RADS classes showed no significant differences in RFS after resection. Conclusions:Biological characteristics of HCC, including differentiation and level of Ki-67 expression, could influence major features of CEUS and impact the CEUS LI-RADS category. HCCs in different CEUS LI-RADS categories showed no significant differences in RFS after resection.

Published
2022
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27. Usefulness of New Shear Wave Elastography Technique for Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B: A Prospective Multicenter Study

Author

Wang, Jinfen, primary, Wu, Manli, primary, Linghu, Runze, primary, Chang, Jiandong, additional, Wu, Min, additional, Feng, Cheng, additional, Ren, Xinping, additional, Liu, Changzhu, additional, Lin, Jie, additional, Song, Tao, additional, Gu, Jionghui, additional, Zhang, Yao, additional, Fang, Ye, additional, Ma, Sumei, additional, Hu, Pingxiang, additional, Wu, Linsong, additional, Han, Xue, additional, Chen, Kaixuan, additional, Shi, Qiusheng, additional, Zhang, Ruifang, additional, Zhou, Qi, additional, Du, Ruiqing, additional, Gao, Yongyan, additional, Jing, Xiang, additional, Yang, Shunshi, additional, Zhou, Chang, additional, Zheng, Jian, additional, Liang, Ping, additional, and Zheng, Rong-Qin, additional

Published
2021
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31. Contrast‐Enhanced Ultrasound for Biliary Ischemia

Author

Zheng, Bo‐Wen, primary, Wu, Tao, additional, Ju, Jin‐Xiu, additional, Wu, Li‐Li, additional, Zhang, Hong‐Jun, additional, Lian, Yu‐Fan, additional, Tong, Ge, additional, Li, Qiao‐Jia, additional, Qiu, Chen, additional, Zhou, Hui‐Chao, additional, Zheng, Rong‐Qin, additional, and Ren, Jie, additional

Published
2020
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33. Two-dimensional real-time shear wave elastography and risk for de novo hepatocellular carcinoma in patients with advanced chronic liver disease

Author

Gu, Wenyi, primary, de Lédinghen, Victor, additional, Aubé, Christophe, additional, Krag, Aleksander, additional, Strassburg, Christian, additional, Castéra, Laurent, additional, Dumortier, Jérôme, additional, Friedrich-Rust, Mireen, additional, Pol, Stanislas, additional, Grgurevic, Ivica, additional, Zheng, Rong-Qin, additional, Francque, Sven, additional, Gottfriedova, Halima, additional, Sporea, Ioan, additional, Margini, Cristina, additional, Cassinotto, Christophe, additional, Boursier, Jerome, additional, Rasmussen, Ditlev, additional, Vilgrain, Valérie, additional, Guibal, Aymeric, additional, Zeuzem, Stefan, additional, Vassord, Camille, additional, Vonghia, Luisa, additional, Senkerikova, Renata, additional, Popescu, Alina, additional, Berzigotti, Annalisa, additional, Wang, Wenping, additional, Thiele, Maja, additional, Jansen, Christian, additional, and Trebicka, Jonel, additional

Published
2020
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34. Improving B-Mode Ultrasound &nbsp;Diagnostic Performance&nbsp;for Focal Liver Lesions Using Deep Learning:&nbsp;A Prospective&nbsp;Multicentre&nbsp;Study

Author

Liang, Ping, primary, Yang, Qi, additional, Wei, Jing-wei, additional, Hao, Xiao-han, additional, Kong, De-xing, additional, Yu, Xiao-ling, additional, Jiang, Tian-an, additional, Xi, Jun-qing, additional, Cai, Wen-jia, additional, Luo, Yan-chun, additional, Jing, Xiang, additional, Yang, Yi-lin, additional, Cheng, Zhi-gang, additional, Wu, Jin-yu, additional, Zhang, Hui-ping, additional, Liao, Jin-tang, additional, Zhou, Pei, additional, Song, Yu, additional, Zhang, Yao, additional, Han, Zhi-yu, additional, Cheng, Wen, additional, Tang, Li-na, additional, Liu, Fang-yi, additional, Dou, Jian-ping, additional, Zheng, Rong-qin, additional, Yu, Jie, additional, and Tian, Jie, additional

Published
2020
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40. Paclitaxel-loaded nanobubble targeted to pro-gastrin-releasing peptide inhibits the growth of small cell lung cancer

Author

Wang,Jin-Ping, Yan,Ji-Ping, Xu,Jing, Yin,Ting-Hui, Zheng,Rong-Qin, and Wang,Wei

Subjects
Cancer Management and Research
Abstract

Jin-Ping Wang,1,2 Ji-Ping Yan,2 Jing Xu,1 Ting-Hui Yin,3 Rong-Qin Zheng,3 Wei Wang11Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, Shanxi 030006, People’s Republic of China; 2Department of Ultrasound, Shanxi Province People’s Hospital, Taiyuan, Shanxi 030012, People’s Republic of China; 3Department of Medical Ultrasonic, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, People’s Republic of ChinaObjective: The aim of this work was to study the effects of paclitaxel-loaded nanobubbles targeting pro-gastrin-releasing peptide, designated as paclitaxel targeting nanobubbles, on small cell lung cancer (SCLC).Methods: Paclitaxel targeting nanobubbles were prepared by Thin-film hydration method. Subsequently, the prepared nanomaterials were tested for their in vitro effects on SCLC H446 cells proliferation, apoptosis and motility using the CCK-8 assay, flow cytometry and cell scratch test. Next, the potential molecular regulatory mechanisms of the prepared nanomaterials on H446 cells were evaluated by RT-PCR, Western blot and immunohistochemical detection. Finally, the in vivo effects of the constructed nanomaterials were assessed on SCLC tumor using tumor-burdened nude mice models.Results: Paclitaxel targeting nanobubbles significantly inhibited SCLC cell proliferation and migration, and promoted cell apoptosis. Moreover, the expression levels of Bcl-2, survivin, CDK2 and MMP-2 significantly decreased in SCLC cells treated with paclitaxel targeting nanobubbles, whereas the expression of caspase-3 and Rb were increased. There was a notable decrease in tumor size in vivo in SCLC nude mice models treated with paclitaxel targeting nanobubbles.Conclusion: Paclitaxel targeting nanobubbles effectively inhibited the proliferation, migration and invasion of SCLC cells and induced SCLC cells apoptosis. Hence, these nanobubbles show potential in SCLC-targeted drug treatment application.Keywords: paclitaxel, nanobubbles, proliferation, targeted therapy, small cell lung cancer

Published
2019

43. Contrast‐Enhanced Ultrasound for Biliary Ischemia: A Possible New Clinical Indication.

Author

Zheng, Bo‐Wen, Wu, Tao, Ju, Jin‐Xiu, Wu, Li‐Li, Zhang, Hong‐Jun, Lian, Yu‐Fan, Tong, Ge, Li, Qiao‐Jia, Qiu, Chen, Zhou, Hui‐Chao, Zheng, Rong‐Qin, and Ren, Jie

Subjects
CONTRAST-enhanced ultrasound, CLINICAL indications, RECEIVER operating characteristic curves, ISCHEMIA, BILIOUS diseases & biliousness
Abstract

Objectives: Biliary perfusion is considered to contribute to biliary diseases, but routine imaging methods are insufficient to show it. This research investigated the ability of contrast‐enhanced ultrasound (CEUS) for biliary perfusion in a biliary ischemia model. Methods: This research consisted of 2 parts. First, to determine whether CEUS enhancement of the tiny biliary wall represents biliary perfusion, a vascular tracer was used as a reference to evaluate the consistency with the enhancement of the biliary wall on CEUS and the staining by the vascular tracer under the conditions of occluded and recovered biliary perfusion. In the second part, the ability of CEUS for biliary ischemia was further evaluated with microvascular density measurement as a reference. The enhancement patterns were assigned CEUS scores, in which higher scores meant more decreased enhancement, and the diagnostic ability of CEUS was assessed by a receiver operating characteristic curve analysis. Results: The biliary wall was unstained by the vascular tracer and nonenhanced on CEUS when biliary perfusion was interrupted and was stained blue and enhanced after recovery. The biliary wall in the ischemia surgery group showed lower microvascular density measurements (P <.001), decreased enhancement levels (P <.001), and higher CEUS scores (P <.001). When a CEUS score of 3 or higher (obvious decrease of the biliary wall to hypoenhancement or nonenhancement in the arterial phase or rapid wash‐out to nonenhancement in the portal venous phase) was applied, CEUS had sensitivity of 87.8%, specificity of 98.3%, accuracy of 93.8%, and an area under the receiver operating characteristic curve of 0.98. Conclusions: Contrast enhancement of the biliary wall on CEUS represents biliary perfusion and has reasonably good diagnostic performance for biliary ischemia in an experimental animal setting. Access the CME test here and search by article title. [ABSTRACT FROM AUTHOR]

Published
2021
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48. Contrast‐EnhancedUltrasound for Biliary Ischemia

Author

Zheng, Bo‐Wen, Wu, Tao, Ju, Jin‐Xiu, Wu, Li‐Li, Zhang, Hong‐Jun, Lian, Yu‐Fan, Tong, Ge, Li, Qiao‐Jia, Qiu, Chen, Zhou, Hui‐Chao, Zheng, Rong‐Qin, and Ren, Jie

Abstract

Biliary perfusion is considered to contribute to biliary diseases, but routine imaging methods are insufficient to show it. This research investigated the ability of contrast‐enhanced ultrasound (CEUS) for biliary perfusion in a biliary ischemia model. This research consisted of 2 parts. First, to determine whether CEUS enhancement of the tiny biliary wall represents biliary perfusion, a vascular tracer was used as a reference to evaluate the consistency with the enhancement of the biliary wall on CEUS and the staining by the vascular tracer under the conditions of occluded and recovered biliary perfusion. In the second part, the ability of CEUS for biliary ischemia was further evaluated with microvascular density measurement as a reference. The enhancement patterns were assigned CEUS scores, in which higher scores meant more decreased enhancement, and the diagnostic ability of CEUS was assessed by a receiver operating characteristic curve analysis. The biliary wall was unstained by the vascular tracer and nonenhanced on CEUS when biliary perfusion was interrupted and was stained blue and enhanced after recovery. The biliary wall in the ischemia surgery group showed lower microvascular density measurements (P< .001), decreased enhancement levels (P< .001), and higher CEUS scores (P< .001). When a CEUS score of 3 or higher (obvious decrease of the biliary wall to hypoenhancement or nonenhancement in the arterial phase or rapid wash‐out to nonenhancement in the portal venous phase) was applied, CEUS had sensitivity of 87.8%, specificity of 98.3%, accuracy of 93.8%, and an area under the receiver operating characteristic curve of 0.98. Contrast enhancement of the biliary wall on CEUS represents biliary perfusion and has reasonably good diagnostic performance for biliary ischemia in an experimental animal setting. Access the CME test hereand search by article title.

Published
2021
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50. Free In-Plane Vibration Analysis of Annular Plates with General Boundary Conditions

Author

Dong Yan Shi, Xian Jie Shi, Wen L. Li, and Zheng Rong Qin

Subjects
Physics, Current (mathematics), Mechanical Engineering, Mathematical analysis, Zero (complex analysis), Stiffness, Vibration, In plane, Classical mechanics, Mechanics of Materials, Homogeneous, medicine, General Materials Science, Boundary value problem, medicine.symptom, Fourier series
Abstract

An analytical method is derived for the free in-plane vibration analysis of annular plates with general boundary conditions. Under this framework, all the classical homogeneous boundary conditions can be treated as the special cases when the stiffness for each restraining springs is equal to either zero or infinity. The improved Fourier series solutions for the in-plane vibrations are obtained by employing the Rayleigh-Ritz method. A numerical example is presented to demonstrate the accuracy and reliability of the current method.

Published
2013

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