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534 results on '"Zheng, Zhihua"'

21. Guidelines for the clinical application of the Xihuang pill for the prevention and treatment of breast hyperplasia diseases

Author

Tang, Hongmei, primary, Lu, Qin, additional, Feng, Shiyin, additional, Xiao, Zhiwei, additional, Wu, Wanyin, additional, Chen, Gaofeng, additional, Deng, Li, additional, Yu, Tianqi, additional, Wu, Junyan, additional, Lin, Hua, additional, Ji, Bo, additional, Lin, Jietao, additional, Zhang, Chengguang, additional, Li, Liming, additional, Liu, Tao, additional, Ouyang, Yong, additional, Lei, Kaijun, additional, Chen, Jun, additional, Peng, Weiwen, additional, Qiu, Zhenwen, additional, Cai, Qingqun, additional, Liang, Qi, additional, Liu, Cuiling, additional, Li, Yuzhen, additional, Zhu, Lixia, additional, Zhang, Zexin, additional, Liu, Xueting, additional, Lin, Lizhu, additional, and Zheng, Zhihua, additional

Published
2024
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28. Experimental study on the effect of different cement content on the improvement of dynamic characteristics of seismic-prone poor soil.

Author

Zhao, Yunhui, Qiao, Feng, Meng, Fanchao, Zheng, Zhihua, Gu, Jiapei, and Li, Haoyu

Subjects
MODULUS of rigidity, CEMENT, SANDY soils, EARTHQUAKE resistant design, ENGINEERING design
Abstract

The improvement of sandy soils with poor seismic properties to modify their dynamic characteristics is of great importance in seismic design for engineering sites. In this study, a series of dynamic tests on sandy soils sandy soils with poor seismic conditions were conducted using the GCTS resonant column system to investigate the improvements effects of different cement contents on dynamic characteristic parameters. The research findings are as follows: The cement content has certain influences on the dynamic shear modulus, dynamic shear modulus ratio, the maximum dynamic shear modulus, and the damping ratio of sandy soils with poor seismic properties. Among them, the influence on dynamic shear modulus is limited, while the damping ratio is significantly affected. The addition of cement to seismic-poor sandy soils significantly enhances their dynamic characteristics. The most noticeable improvement is observed when the cement content is 8%. Through curve fitting analysis, a relationship equation is established between the maximum dynamic shear modulus and the cement content, and the relevant parameters are provided. A comparative test between the improved soils and the remolded soils reveals that the addition of cement significantly improves the seismic performance of the poor soils. The recommended values for the range of variation of the dynamic shear modulus ratio and damping ratio are provided, considering the effect of improvement. These research findings provide reference guidelines for seismic design and engineering sites. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Gate‐Tunable Spectral Response in β‐Ga2O3/Te Hybrid Photogating Structure for Ultrasensitive Broadband Detection.

Author

Liu, Weijie, Peng, Meng, Yu, Yiye, Zheng, Zhihua, Jian, Pengcheng, Zhao, Yongming, Zeng, Yuhui, Xu, Dan, Chen, Maohua, Luo, Yuang, Chen, Changqing, Dai, Jiangnan, and Wu, Feng

Subjects
SPECTRAL sensitivity, OPTICAL communications, OPTOELECTRONIC devices, GALLIUM, TELLURIUM, PHOTOTRANSISTORS, INDIUM gallium zinc oxide, VOLTAGE
Abstract

The increasing demand for multispectral information acquisition and the complexity of application environments have sparked a growing interest in broadband detection. However, achieving a high level of responsivity across a wide response range remains a significant challenge. Herein, an ultrasensitive broadband phototransistor based on hybrid photogating (HPG) structure is demonstrated, which consisted of a quasi‐2D beta‐phase gallium oxide (β‐Ga2O3) nanoflake as the carrier transport channel and a tellurium (Te) nanoflake as the photogating layer. Attributed to the strong doping influence of the Te nanoflake, a low off‐state current of pA level and a high on/off current ratio of ≈108 are obtained. Upon 255 nm wavelength illumination, the device exhibited an ultrahigh responsivity up to 3.82 × 106 A W−1 and a detectivity as high as 1.59 × 1014 Jones across a large gate voltage range. Notably, an exciting infrared response is obtained with a responsivity of 138 A W−1 and a detectivity of 3.70 × 109 Jones under the 1550 nm wavelength illumination, exclusively achievable when the gate voltage exceeded 4 V. Leveraging the gate‐tunable spectral response, an innovative model for secure optical communication was proposed. This work presents an efficient and feasible strategy for fabricating multifunctional optoelectronic devices. [ABSTRACT FROM AUTHOR]

Published
2024
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32. UBE3C tunes autophagy via ATG4B ubiquitination

Author

Sun, Chaonan, primary, Chen, Yuxin, additional, Gu, Qianqian, additional, Fu, Yuanyuan, additional, Wang, Yao, additional, Liu, Cui, additional, Xie, Huazhong, additional, Liao, Yong, additional, Zheng, Zhihua, additional, Liu, Peiqing, additional, and Li, Min, additional

Published
2023
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35. Diagnostic Values of METTL1-Related Genes and Immune Characteristics in Systemic Lupus Erythematosus

Author

Liu, Yu, primary, Zhu, Enyi, additional, Lei, Yan, additional, Luo, Ailing, additional, Yan, Yaping, additional, Cai, Mansi, additional, Liu, Shanshan, additional, Huang, Yan, additional, Guan, Hui, additional, Zhong, Ming, additional, Li, Weinian, additional, Lin, Lian, additional, Hultström, Michael, additional, Lai, Enyin, additional, Zheng, Zhihua, additional, Liu, Xiaoping, additional, and Tang, Chun, additional

Published
2023
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36. Tacrolimus Causes Hypertension by Increasing Vascular Contractility via RhoA (Ras Homolog Family Member A)/ROCK (Rho-Associated Protein Kinase) Pathway in Mice

Author

Wang, Xiaohua, Jiang, Shan, Fei, Lingyan, Dong, Fang, Xie, Lanyu, Qiu, Xingyu, Lei, Yan, Guo, Jie, Zhong, Ming, Ren, Xiaoqiu, Yang, Yi, Zhao, Liang, Zhang, Gensheng, Wang, Honghong, Tang, Chun, Yu, Luyang, Liu, Ruisheng, Patzak, Andreas, Persson, Pontus B., Hultström, Michael, Wei, Qichun, Lai, En Yin, and Zheng, Zhihua

Published
2022
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37. UBE3C tunes autophagy via ATG4B ubiquitination.

Author

Sun, Chaonan, Chen, Yuxin, Gu, Qianqian, Fu, Yuanyuan, Wang, Yao, Liu, Cui, Xie, Huazhong, Liao, Yong, Zheng, Zhihua, Liu, Peiqing, and Li, Min

Subjects
UBIQUITINATION, GREEN fluorescent protein, AUTOPHAGY, POST-translational modification, TUBULINS, PROTEIN stability
Abstract

ATG4B is a core protein and essential for cleaving precursor MAP1LC3/LC3 or deconjugating lipidated LC3-II to drive the formation of autophagosomes. The protein stability and activity of ATG4B regulated by post-translational modification (ubiquitination) will directly affect macroautophagy/autophagy. However, the mechanism involved in ATG4B ubiquitination is largely unclear. In this study, a new E3 ligase of ATG4B, UBE3C, was identified by mass spectra. UBE3C mainly assembles K33-branched ubiquitin chains on ATG4B at Lys119 without causing ATG4B degradation. In addition, the increased ubiquitination of ATG4B caused by UBE3C overexpression inhibits autophagy flux in both normal and starvation conditions, which might be due to the reduced activity of ATG4B and ATG4B-LC3 interaction. This reduction could be reversed once the lysine 119 of ATG4B was mutated to arginine. More important, under starvation conditions the interaction between ATG4B and UBE3C apparently decreased followed by the removal of the K33-branched ubiquitin chain of ATG4B. Thus, starvation-induced autophagy could be partially suppressed by an increased ubiquitination level of ATG4B. In conclusion, our research reveals a novel modification mode of ATG4B in which UBE3C can fine tune ATG4B activity by specific ubiquitination regulating autophagy without causing ATG4B degradation. Abbreviation: ATG: autophagy-related; Baf: bafilomycin A1; CBB: Coomassie Brilliant Blue; CM: complete medium; CQ: chloroquine; GFP: green fluorescent protein; HA-Ub: HA-tagged ubiquitin; IF: immunofluorescence; IP: immunoprecipitation; K: lysine; KO: knockout; K0: all K-to-R mutant; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MS: mass spectrometry; NC: negative control; R: arginine; WCL: whole cell lysate; WT: wild-type. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Pan-cancer analysis of kinesin family members with potential implications in prognosis and immunological role in human cancer

Author

Zhong, Ming, primary, Gong, Lian, additional, Li, Na, additional, Guan, Hui, additional, Gong, Kai, additional, Zhong, Yong, additional, Zhu, Enyi, additional, Wang, Xiaohua, additional, Jiang, Shan, additional, Li, Jinhong, additional, Lei, Yan, additional, Liu, Yu, additional, Chen, Jiasi, additional, and Zheng, Zhihua, additional

Published
2023
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45. Integrating 2D layered materials with 3D bulk materials as van der Waals heterostructures for photodetections: Current status and perspectives

Author

Liu, Weijie, primary, Yu, Yiye, additional, Peng, Meng, additional, Zheng, Zhihua, additional, Jian, Pengcheng, additional, Wang, Yang, additional, Zou, Yuanchen, additional, Zhao, Yongming, additional, Wang, Fang, additional, Wu, Feng, additional, Chen, Changqing, additional, Dai, Jiangnan, additional, Wang, Peng, additional, and Hu, Weida, additional

Published
2023
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46. Piezo1 Mediates Vasodilation Induced by Acute Hyperglycemia in Mouse Renal Arteries and Microvessels

Author

Fei, Lingyan, primary, Xu, Minze, additional, Wang, Honghong, additional, Zhong, Cheng, additional, Jiang, Shan, additional, Lichtenberger, Falk-Bach, additional, Erdoğan, Cem, additional, Wang, Han, additional, Bonk, Julia S., additional, Lai, En Yin, additional, Persson, Pontus B., additional, Kovács, Richard, additional, Zheng, Zhihua, additional, Patzak, Andreas, additional, and Khedkar, Pratik H., additional

Published
2023
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47. A Provably-Secure Two-Factor Authenticated Key Exchange Protocol with Stronger Anonymity

Author

Yang, Xiaoyan, Jiang, Han, Hou, Mengbo, Zheng, Zhihua, Xu, Qiuliang, Choo, Kim-Kwang Raymond, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Au, Man Ho, editor, Yiu, Siu Ming, editor, Li, Jin, editor, Luo, Xiapu, editor, Wang, Cong, editor, Castiglione, Aniello, editor, and Kluczniak, Kamil, editor

Published
2018
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