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17 results on '"Zheng, Si-Lin"'

4. Synergistic effects of ceftazidime/avibactam combined with meropenem in a murine model of infection with KPC-producing Klebsiella pneumoniae.

Author

Zheng, Mei, Li, Fu-Hao, Liu, Juan, Li, Wen-Jie, Yin, Ruo-Xi, Cai, Da-Tong, Andrey, Diego O, Zheng, Si-Lin, Gales, Ana C, Zhang, Wan-Jiang, Sun, Jian, Liao, Xiao-Ping, and Yu, Yang

Subjects
CEFTAZIDIME, MEROPENEM, KLEBSIELLA infections, KLEBSIELLA pneumoniae, WHOLE genome sequencing, FOSFOMYCIN, LINEZOLID
Abstract

Objectives The emergence and expansion of carbapenem-resistant Klebsiella pneumoniae infections is a concern due to the lack of 'first-line' antibiotic treatment options. The ceftazidime/avibactam is an important clinical treatment for carbapenem-resistant K. pneumoniae infections but there is an increasing number of cases of treatment failure and drug resistance. Therefore, a potential solution is combination therapies that result in synergistic activity against K. pneumoniae carbapenemase: producing K. pneumoniae (KPC-Kp) isolates and preventing the emergence of KPC mutants resistant to ceftazidime/avibactam are needed in lieu of novel antibiotics. Methods To evaluate their synergistic activity, antibiotic combinations were tested against 26 KPC-Kp strains. Antibiotic resistance profiles, molecular characteristics and virulence genes were investigated by susceptibility testing and whole-genome sequencing. Antibiotic synergy was evaluated by in vitro chequerboard experiments, time-killing curves and dose–response assays. The mouse thigh model was used to confirm antibiotic combination activities in vivo. Additionally, antibiotic combinations were evaluated for their ability to prevent the emergence of ceftazidime/avibactam resistant mutations of bla KPC. Results The combination of ceftazidime/avibactam plus meropenem showed remarkable synergistic activity against 26 strains and restored susceptibility to both the partnering antibiotics. The significant therapeutic effect of ceftazidime/avibactam combined with meropenem was also confirmed in the mouse model and bacterial loads in the thigh muscle of the combination groups were significantly reduced. Furthermore, ceftazidime/avibactam plus meropenem showed significant activity in preventing the occurrence of resistance mutations. Conclusions Our results indicated that the combination of ceftazidime/avibactam plus meropenem offers viable therapeutic alternatives in treating serious infections due to KPC-Kp. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Implementing an evidence-based somatic acupressure intervention in breast cancer survivors with the symptom cluster of fatigue, sleep disturbance and depression: study protocol of a phase II randomised controlled trial

Author

Wang, Tao, primary, Tan, Jing-Yu (Benjamin), additional, Liu, Xian-Liang, additional, Zheng, Si-Lin, additional, Zhao, Isabella, additional, Eliseeva, Sabina, additional, Polotan, Mary Janice, additional, Cheng, Hui-Lin, additional, and Huang, Hou-Qiang, additional

Published
2022
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15. Global clonal spread of mcr-3-carrying MDR ST34 Salmonella enterica serotype Typhimurium and monophasic 1,4,[5],12:i:− variants from clinical isolates

Author

Sun, Ruan-Yang, primary, Ke, Bi-Xia, primary, Fang, Liang-Xing, primary, Guo, Wen-Ying, primary, Li, Xing-Ping, primary, Yu, Yang, primary, Zheng, Si-Lin, primary, Jiang, Yu-Wei, primary, He, Dong-Mei, primary, Sun, Jian, primary, Ke, Chang-Wen, primary, Liu, Ya-Hong, primary, and Liao, Xiao-Ping, primary

Published
2020
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16. miRNA-101-5p inhibits the growth and aggressiveness of NSCLC cells through targeting CXCL6

Author

Chen,Qi, Liu,Dan, Hu,Zhi, Luo,Cheng, and Zheng,Si Lin

Subjects
lung cancer, miR-101-5p, CXCL6, metastasis, neoplasms, OncoTargets and Therapy, respiratory tract diseases, Original Research
Abstract

Qi Chen,1,2 Dan Liu,3 Zhi Hu,4 Cheng Luo,1 Si Lin Zheng2 1State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China; 2Department of Nursing, The Affiliated Hospital of Southwest Medical University, Sichuan, 646000, China; 3Department of Respiratory and Critical Care Medicine, Pulmonary and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan, 646000, China; 4Department of Thoracic Surgery, The Affiliated Hospital of Southwest Medical University, Sichuan, 646000, China Background: The purpose of this study is to explore the potential biological roles of miR-101-5p in the progression of non-small-cell lung carcinoma (NSCLC). Methods: The levels of miR-101-5p and chemokine (C-X-C motif) ligand 6 (CXCL6) in NSCLC tissues and cells were detected using the quantitative real-time PCR (qRT-PCR) assay. Proliferation, colony formation, migration and invasion assays were conducted using miR-101-5p-transfected NSCLC cells invitro. The expression of CXCL6 was measured using immunofluorescence assay. Xenograft model and lung metastasis model were constructed to further reveal the precise roles of miR-101-5p in the lung metastasis and growth of NSCLC cells invivo. Results: miR-101-5p was underregulated in NSCLC tissues when compared with that in the normal controls. The levels of miR-101-5p were lower in NSCLC cells (H1975, A549, HCC827 and H1650) than in non-tumorigenic human bronchial epithelial cells (BEAS-2B). Overregulation of miR-101-5p restrained the aggressiveness phenotypes of NSCLC cells invitro. Furthermore, overregulation of miR-101-5p reduced the tumor growth and pulmonary metastasis of NSCLC cells invivo. CXCL6 was the target gene of miR-101-5p in NSCLC. The mRNA levels of CXCL6 were negatively associated with the levels of miR-101-5p in NSCLC tissues. Finally, the rescue experiments suggested that the inhibitory role of miR-101-5p was mediated by regulating the expression of CXCL6 in NSCLC. Conclusion: These findings indicated that overregulation of miR-101-5p restrained the progression of NSCLC cells by targeting CXCL6 and might function as a potential therapeutic target for NSCLC. Keywords: lung cancer, miR-101-5p, CXCL6, metastasis

Published
2019

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